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The map label for this gene is sdhA [H]

Identifier: 21242816

GI number: 21242816

Start: 2424363

End: 2426153

Strand: Direct

Name: sdhA [H]

Synonym: XAC2077

Alternate gene names: 21242816

Gene position: 2424363-2426153 (Clockwise)

Preceding gene: 21242815

Following gene: 21242817

Centisome position: 46.84

GC content: 62.93

Gene sequence:

>1791_bases
ATGTCCGCTTACAAGATCACAGAACACAAGTACGACATGGTCGTGGTGGGCGCCGGTGGCGCCGGCCTGCGCGCCACGTT
CGGCCTGGCCCAGAAGGGCCTGCAGACGGTCTGCCTGACCAAGGTCTTCCCGACCCGTTCGCACACCGTGGCAGCGCAGG
GCGGTATTTCCGCAGCGCTGGGCAACATGGGCGAAGACGATTGGCGTTATCACTTTTACGACACCATCAAGGGTTCCGAT
TGGCTGGGCGACCAGGACGCGATCGAGTACATGTGTCGCGAGGCGATTCCGGCCATCATCGAACTCGAGCACTACGGCGT
GCCGTTCTCGCGGACCGAAGAGGGCAAGATCTACCAGCGCCCGTTCGGCGGCATGACCACCAAGTATGGTGAAGGCCCGT
CCGCGCAGCGTACCTGCGCCGCAGCCGATCGTACCGGCCACGCCATGCTGCATACCTTGTATCAGCAGTCGTTGGCGCAC
AACGCACGCTTCATGATCGAGTACTTCGCGCTCGATCTGATCTTCGACGAAGAAGGCGTTTGCCGTGGCGTGCTCGCACT
GGACATGGCCGAAGGTTCGCTGCATCTGTTCCGCGCCCACGGCGTGGTGCTGGCGACCGGCGGTTACGGACGTGCCTACT
TCAGCGCCACCTCCGCACACACCTGTACCGGTGATGGCGGCGGCCTGGTGATGCGTGCGGGCCTGCCTGTGCAGGACATG
GAATTCGTGCAGTTCCATCCCACTGGCATCTACGGTGCGGGCTGCCTGATCACCGAAGGCGTGCGCGGCGAAGGCGGCAT
CCTGCGTAACAGCAATGGCGAGCGCTTCATGGAGCGCTACGCACCGCATTACAAGGACTTGGCTTCGCGCGACGTGGTGT
CGCGTTCGATGACGGTGGAAATTCGCGAAGGCCGCGGTGTAGGCGAGCACAAGGATCACATCCTGCTCGACCTGACCCAC
CTTGGGCCGGAAGTGATCAACGAAAAGTTGCCCGGCATCGCCGAAAGCGCACACATCTTCGCCGGTGTGGACGTGACCAA
GCAGCCGATCCCGGTGCTGCCGACGGTGCACTACAACATGGGCGGTATTCCGACCAACTTCTACGGCGAGGTCGTGCGCA
AGCGGGGCGACGATGCGGATGCCGTGGTGCCGGGCCTGTATGCCATCGGCGAGGCGGCGTGCGTCTCGGTCCATGGTGCA
AACCGTCTGGGCTCGAACTCATTGCTGGACCTGGTGGTGTTCGGTCGCGCGGTCGCCAACCGCTGTGCCGAAACGGTCAA
GCCCAATCAGCCGCACAAGACCTTGCCGTCCGATGCCTGCGACAAGGCCCTGGGCCTGCTGGACAAGCTGCGTCACGCCA
ACGGCTCCACGCCGACGGCCGTGATCCGCGACAACATGCAGCGCACCATGCAGTCGGACGCCGCCGTGTTCCGCACCAGC
AAGACGCTGAAAGAAGGCGTGGACAAGATGGCCGAGATCTTCGCCACCTTCGAGGACGTCAAGGTGTCGGACCGCTCGCT
GGTGTGGAATTCGGACCTGATCGAGACCTATGAATTGAACAACCTGCTGCTCAACGCGGTGGCGACGATCAATTCGGCCG
AACAGCGCAAGGAAAGCCGTGGCGCGCATTCGCACGAAGACTTCCCGGACCGCGACGACGTCAACTGGCAGAAGCACACG
TTGGTGACCGTCGACGACAAGGGCAAGTGCGAGTTCGACTACCGCCCTGTGCACATGTACACGCTGAGCAAGGATGTGGA
CGTGGTCCCGCCGAAGCCGCGCGTTTACTGA

Upstream 100 bases:

>100_bases
TGTTGCCGTGCTGGGCGCCATCGTCAGCGTGTTTGCCGTGGCGCGTATCGCGCTGGGCATGAGCTGAGTCGTCAGCGACC
AAACAGGAACCCATAATTCG

Downstream 100 bases:

>100_bases
TCGATGCGCATGCAGCGACCCACCGTTGCCTTGTCATGGCTCGCCATCGCCTCTGCGCGTGGCAGCGAGCCGGTGCAGCA
GTTTGGTCGTCGCATGACCC

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 596; Mature: 595

Protein sequence:

>596_residues
MSAYKITEHKYDMVVVGAGGAGLRATFGLAQKGLQTVCLTKVFPTRSHTVAAQGGISAALGNMGEDDWRYHFYDTIKGSD
WLGDQDAIEYMCREAIPAIIELEHYGVPFSRTEEGKIYQRPFGGMTTKYGEGPSAQRTCAAADRTGHAMLHTLYQQSLAH
NARFMIEYFALDLIFDEEGVCRGVLALDMAEGSLHLFRAHGVVLATGGYGRAYFSATSAHTCTGDGGGLVMRAGLPVQDM
EFVQFHPTGIYGAGCLITEGVRGEGGILRNSNGERFMERYAPHYKDLASRDVVSRSMTVEIREGRGVGEHKDHILLDLTH
LGPEVINEKLPGIAESAHIFAGVDVTKQPIPVLPTVHYNMGGIPTNFYGEVVRKRGDDADAVVPGLYAIGEAACVSVHGA
NRLGSNSLLDLVVFGRAVANRCAETVKPNQPHKTLPSDACDKALGLLDKLRHANGSTPTAVIRDNMQRTMQSDAAVFRTS
KTLKEGVDKMAEIFATFEDVKVSDRSLVWNSDLIETYELNNLLLNAVATINSAEQRKESRGAHSHEDFPDRDDVNWQKHT
LVTVDDKGKCEFDYRPVHMYTLSKDVDVVPPKPRVY

Sequences:

>Translated_596_residues
MSAYKITEHKYDMVVVGAGGAGLRATFGLAQKGLQTVCLTKVFPTRSHTVAAQGGISAALGNMGEDDWRYHFYDTIKGSD
WLGDQDAIEYMCREAIPAIIELEHYGVPFSRTEEGKIYQRPFGGMTTKYGEGPSAQRTCAAADRTGHAMLHTLYQQSLAH
NARFMIEYFALDLIFDEEGVCRGVLALDMAEGSLHLFRAHGVVLATGGYGRAYFSATSAHTCTGDGGGLVMRAGLPVQDM
EFVQFHPTGIYGAGCLITEGVRGEGGILRNSNGERFMERYAPHYKDLASRDVVSRSMTVEIREGRGVGEHKDHILLDLTH
LGPEVINEKLPGIAESAHIFAGVDVTKQPIPVLPTVHYNMGGIPTNFYGEVVRKRGDDADAVVPGLYAIGEAACVSVHGA
NRLGSNSLLDLVVFGRAVANRCAETVKPNQPHKTLPSDACDKALGLLDKLRHANGSTPTAVIRDNMQRTMQSDAAVFRTS
KTLKEGVDKMAEIFATFEDVKVSDRSLVWNSDLIETYELNNLLLNAVATINSAEQRKESRGAHSHEDFPDRDDVNWQKHT
LVTVDDKGKCEFDYRPVHMYTLSKDVDVVPPKPRVY
>Mature_595_residues
SAYKITEHKYDMVVVGAGGAGLRATFGLAQKGLQTVCLTKVFPTRSHTVAAQGGISAALGNMGEDDWRYHFYDTIKGSDW
LGDQDAIEYMCREAIPAIIELEHYGVPFSRTEEGKIYQRPFGGMTTKYGEGPSAQRTCAAADRTGHAMLHTLYQQSLAHN
ARFMIEYFALDLIFDEEGVCRGVLALDMAEGSLHLFRAHGVVLATGGYGRAYFSATSAHTCTGDGGGLVMRAGLPVQDME
FVQFHPTGIYGAGCLITEGVRGEGGILRNSNGERFMERYAPHYKDLASRDVVSRSMTVEIREGRGVGEHKDHILLDLTHL
GPEVINEKLPGIAESAHIFAGVDVTKQPIPVLPTVHYNMGGIPTNFYGEVVRKRGDDADAVVPGLYAIGEAACVSVHGAN
RLGSNSLLDLVVFGRAVANRCAETVKPNQPHKTLPSDACDKALGLLDKLRHANGSTPTAVIRDNMQRTMQSDAAVFRTSK
TLKEGVDKMAEIFATFEDVKVSDRSLVWNSDLIETYELNNLLLNAVATINSAEQRKESRGAHSHEDFPDRDDVNWQKHTL
VTVDDKGKCEFDYRPVHMYTLSKDVDVVPPKPRVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=614, Percent_Identity=60.7491856677524, Blast_Score=722, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=593, Percent_Identity=51.433389544688, Blast_Score=548, Evalue=1e-157,
Organism=Escherichia coli, GI1790597, Length=575, Percent_Identity=41.3913043478261, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI1788928, Length=565, Percent_Identity=31.6814159292035, Blast_Score=213, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17550100, Length=615, Percent_Identity=60.8130081300813, Blast_Score=726, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505833, Length=613, Percent_Identity=59.5432300163132, Blast_Score=702, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322701, Length=596, Percent_Identity=64.9328859060403, Blast_Score=774, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322416, Length=600, Percent_Identity=65, Blast_Score=769, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6320788, Length=488, Percent_Identity=26.844262295082, Blast_Score=97, Evalue=8e-21,
Organism=Drosophila melanogaster, GI17137288, Length=611, Percent_Identity=64.1571194762684, Blast_Score=774, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655642, Length=611, Percent_Identity=64.1571194762684, Blast_Score=774, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655647, Length=611, Percent_Identity=64.1571194762684, Blast_Score=774, Evalue=0.0,
Organism=Drosophila melanogaster, GI24663005, Length=613, Percent_Identity=56.4437194127243, Blast_Score=686, Evalue=0.0,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 65300; Mature: 65168

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAYKITEHKYDMVVVGAGGAGLRATFGLAQKGLQTVCLTKVFPTRSHTVAAQGGISAAL
CCCEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHH
GNMGEDDWRYHFYDTIKGSDWLGDQDAIEYMCREAIPAIIELEHYGVPFSRTEEGKIYQR
CCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCEEEC
PFGGMTTKYGEGPSAQRTCAAADRTGHAMLHTLYQQSLAHNARFMIEYFALDLIFDEEGV
CCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCHHHEEEEEEEEEEECCCCC
CRGVLALDMAEGSLHLFRAHGVVLATGGYGRAYFSATSAHTCTGDGGGLVMRAGLPVQDM
CCEEEEEEECCCCEEEEEECCEEEEECCCCEEEEECCCCCEEECCCCCEEEECCCCCCCC
EFVQFHPTGIYGAGCLITEGVRGEGGILRNSNGERFMERYAPHYKDLASRDVVSRSMTVE
CEEEECCCCEEECCEEEECCCCCCCCEEECCCHHHHHHHHCCHHHHHHHHHHHCCCEEEE
IREGRGVGEHKDHILLDLTHLGPEVINEKLPGIAESAHIFAGVDVTKQPIPVLPTVHYNM
EECCCCCCCCCCEEEEEEHHCCHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCEEECCC
GGIPTNFYGEVVRKRGDDADAVVPGLYAIGEAACVSVHGANRLGSNSLLDLVVFGRAVAN
CCCCCHHHHHHHHHCCCCCHHHHCHHHHHCCEEEEEEECCCCCCCCHHHHHHHHHHHHHH
RCAETVKPNQPHKTLPSDACDKALGLLDKLRHANGSTPTAVIRDNMQRTMQSDAAVFRTS
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KTLKEGVDKMAEIFATFEDVKVSDRSLVWNSDLIETYELNNLLLNAVATINSAEQRKESR
HHHHHHHHHHHHHHHHHHHCEECCCEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHC
GAHSHEDFPDRDDVNWQKHTLVTVDDKGKCEFDYRPVHMYTLSKDVDVVPPKPRVY
CCCCCCCCCCCCCCCCCEEEEEEECCCCCEEECCCEEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SAYKITEHKYDMVVVGAGGAGLRATFGLAQKGLQTVCLTKVFPTRSHTVAAQGGISAAL
CCEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHH
GNMGEDDWRYHFYDTIKGSDWLGDQDAIEYMCREAIPAIIELEHYGVPFSRTEEGKIYQR
CCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCEEEC
PFGGMTTKYGEGPSAQRTCAAADRTGHAMLHTLYQQSLAHNARFMIEYFALDLIFDEEGV
CCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCHHHEEEEEEEEEEECCCCC
CRGVLALDMAEGSLHLFRAHGVVLATGGYGRAYFSATSAHTCTGDGGGLVMRAGLPVQDM
CCEEEEEEECCCCEEEEEECCEEEEECCCCEEEEECCCCCEEECCCCCEEEECCCCCCCC
EFVQFHPTGIYGAGCLITEGVRGEGGILRNSNGERFMERYAPHYKDLASRDVVSRSMTVE
CEEEECCCCEEECCEEEECCCCCCCCEEECCCHHHHHHHHCCHHHHHHHHHHHCCCEEEE
IREGRGVGEHKDHILLDLTHLGPEVINEKLPGIAESAHIFAGVDVTKQPIPVLPTVHYNM
EECCCCCCCCCCEEEEEEHHCCHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCEEECCC
GGIPTNFYGEVVRKRGDDADAVVPGLYAIGEAACVSVHGANRLGSNSLLDLVVFGRAVAN
CCCCCHHHHHHHHHCCCCCHHHHCHHHHHCCEEEEEEECCCCCCCCHHHHHHHHHHHHHH
RCAETVKPNQPHKTLPSDACDKALGLLDKLRHANGSTPTAVIRDNMQRTMQSDAAVFRTS
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KTLKEGVDKMAEIFATFEDVKVSDRSLVWNSDLIETYELNNLLLNAVATINSAEQRKESR
HHHHHHHHHHHHHHHHHHHCEECCCEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHC
GAHSHEDFPDRDDVNWQKHTLVTVDDKGKCEFDYRPVHMYTLSKDVDVVPPKPRVY
CCCCCCCCCCCCCCCCCEEEEEEECCCCCEEECCCEEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA