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The map label for this gene is murB

Identifier: 21242549

GI number: 21242549

Start: 2077734

End: 2078786

Strand: Reverse

Name: murB

Synonym: XAC1804

Alternate gene names: 21242549

Gene position: 2078786-2077734 (Counterclockwise)

Preceding gene: 21242550

Following gene: 21242548

Centisome position: 40.17

GC content: 65.62

Gene sequence:

>1053_bases
ATGAGCGATGCAGTGCAGACAGGCTGGCAGCTGAGCGAACAGGCGCCGCTGCGTACGCTCAACACCTTCCATGTCGAAGC
CACCGCGCGCTGGTTGCTCAATGTCCAAGCGCCTGAGGCATTGCCGCAGGCATTGGCTGCGCCCGAGATCGCCGGACAAC
CGTTGCTGGTGCTGGGCAGCGGCAGCAATGTCTTGCTGGCCGGCGATCCGCCAGGCTGCGTGCTGTGTTTCGACAACCGC
GAGACCTCCATCATCGCGCACCGTGCCGACCACGCCATCGTGCGGGCCGGCGCCGGCGTGAACTGGCATGCGCTGGTGCT
GTACGCGCTGCAGCAGGGCTTGTCGGGGCTGGAGAACCTGGCTTTGATTCCGGGCACCGTGGGCGCCTGCCCGATCCAGA
ACATCGGTGCGTACGGCGCGCAGGTAGGCGACTTCATCCACGTGGTGGAGGCCTTCGACCGGCATAGCCAGCAGTTCGTG
CGGCTGGATGCGGCCGACTGCGCGTTCGGCTACCGCGACAGCGTGTTCAAGCAGCAGCCCGAGCGTTATCTGATCGTGGC
GGTGGAATTCAATCTACCGCTGCTGCACGAACTGCGGCTGGACTACGCCGGCATTCGCGAGGAACTGGCAAGCATGGGCG
CCGAGCTGGCAGGCGCGGCCGATGTGGCGCAGGCGGTGATCAACATCCGTCGCCGCAAGCTGCCGGACCCGGATGTGCTG
GGCAATGCAGGCAGTTTCTTCAAGAACCCATTGCTGCCGAGCGAACAGATTGCCGCGTTGCAGGCCAGCTTTGCCGACAT
GCCGGTGTATCCGGGCGAGCATGCCGGCCAGGGCAAATTGTCGGCCGCCTGGCTGATCGAGCAATGCGGCTGGAAGGGCA
AGCGCGAAGGCGACGCCGGCGTGTCGCCCGACCATGCGCTGGTGCTGGTCAATTACGGCACCGCCACGGGCGCGCAGTTG
CTGGATTTCGCACGACGCATCGCCGAGTCGGTGCGCGAGCGCTATTCGGTGATTCTGGAGCCGGAACCGCGCATCATCGG
GGCGCATTGGTGA

Upstream 100 bases:

>100_bases
ACAGCGGGTTGGTATATCGCGGCCCGCAGCTCATCGGCGAATGCGTCAACGCCATCCGACGCCGCCGCGAAGCACCCAGC
GGCGGTGCGGTGTCGCCATT

Downstream 100 bases:

>100_bases
CGCCAGCGCAGGTTGCGCGGCGAGCCGCGCTGTGGATGCTCACCAGTACCGTCGCCTTCGGGCTGATGGCAATCACCATC
CGCCTGGCCTCGAGCACCAT

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MSDAVQTGWQLSEQAPLRTLNTFHVEATARWLLNVQAPEALPQALAAPEIAGQPLLVLGSGSNVLLAGDPPGCVLCFDNR
ETSIIAHRADHAIVRAGAGVNWHALVLYALQQGLSGLENLALIPGTVGACPIQNIGAYGAQVGDFIHVVEAFDRHSQQFV
RLDAADCAFGYRDSVFKQQPERYLIVAVEFNLPLLHELRLDYAGIREELASMGAELAGAADVAQAVINIRRRKLPDPDVL
GNAGSFFKNPLLPSEQIAALQASFADMPVYPGEHAGQGKLSAAWLIEQCGWKGKREGDAGVSPDHALVLVNYGTATGAQL
LDFARRIAESVRERYSVILEPEPRIIGAHW

Sequences:

>Translated_350_residues
MSDAVQTGWQLSEQAPLRTLNTFHVEATARWLLNVQAPEALPQALAAPEIAGQPLLVLGSGSNVLLAGDPPGCVLCFDNR
ETSIIAHRADHAIVRAGAGVNWHALVLYALQQGLSGLENLALIPGTVGACPIQNIGAYGAQVGDFIHVVEAFDRHSQQFV
RLDAADCAFGYRDSVFKQQPERYLIVAVEFNLPLLHELRLDYAGIREELASMGAELAGAADVAQAVINIRRRKLPDPDVL
GNAGSFFKNPLLPSEQIAALQASFADMPVYPGEHAGQGKLSAAWLIEQCGWKGKREGDAGVSPDHALVLVNYGTATGAQL
LDFARRIAESVRERYSVILEPEPRIIGAHW
>Mature_349_residues
SDAVQTGWQLSEQAPLRTLNTFHVEATARWLLNVQAPEALPQALAAPEIAGQPLLVLGSGSNVLLAGDPPGCVLCFDNRE
TSIIAHRADHAIVRAGAGVNWHALVLYALQQGLSGLENLALIPGTVGACPIQNIGAYGAQVGDFIHVVEAFDRHSQQFVR
LDAADCAFGYRDSVFKQQPERYLIVAVEFNLPLLHELRLDYAGIREELASMGAELAGAADVAQAVINIRRRKLPDPDVLG
NAGSFFKNPLLPSEQIAALQASFADMPVYPGEHAGQGKLSAAWLIEQCGWKGKREGDAGVSPDHALVLVNYGTATGAQLL
DFARRIAESVRERYSVILEPEPRIIGAHW

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

Organism=Escherichia coli, GI1790407, Length=334, Percent_Identity=42.5149700598802, Blast_Score=238, Evalue=5e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_XANAC (Q8PLJ3)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_642131.1
- ProteinModelPortal:   Q8PLJ3
- SMR:   Q8PLJ3
- GeneID:   1155875
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1804
- NMPDR:   fig|190486.1.peg.1775
- HOGENOM:   HBG686573
- OMA:   GAAPMQN
- ProtClustDB:   PRK00046
- BioCyc:   XAXO190486:XAC1804-MONOMER
- BRENDA:   1.1.1.158
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 37701; Mature: 37570

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 172-172 ACT_SITE 245-245 ACT_SITE 342-342

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDAVQTGWQLSEQAPLRTLNTFHVEATARWLLNVQAPEALPQALAAPEIAGQPLLVLGS
CCCHHHCCCCCCCCCCCHHHHEEEEEEEEEEEEEECCHHHHHHHHCCCCCCCCCEEEEEC
GSNVLLAGDPPGCVLCFDNRETSIIAHRADHAIVRAGAGVNWHALVLYALQQGLSGLENL
CCCEEEECCCCCEEEEECCCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCC
ALIPGTVGACPIQNIGAYGAQVGDFIHVVEAFDRHSQQFVRLDAADCAFGYRDSVFKQQP
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHHCCCCHHHHHHCCC
ERYLIVAVEFNLPLLHELRLDYAGIREELASMGAELAGAADVAQAVINIRRRKLPDPDVL
CEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHHCCCCCCCC
GNAGSFFKNPLLPSEQIAALQASFADMPVYPGEHAGQGKLSAAWLIEQCGWKGKREGDAG
CCCCHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCC
VSPDHALVLVNYGTATGAQLLDFARRIAESVRERYSVILEPEPRIIGAHW
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCEECCCC
>Mature Secondary Structure 
SDAVQTGWQLSEQAPLRTLNTFHVEATARWLLNVQAPEALPQALAAPEIAGQPLLVLGS
CCHHHCCCCCCCCCCCHHHHEEEEEEEEEEEEEECCHHHHHHHHCCCCCCCCCEEEEEC
GSNVLLAGDPPGCVLCFDNRETSIIAHRADHAIVRAGAGVNWHALVLYALQQGLSGLENL
CCCEEEECCCCCEEEEECCCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCC
ALIPGTVGACPIQNIGAYGAQVGDFIHVVEAFDRHSQQFVRLDAADCAFGYRDSVFKQQP
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHHCCCCHHHHHHCCC
ERYLIVAVEFNLPLLHELRLDYAGIREELASMGAELAGAADVAQAVINIRRRKLPDPDVL
CEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHHCCCCCCCC
GNAGSFFKNPLLPSEQIAALQASFADMPVYPGEHAGQGKLSAAWLIEQCGWKGKREGDAG
CCCCHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCC
VSPDHALVLVNYGTATGAQLLDFARRIAESVRERYSVILEPEPRIIGAHW
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217