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The map label for this gene is kdsA [H]

Identifier: 21242466

GI number: 21242466

Start: 1979466

End: 1980296

Strand: Direct

Name: kdsA [H]

Synonym: XAC1717

Alternate gene names: 21242466

Gene position: 1979466-1980296 (Clockwise)

Preceding gene: 21242465

Following gene: 21242467

Centisome position: 38.25

GC content: 61.85

Gene sequence:

>831_bases
ATGAAACTGTGTGACTTTGAAGTTGGCCTGGATCAGCCGTTGTTCCTGATCGCCGGCCCCTGCGTGATCGAATCGATGCA
GCTGCAGCTCGACGTGGCCGGCAAGCTCAAGGAGATCACCGGCAAGCTCGGGGTCAACTTCATCTTCAAGTCGAGTTTCG
ACAAGGCCAATCGCACCTCCGGCACCAGCTTCCGTGGCCCGGGCCTGGAAGAAGGCCTGAAGGTGCTGGATGCGGTAAAG
AAGCAGATCGGCGTGCCGGTGCTCACCGACGTGCACGAATACACCCCGATGAACGAGGTCGCGGCCGTTGTCGACGTGCT
GCAGACCCCGGCATTTTTGGTGCGCCAGACCGACTTCATCAAGAACGTCTGCGCCGCCGGCAAGCCGGTCAATATCAAGA
AGGGCCAGTTCCTGGCGCCGTGGGACATGAAGCCGGTGGTGGACAAGGCCAAGTCCACCGGCAACGAGCAGATCATGGTC
TGCGAGCGTGGCGCGTCCTTCGGCTACAACAATCTGGTCAGCGACATGCGCTCGCTGAGCGTGATGCGCGACACCGGGTG
TCCGGTGGTGTTCGACGCCACCCATTCGGTGCAGTTGCCGGGCGGGCAGGGCAGCAGTTCCGGTGGTCAGCGCGAGTTTG
TGCCGGTACTGGCGCGCGCTGCGGTGGCAGTCGGCATTTCCGGCCTGTTCGCTGAAACCCACCCGGATCCGTCCAAGGCG
CTGTCCGATGGTCCCAATGCGTGGCCGCTGGATCGCATGGAAGAACTGCTCGAAACCCTGATGGAGTTGGACACCGTCAC
CAAGAAGCATGGGTTTGCGCGTTTTGCGTGA

Upstream 100 bases:

>100_bases
CTCATGTGCCTAAATCATTCAACTATTACGTGCCAACCGTACCCTCGCCCCAACCCCTCTCCCAACCGGAGAGGGGCGTC
AATCGAAATAAGGTGACCTG

Downstream 100 bases:

>100_bases
GTTCTGAATCAGTGCGCGGCCGCTGCGGCGCACCGCCAGGATCGGCGGTGCGCCACTGGCCGGGGGGCGTGGACATTGGC
CGCATCGATCGCGGCGTGGG

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MKLCDFEVGLDQPLFLIAGPCVIESMQLQLDVAGKLKEITGKLGVNFIFKSSFDKANRTSGTSFRGPGLEEGLKVLDAVK
KQIGVPVLTDVHEYTPMNEVAAVVDVLQTPAFLVRQTDFIKNVCAAGKPVNIKKGQFLAPWDMKPVVDKAKSTGNEQIMV
CERGASFGYNNLVSDMRSLSVMRDTGCPVVFDATHSVQLPGGQGSSSGGQREFVPVLARAAVAVGISGLFAETHPDPSKA
LSDGPNAWPLDRMEELLETLMELDTVTKKHGFARFA

Sequences:

>Translated_276_residues
MKLCDFEVGLDQPLFLIAGPCVIESMQLQLDVAGKLKEITGKLGVNFIFKSSFDKANRTSGTSFRGPGLEEGLKVLDAVK
KQIGVPVLTDVHEYTPMNEVAAVVDVLQTPAFLVRQTDFIKNVCAAGKPVNIKKGQFLAPWDMKPVVDKAKSTGNEQIMV
CERGASFGYNNLVSDMRSLSVMRDTGCPVVFDATHSVQLPGGQGSSSGGQREFVPVLARAAVAVGISGLFAETHPDPSKA
LSDGPNAWPLDRMEELLETLMELDTVTKKHGFARFA
>Mature_276_residues
MKLCDFEVGLDQPLFLIAGPCVIESMQLQLDVAGKLKEITGKLGVNFIFKSSFDKANRTSGTSFRGPGLEEGLKVLDAVK
KQIGVPVLTDVHEYTPMNEVAAVVDVLQTPAFLVRQTDFIKNVCAAGKPVNIKKGQFLAPWDMKPVVDKAKSTGNEQIMV
CERGASFGYNNLVSDMRSLSVMRDTGCPVVFDATHSVQLPGGQGSSSGGQREFVPVLARAAVAVGISGLFAETHPDPSKA
LSDGPNAWPLDRMEELLETLMELDTVTKKHGFARFA

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family [H]

Homologues:

Organism=Escherichia coli, GI1787466, Length=266, Percent_Identity=46.9924812030075, Blast_Score=255, Evalue=2e-69,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269 [H]

Pfam domain/function: PF00793 DAHP_synth_1 [H]

EC number: =2.5.1.55 [H]

Molecular weight: Translated: 29772; Mature: 29772

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLCDFEVGLDQPLFLIAGPCVIESMQLQLDVAGKLKEITGKLGVNFIFKSSFDKANRTS
CCCCCCCCCCCCCHHEEECHHHHHHHHEEEHHHHHHHHHHHHHCCEEEEECCCCCCCCCC
GTSFRGPGLEEGLKVLDAVKKQIGVPVLTDVHEYTPMNEVAAVVDVLQTPAFLVRQTDFI
CCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHH
KNVCAAGKPVNIKKGQFLAPWDMKPVVDKAKSTGNEQIMVCERGASFGYNNLVSDMRSLS
HHHHHCCCCCCCCCCCEECCCCCCHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHH
VMRDTGCPVVFDATHSVQLPGGQGSSSGGQREFVPVLARAAVAVGISGLFAETHPDPSKA
HHHCCCCCEEEECCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
LSDGPNAWPLDRMEELLETLMELDTVTKKHGFARFA
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKLCDFEVGLDQPLFLIAGPCVIESMQLQLDVAGKLKEITGKLGVNFIFKSSFDKANRTS
CCCCCCCCCCCCCHHEEECHHHHHHHHEEEHHHHHHHHHHHHHCCEEEEECCCCCCCCCC
GTSFRGPGLEEGLKVLDAVKKQIGVPVLTDVHEYTPMNEVAAVVDVLQTPAFLVRQTDFI
CCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHH
KNVCAAGKPVNIKKGQFLAPWDMKPVVDKAKSTGNEQIMVCERGASFGYNNLVSDMRSLS
HHHHHCCCCCCCCCCCEECCCCCCHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHH
VMRDTGCPVVFDATHSVQLPGGQGSSSGGQREFVPVLARAAVAVGISGLFAETHPDPSKA
HHHCCCCCEEEECCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
LSDGPNAWPLDRMEELLETLMELDTVTKKHGFARFA
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA