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The map label for this gene is syrE1 [H]

Identifier: 21242833

GI number: 21242833

Start: 2445193

End: 2449893

Strand: Direct

Name: syrE1 [H]

Synonym: XAC2097

Alternate gene names: 21242833

Gene position: 2445193-2449893 (Clockwise)

Preceding gene: 21242832

Following gene: 21242834

Centisome position: 47.25

GC content: 59.52

Gene sequence:

>4701_bases
ATGCGGAGCGTCACGGGACGAACTGTACCCATCATCAAGGACTATGCAATGCAAACGACCGATCGGTCTGTCTTTCCGCT
GAGCAGTCCTCAGAGAGAGATCTGGTTGGAACAACTGATGCTCGGGCAGTCGGTTTCTTCCAACATCGGTGGCTATATCG
AGATCGATGGCGATATCGATGTCGGATGCTTGCAGCATGCGGCACAAACATTAGTCGATCAATGCGAAGTCCTGCGGATG
TGCATAACGGAAGACGTGGACGAGGAGGGAATCCCGCTGCAGTGCTTCGCTGAGACGATGCATCTGCCCGTGCCATTCGC
CGATATTACGTCTGTGCAGGACCGTCAGGGATGGCTGGAGCAATGGATCCAGGAGCACATGGAGACGCCGTTTCAGTTCG
ACGGCACGCCGCTGATGCGCCTTTCGTTGTGCCGCTTCGATGCTGGCAAGTGGTATCTGATGGTGAGCCTGCACCACATC
CTGATGGATGGCTGGTCCTTGTTCCTGACGATAGAAACTCTGGGCCGCCTCTACAGCGAAATGCGTGAGGGCCGTCCGGC
GACAGTGGACGTCAGATCCTACCGTGACTTCATCGAGAGCGATCGTTCCTACCAGCACTCCGCGCAGTACGAGACCGATC
GTCAATACTGGCTGGCAAAGTATTCCGTGCTTCCAGAACCCCTGTTCTCCACTGCCCCGGGGGCAATGTCCACTGCGGAG
GTGTCGGGTGTCAGCGTCAACCTTGTTCATGAATTTCCTGCCGATCTGCTGGATCGACTGACACGGCTAGCCACCGATCA
CGGCGTATCCCAGTTTCAGATCCTCCTTGTCCTTCTCTATGCCTACTTCTCTCGCACGCAACAGCGTGAAGAGTTGGTCG
TCGGCGTGCCGATCCTCAATCGTGCCGGTCACCAGTTCAAGAATTCGATTGGACTGTGCGCACAGATAAATCCGGTGCGC
ATGCGCTTCGACCCTGCGATGCCTTTCATTGATGCGGTGCGACTAGTGTCGCGAGAATTGCGCAAGGACTACCGTCATCA
GCGCTTTCCTGTCAGCGAGATGGGGCGTGCCTGTGGATTGTGGAAGAGTGGTGCGACGCGCTTTTTCGAGATGGTGTTTT
CCTTCGAGCAAACCGGACACGTGTATCGCTTCGGAGTCGCGCGAGGAGTTTTTGTCAAGGCATCCAATAATCGCGAATAC
AATCCGTTGTCGTTGTACGTCAGGCGCAACGCCAATGACGATATTGCTTGGCTCCATGCGATCTACAACAAGGGCTATTT
TGCTGCCGACCAGGTAGCACAAATGACGCAGCGTCTGGTCCAGCTCATGATGCAGGTGGTGGCGCACCCGAGCCGTCCTT
TGAACCAGATCGAACTATGTACCGCCGATGAGCTGGCATGCCTGGATACCTGGAGTCGCGGCAGGAAAACGCAGATGCCG
GTGGCGACGCTGCCTGCGATGTTCGAGGCGCAGGTAGAGCGGACACCGGATGCGATAGCAGTGGCCTTTGGTGACTTGCG
CCTGACCTATGCCCAGCTCAATGCAAGGTCGAATCAGCTTGCGCATCACTTGATTGCACTTGGGATTGGGCCGGACCAGC
GCATCGCCTTGTGCATGGAGCGCTGCCCCGAATTGGTGGTGGCGTTGCTTGCGGTCCTGAAGGCAGGCAGTGCCTATGTT
CCGCTGGATCCGCGTTATCCGTCCGAGCGTCTGGCTTACATGCTGTCCGACAGCACACCGCGTGCGCTCATCGTCCATTC
GGCAACGCGCGATCTGTTGGAGGACACAAACGCCATCCTGATCGATGTGGATACGCCTGAGTGGCTGCATCGGCCCACCG
ATACTCCGCTGGTCGCAGGGTTTGCGCCGTGCCATCTGGCGTATGTGATCTATACCTCCGGCTCCAGCGGTCGTCCGAAG
GGGGTGATGGTTCCCCACGACGCCCTGAGCAACTACCTGCATTGGGCGATCGACCACTATCACCCCCGGCAAGGCGCAGT
GGTGTCGTCGTCGCTTTCGTTCGATGCAACCGTCACCAGTCTATACCTGCCTTTGCTATGTGGCGGTACCACCGAACTGC
TTCCTGAGCGGGACGAGATCGAGGCCTTGTTGAAGCGAGTCTGCGCCGATCAGCCACTGTGCTTGGTCAAGATCACGCCG
GCCCACCTGGATGTCTTGACGCAGCAGCTGGCTGCCTGTGGCGGTACTCCGTCGGTGTCGTTGTTTGTAGTCGGTGGCGA
GGCCTTGCACGCATCGACGGTCAAGCGATTGCGTCAGCTTGCACCTCATGCGCGCGTGGTCAATGAGTATGGGCCGACCG
AAACGGTGGTCGGATGCGTGGCGTATGAAATCCCACTGGATTGGGACGCAGGCACATTAGCCACCATTCCGATCGGGCGG
CCGATCGACAATATGCGTGTCTATCTGCTGGATGCGAATAGGCAGACGGTTCCTGCTGGTGTGGCCGGAGAACTGTGCAT
CGCTGGCAGCCAGGTCACGCGTGGCTATCTCAATCGTCCAGAGTTGACCGAGCAACGCTTCGTGGTCGATCCATTCGGCA
CTGGGCCGGAGCAACGAATGTATTGCAGCGGCGACCTGGCGCGCTGGATGCCCGACGGAACGCTCGAGTACCTCGGGCGT
AACGATGACCAGATCAAATTGCGCGGTTTTCGGATCGAGCCTGCGGAGGTGAGCTCCAGGATCCTGGACAACCCGTTGGT
GGCCGATGCGGCGGTGGTGATTCACACTGCCGCATCGGGAGAAAAATGTCTTGTGGCGTACTACGTGAGCGACGCGCCCG
AGGTGACTGCCGAGCGTCTGCGCGAGCAGCTGCAGCAGCGGCTTCCCGATTACATGGTGCCTGCGGTTTACATCCGCATG
GACCTATTGCCGATGACACCCAATGGCAAGTTGGATCGTCATGCCTTGCCTGCGCCCGATGCACAGGCGTATGCCCAGCA
GGGGTATGTGTCGCCTGAGGGACCGACCGAACAGTTGCTTGCCGTTCTATGGAGCGATGTCCTGAAGATCGAGCAAGTCG
GTCGATACGATCACTTCTTCGAGCTTGGCGGGCACTCCCTTCTAATCGTCGCGTTATTGGAGCGGATGCGACAGCATGGC
CTTGAAGCCAATGTAAAGTCCCTGCTTGCTCGACCCACCGTGATGGGGATGGCGGCGGCGGTTGGCGCCAGTCGCGACGA
GAAGATTCCCGAGCCGCGCATTCCAGAAGGGTGCGACCGCATCACGCCGGATCTGCTTCCGCTGGTGGAGCTGTCACAGC
AAGCAATCGATACCATCGTCAGCACGGTGCCCGGTGGTGCGCGCAACGTGCAGGACATCTATCCGGCGGCACCACTGCAG
GAAGGCATTGCCTACCATCATTTGACAGCGACTCAGGGCGATCCCTATCTGCAATATGCGCTGTTCGTTTTTTCGGATCG
GGCTCGCCTGGATGCATTCGCAGCCGCGCTCCAGTGCGTGGTCGCACGTTACGACATTCTGCGCACTGCGTTGATCTGGG
AGCAGTTGGATGCGCCGCTCCAGGTGGTCTGGCGGCAGGCGACCGTGCCGATGATCGAGATTGCGGTGGGTCCTGCTGAG
GAGGATGTCCTACAACTGCTGCGTGCCCACCTGGATCCGGCGCGCCAGCAACTCGATCTGCGGCAAGCTCCCTTGCTGCG
TCTGTGCTATGCCTACGATGGCGTCGGCCAACGTTGGGTGGGCGGGCTACTGTTCCACCATTTGGTCGGAGACGCTGCGT
CCCTGACAGGGTTGCTGGAAGAGATCGACAGCCATCTGCGCGGAGACGGCGCACGATTGCCGCCGCCGTTCCGGTATCGC
ACCTATACCATGCATGCCCGCCGCGATCAGCACGCAGAGGAACACGCGCGCTTTTTCAAGGAAATGCTCGGCGATGTGTG
CGAGCCGACCATTGCATTCGGGTTGCAGGATCAAGGTGTGGTTGACCAGCAAGTGCGCAAGGCAGTCATCCAGATCGACG
CCTCGATTGCGCAGCGGTTGCAAGTACAGGCGAGGCGATTGGGGGTTAGCGTTGCCACGTTGTGTCACGTCGCCTGGGCG
CAGGTGCTTTCCGCAGCGTCGGGGCAGCAGGACGTGGTCTTCGGCACCGTCATGCTGGGGAGAACGCAGGGAAAGGAGAT
CGAACGTGCCATCGGAATGTTCATCAACACGTTGCCGATCCGGGTTCGCTTGGGTCGGGCCAGCGTGCGTGCCGTCATCA
AGCAGACGCATGCCTGGCTGAGTGAGCTGTTGGCGCATGAACACGCTTCGCTGTCGCTGGCGCAGCGTTGTAGCCGCATG
TACACACAGCGCGTGTTGTTCAATGCATTGTTCAACTATCGCCGGCTGAGTCGGGCCAATCTCAATGGCACCGTGCTGCA
GGCGTGGCCGGGGATTGATGTTCTGGGGGGAGAAGAACGTAGCACCTATCCGGTGAGCCTCTCCATGGATGATCTTGGCG
ATGGTTTCCAACTGACGGCGCAGGCCTCGGCAGACGGCGTGCCCGCCAGAATGTGTGCCTACATGCAAACCGCATTGCAG
CAGCTGGCCGACGCGCTCGAGCATGAGCGGGAGACGCCGATCAGCCAGCTGTGCGTGCTGCCGCCAGCAGAGCGCCAGCG
TTTGCTGGGCTTCAACCTGCAGCATCGCGCGGCTGAGGCAGTGGATTCGTTGGCGCCGTGA

Upstream 100 bases:

>100_bases
TAACTGTGCCTCAATCAAATGGGCAGGCTGGAATATAAAAAAGTAGCGCCCATCATCTCCCCTATCACTTGGGCAACAGT
ATTCGGTCGCCGCATTCTTC

Downstream 100 bases:

>100_bases
CCAGGTATCACCGTGTTGCAGACGCAGGGAGTCAATCACTACCCGGTGGTGCTCGACGTAGAGGAAATGGATGACGGGAT
TCGCCTGACGGGTTATTTGC

Product: ATP-dependent serine activating enzyme

Products: pyrophosphate; AMP; enterobactin; pyrophosphate; L-Seryl-AMP [C]

Alternate protein names: Tyrocidine synthase III; ATP-dependent asparagine adenylase; AsnA; Asparagine activase; ATP-dependent glutamine adenylase; GlnA; Glutamine activase; ATP-dependent tyrosine adenylase; TyrA; Tyrosine activase; ATP-dependent valine adenylase; ValA; Valine activase; ATP-dependent ornithine adenylase; OrnA; Ornithine activase; ATP-dependent leucine adenylase; LeuA; Leucine activase [H]

Number of amino acids: Translated: 1566; Mature: 1566

Protein sequence:

>1566_residues
MRSVTGRTVPIIKDYAMQTTDRSVFPLSSPQREIWLEQLMLGQSVSSNIGGYIEIDGDIDVGCLQHAAQTLVDQCEVLRM
CITEDVDEEGIPLQCFAETMHLPVPFADITSVQDRQGWLEQWIQEHMETPFQFDGTPLMRLSLCRFDAGKWYLMVSLHHI
LMDGWSLFLTIETLGRLYSEMREGRPATVDVRSYRDFIESDRSYQHSAQYETDRQYWLAKYSVLPEPLFSTAPGAMSTAE
VSGVSVNLVHEFPADLLDRLTRLATDHGVSQFQILLVLLYAYFSRTQQREELVVGVPILNRAGHQFKNSIGLCAQINPVR
MRFDPAMPFIDAVRLVSRELRKDYRHQRFPVSEMGRACGLWKSGATRFFEMVFSFEQTGHVYRFGVARGVFVKASNNREY
NPLSLYVRRNANDDIAWLHAIYNKGYFAADQVAQMTQRLVQLMMQVVAHPSRPLNQIELCTADELACLDTWSRGRKTQMP
VATLPAMFEAQVERTPDAIAVAFGDLRLTYAQLNARSNQLAHHLIALGIGPDQRIALCMERCPELVVALLAVLKAGSAYV
PLDPRYPSERLAYMLSDSTPRALIVHSATRDLLEDTNAILIDVDTPEWLHRPTDTPLVAGFAPCHLAYVIYTSGSSGRPK
GVMVPHDALSNYLHWAIDHYHPRQGAVVSSSLSFDATVTSLYLPLLCGGTTELLPERDEIEALLKRVCADQPLCLVKITP
AHLDVLTQQLAACGGTPSVSLFVVGGEALHASTVKRLRQLAPHARVVNEYGPTETVVGCVAYEIPLDWDAGTLATIPIGR
PIDNMRVYLLDANRQTVPAGVAGELCIAGSQVTRGYLNRPELTEQRFVVDPFGTGPEQRMYCSGDLARWMPDGTLEYLGR
NDDQIKLRGFRIEPAEVSSRILDNPLVADAAVVIHTAASGEKCLVAYYVSDAPEVTAERLREQLQQRLPDYMVPAVYIRM
DLLPMTPNGKLDRHALPAPDAQAYAQQGYVSPEGPTEQLLAVLWSDVLKIEQVGRYDHFFELGGHSLLIVALLERMRQHG
LEANVKSLLARPTVMGMAAAVGASRDEKIPEPRIPEGCDRITPDLLPLVELSQQAIDTIVSTVPGGARNVQDIYPAAPLQ
EGIAYHHLTATQGDPYLQYALFVFSDRARLDAFAAALQCVVARYDILRTALIWEQLDAPLQVVWRQATVPMIEIAVGPAE
EDVLQLLRAHLDPARQQLDLRQAPLLRLCYAYDGVGQRWVGGLLFHHLVGDAASLTGLLEEIDSHLRGDGARLPPPFRYR
TYTMHARRDQHAEEHARFFKEMLGDVCEPTIAFGLQDQGVVDQQVRKAVIQIDASIAQRLQVQARRLGVSVATLCHVAWA
QVLSAASGQQDVVFGTVMLGRTQGKEIERAIGMFINTLPIRVRLGRASVRAVIKQTHAWLSELLAHEHASLSLAQRCSRM
YTQRVLFNALFNYRRLSRANLNGTVLQAWPGIDVLGGEERSTYPVSLSMDDLGDGFQLTAQASADGVPARMCAYMQTALQ
QLADALEHERETPISQLCVLPPAERQRLLGFNLQHRAAEAVDSLAP

Sequences:

>Translated_1566_residues
MRSVTGRTVPIIKDYAMQTTDRSVFPLSSPQREIWLEQLMLGQSVSSNIGGYIEIDGDIDVGCLQHAAQTLVDQCEVLRM
CITEDVDEEGIPLQCFAETMHLPVPFADITSVQDRQGWLEQWIQEHMETPFQFDGTPLMRLSLCRFDAGKWYLMVSLHHI
LMDGWSLFLTIETLGRLYSEMREGRPATVDVRSYRDFIESDRSYQHSAQYETDRQYWLAKYSVLPEPLFSTAPGAMSTAE
VSGVSVNLVHEFPADLLDRLTRLATDHGVSQFQILLVLLYAYFSRTQQREELVVGVPILNRAGHQFKNSIGLCAQINPVR
MRFDPAMPFIDAVRLVSRELRKDYRHQRFPVSEMGRACGLWKSGATRFFEMVFSFEQTGHVYRFGVARGVFVKASNNREY
NPLSLYVRRNANDDIAWLHAIYNKGYFAADQVAQMTQRLVQLMMQVVAHPSRPLNQIELCTADELACLDTWSRGRKTQMP
VATLPAMFEAQVERTPDAIAVAFGDLRLTYAQLNARSNQLAHHLIALGIGPDQRIALCMERCPELVVALLAVLKAGSAYV
PLDPRYPSERLAYMLSDSTPRALIVHSATRDLLEDTNAILIDVDTPEWLHRPTDTPLVAGFAPCHLAYVIYTSGSSGRPK
GVMVPHDALSNYLHWAIDHYHPRQGAVVSSSLSFDATVTSLYLPLLCGGTTELLPERDEIEALLKRVCADQPLCLVKITP
AHLDVLTQQLAACGGTPSVSLFVVGGEALHASTVKRLRQLAPHARVVNEYGPTETVVGCVAYEIPLDWDAGTLATIPIGR
PIDNMRVYLLDANRQTVPAGVAGELCIAGSQVTRGYLNRPELTEQRFVVDPFGTGPEQRMYCSGDLARWMPDGTLEYLGR
NDDQIKLRGFRIEPAEVSSRILDNPLVADAAVVIHTAASGEKCLVAYYVSDAPEVTAERLREQLQQRLPDYMVPAVYIRM
DLLPMTPNGKLDRHALPAPDAQAYAQQGYVSPEGPTEQLLAVLWSDVLKIEQVGRYDHFFELGGHSLLIVALLERMRQHG
LEANVKSLLARPTVMGMAAAVGASRDEKIPEPRIPEGCDRITPDLLPLVELSQQAIDTIVSTVPGGARNVQDIYPAAPLQ
EGIAYHHLTATQGDPYLQYALFVFSDRARLDAFAAALQCVVARYDILRTALIWEQLDAPLQVVWRQATVPMIEIAVGPAE
EDVLQLLRAHLDPARQQLDLRQAPLLRLCYAYDGVGQRWVGGLLFHHLVGDAASLTGLLEEIDSHLRGDGARLPPPFRYR
TYTMHARRDQHAEEHARFFKEMLGDVCEPTIAFGLQDQGVVDQQVRKAVIQIDASIAQRLQVQARRLGVSVATLCHVAWA
QVLSAASGQQDVVFGTVMLGRTQGKEIERAIGMFINTLPIRVRLGRASVRAVIKQTHAWLSELLAHEHASLSLAQRCSRM
YTQRVLFNALFNYRRLSRANLNGTVLQAWPGIDVLGGEERSTYPVSLSMDDLGDGFQLTAQASADGVPARMCAYMQTALQ
QLADALEHERETPISQLCVLPPAERQRLLGFNLQHRAAEAVDSLAP
>Mature_1566_residues
MRSVTGRTVPIIKDYAMQTTDRSVFPLSSPQREIWLEQLMLGQSVSSNIGGYIEIDGDIDVGCLQHAAQTLVDQCEVLRM
CITEDVDEEGIPLQCFAETMHLPVPFADITSVQDRQGWLEQWIQEHMETPFQFDGTPLMRLSLCRFDAGKWYLMVSLHHI
LMDGWSLFLTIETLGRLYSEMREGRPATVDVRSYRDFIESDRSYQHSAQYETDRQYWLAKYSVLPEPLFSTAPGAMSTAE
VSGVSVNLVHEFPADLLDRLTRLATDHGVSQFQILLVLLYAYFSRTQQREELVVGVPILNRAGHQFKNSIGLCAQINPVR
MRFDPAMPFIDAVRLVSRELRKDYRHQRFPVSEMGRACGLWKSGATRFFEMVFSFEQTGHVYRFGVARGVFVKASNNREY
NPLSLYVRRNANDDIAWLHAIYNKGYFAADQVAQMTQRLVQLMMQVVAHPSRPLNQIELCTADELACLDTWSRGRKTQMP
VATLPAMFEAQVERTPDAIAVAFGDLRLTYAQLNARSNQLAHHLIALGIGPDQRIALCMERCPELVVALLAVLKAGSAYV
PLDPRYPSERLAYMLSDSTPRALIVHSATRDLLEDTNAILIDVDTPEWLHRPTDTPLVAGFAPCHLAYVIYTSGSSGRPK
GVMVPHDALSNYLHWAIDHYHPRQGAVVSSSLSFDATVTSLYLPLLCGGTTELLPERDEIEALLKRVCADQPLCLVKITP
AHLDVLTQQLAACGGTPSVSLFVVGGEALHASTVKRLRQLAPHARVVNEYGPTETVVGCVAYEIPLDWDAGTLATIPIGR
PIDNMRVYLLDANRQTVPAGVAGELCIAGSQVTRGYLNRPELTEQRFVVDPFGTGPEQRMYCSGDLARWMPDGTLEYLGR
NDDQIKLRGFRIEPAEVSSRILDNPLVADAAVVIHTAASGEKCLVAYYVSDAPEVTAERLREQLQQRLPDYMVPAVYIRM
DLLPMTPNGKLDRHALPAPDAQAYAQQGYVSPEGPTEQLLAVLWSDVLKIEQVGRYDHFFELGGHSLLIVALLERMRQHG
LEANVKSLLARPTVMGMAAAVGASRDEKIPEPRIPEGCDRITPDLLPLVELSQQAIDTIVSTVPGGARNVQDIYPAAPLQ
EGIAYHHLTATQGDPYLQYALFVFSDRARLDAFAAALQCVVARYDILRTALIWEQLDAPLQVVWRQATVPMIEIAVGPAE
EDVLQLLRAHLDPARQQLDLRQAPLLRLCYAYDGVGQRWVGGLLFHHLVGDAASLTGLLEEIDSHLRGDGARLPPPFRYR
TYTMHARRDQHAEEHARFFKEMLGDVCEPTIAFGLQDQGVVDQQVRKAVIQIDASIAQRLQVQARRLGVSVATLCHVAWA
QVLSAASGQQDVVFGTVMLGRTQGKEIERAIGMFINTLPIRVRLGRASVRAVIKQTHAWLSELLAHEHASLSLAQRCSRM
YTQRVLFNALFNYRRLSRANLNGTVLQAWPGIDVLGGEERSTYPVSLSMDDLGDGFQLTAQASADGVPARMCAYMQTALQ
QLADALEHERETPISQLCVLPPAERQRLLGFNLQHRAAEAVDSLAP

Specific function: Incorporates six amino acids (for tyrocidine A, Asn, Gln, Tyr, Val, Orn, and Leu) in their L-configuration into the peptide product [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 6 acyl carrier domains [H]

Homologues:

Organism=Homo sapiens, GI45580730, Length=548, Percent_Identity=24.8175182481752, Blast_Score=108, Evalue=4e-23,
Organism=Homo sapiens, GI187761345, Length=542, Percent_Identity=24.3542435424354, Blast_Score=108, Evalue=5e-23,
Organism=Homo sapiens, GI187761343, Length=542, Percent_Identity=24.3542435424354, Blast_Score=108, Evalue=5e-23,
Organism=Homo sapiens, GI156151445, Length=551, Percent_Identity=22.5045372050817, Blast_Score=99, Evalue=5e-20,
Organism=Homo sapiens, GI38505220, Length=503, Percent_Identity=23.4592445328032, Blast_Score=97, Evalue=1e-19,
Organism=Homo sapiens, GI42544132, Length=503, Percent_Identity=23.4592445328032, Blast_Score=93, Evalue=2e-18,
Organism=Homo sapiens, GI58082049, Length=515, Percent_Identity=23.1067961165049, Blast_Score=91, Evalue=1e-17,
Organism=Homo sapiens, GI157311624, Length=516, Percent_Identity=23.2558139534884, Blast_Score=89, Evalue=3e-17,
Organism=Homo sapiens, GI157311622, Length=516, Percent_Identity=23.2558139534884, Blast_Score=89, Evalue=3e-17,
Organism=Homo sapiens, GI122937307, Length=562, Percent_Identity=21.7081850533808, Blast_Score=84, Evalue=1e-15,
Organism=Homo sapiens, GI115511026, Length=510, Percent_Identity=22.156862745098, Blast_Score=73, Evalue=2e-12,
Organism=Escherichia coli, GI1786801, Length=1076, Percent_Identity=28.996282527881, Blast_Score=352, Evalue=2e-97,
Organism=Escherichia coli, GI1788107, Length=547, Percent_Identity=26.691042047532, Blast_Score=126, Evalue=1e-29,
Organism=Escherichia coli, GI145693145, Length=535, Percent_Identity=26.1682242990654, Blast_Score=107, Evalue=5e-24,
Organism=Escherichia coli, GI1790505, Length=557, Percent_Identity=25.673249551167, Blast_Score=97, Evalue=9e-21,
Organism=Escherichia coli, GI1786810, Length=511, Percent_Identity=23.8747553816047, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17556356, Length=608, Percent_Identity=25.3289473684211, Blast_Score=140, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17538037, Length=534, Percent_Identity=23.7827715355805, Blast_Score=107, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17550940, Length=531, Percent_Identity=22.9755178907721, Blast_Score=102, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI32563687, Length=509, Percent_Identity=22.3968565815324, Blast_Score=98, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17531443, Length=525, Percent_Identity=22.6666666666667, Blast_Score=92, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17560140, Length=526, Percent_Identity=20.532319391635, Blast_Score=78, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17559526, Length=338, Percent_Identity=23.0769230769231, Blast_Score=74, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6319591, Length=755, Percent_Identity=26.887417218543, Blast_Score=237, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6319699, Length=570, Percent_Identity=21.4035087719298, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24648676, Length=692, Percent_Identity=28.6127167630058, Blast_Score=223, Evalue=8e-58,
Organism=Drosophila melanogaster, GI19922652, Length=503, Percent_Identity=22.2664015904573, Blast_Score=95, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24581924, Length=532, Percent_Identity=21.9924812030075, Blast_Score=91, Evalue=5e-18,
Organism=Drosophila melanogaster, GI21356947, Length=498, Percent_Identity=21.285140562249, Blast_Score=91, Evalue=8e-18,
Organism=Drosophila melanogaster, GI21358303, Length=513, Percent_Identity=21.4424951267057, Blast_Score=82, Evalue=3e-15,
Organism=Drosophila melanogaster, GI18859661, Length=538, Percent_Identity=23.6059479553903, Blast_Score=81, Evalue=5e-15,
Organism=Drosophila melanogaster, GI281365686, Length=521, Percent_Identity=21.4971209213052, Blast_Score=79, Evalue=3e-14,
Organism=Drosophila melanogaster, GI20130357, Length=353, Percent_Identity=24.929178470255, Blast_Score=74, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24648260, Length=443, Percent_Identity=21.6704288939052, Blast_Score=70, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR001242
- InterPro:   IPR006163
- InterPro:   IPR020806
- InterPro:   IPR006162
- InterPro:   IPR001031 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF00550 PP-binding; PF00975 Thioesterase [H]

EC number: 2.7.7.- [C]

Molecular weight: Translated: 174402; Mature: 174402

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS50075 ACP_DOMAIN ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSVTGRTVPIIKDYAMQTTDRSVFPLSSPQREIWLEQLMLGQSVSSNIGGYIEIDGDID
CCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCHHHCCCCCEEEECCCCC
VGCLQHAAQTLVDQCEVLRMCITEDVDEEGIPLQCFAETMHLPVPFADITSVQDRQGWLE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHHCCCHHHHHHHH
QWIQEHMETPFQFDGTPLMRLSLCRFDAGKWYLMVSLHHILMDGWSLFLTIETLGRLYSE
HHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHCCHHHEEEHHHHHHHHHH
MREGRPATVDVRSYRDFIESDRSYQHSAQYETDRQYWLAKYSVLPEPLFSTAPGAMSTAE
HHCCCCCEEEHHHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHCCCCCHHCCCCCCCCEEE
VSGVSVNLVHEFPADLLDRLTRLATDHGVSQFQILLVLLYAYFSRTQQREELVVGVPILN
CCCCEEEEHHHCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHEEEECCHHH
RAGHQFKNSIGLCAQINPVRMRFDPAMPFIDAVRLVSRELRKDYRHQRFPVSEMGRACGL
HCCHHHHHCCCCEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCC
WKSGATRFFEMVFSFEQTGHVYRFGVARGVFVKASNNREYNPLSLYVRRNANDDIAWLHA
HHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEECCCCCCCCEEEEEEECCCCCHHHHHH
IYNKGYFAADQVAQMTQRLVQLMMQVVAHPSRPLNQIELCTADELACLDTWSRGRKTQMP
HHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHCCCCCCCCC
VATLPAMFEAQVERTPDAIAVAFGDLRLTYAQLNARSNQLAHHLIALGIGPDQRIALCME
HHHHHHHHHHHHHCCCCEEEEEECCCEEEHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHH
RCPELVVALLAVLKAGSAYVPLDPRYPSERLAYMLSDSTPRALIVHSATRDLLEDTNAIL
HHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEHHHHHHHCCCCEEE
IDVDTPEWLHRPTDTPLVAGFAPCHLAYVIYTSGSSGRPKGVMVPHDALSNYLHWAIDHY
EECCCHHHHCCCCCCCEEECCCHHEEEEEEEECCCCCCCCCEECCHHHHHHHHHHHHHCC
HPRQGAVVSSSLSFDATVTSLYLPLLCGGTTELLPERDEIEALLKRVCADQPLCLVKITP
CCCCCCEEECCCCCHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHCCCCEEEEEECH
AHLDVLTQQLAACGGTPSVSLFVVGGEALHASTVKRLRQLAPHARVVNEYGPTETVVGCV
HHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHE
AYEIPLDWDAGTLATIPIGRPIDNMRVYLLDANRQTVPAGVAGELCIAGSQVTRGYLNRP
EEEECCCCCCCCEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCEECCCHHHHCCCCCC
ELTEQRFVVDPFGTGPEQRMYCSGDLARWMPDGTLEYLGRNDDQIKLRGFRIEPAEVSSR
CCCCCCEEECCCCCCCCCCEEECCCHHHHCCCCHHHHCCCCCCEEEEEEEECCHHHHHHH
ILDNPLVADAAVVIHTAASGEKCLVAYYVSDAPEVTAERLREQLQQRLPDYMVPAVYIRM
HHCCCHHHCCEEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCHHHCCHHHEEE
DLLPMTPNGKLDRHALPAPDAQAYAQQGYVSPEGPTEQLLAVLWSDVLKIEQVGRYDHFF
EEEECCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHH
ELGGHSLLIVALLERMRQHGLEANVKSLLARPTVMGMAAAVGASRDEKIPEPRIPEGCDR
HHCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCHHH
ITPDLLPLVELSQQAIDTIVSTVPGGARNVQDIYPAAPLQEGIAYHHLTATQGDPYLQYA
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCHHHCCEEEEEECCCCCHHHHHH
LFVFSDRARLDAFAAALQCVVARYDILRTALIWEQLDAPLQVVWRQATVPMIEIAVGPAE
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEECCCH
EDVLQLLRAHLDPARQQLDLRQAPLLRLCYAYDGVGQRWVGGLLFHHLVGDAASLTGLLE
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHH
EIDSHLRGDGARLPPPFRYRTYTMHARRDQHAEEHARFFKEMLGDVCEPTIAFGLQDQGV
HHHHHHCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCC
VDQQVRKAVIQIDASIAQRLQVQARRLGVSVATLCHVAWAQVLSAASGQQDVVFGTVMLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEC
RTQGKEIERAIGMFINTLPIRVRLGRASVRAVIKQTHAWLSELLAHEHASLSLAQRCSRM
CCCCHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YTQRVLFNALFNYRRLSRANLNGTVLQAWPGIDVLGGEERSTYPVSLSMDDLGDGFQLTA
HHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEECCCCCCCEEEEEEHHCCCCCEEEEE
QASADGVPARMCAYMQTALQQLADALEHERETPISQLCVLPPAERQRLLGFNLQHRAAEA
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEECCCCHHHHHHHCCCHHHHHHHH
VDSLAP
HHHCCC
>Mature Secondary Structure
MRSVTGRTVPIIKDYAMQTTDRSVFPLSSPQREIWLEQLMLGQSVSSNIGGYIEIDGDID
CCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCHHHCCCCCEEEECCCCC
VGCLQHAAQTLVDQCEVLRMCITEDVDEEGIPLQCFAETMHLPVPFADITSVQDRQGWLE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHHCCCHHHHHHHH
QWIQEHMETPFQFDGTPLMRLSLCRFDAGKWYLMVSLHHILMDGWSLFLTIETLGRLYSE
HHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHCCHHHEEEHHHHHHHHHH
MREGRPATVDVRSYRDFIESDRSYQHSAQYETDRQYWLAKYSVLPEPLFSTAPGAMSTAE
HHCCCCCEEEHHHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHCCCCCHHCCCCCCCCEEE
VSGVSVNLVHEFPADLLDRLTRLATDHGVSQFQILLVLLYAYFSRTQQREELVVGVPILN
CCCCEEEEHHHCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHEEEECCHHH
RAGHQFKNSIGLCAQINPVRMRFDPAMPFIDAVRLVSRELRKDYRHQRFPVSEMGRACGL
HCCHHHHHCCCCEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCC
WKSGATRFFEMVFSFEQTGHVYRFGVARGVFVKASNNREYNPLSLYVRRNANDDIAWLHA
HHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEECCCCCCCCEEEEEEECCCCCHHHHHH
IYNKGYFAADQVAQMTQRLVQLMMQVVAHPSRPLNQIELCTADELACLDTWSRGRKTQMP
HHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHCCCCCCCCC
VATLPAMFEAQVERTPDAIAVAFGDLRLTYAQLNARSNQLAHHLIALGIGPDQRIALCME
HHHHHHHHHHHHHCCCCEEEEEECCCEEEHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHH
RCPELVVALLAVLKAGSAYVPLDPRYPSERLAYMLSDSTPRALIVHSATRDLLEDTNAIL
HHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEHHHHHHHCCCCEEE
IDVDTPEWLHRPTDTPLVAGFAPCHLAYVIYTSGSSGRPKGVMVPHDALSNYLHWAIDHY
EECCCHHHHCCCCCCCEEECCCHHEEEEEEEECCCCCCCCCEECCHHHHHHHHHHHHHCC
HPRQGAVVSSSLSFDATVTSLYLPLLCGGTTELLPERDEIEALLKRVCADQPLCLVKITP
CCCCCCEEECCCCCHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHCCCCEEEEEECH
AHLDVLTQQLAACGGTPSVSLFVVGGEALHASTVKRLRQLAPHARVVNEYGPTETVVGCV
HHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHE
AYEIPLDWDAGTLATIPIGRPIDNMRVYLLDANRQTVPAGVAGELCIAGSQVTRGYLNRP
EEEECCCCCCCCEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCEECCCHHHHCCCCCC
ELTEQRFVVDPFGTGPEQRMYCSGDLARWMPDGTLEYLGRNDDQIKLRGFRIEPAEVSSR
CCCCCCEEECCCCCCCCCCEEECCCHHHHCCCCHHHHCCCCCCEEEEEEEECCHHHHHHH
ILDNPLVADAAVVIHTAASGEKCLVAYYVSDAPEVTAERLREQLQQRLPDYMVPAVYIRM
HHCCCHHHCCEEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCHHHCCHHHEEE
DLLPMTPNGKLDRHALPAPDAQAYAQQGYVSPEGPTEQLLAVLWSDVLKIEQVGRYDHFF
EEEECCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHH
ELGGHSLLIVALLERMRQHGLEANVKSLLARPTVMGMAAAVGASRDEKIPEPRIPEGCDR
HHCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCHHH
ITPDLLPLVELSQQAIDTIVSTVPGGARNVQDIYPAAPLQEGIAYHHLTATQGDPYLQYA
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCHHHCCEEEEEECCCCCHHHHHH
LFVFSDRARLDAFAAALQCVVARYDILRTALIWEQLDAPLQVVWRQATVPMIEIAVGPAE
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEECCCH
EDVLQLLRAHLDPARQQLDLRQAPLLRLCYAYDGVGQRWVGGLLFHHLVGDAASLTGLLE
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHH
EIDSHLRGDGARLPPPFRYRTYTMHARRDQHAEEHARFFKEMLGDVCEPTIAFGLQDQGV
HHHHHHCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCC
VDQQVRKAVIQIDASIAQRLQVQARRLGVSVATLCHVAWAQVLSAASGQQDVVFGTVMLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEC
RTQGKEIERAIGMFINTLPIRVRLGRASVRAVIKQTHAWLSELLAHEHASLSLAQRCSRM
CCCCHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YTQRVLFNALFNYRRLSRANLNGTVLQAWPGIDVLGGEERSTYPVSLSMDDLGDGFQLTA
HHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEECCCCCCCEEEEEEHHCCCCCEEEEE
QASADGVPARMCAYMQTALQQLADALEHERETPISQLCVLPPAERQRLLGFNLQHRAAEA
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEECCCCHHHHHHHCCCHHHHHHHH
VDSLAP
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Phosphopantetheine. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 6 ATP; L-serine; 2,3-dihydroxybenzoate [C]

Specific reaction: 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Seryl-AMP 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Ser

General reaction: Transferases; Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9352938; 10801488 [H]