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The map label for this gene is pyrD

Identifier: 21242550

GI number: 21242550

Start: 2078783

End: 2079838

Strand: Reverse

Name: pyrD

Synonym: XAC1805

Alternate gene names: 21242550

Gene position: 2079838-2078783 (Counterclockwise)

Preceding gene: 21242551

Following gene: 21242549

Centisome position: 40.19

GC content: 66.38

Gene sequence:

>1056_bases
ATGTATTCGCTCGCCCGCCCCTTCCTGTTTTCCTTGGATGCCGAGCGCGCCCACGCGCTGGCGTTGCGCTCCATCGACAC
CGCCTACCGCACCGGCACCACGGCGTTGCTGGCCAGGCGCCCGGTGCCGCTGCCCACCCCGGCTTTCGGCCTGATGTTCC
CCAACCCGGTCGGGCTGGGTGCCGGGTTGGACAAGAACGGTGAGCACATCGATGCGTTGTTTGCGCTGGGCTTCGGCTTT
GTCGAGATCGGCACGGTGACGCCGCGCGCGCAGGAGGGCAACCCGAAGCCACGTATGTTCCGATTGCCGGAATACCAGGC
GGTGATCAACCGCATGGGCTTCAACAACCTGGGCGTGGATGCGCTGGTGGCCAACGTGCAGCGCGCACGCCGCACGGGAG
GCCTGCTCGGCATCAACATCGGCAAGAACAAGGACACGTCCAACGAAGAGGCCACCAGCGACTACCGTTACTGCATGGAG
CGCGTGTATCCGCTGGCCGACTACATCACGGTCAACATCTCCTCGCCCAACACCGCAGGCTTGCGCGAGTTGCAGGAAGA
ACAATCGCTGCGCCGCCTGATTTCCGACTTGCGCGAAACCCAGGAAGCGCTAAGCGCGCAACACGGCAAACGTGTGCCGA
TGCTGGTCAAGGTGGCGCCGGACCTCAACGACCGCGACATCGATGCCGCCGCACGCGTGCTGGCCGACCTGGCGGTGGAT
GGCGTGATCGCCACCAATACCACGGTGACGCGCACGCTGGTGGCCAATCACCCGCTAGCTGCCGAAGCCGGCGGTCTGTC
CGGCGCGCCGCTGCTGGGGCAATCCACGCTGGTGCTGCGGCGCCTGCGCGCGCGCCTGCCCGAATCGATTCCGTTGATTG
GCGTGGGCGGCATCAACTCCGGCGCCGATGCGGTGGCCAAGATGGCAGCCGGTGCGAGCCTGGTGCAGTGCTACAGCGGG
TTGGTATATCGCGGCCCGCAGCTCATCGGCGAATGCGTCAACGCCATCCGACGCCGCCGCGAAGCACCCAGCGGCGGTGC
GGTGTCGCCATTATGA

Upstream 100 bases:

>100_bases
TCGCCGCGCTACGCACGTTGTTCGATGCGTATGCGCACGATGGGCTGATCGACTTCCAATACCAAACCCGCGTGTTCGCC
GGGAGATTGAACTGACCCGC

Downstream 100 bases:

>100_bases
GCGATGCAGTGCAGACAGGCTGGCAGCTGAGCGAACAGGCGCCGCTGCGTACGCTCAACACCTTCCATGTCGAAGCCACC
GCGCGCTGGTTGCTCAATGT

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MYSLARPFLFSLDAERAHALALRSIDTAYRTGTTALLARRPVPLPTPAFGLMFPNPVGLGAGLDKNGEHIDALFALGFGF
VEIGTVTPRAQEGNPKPRMFRLPEYQAVINRMGFNNLGVDALVANVQRARRTGGLLGINIGKNKDTSNEEATSDYRYCME
RVYPLADYITVNISSPNTAGLRELQEEQSLRRLISDLRETQEALSAQHGKRVPMLVKVAPDLNDRDIDAAARVLADLAVD
GVIATNTTVTRTLVANHPLAAEAGGLSGAPLLGQSTLVLRRLRARLPESIPLIGVGGINSGADAVAKMAAGASLVQCYSG
LVYRGPQLIGECVNAIRRRREAPSGGAVSPL

Sequences:

>Translated_351_residues
MYSLARPFLFSLDAERAHALALRSIDTAYRTGTTALLARRPVPLPTPAFGLMFPNPVGLGAGLDKNGEHIDALFALGFGF
VEIGTVTPRAQEGNPKPRMFRLPEYQAVINRMGFNNLGVDALVANVQRARRTGGLLGINIGKNKDTSNEEATSDYRYCME
RVYPLADYITVNISSPNTAGLRELQEEQSLRRLISDLRETQEALSAQHGKRVPMLVKVAPDLNDRDIDAAARVLADLAVD
GVIATNTTVTRTLVANHPLAAEAGGLSGAPLLGQSTLVLRRLRARLPESIPLIGVGGINSGADAVAKMAAGASLVQCYSG
LVYRGPQLIGECVNAIRRRREAPSGGAVSPL
>Mature_351_residues
MYSLARPFLFSLDAERAHALALRSIDTAYRTGTTALLARRPVPLPTPAFGLMFPNPVGLGAGLDKNGEHIDALFALGFGF
VEIGTVTPRAQEGNPKPRMFRLPEYQAVINRMGFNNLGVDALVANVQRARRTGGLLGINIGKNKDTSNEEATSDYRYCME
RVYPLADYITVNISSPNTAGLRELQEEQSLRRLISDLRETQEALSAQHGKRVPMLVKVAPDLNDRDIDAAARVLADLAVD
GVIATNTTVTRTLVANHPLAAEAGGLSGAPLLGQSTLVLRRLRARLPESIPLIGVGGINSGADAVAKMAAGASLVQCYSG
LVYRGPQLIGECVNAIRRRREAPSGGAVSPL

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=343, Percent_Identity=46.064139941691, Blast_Score=268, Evalue=5e-72,
Organism=Escherichia coli, GI1787177, Length=335, Percent_Identity=51.9402985074627, Blast_Score=327, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI17509475, Length=342, Percent_Identity=40.0584795321637, Blast_Score=219, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6322633, Length=273, Percent_Identity=24.9084249084249, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281361352, Length=332, Percent_Identity=43.0722891566265, Blast_Score=256, Evalue=2e-68,
Organism=Drosophila melanogaster, GI17137316, Length=332, Percent_Identity=43.0722891566265, Blast_Score=256, Evalue=2e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_XANAC (Q8PLJ2)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_642132.1
- ProteinModelPortal:   Q8PLJ2
- SMR:   Q8PLJ2
- GeneID:   1155876
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1805
- NMPDR:   fig|190486.1.peg.1776
- HOGENOM:   HBG351027
- OMA:   AALNRMG
- ProtClustDB:   PRK05286
- BioCyc:   XAXO190486:XAC1805-MONOMER
- BRENDA:   1.3.3.1
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 37531; Mature: 37531

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 175-175

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSLARPFLFSLDAERAHALALRSIDTAYRTGTTALLARRPVPLPTPAFGLMFPNPVGLG
CCCCCCCHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCCCC
AGLDKNGEHIDALFALGFGFVEIGTVTPRAQEGNPKPRMFRLPEYQAVINRMGFNNLGVD
CCCCCCCCHHHHHHHHHHCCEEECCCCCCCCCCCCCCCEEECCHHHHHHHHCCCCCCCHH
ALVANVQRARRTGGLLGINIGKNKDTSNEEATSDYRYCMERVYPLADYITVNISSPNTAG
HHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEEECCCCHHH
LRELQEEQSLRRLISDLRETQEALSAQHGKRVPMLVKVAPDLNDRDIDAAARVLADLAVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHC
GVIATNTTVTRTLVANHPLAAEAGGLSGAPLLGQSTLVLRRLRARLPESIPLIGVGGINS
CEEECCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCC
GADAVAKMAAGASLVQCYSGLVYRGPQLIGECVNAIRRRREAPSGGAVSPL
CHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MYSLARPFLFSLDAERAHALALRSIDTAYRTGTTALLARRPVPLPTPAFGLMFPNPVGLG
CCCCCCCHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCCCC
AGLDKNGEHIDALFALGFGFVEIGTVTPRAQEGNPKPRMFRLPEYQAVINRMGFNNLGVD
CCCCCCCCHHHHHHHHHHCCEEECCCCCCCCCCCCCCCEEECCHHHHHHHHCCCCCCCHH
ALVANVQRARRTGGLLGINIGKNKDTSNEEATSDYRYCMERVYPLADYITVNISSPNTAG
HHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEEECCCCHHH
LRELQEEQSLRRLISDLRETQEALSAQHGKRVPMLVKVAPDLNDRDIDAAARVLADLAVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHC
GVIATNTTVTRTLVANHPLAAEAGGLSGAPLLGQSTLVLRRLRARLPESIPLIGVGGINS
CEEECCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCC
GADAVAKMAAGASLVQCYSGLVYRGPQLIGECVNAIRRRREAPSGGAVSPL
CHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12024217