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The map label for this gene is hisS [H]

Identifier: 21242570

GI number: 21242570

Start: 2121571

End: 2123007

Strand: Direct

Name: hisS [H]

Synonym: XAC1826

Alternate gene names: 21242570

Gene position: 2121571-2123007 (Clockwise)

Preceding gene: 21242568

Following gene: 21242571

Centisome position: 40.99

GC content: 66.32

Gene sequence:

>1437_bases
GTGATCAAGCCCCGTACGCCGCCCGGCATCATGGAATTGCTGCCGCGCGAGCAGATCGCGTTCCAGCGCATGCTGGACGT
CATCCGCCGCAACTACGAGCGGTTCGGGTTCCTGCCGGTCGAAACGCCGGTGTTCGAGCTGTCCGATGTACTGCTGACCA
AATCCGGCGGCGAAACCGAGCGCCAGGTGTATTTCGTGCAGTCCACCGGCGCGCTGGCCAATGCCGCCGCTGCGGCCGAT
GAGGGCGCCGAGAACGGCGGCTTGCCGGAGCTTGCGCTGCGCTTCGACCTGACCGTGCCGCTGGCACGCTACGTCGCCGA
GCACGAGCATGACTTGAGCTTCCCGTTCCGGCGCTACCAGATGCAGCGCGTGTATCGCGGCGAGCGCGCACAGCGTGGGC
GATTCCGCGAGTTCTACCAGTGCGACATCGACGTCATCGGCAAGGATGCGCTGAGCATCCGCTACGACGCCGAAGTGCTG
GCGGTGATCCATGCGGTGTTTGCCGAGCTGGGCATCGGCGACTTCAAGGTGCAGTTGAACAATCGCAAGCTGCTGCGCGG
CTTCTTCGAAAGCCTGGGCGTGGCCGAAGGCGAGTTGCAGCTGGCGGTGCTGCGCGAGGTCGACAAGATCGACAAGCGTG
GCGCCGATTACGTGCGCGACACACTGGTGGGCGAGGGCTTTGGCATTCCTGCCGAGCAGGTCGCCAGGATTCTCGCCTTC
GTGGCGGTGCGCTCCAACGGGCATGCCGATGCGCTGGCGCAGTTGCAGGCGCTGGAAGGCTCGGTCGGGGCCAGCGCGAC
GCTGGGCGAAGGCATCGCCGAGTTGCGCGAAGTGCTGGAGCTGGTCAAGGCGCTGGGCGTGCCGGAGAGCGCGTACTGCC
TGAACTTCTCGATCGCGCGCGGGCTGGACTACTACACCGGCACCGTCTACGAAACCACCCTGACCGACCACCCGCAGATC
GGCTCGATCTGCTCGGGCGGCCGTTACGACAGCCTGGCCAGCCACTACACCAAGTCCAAATTGCCCGGCGTGGGCATCTC
GATCGGCCTGACCCGCCTGTTCTGGCAGCTGCGCGAGGCCGGCCTGATCCAGGGTATCGCCGAAAGCAGCGTGCAGGCGA
TGGTGGCGCTGATGGACGAGACCCGCCTGGACGACGCGCTGGATATCGCGCGCCGGCTGCGCATCGGCGGCATCAACACC
GAAGTGCAGATGGAGCCGAAGAAAATCGGCAAGCAGTTCCAGTATGCGGCTCGTGCCGGCATCCGCTTCGTGGTGCTGGC
CGGCGACGACGAACTGGCCCGCGGCGTGGTGGCAGTGAAAGACCTGGTGCGCGAGCAGCAGTTCGATGTGGCCCGCGATG
AGCTGGCCAGCACCTTGCAGGTGGAGCTGGAGCAGGCCAGGGCGATGCTGGTGGCTGGCAGCGTCCAGGGCGACTGA

Upstream 100 bases:

>100_bases
GCACTGCTGGGACGCATTGAATGATACGCCATGCGGTCAGCGCGGCCGCCCAGCCGTTAGAATTGTGCGTTCGCCACATT
GTCCTGCAGGAGTTTCGCTC

Downstream 100 bases:

>100_bases
TCCTGTCAATTTGAAGATTTCACGGGTCTGGTGACCATTTCGCCGGCCAACTACGCGCCGTCGCGCAGAACGCGCCCACT
GACATCCGGATGTCAGTGGG

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS [H]

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MIKPRTPPGIMELLPREQIAFQRMLDVIRRNYERFGFLPVETPVFELSDVLLTKSGGETERQVYFVQSTGALANAAAAAD
EGAENGGLPELALRFDLTVPLARYVAEHEHDLSFPFRRYQMQRVYRGERAQRGRFREFYQCDIDVIGKDALSIRYDAEVL
AVIHAVFAELGIGDFKVQLNNRKLLRGFFESLGVAEGELQLAVLREVDKIDKRGADYVRDTLVGEGFGIPAEQVARILAF
VAVRSNGHADALAQLQALEGSVGASATLGEGIAELREVLELVKALGVPESAYCLNFSIARGLDYYTGTVYETTLTDHPQI
GSICSGGRYDSLASHYTKSKLPGVGISIGLTRLFWQLREAGLIQGIAESSVQAMVALMDETRLDDALDIARRLRIGGINT
EVQMEPKKIGKQFQYAARAGIRFVVLAGDDELARGVVAVKDLVREQQFDVARDELASTLQVELEQARAMLVAGSVQGD

Sequences:

>Translated_478_residues
MIKPRTPPGIMELLPREQIAFQRMLDVIRRNYERFGFLPVETPVFELSDVLLTKSGGETERQVYFVQSTGALANAAAAAD
EGAENGGLPELALRFDLTVPLARYVAEHEHDLSFPFRRYQMQRVYRGERAQRGRFREFYQCDIDVIGKDALSIRYDAEVL
AVIHAVFAELGIGDFKVQLNNRKLLRGFFESLGVAEGELQLAVLREVDKIDKRGADYVRDTLVGEGFGIPAEQVARILAF
VAVRSNGHADALAQLQALEGSVGASATLGEGIAELREVLELVKALGVPESAYCLNFSIARGLDYYTGTVYETTLTDHPQI
GSICSGGRYDSLASHYTKSKLPGVGISIGLTRLFWQLREAGLIQGIAESSVQAMVALMDETRLDDALDIARRLRIGGINT
EVQMEPKKIGKQFQYAARAGIRFVVLAGDDELARGVVAVKDLVREQQFDVARDELASTLQVELEQARAMLVAGSVQGD
>Mature_478_residues
MIKPRTPPGIMELLPREQIAFQRMLDVIRRNYERFGFLPVETPVFELSDVLLTKSGGETERQVYFVQSTGALANAAAAAD
EGAENGGLPELALRFDLTVPLARYVAEHEHDLSFPFRRYQMQRVYRGERAQRGRFREFYQCDIDVIGKDALSIRYDAEVL
AVIHAVFAELGIGDFKVQLNNRKLLRGFFESLGVAEGELQLAVLREVDKIDKRGADYVRDTLVGEGFGIPAEQVARILAF
VAVRSNGHADALAQLQALEGSVGASATLGEGIAELREVLELVKALGVPESAYCLNFSIARGLDYYTGTVYETTLTDHPQI
GSICSGGRYDSLASHYTKSKLPGVGISIGLTRLFWQLREAGLIQGIAESSVQAMVALMDETRLDDALDIARRLRIGGINT
EVQMEPKKIGKQFQYAARAGIRFVVLAGDDELARGVVAVKDLVREQQFDVARDELASTLQVELEQARAMLVAGSVQGD

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI6996014, Length=472, Percent_Identity=32.8389830508475, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI15029520, Length=478, Percent_Identity=29.4979079497908, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI65287717, Length=451, Percent_Identity=21.2860310421286, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1788861, Length=482, Percent_Identity=25.3112033195021, Blast_Score=103, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71993693, Length=479, Percent_Identity=31.1064718162839, Blast_Score=205, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI71993686, Length=479, Percent_Identity=31.1064718162839, Blast_Score=205, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6325290, Length=478, Percent_Identity=28.8702928870293, Blast_Score=179, Evalue=9e-46,
Organism=Drosophila melanogaster, GI24643061, Length=485, Percent_Identity=30.7216494845361, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24643059, Length=490, Percent_Identity=29.7959183673469, Blast_Score=186, Evalue=4e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.21 [H]

Molecular weight: Translated: 52631; Mature: 52631

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKPRTPPGIMELLPREQIAFQRMLDVIRRNYERFGFLPVETPVFELSDVLLTKSGGETE
CCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHEECCCCCCC
RQVYFVQSTGALANAAAAADEGAENGGLPELALRFDLTVPLARYVAEHEHDLSFPFRRYQ
EEEEEEECCCCHHHHHHHHCCCCCCCCCCCEEEEEECHHHHHHHHHHCCCCCCCCHHHHH
MQRVYRGERAQRGRFREFYQCDIDVIGKDALSIRYDAEVLAVIHAVFAELGIGDFKVQLN
HHHHHCCCHHHCCHHHHHHHCCHHEECCCCEEEEECHHHHHHHHHHHHHCCCCEEEEEEC
NRKLLRGFFESLGVAEGELQLAVLREVDKIDKRGADYVRDTLVGEGFGIPAEQVARILAF
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHH
VAVRSNGHADALAQLQALEGSVGASATLGEGIAELREVLELVKALGVPESAYCLNFSIAR
HHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEEHHHH
GLDYYTGTVYETTLTDHPQIGSICSGGRYDSLASHYTKSKLPGVGISIGLTRLFWQLREA
CCCHHCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
GLIQGIAESSVQAMVALMDETRLDDALDIARRLRIGGINTEVQMEPKKIGKQFQYAARAG
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHCC
IRFVVLAGDDELARGVVAVKDLVREQQFDVARDELASTLQVELEQARAMLVAGSVQGD
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCC
>Mature Secondary Structure
MIKPRTPPGIMELLPREQIAFQRMLDVIRRNYERFGFLPVETPVFELSDVLLTKSGGETE
CCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHEECCCCCCC
RQVYFVQSTGALANAAAAADEGAENGGLPELALRFDLTVPLARYVAEHEHDLSFPFRRYQ
EEEEEEECCCCHHHHHHHHCCCCCCCCCCCEEEEEECHHHHHHHHHHCCCCCCCCHHHHH
MQRVYRGERAQRGRFREFYQCDIDVIGKDALSIRYDAEVLAVIHAVFAELGIGDFKVQLN
HHHHHCCCHHHCCHHHHHHHCCHHEECCCCEEEEECHHHHHHHHHHHHHCCCCEEEEEEC
NRKLLRGFFESLGVAEGELQLAVLREVDKIDKRGADYVRDTLVGEGFGIPAEQVARILAF
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHH
VAVRSNGHADALAQLQALEGSVGASATLGEGIAELREVLELVKALGVPESAYCLNFSIAR
HHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEEHHHH
GLDYYTGTVYETTLTDHPQIGSICSGGRYDSLASHYTKSKLPGVGISIGLTRLFWQLREA
CCCHHCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
GLIQGIAESSVQAMVALMDETRLDDALDIARRLRIGGINTEVQMEPKKIGKQFQYAARAG
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHCC
IRFVVLAGDDELARGVVAVKDLVREQQFDVARDELASTLQVELEQARAMLVAGSVQGD
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA