Click here to switch to the map view.

The map label for this gene is yhdG [H]

Identifier: 21242586

GI number: 21242586

Start: 2137683

End: 2139164

Strand: Reverse

Name: yhdG [H]

Synonym: XAC1842

Alternate gene names: 21242586

Gene position: 2139164-2137683 (Counterclockwise)

Preceding gene: 21242588

Following gene: 21242585

Centisome position: 41.33

GC content: 64.64

Gene sequence:

>1482_bases
ATGTACCGAATGCTGAAGTCTCTGTTGAGGGTCAAACCGATCGAGCCCGCCGGCCACGTCGATGCGGGCGAACCGGTCGA
AGGTAGCCTGCAAGGCGAAGCCACGTTGCAACGGACCCTCACAGCCAAGCACCTGATCATGCTCGGTATCGGCGCGGTGA
TCGGCGCCGGCATCTTCGTGCTGACCGGCCAGGCCGCGGCCAATCACGCCGGCCCGGCGGTGATGCTGTCGTTCGTGTTC
GCTGGTATCGCCTGCGCCTTCGCCGGCCTGTGCTACGCCGAATTCGCCGCGATGATGCCGGTCTCCGGCAGCGCCTATTC
GTATTCATACGCCACGCTCGGCGAAGGCATCGCCTGGTTCATCGGCTGGTGTCTGGTGCTGGAATACCTGTTCGCCGGCT
CCAGCGTTGCGGTCGGCTGGTCTGCCTACCTGATCAGCTTCATCACCGGGACCCTGGGGTTGCCGTTCCCCGCAGAGTTG
GCGGGTGCGCCGCTGGCCTGGGACGGCCACGGCTTTGTCAGCTCCGGCAACCTGGTCAACCTGCCGGCCGTGCTGATCGT
CGCCGCAGTGAGCATCCTGTGCTACGTCGGCGTCACTCAGTCGGCGTTCGCCAACGCGATCGTGGTTGCGATCAAGGTCG
TGGTGATCTGCCTGTTCGTGGGTTTCGGCATTGCCTATATCGACCCGGCGAACTGGCACCCCTTCATCCCGGAAAATACC
GGCCCTGGCCAGTTCGGCTGGGACGGGGTGTTTCGCGCCGCGTCCATCGTGTTCTTCTCCTACATCGGCTTCGACGCGGT
TTCCACCTCGGCCGGCGAGACCAAGGACCCGCAGAAGAACATGCCGATCGGCATCCTGGTGTCGCTGGCGATCTGCACCA
TCATCTACATCATCGTCTGCGCAGTGCTGACCGGCCTGCTGCCCTACACCCAGCTCGGCACCGCCAAGCCGGTGGCCACC
GCGCTGGAAGCCCATCCGCAACTGACCTGGCTCAAGACCGCGGTGGAAATCGGTGCCATCGCCGGCCTGTCATCGGTGGT
GCTGGTGATGCTGATGGCACAGCCGCGCATCTTCTACACCATGGCCAAGGATGGGCTGATGCCCAAGCTGTTCGGCAAGG
TGCACCCGAAATTCCGCACGCCTTACGTCGGCACGCTCTTCGTGGGCGTGGTCGCCGCGCTGCTGGCCGGGGTCATCCCG
TTGAACGTGCTGGGCGAACTCGTCTCGATGGGTACCCTGCTCGCCTTCGCCACGGTCTGCGCTGGCGTGCTGGTGCTGCG
CTTCACCAAGCCCGACCTGGCGCGCCCGTTCCGGGTGCCGCTGGCGATGGTGATCTGCCCGCTGGGCGCGTTGGCCTGTC
TGTTCCTGTTCTTCCAGGCCTTCCAGGAACACTGGAAGGTGTTCGTGGGCTGGACCGTGATTGGCCTGGCGATCTACTTC
GGCTACGGCATCCACCACAGTCGCCTCGCGAAACGGGCCTAA

Upstream 100 bases:

>100_bases
TGAGCGTGTAGCTTTGGCAAGGTAGGCCGCTTGCCTGTCCCATCGGGATGCGGCGCACCAATTCGTCCGGGCGCCTGCGC
CTGCGCTTTGCCACTTAGGG

Downstream 100 bases:

>100_bases
CCTTCTCTCAAGACCGGCGCGCGACGCCGGTCTTCTTGTTCAATGATCGCGCGTAGCGCCAAGCCGGAACCGCTTCATGT
TCAAACAACTTTGGGCCACC

Product: cationic amino acid transporter

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MYRMLKSLLRVKPIEPAGHVDAGEPVEGSLQGEATLQRTLTAKHLIMLGIGAVIGAGIFVLTGQAAANHAGPAVMLSFVF
AGIACAFAGLCYAEFAAMMPVSGSAYSYSYATLGEGIAWFIGWCLVLEYLFAGSSVAVGWSAYLISFITGTLGLPFPAEL
AGAPLAWDGHGFVSSGNLVNLPAVLIVAAVSILCYVGVTQSAFANAIVVAIKVVVICLFVGFGIAYIDPANWHPFIPENT
GPGQFGWDGVFRAASIVFFSYIGFDAVSTSAGETKDPQKNMPIGILVSLAICTIIYIIVCAVLTGLLPYTQLGTAKPVAT
ALEAHPQLTWLKTAVEIGAIAGLSSVVLVMLMAQPRIFYTMAKDGLMPKLFGKVHPKFRTPYVGTLFVGVVAALLAGVIP
LNVLGELVSMGTLLAFATVCAGVLVLRFTKPDLARPFRVPLAMVICPLGALACLFLFFQAFQEHWKVFVGWTVIGLAIYF
GYGIHHSRLAKRA

Sequences:

>Translated_493_residues
MYRMLKSLLRVKPIEPAGHVDAGEPVEGSLQGEATLQRTLTAKHLIMLGIGAVIGAGIFVLTGQAAANHAGPAVMLSFVF
AGIACAFAGLCYAEFAAMMPVSGSAYSYSYATLGEGIAWFIGWCLVLEYLFAGSSVAVGWSAYLISFITGTLGLPFPAEL
AGAPLAWDGHGFVSSGNLVNLPAVLIVAAVSILCYVGVTQSAFANAIVVAIKVVVICLFVGFGIAYIDPANWHPFIPENT
GPGQFGWDGVFRAASIVFFSYIGFDAVSTSAGETKDPQKNMPIGILVSLAICTIIYIIVCAVLTGLLPYTQLGTAKPVAT
ALEAHPQLTWLKTAVEIGAIAGLSSVVLVMLMAQPRIFYTMAKDGLMPKLFGKVHPKFRTPYVGTLFVGVVAALLAGVIP
LNVLGELVSMGTLLAFATVCAGVLVLRFTKPDLARPFRVPLAMVICPLGALACLFLFFQAFQEHWKVFVGWTVIGLAIYF
GYGIHHSRLAKRA
>Mature_493_residues
MYRMLKSLLRVKPIEPAGHVDAGEPVEGSLQGEATLQRTLTAKHLIMLGIGAVIGAGIFVLTGQAAANHAGPAVMLSFVF
AGIACAFAGLCYAEFAAMMPVSGSAYSYSYATLGEGIAWFIGWCLVLEYLFAGSSVAVGWSAYLISFITGTLGLPFPAEL
AGAPLAWDGHGFVSSGNLVNLPAVLIVAAVSILCYVGVTQSAFANAIVVAIKVVVICLFVGFGIAYIDPANWHPFIPENT
GPGQFGWDGVFRAASIVFFSYIGFDAVSTSAGETKDPQKNMPIGILVSLAICTIIYIIVCAVLTGLLPYTQLGTAKPVAT
ALEAHPQLTWLKTAVEIGAIAGLSSVVLVMLMAQPRIFYTMAKDGLMPKLFGKVHPKFRTPYVGTLFVGVVAALLAGVIP
LNVLGELVSMGTLLAFATVCAGVLVLRFTKPDLARPFRVPLAMVICPLGALACLFLFFQAFQEHWKVFVGWTVIGLAIYF
GYGIHHSRLAKRA

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of Lysine. [C]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI4507047, Length=425, Percent_Identity=36.7058823529412, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI114326544, Length=429, Percent_Identity=33.1002331002331, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI114326550, Length=429, Percent_Identity=33.1002331002331, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI258614005, Length=425, Percent_Identity=33.6470588235294, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI258614003, Length=425, Percent_Identity=33.6470588235294, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI258645169, Length=425, Percent_Identity=33.1764705882353, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI181337167, Length=435, Percent_Identity=35.632183908046, Blast_Score=218, Evalue=9e-57,
Organism=Homo sapiens, GI110347453, Length=430, Percent_Identity=34.8837209302326, Blast_Score=215, Evalue=6e-56,
Organism=Homo sapiens, GI71979932, Length=474, Percent_Identity=27.4261603375527, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI33286428, Length=455, Percent_Identity=25.7142857142857, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI186910308, Length=430, Percent_Identity=24.4186046511628, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI186910306, Length=430, Percent_Identity=24.4186046511628, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI186910304, Length=430, Percent_Identity=24.4186046511628, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI187423910, Length=459, Percent_Identity=23.3115468409586, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI7657591, Length=459, Percent_Identity=23.3115468409586, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI115648063, Length=446, Percent_Identity=23.3183856502242, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI115648022, Length=446, Percent_Identity=23.3183856502242, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI71999149, Length=420, Percent_Identity=25.4761904761905, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI7657683, Length=380, Percent_Identity=22.1052631578947, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI33286430, Length=202, Percent_Identity=26.7326732673267, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1788480, Length=358, Percent_Identity=27.3743016759777, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI87082023, Length=458, Percent_Identity=26.6375545851528, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI87081869, Length=471, Percent_Identity=26.963906581741, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87082250, Length=366, Percent_Identity=27.3224043715847, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1786694, Length=388, Percent_Identity=26.5463917525773, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1786602, Length=428, Percent_Identity=23.8317757009346, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790653, Length=433, Percent_Identity=23.3256351039261, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1789017, Length=429, Percent_Identity=25.8741258741259, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI87081708, Length=449, Percent_Identity=21.1581291759465, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786789, Length=433, Percent_Identity=22.8637413394919, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI87081915, Length=405, Percent_Identity=24.4444444444444, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1786302, Length=443, Percent_Identity=24.6049661399549, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI48994972, Length=362, Percent_Identity=24.0331491712707, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=399, Percent_Identity=34.0852130325814, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17533459, Length=410, Percent_Identity=34.1463414634146, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI17531343, Length=407, Percent_Identity=33.9066339066339, Blast_Score=202, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17540018, Length=446, Percent_Identity=24.2152466367713, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17568033, Length=378, Percent_Identity=23.8095238095238, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI32566699, Length=384, Percent_Identity=23.1770833333333, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17537453, Length=427, Percent_Identity=21.0772833723653, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71993915, Length=433, Percent_Identity=23.094688221709, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322892, Length=408, Percent_Identity=23.5294117647059, Blast_Score=67, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6324553, Length=384, Percent_Identity=24.7395833333333, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221512776, Length=428, Percent_Identity=35.7476635514019, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24666159, Length=428, Percent_Identity=35.7476635514019, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI24668806, Length=419, Percent_Identity=37.4701670644391, Blast_Score=248, Evalue=9e-66,
Organism=Drosophila melanogaster, GI21356285, Length=419, Percent_Identity=37.4701670644391, Blast_Score=248, Evalue=9e-66,
Organism=Drosophila melanogaster, GI24668802, Length=419, Percent_Identity=37.4701670644391, Blast_Score=248, Evalue=9e-66,
Organism=Drosophila melanogaster, GI24667468, Length=422, Percent_Identity=36.2559241706161, Blast_Score=241, Evalue=7e-64,
Organism=Drosophila melanogaster, GI281366235, Length=434, Percent_Identity=35.9447004608295, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI116007820, Length=434, Percent_Identity=35.9447004608295, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI116007818, Length=418, Percent_Identity=35.8851674641148, Blast_Score=218, Evalue=7e-57,
Organism=Drosophila melanogaster, GI85725152, Length=418, Percent_Identity=35.8851674641148, Blast_Score=218, Evalue=7e-57,
Organism=Drosophila melanogaster, GI161077963, Length=431, Percent_Identity=32.0185614849188, Blast_Score=191, Evalue=7e-49,
Organism=Drosophila melanogaster, GI45550968, Length=482, Percent_Identity=22.6141078838174, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19921172, Length=482, Percent_Identity=22.6141078838174, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI221331183, Length=489, Percent_Identity=24.3353783231084, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI17647653, Length=489, Percent_Identity=24.3353783231084, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24664379, Length=489, Percent_Identity=24.3353783231084, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24651635, Length=422, Percent_Identity=24.6445497630332, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24651633, Length=422, Percent_Identity=24.6445497630332, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21357367, Length=467, Percent_Identity=23.7687366167024, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR015606 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 52121; Mature: 52121

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYRMLKSLLRVKPIEPAGHVDAGEPVEGSLQGEATLQRTLTAKHLIMLGIGAVIGAGIFV
CHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHE
LTGQAAANHAGPAVMLSFVFAGIACAFAGLCYAEFAAMMPVSGSAYSYSYATLGEGIAWF
EECCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHH
IGWCLVLEYLFAGSSVAVGWSAYLISFITGTLGLPFPAELAGAPLAWDGHGFVSSGNLVN
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHCCCCEEECCCCEECCCCEEC
LPAVLIVAAVSILCYVGVTQSAFANAIVVAIKVVVICLFVGFGIAYIDPANWHPFIPENT
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCC
GPGQFGWDGVFRAASIVFFSYIGFDAVSTSAGETKDPQKNMPIGILVSLAICTIIYIIVC
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AVLTGLLPYTQLGTAKPVATALEAHPQLTWLKTAVEIGAIAGLSSVVLVMLMAQPRIFYT
HHHHHHCCHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
MAKDGLMPKLFGKVHPKFRTPYVGTLFVGVVAALLAGVIPLNVLGELVSMGTLLAFATVC
ECCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGVLVLRFTKPDLARPFRVPLAMVICPLGALACLFLFFQAFQEHWKVFVGWTVIGLAIYF
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GYGIHHSRLAKRA
HCCCHHHHHHHCC
>Mature Secondary Structure
MYRMLKSLLRVKPIEPAGHVDAGEPVEGSLQGEATLQRTLTAKHLIMLGIGAVIGAGIFV
CHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHE
LTGQAAANHAGPAVMLSFVFAGIACAFAGLCYAEFAAMMPVSGSAYSYSYATLGEGIAWF
EECCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHH
IGWCLVLEYLFAGSSVAVGWSAYLISFITGTLGLPFPAELAGAPLAWDGHGFVSSGNLVN
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHCCCCEEECCCCEECCCCEEC
LPAVLIVAAVSILCYVGVTQSAFANAIVVAIKVVVICLFVGFGIAYIDPANWHPFIPENT
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCC
GPGQFGWDGVFRAASIVFFSYIGFDAVSTSAGETKDPQKNMPIGILVSLAICTIIYIIVC
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AVLTGLLPYTQLGTAKPVATALEAHPQLTWLKTAVEIGAIAGLSSVVLVMLMAQPRIFYT
HHHHHHCCHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
MAKDGLMPKLFGKVHPKFRTPYVGTLFVGVVAALLAGVIPLNVLGELVSMGTLLAFATVC
ECCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGVLVLRFTKPDLARPFRVPLAMVICPLGALACLFLFFQAFQEHWKVFVGWTVIGLAIYF
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GYGIHHSRLAKRA
HCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9141694; 9384377 [H]