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The map label for this gene is zwf [H]

Identifier: 21242810

GI number: 21242810

Start: 2419342

End: 2420772

Strand: Reverse

Name: zwf [H]

Synonym: XAC2071

Alternate gene names: 21242810

Gene position: 2420772-2419342 (Counterclockwise)

Preceding gene: 21242812

Following gene: 21242809

Centisome position: 46.77

GC content: 67.23

Gene sequence:

>1431_bases
ATGCACAACACCCTGATCCTGTTCGGCGCCACCGGCGATCTTGCCCAGCGCTATCTCTTTCCTTCCCTGCTGCGTCTGTT
CATCGACGGTCTGTTGCCGGAGGACTTCCGCATCCGTGCGCTGGCGCTGTCGCCGCACGACACCGATGCATTTCGCGACG
TGCTGCGGCCGCGCCTGACCGAAGCGCTGCCGATCGCGACCGCCGAACAGATCGACACGCTGCTACAACGGGTCGACTAT
CGCTCGGTGGATCTGCGCAATGCCGATTCGGTGGCCGACGCGGTCCGCGAACTGGCCAGCCGTCGGTGTGTGAGCTATCT
GGCGATCCCGCCGGGCCTGTACATCAGCACCTGCCAGGGCCTGGCGCTGGGTGGCGCCCTGGCGGCACCGCATCGCTTGA
TGCTGGAAAAACCGATCGGCCACGACTCGGACAGCGCCCGCGACATCCTGCAGTCGATCGGCGCGCTGATCGACGAAGAC
CGCGTGTTCCGCCTGGACCATTACTTGGGCAAGGCAGCGGTGCAGAACCTGATCGCGCTGCGCTTCGGCAACACGCTGCT
GGAGGCGGTCTGGAACCGGACCTACATCGAGTCGGTGCAGATCCTGGTCGCCGAAAGCGAAGGCGTCGACGGGCGCGATG
CCTACTACGCCCGCTCCGGCGCCCTGCGCGACATGGTGCAGAGCCATATCCTGCAGCTGTTGTGCCTGGTGGCAATGGAG
CCGCCGGCCTCGCTGGAAGCCGACCGCATCCGCGATGAGAAGGTCAAGGTGCTGCGCGCCCTGCGCCCGATGACCGCCGA
GCACGCCGCGCACGACTGCGTGCGCGGCCGCTACACCGCCGGCAGCATCAACGGCCAGCCGGCGCAGGCCTACCACCCGC
CGGAAGGCAGCGACGTGGAAACCTTTGTCGCCGTCACCGCGCATATCGATAACTGGCGCTGGGCCGGCGTGCCGTTCCAC
CTGTGCACCGGCAAGCGTCTGGCCGAGCGCTCCACCCGCATCGTGGTGACGCTCAAGCCGGTGACGCACTGGCTGTTCGA
ACGCCCCGACCGCCAGAACGCGGTGCCGAACCGCCTGACCTTCCAGTTGCAGCCGCAGGAAAACATCGAGCTCGGCCTGA
TGAGCAGCCTGGCTGGCCCGGAATGGGGTGCGATCGAACTGCAGCCGCTGGAACTGGAACTGTCGGTGCCGACCGGCCTG
CACCGTCGTATCGCCTACGAACGTCTGTTCGTCGACGCCTTCAACGGTAACCCCGCGCTGTTCGTGCGCGACGACGAGGT
CAAGGCGGCGTGGTCGTGGATCGACAGCGTGAGCGACGCCTGGAAAGACGCCGCGCTGCCGCTGCAGCCCTACCCGGCCG
GCAGCTGGGGTCCCGAATCGGCCGCCCACTTCCTGCCCCCGGCCACCGACGCACAGGGAAACAACGCATGA

Upstream 100 bases:

>100_bases
CGCAAGTGTCGCTCAGGAACAGACGTACCGACCGCCGGCCGACCGGCGCCTTTCCGCCAAGCTGCTGATAACGATGTCTC
CAGAATCTGAAACGCGGTCC

Downstream 100 bases:

>100_bases
CCGCTCCTTCCAAGCCGGTGCTGGTTGCCGATATCGGCGGTACCAATGCGCGCTTCGCGCTGGCCGATGTCGACGCCTCG
GTGCCGTTGCTGGATGACAC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MHNTLILFGATGDLAQRYLFPSLLRLFIDGLLPEDFRIRALALSPHDTDAFRDVLRPRLTEALPIATAEQIDTLLQRVDY
RSVDLRNADSVADAVRELASRRCVSYLAIPPGLYISTCQGLALGGALAAPHRLMLEKPIGHDSDSARDILQSIGALIDED
RVFRLDHYLGKAAVQNLIALRFGNTLLEAVWNRTYIESVQILVAESEGVDGRDAYYARSGALRDMVQSHILQLLCLVAME
PPASLEADRIRDEKVKVLRALRPMTAEHAAHDCVRGRYTAGSINGQPAQAYHPPEGSDVETFVAVTAHIDNWRWAGVPFH
LCTGKRLAERSTRIVVTLKPVTHWLFERPDRQNAVPNRLTFQLQPQENIELGLMSSLAGPEWGAIELQPLELELSVPTGL
HRRIAYERLFVDAFNGNPALFVRDDEVKAAWSWIDSVSDAWKDAALPLQPYPAGSWGPESAAHFLPPATDAQGNNA

Sequences:

>Translated_476_residues
MHNTLILFGATGDLAQRYLFPSLLRLFIDGLLPEDFRIRALALSPHDTDAFRDVLRPRLTEALPIATAEQIDTLLQRVDY
RSVDLRNADSVADAVRELASRRCVSYLAIPPGLYISTCQGLALGGALAAPHRLMLEKPIGHDSDSARDILQSIGALIDED
RVFRLDHYLGKAAVQNLIALRFGNTLLEAVWNRTYIESVQILVAESEGVDGRDAYYARSGALRDMVQSHILQLLCLVAME
PPASLEADRIRDEKVKVLRALRPMTAEHAAHDCVRGRYTAGSINGQPAQAYHPPEGSDVETFVAVTAHIDNWRWAGVPFH
LCTGKRLAERSTRIVVTLKPVTHWLFERPDRQNAVPNRLTFQLQPQENIELGLMSSLAGPEWGAIELQPLELELSVPTGL
HRRIAYERLFVDAFNGNPALFVRDDEVKAAWSWIDSVSDAWKDAALPLQPYPAGSWGPESAAHFLPPATDAQGNNA
>Mature_476_residues
MHNTLILFGATGDLAQRYLFPSLLRLFIDGLLPEDFRIRALALSPHDTDAFRDVLRPRLTEALPIATAEQIDTLLQRVDY
RSVDLRNADSVADAVRELASRRCVSYLAIPPGLYISTCQGLALGGALAAPHRLMLEKPIGHDSDSARDILQSIGALIDED
RVFRLDHYLGKAAVQNLIALRFGNTLLEAVWNRTYIESVQILVAESEGVDGRDAYYARSGALRDMVQSHILQLLCLVAME
PPASLEADRIRDEKVKVLRALRPMTAEHAAHDCVRGRYTAGSINGQPAQAYHPPEGSDVETFVAVTAHIDNWRWAGVPFH
LCTGKRLAERSTRIVVTLKPVTHWLFERPDRQNAVPNRLTFQLQPQENIELGLMSSLAGPEWGAIELQPLELELSVPTGL
HRRIAYERLFVDAFNGNPALFVRDDEVKAAWSWIDSVSDAWKDAALPLQPYPAGSWGPESAAHFLPPATDAQGNNA

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=481, Percent_Identity=33.4719334719335, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI108773793, Length=481, Percent_Identity=33.4719334719335, Blast_Score=243, Evalue=4e-64,
Organism=Homo sapiens, GI52145310, Length=494, Percent_Identity=28.9473684210526, Blast_Score=174, Evalue=2e-43,
Organism=Escherichia coli, GI1788158, Length=464, Percent_Identity=40.948275862069, Blast_Score=349, Evalue=2e-97,
Organism=Caenorhabditis elegans, GI17538218, Length=477, Percent_Identity=33.7526205450734, Blast_Score=252, Evalue=4e-67,
Organism=Saccharomyces cerevisiae, GI6324088, Length=487, Percent_Identity=32.6488706365503, Blast_Score=233, Evalue=5e-62,
Organism=Drosophila melanogaster, GI24643352, Length=477, Percent_Identity=32.2851153039832, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24643350, Length=477, Percent_Identity=32.2851153039832, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI221513548, Length=476, Percent_Identity=27.3109243697479, Blast_Score=155, Evalue=5e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 52787; Mature: 52787

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNTLILFGATGDLAQRYLFPSLLRLFIDGLLPEDFRIRALALSPHDTDAFRDVLRPRLT
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHH
EALPIATAEQIDTLLQRVDYRSVDLRNADSVADAVRELASRRCVSYLAIPPGLYISTCQG
HHCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCC
LALGGALAAPHRLMLEKPIGHDSDSARDILQSIGALIDEDRVFRLDHYLGKAAVQNLIAL
HHHCCHHHCCCHHEEECCCCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHH
RFGNTLLEAVWNRTYIESVQILVAESEGVDGRDAYYARSGALRDMVQSHILQLLCLVAME
HHHHHHHHHHHCHHHHHEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PPASLEADRIRDEKVKVLRALRPMTAEHAAHDCVRGRYTAGSINGQPAQAYHPPEGSDVE
CCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCE
TFVAVTAHIDNWRWAGVPFHLCTGKRLAERSTRIVVTLKPVTHWLFERPDRQNAVPNRLT
EEEEEEEEECCCEECCCCEEECCCCHHHCCCCEEEEEECHHHHHHHCCCCCCCCCCCCEE
FQLQPQENIELGLMSSLAGPEWGAIELQPLELELSVPTGLHRRIAYERLFVDAFNGNPAL
EEECCCCCCCHHHHHHCCCCCCCEEEEEEEEEEEECCCCHHHHHHHHHHEEEEECCCEEE
FVRDDEVKAAWSWIDSVSDAWKDAALPLQPYPAGSWGPESAAHFLPPATDAQGNNA
EEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCC
>Mature Secondary Structure
MHNTLILFGATGDLAQRYLFPSLLRLFIDGLLPEDFRIRALALSPHDTDAFRDVLRPRLT
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHH
EALPIATAEQIDTLLQRVDYRSVDLRNADSVADAVRELASRRCVSYLAIPPGLYISTCQG
HHCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCC
LALGGALAAPHRLMLEKPIGHDSDSARDILQSIGALIDEDRVFRLDHYLGKAAVQNLIAL
HHHCCHHHCCCHHEEECCCCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHH
RFGNTLLEAVWNRTYIESVQILVAESEGVDGRDAYYARSGALRDMVQSHILQLLCLVAME
HHHHHHHHHHHCHHHHHEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PPASLEADRIRDEKVKVLRALRPMTAEHAAHDCVRGRYTAGSINGQPAQAYHPPEGSDVE
CCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCE
TFVAVTAHIDNWRWAGVPFHLCTGKRLAERSTRIVVTLKPVTHWLFERPDRQNAVPNRLT
EEEEEEEEECCCEECCCCEEECCCCHHHCCCCEEEEEECHHHHHHHCCCCCCCCCCCCEE
FQLQPQENIELGLMSSLAGPEWGAIELQPLELELSVPTGLHRRIAYERLFVDAFNGNPAL
EEECCCCCCCHHHHHHCCCCCCCEEEEEEEEEEEECCCCHHHHHHHHHHEEEEECCCEEE
FVRDDEVKAAWSWIDSVSDAWKDAALPLQPYPAGSWGPESAAHFLPPATDAQGNNA
EEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2254282 [H]