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The map label for this gene is mvaB [H]

Identifier: 21242595

GI number: 21242595

Start: 2147288

End: 2148184

Strand: Reverse

Name: mvaB [H]

Synonym: XAC1851

Alternate gene names: 21242595

Gene position: 2148184-2147288 (Counterclockwise)

Preceding gene: 21242596

Following gene: 21242594

Centisome position: 41.51

GC content: 68.23

Gene sequence:

>897_bases
ATGAGCGACTTCGTCCGCATTGTCGAAGTTGGCCCACGCGATGGCCTGCAAAACGAAGCGCAGCCGATCGCCACTGCCGA
CAAGATCGCGTTGATCGATCAACTCTCGGCCACCGGGCTGCGCACGATCGAAGCGACCAGCTTCGTCAGCCCACGCTGGG
TACCGCAGCTGGCCGACGCCGCCGAGGTGTTTGCCGGCATCGCGCAGGCGCCGGGCATCGAATATCCGGTGCTGGTACCC
AACCTGCAGGGCTACGAACGCGCACGCGCCGCGGGGGCGCAGGAAGTGGCGGTATTCACCGCAGCATCGGAGGCGTTCAA
TCGCACCAATACCAACGCCGGCATCGACGAATCGATCGAACGGTTTCGGCCAATCCTGCAGCAGGCCGCGCTCGATGGGA
TACGCGTGCGCGGCTACGTCTCCACCGTGCTGGGCTGCCCGTACCAGGGCGAGGTGCCGGTGACCGACGTGGTGGATGTG
GCGCAACGTCTGCACGCGCTCGGCTGCTATGAAATCTCGCTGGGCGACACCATTGGCGTGGGCACGCCGGTCAAGGCGCG
TCGGATGCTGGCCGCAGTGGCGCAGGCCGTGCCGATGCCGGCGTTGGCGGTGCATTTCCACGATACCTACGGGCAGGCGC
TGGCCAATATCGCGGCCTGCCTGGAGCAAGGCGTACGCGTGATCGATGCGGCCGTGTCCGGTGCGGGCGGCTGCCCGTAT
GCCAGGGGCGCCAGCGGCAACGTGGCCAGCGAAGACGTGGTGTACCTGTTGCAGGGGCTGGGCATGCCCACCGGCATCGA
CCTGCCCGCCCTGGCCCGCACCGGCCGCTGGCTGGCGCGGCTGCTCGGTCGCGACACCGGCAGCAAGGTCGGCAAGGCGT
TGGCTGCCGCCGGCTGA

Upstream 100 bases:

>100_bases
TTCCGATGTCCCTGGATTCCTTATTCGCGCATTCGGCCGCCACCACGCATGCGGTTGTGGCGATGCCTGTATGCGGTCAT
GCGCGCCGCGATGTGAGCGC

Downstream 100 bases:

>100_bases
GATCTGCCTGCCCGCGCATCGTGCATCACCTACCACCGCGATCACGCAGGGGCTTGGGCTAGAATGGCCGACCGCTCCGC
CGATCGTTCGTTTGCCGCCA

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MSDFVRIVEVGPRDGLQNEAQPIATADKIALIDQLSATGLRTIEATSFVSPRWVPQLADAAEVFAGIAQAPGIEYPVLVP
NLQGYERARAAGAQEVAVFTAASEAFNRTNTNAGIDESIERFRPILQQAALDGIRVRGYVSTVLGCPYQGEVPVTDVVDV
AQRLHALGCYEISLGDTIGVGTPVKARRMLAAVAQAVPMPALAVHFHDTYGQALANIAACLEQGVRVIDAAVSGAGGCPY
ARGASGNVASEDVVYLLQGLGMPTGIDLPALARTGRWLARLLGRDTGSKVGKALAAAG

Sequences:

>Translated_298_residues
MSDFVRIVEVGPRDGLQNEAQPIATADKIALIDQLSATGLRTIEATSFVSPRWVPQLADAAEVFAGIAQAPGIEYPVLVP
NLQGYERARAAGAQEVAVFTAASEAFNRTNTNAGIDESIERFRPILQQAALDGIRVRGYVSTVLGCPYQGEVPVTDVVDV
AQRLHALGCYEISLGDTIGVGTPVKARRMLAAVAQAVPMPALAVHFHDTYGQALANIAACLEQGVRVIDAAVSGAGGCPY
ARGASGNVASEDVVYLLQGLGMPTGIDLPALARTGRWLARLLGRDTGSKVGKALAAAG
>Mature_297_residues
SDFVRIVEVGPRDGLQNEAQPIATADKIALIDQLSATGLRTIEATSFVSPRWVPQLADAAEVFAGIAQAPGIEYPVLVPN
LQGYERARAAGAQEVAVFTAASEAFNRTNTNAGIDESIERFRPILQQAALDGIRVRGYVSTVLGCPYQGEVPVTDVVDVA
QRLHALGCYEISLGDTIGVGTPVKARRMLAAVAQAVPMPALAVHFHDTYGQALANIAACLEQGVRVIDAAVSGAGGCPYA
RGASGNVASEDVVYLLQGLGMPTGIDLPALARTGRWLARLLGRDTGSKVGKALAAAG

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=289, Percent_Identity=58.1314878892734, Blast_Score=356, Evalue=1e-98,
Organism=Homo sapiens, GI109150422, Length=293, Percent_Identity=55.9726962457338, Blast_Score=352, Evalue=3e-97,
Organism=Homo sapiens, GI109150427, Length=293, Percent_Identity=55.9726962457338, Blast_Score=351, Evalue=4e-97,
Organism=Homo sapiens, GI260654708, Length=134, Percent_Identity=58.2089552238806, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17510563, Length=292, Percent_Identity=50.6849315068493, Blast_Score=310, Evalue=5e-85,
Organism=Drosophila melanogaster, GI24582381, Length=289, Percent_Identity=62.2837370242215, Blast_Score=370, Evalue=1e-103,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000138
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 31060; Mature: 30929

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00104 EPSP_SYNTHASE_1 ; PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDFVRIVEVGPRDGLQNEAQPIATADKIALIDQLSATGLRTIEATSFVSPRWVPQLADA
CCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHH
AEVFAGIAQAPGIEYPVLVPNLQGYERARAAGAQEVAVFTAASEAFNRTNTNAGIDESIE
HHHHHHHHHCCCCCCCEECCCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHH
RFRPILQQAALDGIRVRGYVSTVLGCPYQGEVPVTDVVDVAQRLHALGCYEISLGDTIGV
HHHHHHHHHHHCCEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCEEEECCCCCCC
GTPVKARRMLAAVAQAVPMPALAVHFHDTYGQALANIAACLEQGVRVIDAAVSGAGGCPY
CCCHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ARGASGNVASEDVVYLLQGLGMPTGIDLPALARTGRWLARLLGRDTGSKVGKALAAAG
CCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SDFVRIVEVGPRDGLQNEAQPIATADKIALIDQLSATGLRTIEATSFVSPRWVPQLADA
CCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHH
AEVFAGIAQAPGIEYPVLVPNLQGYERARAAGAQEVAVFTAASEAFNRTNTNAGIDESIE
HHHHHHHHHCCCCCCCEECCCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHH
RFRPILQQAALDGIRVRGYVSTVLGCPYQGEVPVTDVVDVAQRLHALGCYEISLGDTIGV
HHHHHHHHHHHCCEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCEEEECCCCCCC
GTPVKARRMLAAVAQAVPMPALAVHFHDTYGQALANIAACLEQGVRVIDAAVSGAGGCPY
CCCHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ARGASGNVASEDVVYLLQGLGMPTGIDLPALARTGRWLARLLGRDTGSKVGKALAAAG
CCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2687236; 2656635; 1637819 [H]