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The map label for this gene is kdsB

Identifier: 21242828

GI number: 21242828

Start: 2438154

End: 2438933

Strand: Direct

Name: kdsB

Synonym: XAC2089

Alternate gene names: 21242828

Gene position: 2438154-2438933 (Clockwise)

Preceding gene: 21242827

Following gene: 21242829

Centisome position: 47.11

GC content: 66.41

Gene sequence:

>780_bases
ATGACACCCACCACGCCTGCCGATTTCGTTGTCGCCATTCCCGCCCGTTACGCTTCCACGCGGCTGCCGGGTAAACCGCT
GCAACTGATCGGCGATCGACCGATGATCCAGCACGTGGCCGAGCGTGCATTGCTGGCGGGTGCGCGCGAGGTGTGGGTGG
CCACCGACGACGCGCGTATCGTAGCGGCGATCGAGCATCTGCCAGGAGTGCATGTGGCGATGACCGGCACCGCGCATCTT
TCCGGCACCGACCGCCTTGCCGAATGCGCGCGCATTGCCGGATGGGACGACCAGGCCTGCGTGGTCAATCTGCAAGGCGA
CGAGCCGTTTGCGCCGGCTGCGGGCATCCGCGCTGTTGCAGATCTGCTGCAGCGCTCCGGTGCCCAGATGGCCACGCTGG
CCGCGCCGGTGGACAACGCGCACGACCTGTTCGATCCCAACGTGGTGAAGCTGGTGCGCACGGCCGGCGGCGACGCGCTG
TATTTCAGCCGTGCGCCGATTCCCTGGCACCGCGACAGCTTCGCCAGCCAGCACGATAGCGTGCCTGCAGAAGGTCAGTG
GCTGCGTCACATCGGCATCTACGCCTATCGCGCAGGCTTCCTGCAACGCTTCGCAGCCATGCCGCCCGGCATGCTGGAGC
GCACCGAATCGCTGGAACAATTGCGCGTGATGGAAGCCGGCTATCGCATCGCCGTGGCGGTGACGCCTGAGCCGTTTCCG
CCAGGCATCGATACCGCGGACGATCTCGTTCGCGCGCAGATGCGGGTGGCTTCTGCATGA

Upstream 100 bases:

>100_bases
CGCCAACTGAATACCGCCACTTCGCTCAATCACACATCGGCATCAAGCGATTCGGTTCTCTCGCTTCCCCTACTTCCTAC
TGCATCCAGAGCGCGCACGT

Downstream 100 bases:

>100_bases
AGGTGCTGATCGTCTGCCTGGGCAATATCTGCCGGTCACCGATGGGCGAGGGTGCCTTGCGTGCGCAACTGGACAAGGCA
CGGCTGTCGCGGCGCATCGA

Product: 3-deoxy-manno-octulosonate cytidylyltransferase

Products: NA

Alternate protein names: CMP-2-keto-3-deoxyoctulosonic acid synthase; CKS; CMP-KDO synthase

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MTPTTPADFVVAIPARYASTRLPGKPLQLIGDRPMIQHVAERALLAGAREVWVATDDARIVAAIEHLPGVHVAMTGTAHL
SGTDRLAECARIAGWDDQACVVNLQGDEPFAPAAGIRAVADLLQRSGAQMATLAAPVDNAHDLFDPNVVKLVRTAGGDAL
YFSRAPIPWHRDSFASQHDSVPAEGQWLRHIGIYAYRAGFLQRFAAMPPGMLERTESLEQLRVMEAGYRIAVAVTPEPFP
PGIDTADDLVRAQMRVASA

Sequences:

>Translated_259_residues
MTPTTPADFVVAIPARYASTRLPGKPLQLIGDRPMIQHVAERALLAGAREVWVATDDARIVAAIEHLPGVHVAMTGTAHL
SGTDRLAECARIAGWDDQACVVNLQGDEPFAPAAGIRAVADLLQRSGAQMATLAAPVDNAHDLFDPNVVKLVRTAGGDAL
YFSRAPIPWHRDSFASQHDSVPAEGQWLRHIGIYAYRAGFLQRFAAMPPGMLERTESLEQLRVMEAGYRIAVAVTPEPFP
PGIDTADDLVRAQMRVASA
>Mature_258_residues
TPTTPADFVVAIPARYASTRLPGKPLQLIGDRPMIQHVAERALLAGAREVWVATDDARIVAAIEHLPGVHVAMTGTAHLS
GTDRLAECARIAGWDDQACVVNLQGDEPFAPAAGIRAVADLLQRSGAQMATLAAPVDNAHDLFDPNVVKLVRTAGGDALY
FSRAPIPWHRDSFASQHDSVPAEGQWLRHIGIYAYRAGFLQRFAAMPPGMLERTESLEQLRVMEAGYRIAVAVTPEPFPP
GIDTADDLVRAQMRVASA

Specific function: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria

COG id: COG1212

COG function: function code M; CMP-2-keto-3-deoxyoctulosonic acid synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsB family

Homologues:

Organism=Escherichia coli, GI1787147, Length=249, Percent_Identity=53.0120481927711, Blast_Score=231, Evalue=4e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KDSB_XANAC (Q8PKS3)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_642410.1
- HSSP:   P04951
- ProteinModelPortal:   Q8PKS3
- SMR:   Q8PKS3
- GeneID:   1156160
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC2089
- NMPDR:   fig|190486.1.peg.2054
- HOGENOM:   HBG637773
- OMA:   IIPARLK
- ProtClustDB:   PRK05450
- BioCyc:   XAXO190486:XAC2089-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00057
- InterPro:   IPR003329
- InterPro:   IPR004528
- TIGRFAMs:   TIGR00466

Pfam domain/function: PF02348 CTP_transf_3

EC number: =2.7.7.38

Molecular weight: Translated: 27900; Mature: 27769

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPTTPADFVVAIPARYASTRLPGKPLQLIGDRPMIQHVAERALLAGAREVWVATDDARI
CCCCCCCCEEEEECCHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCHH
VAAIEHLPGVHVAMTGTAHLSGTDRLAECARIAGWDDQACVVNLQGDEPFAPAAGIRAVA
HHHHHHCCCCEEEEECCEECCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHH
DLLQRSGAQMATLAAPVDNAHDLFDPNVVKLVRTAGGDALYFSRAPIPWHRDSFASQHDS
HHHHHCCCCEEEEECCCCCCHHCCCCHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHCCC
VPAEGQWLRHIGIYAYRAGFLQRFAAMPPGMLERTESLEQLRVMEAGYRIAVAVTPEPFP
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCC
PGIDTADDLVRAQMRVASA
CCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TPTTPADFVVAIPARYASTRLPGKPLQLIGDRPMIQHVAERALLAGAREVWVATDDARI
CCCCCCCEEEEECCHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCHH
VAAIEHLPGVHVAMTGTAHLSGTDRLAECARIAGWDDQACVVNLQGDEPFAPAAGIRAVA
HHHHHHCCCCEEEEECCEECCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHH
DLLQRSGAQMATLAAPVDNAHDLFDPNVVKLVRTAGGDALYFSRAPIPWHRDSFASQHDS
HHHHHCCCCEEEEECCCCCCHHCCCCHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHCCC
VPAEGQWLRHIGIYAYRAGFLQRFAAMPPGMLERTESLEQLRVMEAGYRIAVAVTPEPFP
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCC
PGIDTADDLVRAQMRVASA
CCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217