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The map label for this gene is serA [H]

Identifier: 21242588

GI number: 21242588

Start: 2140048

End: 2141289

Strand: Reverse

Name: serA [H]

Synonym: XAC1844

Alternate gene names: 21242588

Gene position: 2141289-2140048 (Counterclockwise)

Preceding gene: 21242592

Following gene: 21242586

Centisome position: 41.37

GC content: 64.41

Gene sequence:

>1242_bases
ATGTCGCCGAAGAAAACCTCGTTTCCCAAGCAGGACATCCGCGTGCTGTTGCTGGAAGGGATCAGCCCGACCGCCGTGGA
CGTGTTCCGCGCCGCCGGCTACTCGCAGATCGAACTGCACGCCAAATCGCTGCCGGAAGACGAGTTGATCGCCCGCATCG
CAGACGCGCATATCGTCGGTATCCGCTCGCGCACGCAGCTGAGCGCCGACGTGCTGGCGCACGCCAAGCGCCTGATCGCA
GTCGGCTGCTTCTGCATCGGCACCAACCAGGTCGACCTGGACGCGGCCGAGCTGGCTGGCATCCCGGTATTCAACGCACC
CTACTCCAACACCCGCAGCGTGGCCGAACTGGTCATCGCCGAGGCGATCCTGCTATTGCGCGGCATTCCGCAGAAGAACG
CGCAATGCCATCGCGGTGGCTGGTCGAAATCGGCCGCCGGCAGCCACGAAACGCGCGGCAAGGTGCTGGGCATCGTCGGC
TACGGGCATATCGGCACCCAGGTCGGCGTGCTGGCCGAATCGCTGGGCATGCAGGTGATCTTCCACGATATCGAAACCAA
GCTGTCGTTGGGCAATGCCCGCGCGGCGATCGATCTGGACGACCTGCTGGCACGCGCAGACGTGGTGACCTTGCACGTGC
CGGAAACGCCGTCGACCAAGGACATGATCGGCGCGCCGGAGATCGCCCGCATGAAACCCGGCGCGCATCTCATCAACGCC
TCGCGTGGCACCGTCATCGACATCGACGCGCTGGATGCGGCGCTCACCTCCGGCCAGATCGGCGGCGCGGCGGTGGATGT
CTTCCCGATCGAGCCCAAGGGCAATGGCGATGCGTTCGAATCGCCGCTCACTGCGCACGACAACGTGATCCTGACCCCGC
ACGTGGGCGGCAGCACGCTGGAAGCGCAGGACAACATCGGCATCGAGGTCGCCGCCAAACTGGTGCGCTATAGCGACAAC
GGCAGCACCTTGTCGGCGGTGAACTTCCCGGAGGTCACCCTGCCCGAGCACGCTGAAAGCCTGCGTTTGCTGCACATCCA
TCGCAACGTGCCGGGCGTGCTGTCGCAGATCAACGAACTGTTTTCGCGCCATAACGTCAATATCGATGGCCAGTTCCTGC
GCACCGACCCCAAGGTGGGCTACGTGGTCATCGATGTCGGCGCCAGCGAGGAACTTGCCGGCGTACTGAAGGACGAGCTG
GGGCAGATCACCGGCACCTTGCGGACCCGGATCCTTTATTGA

Upstream 100 bases:

>100_bases
ACCGCAAGGGCTTGGCCGGTGCGAACACTGCGTTGCGGCCACCCAATCGCGCACCCCATCTGGCATAGTTGCCGACCCGA
TTGCTGCATTGCGTTCCCCC

Downstream 100 bases:

>100_bases
GCGGGATTGGGGAATCGGGATTCGGGATTCGGGATTCGCAACAGCGCTGCGCGGCAACCTGTGGGTTCACCGGTCCAATC
ACGCTGTAGGAGGTAGAACA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MSPKKTSFPKQDIRVLLLEGISPTAVDVFRAAGYSQIELHAKSLPEDELIARIADAHIVGIRSRTQLSADVLAHAKRLIA
VGCFCIGTNQVDLDAAELAGIPVFNAPYSNTRSVAELVIAEAILLLRGIPQKNAQCHRGGWSKSAAGSHETRGKVLGIVG
YGHIGTQVGVLAESLGMQVIFHDIETKLSLGNARAAIDLDDLLARADVVTLHVPETPSTKDMIGAPEIARMKPGAHLINA
SRGTVIDIDALDAALTSGQIGGAAVDVFPIEPKGNGDAFESPLTAHDNVILTPHVGGSTLEAQDNIGIEVAAKLVRYSDN
GSTLSAVNFPEVTLPEHAESLRLLHIHRNVPGVLSQINELFSRHNVNIDGQFLRTDPKVGYVVIDVGASEELAGVLKDEL
GQITGTLRTRILY

Sequences:

>Translated_413_residues
MSPKKTSFPKQDIRVLLLEGISPTAVDVFRAAGYSQIELHAKSLPEDELIARIADAHIVGIRSRTQLSADVLAHAKRLIA
VGCFCIGTNQVDLDAAELAGIPVFNAPYSNTRSVAELVIAEAILLLRGIPQKNAQCHRGGWSKSAAGSHETRGKVLGIVG
YGHIGTQVGVLAESLGMQVIFHDIETKLSLGNARAAIDLDDLLARADVVTLHVPETPSTKDMIGAPEIARMKPGAHLINA
SRGTVIDIDALDAALTSGQIGGAAVDVFPIEPKGNGDAFESPLTAHDNVILTPHVGGSTLEAQDNIGIEVAAKLVRYSDN
GSTLSAVNFPEVTLPEHAESLRLLHIHRNVPGVLSQINELFSRHNVNIDGQFLRTDPKVGYVVIDVGASEELAGVLKDEL
GQITGTLRTRILY
>Mature_412_residues
SPKKTSFPKQDIRVLLLEGISPTAVDVFRAAGYSQIELHAKSLPEDELIARIADAHIVGIRSRTQLSADVLAHAKRLIAV
GCFCIGTNQVDLDAAELAGIPVFNAPYSNTRSVAELVIAEAILLLRGIPQKNAQCHRGGWSKSAAGSHETRGKVLGIVGY
GHIGTQVGVLAESLGMQVIFHDIETKLSLGNARAAIDLDDLLARADVVTLHVPETPSTKDMIGAPEIARMKPGAHLINAS
RGTVIDIDALDAALTSGQIGGAAVDVFPIEPKGNGDAFESPLTAHDNVILTPHVGGSTLEAQDNIGIEVAAKLVRYSDNG
STLSAVNFPEVTLPEHAESLRLLHIHRNVPGVLSQINELFSRHNVNIDGQFLRTDPKVGYVVIDVGASEELAGVLKDELG
QITGTLRTRILY

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=322, Percent_Identity=35.4037267080745, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI145580578, Length=246, Percent_Identity=33.3333333333333, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI4557499, Length=246, Percent_Identity=33.3333333333333, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI61743967, Length=282, Percent_Identity=30.4964539007092, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI4557497, Length=282, Percent_Identity=30.4964539007092, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI145580575, Length=246, Percent_Identity=33.3333333333333, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI6912396, Length=282, Percent_Identity=25.886524822695, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI1789279, Length=409, Percent_Identity=61.3691931540342, Blast_Score=508, Evalue=1e-145,
Organism=Escherichia coli, GI87082289, Length=249, Percent_Identity=32.9317269076305, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1787645, Length=244, Percent_Identity=30.7377049180328, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788660, Length=295, Percent_Identity=29.8305084745763, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI87081824, Length=150, Percent_Identity=32.6666666666667, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=323, Percent_Identity=33.1269349845201, Blast_Score=160, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI25147481, Length=276, Percent_Identity=29.7101449275362, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320925, Length=421, Percent_Identity=48.6935866983373, Blast_Score=417, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6322116, Length=435, Percent_Identity=47.3563218390805, Blast_Score=413, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6324055, Length=242, Percent_Identity=28.099173553719, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324964, Length=261, Percent_Identity=27.9693486590038, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6325144, Length=152, Percent_Identity=32.8947368421053, Blast_Score=73, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6321253, Length=156, Percent_Identity=30.1282051282051, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI19921140, Length=308, Percent_Identity=31.8181818181818, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24646446, Length=219, Percent_Identity=33.7899543378995, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24646448, Length=219, Percent_Identity=33.7899543378995, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24646452, Length=219, Percent_Identity=33.7899543378995, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24646450, Length=219, Percent_Identity=33.7899543378995, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI62472511, Length=219, Percent_Identity=33.7899543378995, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI28574286, Length=261, Percent_Identity=29.5019157088123, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28571528, Length=296, Percent_Identity=26.6891891891892, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24585516, Length=297, Percent_Identity=23.9057239057239, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI28574284, Length=262, Percent_Identity=25.1908396946565, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45551003, Length=262, Percent_Identity=25.1908396946565, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45552429, Length=262, Percent_Identity=25.1908396946565, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24585514, Length=262, Percent_Identity=25.1908396946565, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28574282, Length=262, Percent_Identity=25.1908396946565, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR010771
- InterPro:   IPR016040
- ProDom:   PD147088 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 43913; Mature: 43781

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPKKTSFPKQDIRVLLLEGISPTAVDVFRAAGYSQIELHAKSLPEDELIARIADAHIVG
CCCCCCCCCHHHEEEEEECCCCCHHHHHHHHCCCCEEEEEHHCCCHHHHHHHHHCCEEEE
IRSRTQLSADVLAHAKRLIAVGCFCIGTNQVDLDAAELAGIPVFNAPYSNTRSVAELVIA
ECCCHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHCCCCEECCCCCCHHHHHHHHHH
EAILLLRGIPQKNAQCHRGGWSKSAAGSHETRGKVLGIVGYGHIGTQVGVLAESLGMQVI
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCEEE
FHDIETKLSLGNARAAIDLDDLLARADVVTLHVPETPSTKDMIGAPEIARMKPGAHLINA
EEHHHHHEECCCCEEEEEHHHHHHHCCEEEEECCCCCCCCCCCCCCHHHHCCCCCEEEEC
SRGTVIDIDALDAALTSGQIGGAAVDVFPIEPKGNGDAFESPLTAHDNVILTPHVGGSTL
CCCCEEEEHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCEE
EAQDNIGIEVAAKLVRYSDNGSTLSAVNFPEVTLPEHAESLRLLHIHRNVPGVLSQINEL
ECCCCCCHHHHEEHHEECCCCCEEEEECCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHH
FSRHNVNIDGQFLRTDPKVGYVVIDVGASEELAGVLKDELGQITGTLRTRILY
HHHCCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHEECC
>Mature Secondary Structure 
SPKKTSFPKQDIRVLLLEGISPTAVDVFRAAGYSQIELHAKSLPEDELIARIADAHIVG
CCCCCCCCHHHEEEEEECCCCCHHHHHHHHCCCCEEEEEHHCCCHHHHHHHHHCCEEEE
IRSRTQLSADVLAHAKRLIAVGCFCIGTNQVDLDAAELAGIPVFNAPYSNTRSVAELVIA
ECCCHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHCCCCEECCCCCCHHHHHHHHHH
EAILLLRGIPQKNAQCHRGGWSKSAAGSHETRGKVLGIVGYGHIGTQVGVLAESLGMQVI
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCEEE
FHDIETKLSLGNARAAIDLDDLLARADVVTLHVPETPSTKDMIGAPEIARMKPGAHLINA
EEHHHHHEECCCCEEEEEHHHHHHHCCEEEEECCCCCCCCCCCCCCHHHHCCCCCEEEEC
SRGTVIDIDALDAALTSGQIGGAAVDVFPIEPKGNGDAFESPLTAHDNVILTPHVGGSTL
CCCCEEEEHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCEE
EAQDNIGIEVAAKLVRYSDNGSTLSAVNFPEVTLPEHAESLRLLHIHRNVPGVLSQINEL
ECCCCCCHHHHEEHHEECCCCCEEEEECCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHH
FSRHNVNIDGQFLRTDPKVGYVVIDVGASEELAGVLKDELGQITGTLRTRILY
HHHCCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]