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The map label for this gene is 21242863

Identifier: 21242863

GI number: 21242863

Start: 2483624

End: 2485150

Strand: Direct

Name: 21242863

Synonym: XAC2128

Alternate gene names: NA

Gene position: 2483624-2485150 (Clockwise)

Preceding gene: 21242862

Following gene: 21242864

Centisome position: 47.99

GC content: 64.9

Gene sequence:

>1527_bases
ATGAGCAACGCTGGTGGTCAGGACAGCGTCGATGTGGTGGTGGTCGGCAGCGGAGCGGGGGGAGGCCCGCTCGCAGCGCG
GCTTGCGCAAGCCGGCGTTTCGGTGGTCGTACTGGAAGCCGGCGCGGCATTTACGCCGGATTCGCACATTCCCGATGAGT
TGACCACCGGCATCTATTGGATGGACGAGCGCCTGAGCGGTGGGCAAACGCCCACTGCGTTCGGGCCGAATAATTCGGGC
TCCGGGCTCGGTGGTTCGACGTTGCATTGGGGCGCTTTTTGTCCATGGCCGGACAAGCGCGATCTCAGCCTTCTGACCCA
GACAGGGCAGGGCACCGACTGGCCGATCCCGCATCATGAGTTGGTCGCTTACGTTCGTCGCGTGGAGACCTTCATCGGGG
TCTCCGGTCCCATGCATTATCCGTGGGACCCCGAGCGCAGCTATGCGTATCGGCCACCACAACGCAATGCGTCGGCCACG
GCCATGGAACGCGGTTGCGGCGCACTTGGCATCCGGACCACCGATGCACCCGCCGCGTTGGTCACCAGGCCGCATCAGCA
GCCGCATTGGGGCCAGCGTGCGGCTTGCAACAACTGTGGTGCCTGTCACCAGGGCTGCAGCAACGCCGCCAAGGTGAGCG
TGGACATCACATGGCTGCCGTTGGCCAAAGCGCATGGTGCGCAATTGCGCACCGACAGCCGGGTAGTCGATCTTGAACGC
GACAGCCACGGCGCAGCGACTGCGGTGACCTATCGCCAGCATGGGCAGGAGTATCGCCAGCGCTGCAGCACCGTCTTCCT
GTGCGCAGGAGGTGTGGAGACACCGCGCTTGTTGCTCAACCTGGGGCTGGCCAACTCCAGCGGGCAGGTGGGGCGCAATT
TCATGGCGCACGTGGCGACCCAGGTGTGGGGTGAGTTCGACGCAGACATGCGCATGAATCGAGGGTATCCATCTTCGCTC
ATTACCGAAGACATGGTGCGCCCGGCGGATGCCAGCTTCATCGGCGGCTATCTGGTGCAGAGCCTGGGCGTACAGCCGGT
CACGCTCGCGAACACGCTGGCGCGCGGTGCCGGCCTGTGGGGCAGGGACCTGGTCGCAACGCTGCTGCGCTACAACCGTC
TGGCAGGTATCGGCATCAATGGCGAATGCCTGCCGCAGGACGCCAATCGCCTGACCTTGTCCGACGAACGGGACGCCTTC
GGGCAGCGCAAGGCGCGCATCGATTTCAGTTACGGTCCCAACGAGCAGGCCATCGACGCCCATGCGCGCGCATTGCTTCA
ATCGGTCTGGCAAGCCGCAGGCGCCCGCAACATCTTCGCGGCTGCGCGCTCGGCGCATACGCTCGGTACCTGCCGCATGG
GGACCGAACCTGCACAGGCCGTGGTCGATCCAGATGGCCGCACCTTCGACGTGCCGAACCTCTACATCTGCGACAACTCG
GTGTTTCCCAGCGCACTGGCAGCCAATCCGGCACTGACCCAGATGGCACTCGCGCTGCGCACCGCAGAACGTTTCCTTGC
GCGCTAG

Upstream 100 bases:

>100_bases
TTGCTGTCGGCAACGACACGGGCAATGGCCCCGTGGGCTATGTAGAGACGGCAGCGGGTCGGGATGAGCACTGGCAATTG
CGTGCGCCCGAGACTGCCCA

Downstream 100 bases:

>100_bases
CAGCACTGCGCCACCACGTACTCAACGACCAGGAGCTCAATATGGATCTCGGAATCAAACAGCGGATCGCCCTCATCAGT
GGCGGCGACTCCGGCATGGG

Product: 2-keto-gluconate dehydrogenase

Products: NA

Alternate protein names: GA 2-DH dehydrogenase subunit; GADH dehydrogenase subunit [H]

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MSNAGGQDSVDVVVVGSGAGGGPLAARLAQAGVSVVVLEAGAAFTPDSHIPDELTTGIYWMDERLSGGQTPTAFGPNNSG
SGLGGSTLHWGAFCPWPDKRDLSLLTQTGQGTDWPIPHHELVAYVRRVETFIGVSGPMHYPWDPERSYAYRPPQRNASAT
AMERGCGALGIRTTDAPAALVTRPHQQPHWGQRAACNNCGACHQGCSNAAKVSVDITWLPLAKAHGAQLRTDSRVVDLER
DSHGAATAVTYRQHGQEYRQRCSTVFLCAGGVETPRLLLNLGLANSSGQVGRNFMAHVATQVWGEFDADMRMNRGYPSSL
ITEDMVRPADASFIGGYLVQSLGVQPVTLANTLARGAGLWGRDLVATLLRYNRLAGIGINGECLPQDANRLTLSDERDAF
GQRKARIDFSYGPNEQAIDAHARALLQSVWQAAGARNIFAAARSAHTLGTCRMGTEPAQAVVDPDGRTFDVPNLYICDNS
VFPSALAANPALTQMALALRTAERFLAR

Sequences:

>Translated_508_residues
MSNAGGQDSVDVVVVGSGAGGGPLAARLAQAGVSVVVLEAGAAFTPDSHIPDELTTGIYWMDERLSGGQTPTAFGPNNSG
SGLGGSTLHWGAFCPWPDKRDLSLLTQTGQGTDWPIPHHELVAYVRRVETFIGVSGPMHYPWDPERSYAYRPPQRNASAT
AMERGCGALGIRTTDAPAALVTRPHQQPHWGQRAACNNCGACHQGCSNAAKVSVDITWLPLAKAHGAQLRTDSRVVDLER
DSHGAATAVTYRQHGQEYRQRCSTVFLCAGGVETPRLLLNLGLANSSGQVGRNFMAHVATQVWGEFDADMRMNRGYPSSL
ITEDMVRPADASFIGGYLVQSLGVQPVTLANTLARGAGLWGRDLVATLLRYNRLAGIGINGECLPQDANRLTLSDERDAF
GQRKARIDFSYGPNEQAIDAHARALLQSVWQAAGARNIFAAARSAHTLGTCRMGTEPAQAVVDPDGRTFDVPNLYICDNS
VFPSALAANPALTQMALALRTAERFLAR
>Mature_507_residues
SNAGGQDSVDVVVVGSGAGGGPLAARLAQAGVSVVVLEAGAAFTPDSHIPDELTTGIYWMDERLSGGQTPTAFGPNNSGS
GLGGSTLHWGAFCPWPDKRDLSLLTQTGQGTDWPIPHHELVAYVRRVETFIGVSGPMHYPWDPERSYAYRPPQRNASATA
MERGCGALGIRTTDAPAALVTRPHQQPHWGQRAACNNCGACHQGCSNAAKVSVDITWLPLAKAHGAQLRTDSRVVDLERD
SHGAATAVTYRQHGQEYRQRCSTVFLCAGGVETPRLLLNLGLANSSGQVGRNFMAHVATQVWGEFDADMRMNRGYPSSLI
TEDMVRPADASFIGGYLVQSLGVQPVTLANTLARGAGLWGRDLVATLLRYNRLAGIGINGECLPQDANRLTLSDERDAFG
QRKARIDFSYGPNEQAIDAHARALLQSVWQAAGARNIFAAARSAHTLGTCRMGTEPAQAVVDPDGRTFDVPNLYICDNSV
FPSALAANPALTQMALALRTAERFLAR

Specific function: Part of the heterotrimer that catalyzes the conversion of D-gluconate to 2-dehydro-D-gluconate. This subunit functions as the dehydrogenase [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Periplasmic side (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.3 [H]

Molecular weight: Translated: 54270; Mature: 54138

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNAGGQDSVDVVVVGSGAGGGPLAARLAQAGVSVVVLEAGAAFTPDSHIPDELTTGIYW
CCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHCCEEE
MDERLSGGQTPTAFGPNNSGSGLGGSTLHWGAFCPWPDKRDLSLLTQTGQGTDWPIPHHE
EEHHCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCHHEEECCCCCCCCCCHHH
LVAYVRRVETFIGVSGPMHYPWDPERSYAYRPPQRNASATAMERGCGALGIRTTDAPAAL
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEEEECCCCCHHH
VTRPHQQPHWGQRAACNNCGACHQGCSNAAKVSVDITWLPLAKAHGAQLRTDSRVVDLER
HCCCCCCCCCCCHHHHCCCCHHHHCCCCCEEEEEEEEEEECCCCCCCEECCCCEEEEEEC
DSHGAATAVTYRQHGQEYRQRCSTVFLCAGGVETPRLLLNLGLANSSGQVGRNFMAHVAT
CCCCCEEEHHHHHHHHHHHHHCCEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHH
QVWGEFDADMRMNRGYPSSLITEDMVRPADASFIGGYLVQSLGVQPVTLANTLARGAGLW
HHHCCCCCCHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCC
GRDLVATLLRYNRLAGIGINGECLPQDANRLTLSDERDAFGQRKARIDFSYGPNEQAIDA
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCHHHHCCCCEEEEECCCCCCHHHHH
HARALLQSVWQAAGARNIFAAARSAHTLGTCRMGTEPAQAVVDPDGRTFDVPNLYICDNS
HHHHHHHHHHHHCCCHHHHHHHHCCCCCEEECCCCCCCCEEECCCCCEECCCEEEEECCC
VFPSALAANPALTQMALALRTAERFLAR
CCCHHHHCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNAGGQDSVDVVVVGSGAGGGPLAARLAQAGVSVVVLEAGAAFTPDSHIPDELTTGIYW
CCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHCCEEE
MDERLSGGQTPTAFGPNNSGSGLGGSTLHWGAFCPWPDKRDLSLLTQTGQGTDWPIPHHE
EEHHCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCHHEEECCCCCCCCCCHHH
LVAYVRRVETFIGVSGPMHYPWDPERSYAYRPPQRNASATAMERGCGALGIRTTDAPAAL
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEEEECCCCCHHH
VTRPHQQPHWGQRAACNNCGACHQGCSNAAKVSVDITWLPLAKAHGAQLRTDSRVVDLER
HCCCCCCCCCCCHHHHCCCCHHHHCCCCCEEEEEEEEEEECCCCCCCEECCCCEEEEEEC
DSHGAATAVTYRQHGQEYRQRCSTVFLCAGGVETPRLLLNLGLANSSGQVGRNFMAHVAT
CCCCCEEEHHHHHHHHHHHHHCCEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHH
QVWGEFDADMRMNRGYPSSLITEDMVRPADASFIGGYLVQSLGVQPVTLANTLARGAGLW
HHHCCCCCCHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCC
GRDLVATLLRYNRLAGIGINGECLPQDANRLTLSDERDAFGQRKARIDFSYGPNEQAIDA
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCHHHHCCCCEEEEECCCCCCHHHHH
HARALLQSVWQAAGARNIFAAARSAHTLGTCRMGTEPAQAVVDPDGRTFDVPNLYICDNS
HHHHHHHHHHHHCCCHHHHHHHHCCCCCEEECCCCCCCCEEECCCCCEECCCEEEEECCC
VFPSALAANPALTQMALALRTAERFLAR
CCCHHHHCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9352901 [H]