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The map label for this gene is lpxK [H]

Identifier: 21242827

GI number: 21242827

Start: 2436824

End: 2437861

Strand: Direct

Name: lpxK [H]

Synonym: XAC2088

Alternate gene names: 21242827

Gene position: 2436824-2437861 (Clockwise)

Preceding gene: 21242826

Following gene: 21242828

Centisome position: 47.08

GC content: 68.21

Gene sequence:

>1038_bases
ATGAGCAAGCGCGGCACCCGCACCCCGGGTTACTGGTACGACAACACGCCGATTCCGCTGCCGGCGCGCATCCTGGCACC
GGTCTACGGCGCTGCGATCGCGTTGCGACGGGCGCTGTATCGCCGCGGCTGGCGCAGGCGCCACGGTGTGCCGGTGCCGG
TGATCGTGGTCGGCAATGTCACCGCCGGCGGCACCGGCAAGACGCCGCTGACGATTGCCTTGGTCGCGAAGCTGCAGGAA
GCCGGCTGGACCCCTGGCGTCGCCAGCCGTGGCTACGGCCGCGATGACGCCGGTACCGCCCGCTGGGTCGAAGCGGACAC
GCCGGTGGCGCTCGGCGGCGACGAGCCGGTGTTGATCGCCTGGAAGACCGGTGCGCGCGTGCGCGTCGACAGCGACCGGC
TCGCTGCTGCGCGGGCGCTGGTCGAGGCGGGCTGCGACATCGTGATCTGCGACGATGGCCTGCAGCATTACCGTCTGGCC
CGCGATGTCGAAATCGAAGTGGTCGATGGCCAGCGGCGCTACGGCAACGGACGCCTGTTGCCTGCTGGGCCGCTACGCGA
ACCGGCCGCGCGGGCGCAGGATTGCGATTTTCGCGTGGTCAATCTCGGCCAGGCCAGTGCAACTGCCACACCGCAGGCGC
CGGATGATGCCGGTTTCGGCAAATGGCAGATGCGTTTGAGCATCGACAGCGTGCAGCCAATGGACGGCAAGCGTGCGCAG
CCCTTGAGCATGCTTGCCGGACAGCGCGTGCATGCCGTGGCGGGCATCGCGCATCCGGAACGTTTCTTCGCCATGCTGCG
CGCGCGCGGCATTGGCGTGGTGCCGCACGCGTTTGCGGATCATCACGTCTATCGCGCCGCGGATTTCAGCTTCGGAAGCC
GCCTGCCGGTGCTGATGACCGAAAAGGACGCGGTGAAATGCCGTCCGTTCGCCGACGAGTGGCTGTACAGCGTGCCACTG
AAGGCGGAACTGCCGGCCGCGTTCTGGGTGAGCCTGCTGGACCGATTGAACAAATTGGCGAGCCGGCAGGGCGTGTGA

Upstream 100 bases:

>100_bases
ACCAGGGCCGGATCGTCGAGCGTGGTACGCATCACCAATTGCTGGCGCAGGGCGGCTTGTATTCGCACCTGCACGGCATG
CAATTCCGCGAACGCCAGGC

Downstream 100 bases:

>100_bases
GCGAGTCAGCTTGCAGTTGGACGGTTGCTGGCCAAGCATCCCGAGCCAGGCGTTGAGTGCGCTCTTGCGGCTGCGATGTG
TCATCCATGCTGGATGACAC

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MSKRGTRTPGYWYDNTPIPLPARILAPVYGAAIALRRALYRRGWRRRHGVPVPVIVVGNVTAGGTGKTPLTIALVAKLQE
AGWTPGVASRGYGRDDAGTARWVEADTPVALGGDEPVLIAWKTGARVRVDSDRLAAARALVEAGCDIVICDDGLQHYRLA
RDVEIEVVDGQRRYGNGRLLPAGPLREPAARAQDCDFRVVNLGQASATATPQAPDDAGFGKWQMRLSIDSVQPMDGKRAQ
PLSMLAGQRVHAVAGIAHPERFFAMLRARGIGVVPHAFADHHVYRAADFSFGSRLPVLMTEKDAVKCRPFADEWLYSVPL
KAELPAAFWVSLLDRLNKLASRQGV

Sequences:

>Translated_345_residues
MSKRGTRTPGYWYDNTPIPLPARILAPVYGAAIALRRALYRRGWRRRHGVPVPVIVVGNVTAGGTGKTPLTIALVAKLQE
AGWTPGVASRGYGRDDAGTARWVEADTPVALGGDEPVLIAWKTGARVRVDSDRLAAARALVEAGCDIVICDDGLQHYRLA
RDVEIEVVDGQRRYGNGRLLPAGPLREPAARAQDCDFRVVNLGQASATATPQAPDDAGFGKWQMRLSIDSVQPMDGKRAQ
PLSMLAGQRVHAVAGIAHPERFFAMLRARGIGVVPHAFADHHVYRAADFSFGSRLPVLMTEKDAVKCRPFADEWLYSVPL
KAELPAAFWVSLLDRLNKLASRQGV
>Mature_344_residues
SKRGTRTPGYWYDNTPIPLPARILAPVYGAAIALRRALYRRGWRRRHGVPVPVIVVGNVTAGGTGKTPLTIALVAKLQEA
GWTPGVASRGYGRDDAGTARWVEADTPVALGGDEPVLIAWKTGARVRVDSDRLAAARALVEAGCDIVICDDGLQHYRLAR
DVEIEVVDGQRRYGNGRLLPAGPLREPAARAQDCDFRVVNLGQASATATPQAPDDAGFGKWQMRLSIDSVQPMDGKRAQP
LSMLAGQRVHAVAGIAHPERFFAMLRARGIGVVPHAFADHHVYRAADFSFGSRLPVLMTEKDAVKCRPFADEWLYSVPLK
AELPAAFWVSLLDRLNKLASRQGV

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) [H]

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family [H]

Homologues:

Organism=Escherichia coli, GI1787144, Length=340, Percent_Identity=41.7647058823529, Blast_Score=203, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003758 [H]

Pfam domain/function: PF02606 LpxK [H]

EC number: =2.7.1.130 [H]

Molecular weight: Translated: 37494; Mature: 37363

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRGTRTPGYWYDNTPIPLPARILAPVYGAAIALRRALYRRGWRRRHGVPVPVIVVGNV
CCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECC
TAGGTGKTPLTIALVAKLQEAGWTPGVASRGYGRDDAGTARWVEADTPVALGGDEPVLIA
CCCCCCCCCEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCEEECCCCCEEEE
WKTGARVRVDSDRLAAARALVEAGCDIVICDDGLQHYRLARDVEIEVVDGQRRYGNGRLL
EECCCEEEECCHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCEEEEECCCEECCCCEEC
PAGPLREPAARAQDCDFRVVNLGQASATATPQAPDDAGFGKWQMRLSIDSVQPMDGKRAQ
CCCCCCCCHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCC
PLSMLAGQRVHAVAGIAHPERFFAMLRARGIGVVPHAFADHHVYRAADFSFGSRLPVLMT
CHHHHHCCHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHCCCCEEEEECCCCCCCCCEEEE
EKDAVKCRPFADEWLYSVPLKAELPAAFWVSLLDRLNKLASRQGV
CCCCEEECCCHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKRGTRTPGYWYDNTPIPLPARILAPVYGAAIALRRALYRRGWRRRHGVPVPVIVVGNV
CCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECC
TAGGTGKTPLTIALVAKLQEAGWTPGVASRGYGRDDAGTARWVEADTPVALGGDEPVLIA
CCCCCCCCCEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCEEECCCCCEEEE
WKTGARVRVDSDRLAAARALVEAGCDIVICDDGLQHYRLARDVEIEVVDGQRRYGNGRLL
EECCCEEEECCHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCEEEEECCCEECCCCEEC
PAGPLREPAARAQDCDFRVVNLGQASATATPQAPDDAGFGKWQMRLSIDSVQPMDGKRAQ
CCCCCCCCHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCC
PLSMLAGQRVHAVAGIAHPERFFAMLRARGIGVVPHAFADHHVYRAADFSFGSRLPVLMT
CHHHHHCCHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHCCCCEEEEECCCCCCCCCEEEE
EKDAVKCRPFADEWLYSVPLKAELPAAFWVSLLDRLNKLASRQGV
CCCCEEECCCHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA