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The map label for this gene is manA [H]

Identifier: 21242541

GI number: 21242541

Start: 2069059

End: 2070045

Strand: Direct

Name: manA [H]

Synonym: XAC1796

Alternate gene names: 21242541

Gene position: 2069059-2070045 (Clockwise)

Preceding gene: 21242539

Following gene: 21242544

Centisome position: 39.98

GC content: 63.32

Gene sequence:

>987_bases
GTGAATTCATTGCTGTCCTTTGCACAACGCACGCTCCTGGTCGTCGCCGGTCTGGCCGCGTCGTCTGCCGCCCATGCAGG
GCTCACGGTGTCCGGCACGCAGTTACGCGAGTCCAATGGCAATGCATTGGTGCTGCGCGGCGTCAACCTGCCGCATGCCT
GGTATGCGGGCCGCACCGATGCGGCGTTGGCAGCCATCGCGGCCACCGGCGCCAACAGCGTGCGCGTCGTGCTCAGTTCC
GGCTACCGCTGGACGCGCACACCGGAGGCCGATGTGGCCCGCATCATCGCGCGCTGCAAAAGCCTGGGCTTGATCGCCGT
GCTGGAGGTCCACGACACCACCGGCTATGGCGAAGACACCGCCGCTGCGAATCTGGTCAATGCGACCAATTACTGGGTCG
GCATCCGCAAGGCGCTGATCGGCAACGAAGACCATGTGGTCATCAATATCGCCAACGAACCGTTCGGCAACAGTCTTGCT
GCCAGCGAATGGGTCAACGGCCATGCCACCGCCATCGCCACCTTGCGCAAGAATGGACTGACCCACGCCTTGATGGTGGA
TGCGCCCAACTGGGGCCAGGACTGGAAATTCTACATGCGCGACAACGCCGCTGTTCTGCTGGCGCGCGACAGCCGCCGCA
ACCTGATGTTCAGCGTGCACATGTACGAAGTGTTCGGCAGCGATGCCACGATCAACAATTACTTGCGCGCCTTCAACGAT
AAAAAGCTGGCGCTGGTGATCGGCGAATTCGGTGGGGACCATCGCGGTGCGCACGTGGACGAAGCGGCGATCATGCGCCG
CGCGCGCGACTACAACGTCGGCTACATGGGCTGGTCATGGTCGGGCAACGACAGCAGTACGAAGTCGCTGGACATCGCGA
TCGGCTGGAATGCGGCACAACTGAGCACCTGGGGGCGCAACTTGATCCTGGGCACCGATGGCATCGCAGCAACCTCGCGT
CGGGCGAGCGTGTTCGGCCCGCTGTGA

Upstream 100 bases:

>100_bases
TGATGTGCATTCGACTCATGGGTGTCACGAATCGACACAGTCTTCACCCGTGCTGTGAATCTCGCCATCGCGGTTTTGTC
ACTTCTATTTTGGAATCATC

Downstream 100 bases:

>100_bases
GATTGAAGTCCTGCAGTCGGCGGCTGTAGTTTTCCGAAACGCATTGAAGCGCACTGCAAAGCTGTCGAACTGCGGCCCGT
TGCGGGGCCGGTGCCGGCAC

Product: mannan endo-1,4-beta-mannosidase

Products: NA

Alternate protein names: Mannan endo-1,4-beta-mannosidase A; Beta-mannanase; Endo-1,4-mannanase; Endo-1,4-beta-glucanase; Cellulase [H]

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MNSLLSFAQRTLLVVAGLAASSAAHAGLTVSGTQLRESNGNALVLRGVNLPHAWYAGRTDAALAAIAATGANSVRVVLSS
GYRWTRTPEADVARIIARCKSLGLIAVLEVHDTTGYGEDTAAANLVNATNYWVGIRKALIGNEDHVVINIANEPFGNSLA
ASEWVNGHATAIATLRKNGLTHALMVDAPNWGQDWKFYMRDNAAVLLARDSRRNLMFSVHMYEVFGSDATINNYLRAFND
KKLALVIGEFGGDHRGAHVDEAAIMRRARDYNVGYMGWSWSGNDSSTKSLDIAIGWNAAQLSTWGRNLILGTDGIAATSR
RASVFGPL

Sequences:

>Translated_328_residues
MNSLLSFAQRTLLVVAGLAASSAAHAGLTVSGTQLRESNGNALVLRGVNLPHAWYAGRTDAALAAIAATGANSVRVVLSS
GYRWTRTPEADVARIIARCKSLGLIAVLEVHDTTGYGEDTAAANLVNATNYWVGIRKALIGNEDHVVINIANEPFGNSLA
ASEWVNGHATAIATLRKNGLTHALMVDAPNWGQDWKFYMRDNAAVLLARDSRRNLMFSVHMYEVFGSDATINNYLRAFND
KKLALVIGEFGGDHRGAHVDEAAIMRRARDYNVGYMGWSWSGNDSSTKSLDIAIGWNAAQLSTWGRNLILGTDGIAATSR
RASVFGPL
>Mature_328_residues
MNSLLSFAQRTLLVVAGLAASSAAHAGLTVSGTQLRESNGNALVLRGVNLPHAWYAGRTDAALAAIAATGANSVRVVLSS
GYRWTRTPEADVARIIARCKSLGLIAVLEVHDTTGYGEDTAAANLVNATNYWVGIRKALIGNEDHVVINIANEPFGNSLA
ASEWVNGHATAIATLRKNGLTHALMVDAPNWGQDWKFYMRDNAAVLLARDSRRNLMFSVHMYEVFGSDATINNYLRAFND
KKLALVIGEFGGDHRGAHVDEAAIMRRARDYNVGYMGWSWSGNDSSTKSLDIAIGWNAAQLSTWGRNLILGTDGIAATSR
RASVFGPL

Specific function: Degradation of hemicelluloses, the second most abundant polysaccharides in nature. Contains two catalytic domains with mannanase and endoglucanase activities [H]

COG id: COG2730

COG function: function code G; Endoglucanase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBM3 (carbohydrate binding type-3) domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008965
- InterPro:   IPR001956
- InterPro:   IPR001547
- InterPro:   IPR018087
- InterPro:   IPR017853
- InterPro:   IPR013781 [H]

Pfam domain/function: PF00942 CBM_3; PF00150 Cellulase [H]

EC number: =3.2.1.78; =3.2.1.4 [H]

Molecular weight: Translated: 35256; Mature: 35256

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: PS00659 GLYCOSYL_HYDROL_F5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSLLSFAQRTLLVVAGLAASSAAHAGLTVSGTQLRESNGNALVLRGVNLPHAWYAGRTD
CCHHHHHHHHHHHHHCCHHHCCCCCCCEEEECCEEEECCCCEEEEECCCCCCCEECCCCC
AALAAIAATGANSVRVVLSSGYRWTRTPEADVARIIARCKSLGLIAVLEVHDTTGYGEDT
HHHHEEECCCCCCEEEEEECCCEECCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCH
AAANLVNATNYWVGIRKALIGNEDHVVINIANEPFGNSLAASEWVNGHATAIATLRKNGL
HHHHEECCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHCCCCCCEEEEEEHHCCC
THALMVDAPNWGQDWKFYMRDNAAVLLARDSRRNLMFSVHMYEVFGSDATINNYLRAFND
EEEEEEECCCCCCCCEEEEECCEEEEEEECCCCCEEEEEEEEEEECCCCHHHHHHHHCCC
KKLALVIGEFGGDHRGAHVDEAAIMRRARDYNVGYMGWSWSGNDSSTKSLDIAIGWNAAQ
CEEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEEEEECCHHH
LSTWGRNLILGTDGIAATSRRASVFGPL
HHHCCCEEEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNSLLSFAQRTLLVVAGLAASSAAHAGLTVSGTQLRESNGNALVLRGVNLPHAWYAGRTD
CCHHHHHHHHHHHHHCCHHHCCCCCCCEEEECCEEEECCCCEEEEECCCCCCCEECCCCC
AALAAIAATGANSVRVVLSSGYRWTRTPEADVARIIARCKSLGLIAVLEVHDTTGYGEDT
HHHHEEECCCCCCEEEEEECCCEECCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCH
AAANLVNATNYWVGIRKALIGNEDHVVINIANEPFGNSLAASEWVNGHATAIATLRKNGL
HHHHEECCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHCCCCCCEEEEEEHHCCC
THALMVDAPNWGQDWKFYMRDNAAVLLARDSRRNLMFSVHMYEVFGSDATINNYLRAFND
EEEEEEECCCCCCCCEEEEECCEEEEEEECCCCCEEEEEEEEEEECCCCHHHHHHHHCCC
KKLALVIGEFGGDHRGAHVDEAAIMRRARDYNVGYMGWSWSGNDSSTKSLDIAIGWNAAQ
CEEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEEEEECCHHH
LSTWGRNLILGTDGIAATSRRASVFGPL
HHHCCCEEEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1476429; 2039230 [H]