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The map label for this gene is folE2

Identifier: 21242527

GI number: 21242527

Start: 2050915

End: 2051832

Strand: Direct

Name: folE2

Synonym: XAC1781

Alternate gene names: 21242527

Gene position: 2050915-2051832 (Clockwise)

Preceding gene: 21242526

Following gene: 21242528

Centisome position: 39.63

GC content: 65.36

Gene sequence:

>918_bases
ATGTCCCCTACGCTTCCCGATGTTGCTGTGACCGAACCATCAACGCTGAGCGCGCCCCTGCGATGGGTGGGCATGCAGGA
CATCGCCATTCCCGTGCAGTTGGAGACCGGTAGCAGCCAGCTTGCCGCGCGCGCCAGCGTGCAGGTCGACCTGCCGCGGG
CAGAGCTGAAAGGCATCCACATGTCGCGGCTGTACCGCCTGCTGGATACGCATCTGCAGCAGCCATTGTCGCCGGCCATG
CTCTCGCAGTTATTGCAGGCGCTGATCGACAGCCATGCCGATTGCGCGAGCCGCGCCGCTCGGCTGACGCTCAGCTTCGA
ACTGATGTTACGCACGCCGGCATTGCGCAGTGAGGGACTGAGTGGCTGGCGTGCCTATCCGGTGCACATCGCCGCGCAAT
GCAGGGCAGGGCGCACCACGATCCAGCTCCAGATCGAGGTGTTGTACGCCTCCACCTGCCCCTGTTCGGCAGCCTTGTCG
CGGCAGCTGCTGAGCGATGCATTCGTGCAGCAACATGCCGGGCGCGATACGCTGCCGCTGCGCGATGTTGTGCAATGGCT
GCAGGACCACGGTACCTACGCCACGCCGCATAGCCAACGCAGCGTGGCGCAGGTACGCGTCGAGCTGCCCGCCGATGCGC
AGCGCTTGGCCATCCAGCAACTGGTCGGTCTGTGCGAGCAGGCGTTGGCGACGCCGGTGCAGGCAGCAGTGCGGCGACCA
GACGAACAGGCATTTGCGCGCCTGAATGGCGCAAACCTGATGTGTGTCGAAGATGCGGCGCGACGCCTGCGCAAGCCGCT
GGCAGAGCACTACGCGGCCTTTCATGTAGCGGTACGCCATCTGGAAAGCCTGCATGCCCACGACGCCGTCGCCGAAACCG
GCAGCGACGACGCGGTGCTTGGCCCGACAACCATGTGA

Upstream 100 bases:

>100_bases
ACTCGCGCAGACATTGCATGCGGGAATCGACGATTACTTCGCTGCGTTTCCTGGCCGCGCCTGAGGCGCGGTCGTCACCT
TTATCTTCGACGAGACCCCG

Downstream 100 bases:

>100_bases
GCAGACGCGATGCACTGCAAATTCCCAAGGCGGTCGGCACGCATGGTGCACAGACACAACACGTCGACTCACGTCGCCGC
GCAGCGAATGCGCACCGCCG

Product: GTP cyclohydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MSPTLPDVAVTEPSTLSAPLRWVGMQDIAIPVQLETGSSQLAARASVQVDLPRAELKGIHMSRLYRLLDTHLQQPLSPAM
LSQLLQALIDSHADCASRAARLTLSFELMLRTPALRSEGLSGWRAYPVHIAAQCRAGRTTIQLQIEVLYASTCPCSAALS
RQLLSDAFVQQHAGRDTLPLRDVVQWLQDHGTYATPHSQRSVAQVRVELPADAQRLAIQQLVGLCEQALATPVQAAVRRP
DEQAFARLNGANLMCVEDAARRLRKPLAEHYAAFHVAVRHLESLHAHDAVAETGSDDAVLGPTTM

Sequences:

>Translated_305_residues
MSPTLPDVAVTEPSTLSAPLRWVGMQDIAIPVQLETGSSQLAARASVQVDLPRAELKGIHMSRLYRLLDTHLQQPLSPAM
LSQLLQALIDSHADCASRAARLTLSFELMLRTPALRSEGLSGWRAYPVHIAAQCRAGRTTIQLQIEVLYASTCPCSAALS
RQLLSDAFVQQHAGRDTLPLRDVVQWLQDHGTYATPHSQRSVAQVRVELPADAQRLAIQQLVGLCEQALATPVQAAVRRP
DEQAFARLNGANLMCVEDAARRLRKPLAEHYAAFHVAVRHLESLHAHDAVAETGSDDAVLGPTTM
>Mature_304_residues
SPTLPDVAVTEPSTLSAPLRWVGMQDIAIPVQLETGSSQLAARASVQVDLPRAELKGIHMSRLYRLLDTHLQQPLSPAML
SQLLQALIDSHADCASRAARLTLSFELMLRTPALRSEGLSGWRAYPVHIAAQCRAGRTTIQLQIEVLYASTCPCSAALSR
QLLSDAFVQQHAGRDTLPLRDVVQWLQDHGTYATPHSQRSVAQVRVELPADAQRLAIQQLVGLCEQALATPVQAAVRRPD
EQAFARLNGANLMCVEDAARRLRKPLAEHYAAFHVAVRHLESLHAHDAVAETGSDDAVLGPTTM

Specific function: Converts GTP to 7,8-dihydroneopterin triphosphate

COG id: COG1469

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase IV family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCH4_XANAC (Q8PLL4)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_642109.1
- ProteinModelPortal:   Q8PLL4
- SMR:   Q8PLL4
- GeneID:   1155852
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1781
- NMPDR:   fig|190486.1.peg.1753
- HOGENOM:   HBG466315
- OMA:   FCEDAAR
- ProtClustDB:   PRK13674
- BioCyc:   XAXO190486:XAC1781-MONOMER
- HAMAP:   MF_01527_B
- InterPro:   IPR022838
- InterPro:   IPR003801
- InterPro:   IPR002042
- Gene3D:   G3DSA:3.10.270.10

Pfam domain/function: PF02649 DUF198

EC number: =3.5.4.16

Molecular weight: Translated: 33253; Mature: 33122

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPTLPDVAVTEPSTLSAPLRWVGMQDIAIPVQLETGSSQLAARASVQVDLPRAELKGIH
CCCCCCCCCCCCCCCCCCCHHHCCCCCEEEEEEEECCCHHHHHHCEEEEECCHHHHCCCH
MSRLYRLLDTHLQQPLSPAMLSQLLQALIDSHADCASRAARLTLSFELMLRTPALRSEGL
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHEEEEEEECCCCHHHHCCC
SGWRAYPVHIAAQCRAGRTTIQLQIEVLYASTCPCSAALSRQLLSDAFVQQHAGRDTLPL
CCCEEEEEEEEEECCCCCEEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCH
RDVVQWLQDHGTYATPHSQRSVAQVRVELPADAQRLAIQQLVGLCEQALATPVQAAVRRP
HHHHHHHHHCCCCCCCCCCCCHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DEQAFARLNGANLMCVEDAARRLRKPLAEHYAAFHVAVRHLESLHAHDAVAETGSDDAVL
CHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GPTTM
CCCCC
>Mature Secondary Structure 
SPTLPDVAVTEPSTLSAPLRWVGMQDIAIPVQLETGSSQLAARASVQVDLPRAELKGIH
CCCCCCCCCCCCCCCCCCHHHCCCCCEEEEEEEECCCHHHHHHCEEEEECCHHHHCCCH
MSRLYRLLDTHLQQPLSPAMLSQLLQALIDSHADCASRAARLTLSFELMLRTPALRSEGL
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHEEEEEEECCCCHHHHCCC
SGWRAYPVHIAAQCRAGRTTIQLQIEVLYASTCPCSAALSRQLLSDAFVQQHAGRDTLPL
CCCEEEEEEEEEECCCCCEEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCH
RDVVQWLQDHGTYATPHSQRSVAQVRVELPADAQRLAIQQLVGLCEQALATPVQAAVRRP
HHHHHHHHHCCCCCCCCCCCCHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DEQAFARLNGANLMCVEDAARRLRKPLAEHYAAFHVAVRHLESLHAHDAVAETGSDDAVL
CHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GPTTM
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217