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The map label for this gene is pyrG [H]

Identifier: 21242465

GI number: 21242465

Start: 1977450

End: 1979114

Strand: Direct

Name: pyrG [H]

Synonym: XAC1716

Alternate gene names: 21242465

Gene position: 1977450-1979114 (Clockwise)

Preceding gene: 21242464

Following gene: 21242466

Centisome position: 38.21

GC content: 63.78

Gene sequence:

>1665_bases
ATGACCCCCCTGATTTTCGTTACCGGCGGCGTAGTGTCCTCGCTAGGCAAGGGCATTGCCGCCGCTTCGCTTGCGTCCAT
TCTTGAAGCGCGTGGCCTGAAGGTCACGATGATGAAGCTGGACCCGTATATCAACGTAGACCCGGGCACGATGAGCCCGT
TCCAGCATGGCGAGGTCTACGTCACCGACGACGGTGCCGAAACCGACCTGGATTTGGGCCACTACGAGCGTTATGTGCGC
ACGCGCCTGTCGCGCAAGAACTCGGTGACCACCGGCCGCATCTACGAGAACGTCATCCGCAAGGAGCGTCGCGGCGATTA
TCTGGGCGCCACCGTGCAGGTGATTCCGCATATCACCGACGAAATCCGTCGCTGCATCGACGAGGCCACGGCCGGGTTCG
ATGTCGCGTTGATCGAAATCGGCGGCACCGTCGGCGACATCGAATCGCTGCCGTTCCTGGAGGCGATCCGCCAGGTGCGC
ACCGAGCGCGGCGCCGAAAAGGCAATGTTCATGCATCTGACGCTGGTGCCGTACATCGCGGCAGCCGGCGAGTTGAAGAC
CAAGCCGACCCAGCATTCGGTCAAGGAACTGCGCTCGATCGGCATCCAGCCGGACGTGCTGCTGTGCCGGTCCGAGCAGG
CGGTGCCGGATTCGGAACGCCGCAAGATTGCGCTGTTCACCAATGTCTCCGAGCGTGCGGTGATCAGTTGCCCGGATATC
GACGTGCTGTACGGCATGCCGCTGGAGTTGCTGCGCCAGGGACTGGACGAATTGGTCATCGACCAATTCAAGCTGCGCGA
CAAGGTGGCTGCAGCGGATCTGTCGGAGTGGGCGGCCGTGGTGGACGCGGTCAAGCATCCGCTGGACGAGGTCAACATCG
CCGTGGTCGGCAAGTACGTCGATCACCAGGATGCCTACAAGTCCGTGGCCGAAGCGCTGCGTCACGGCGGCCTGCGTCAG
CGCACCAAGGTCAACCTGAAGTGGCTGGAAGCGCAGGATCTTGAGGGCAGCGACATGTCTGCCTTGCAGGACATCGACGG
CATCCTGGTGCCGGGCGGTTTCGGCGATCGCGGTTTCGAAGGCAAGGTGCAGACCTCCAAGTTCGCGCGTGAGCAGAAGG
TACCGTATTTCGGTATCTGCTACGGCATGCAGGCGGCCGTGGTGGACTATGCCCGCCACGTCGCCGACCTGGATGCGGCC
AACAGCACCGAGAACGATCGCCAGTCGCCGCACCCGGTGATCGGCCTGATCACCGAATGGCGCACCGCCACCGGTGAAGT
GGAAAAGCGCGACGAAAAATCCGACCTGGGCGGCACCATGCGCCTGGGCCTGCAGGAGCAACGCCTGAAGCCCGGCACGC
TGGCGCGCGAGGTGTACGGCAAGGACGTTGTGGCCGAGCGGCATCGTCACCGTTACGAGTTCAACAACCGCTATCGCACC
CAGCTGGAAGACGCCGGGCTGGTGATCTCCGGCAAGTCGATGGACGACACCCTGGTGGAAGTGGTGGAGCTGCCGCGCGA
CACGCACCCGTGGTTCTTGGCCTGCCAGGCGCATCCGGAATTCCTGTCCACCCCGCGCGACGGCCATCCGCTGTTCATCG
GCTTCGTGCGTGCGGCGCGCGAGAAGAAGGCCGGCGGGAAGTTGTTGAAGGAAGCGCGCGCGTGA

Upstream 100 bases:

>100_bases
CATGCACTGTTTCAACGTGTGATGACCTTGTCGTCACGCAACCCTTGGGCATTCGCCCGTCACCCGCTAAACTATGGCTT
TCCGGGAGGCTTCAAGCCCC

Downstream 100 bases:

>100_bases
GCAGTCCCTTCTCCTGTCGGGAGAAGGTGGCGCGAAGCGCCGGATGAGGGGGCGCCGCAACGCACTGGAAGATGACAGCC
ATGACGAGCGCGTCACCACG

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 554; Mature: 553

Protein sequence:

>554_residues
MTPLIFVTGGVVSSLGKGIAAASLASILEARGLKVTMMKLDPYINVDPGTMSPFQHGEVYVTDDGAETDLDLGHYERYVR
TRLSRKNSVTTGRIYENVIRKERRGDYLGATVQVIPHITDEIRRCIDEATAGFDVALIEIGGTVGDIESLPFLEAIRQVR
TERGAEKAMFMHLTLVPYIAAAGELKTKPTQHSVKELRSIGIQPDVLLCRSEQAVPDSERRKIALFTNVSERAVISCPDI
DVLYGMPLELLRQGLDELVIDQFKLRDKVAAADLSEWAAVVDAVKHPLDEVNIAVVGKYVDHQDAYKSVAEALRHGGLRQ
RTKVNLKWLEAQDLEGSDMSALQDIDGILVPGGFGDRGFEGKVQTSKFAREQKVPYFGICYGMQAAVVDYARHVADLDAA
NSTENDRQSPHPVIGLITEWRTATGEVEKRDEKSDLGGTMRLGLQEQRLKPGTLAREVYGKDVVAERHRHRYEFNNRYRT
QLEDAGLVISGKSMDDTLVEVVELPRDTHPWFLACQAHPEFLSTPRDGHPLFIGFVRAAREKKAGGKLLKEARA

Sequences:

>Translated_554_residues
MTPLIFVTGGVVSSLGKGIAAASLASILEARGLKVTMMKLDPYINVDPGTMSPFQHGEVYVTDDGAETDLDLGHYERYVR
TRLSRKNSVTTGRIYENVIRKERRGDYLGATVQVIPHITDEIRRCIDEATAGFDVALIEIGGTVGDIESLPFLEAIRQVR
TERGAEKAMFMHLTLVPYIAAAGELKTKPTQHSVKELRSIGIQPDVLLCRSEQAVPDSERRKIALFTNVSERAVISCPDI
DVLYGMPLELLRQGLDELVIDQFKLRDKVAAADLSEWAAVVDAVKHPLDEVNIAVVGKYVDHQDAYKSVAEALRHGGLRQ
RTKVNLKWLEAQDLEGSDMSALQDIDGILVPGGFGDRGFEGKVQTSKFAREQKVPYFGICYGMQAAVVDYARHVADLDAA
NSTENDRQSPHPVIGLITEWRTATGEVEKRDEKSDLGGTMRLGLQEQRLKPGTLAREVYGKDVVAERHRHRYEFNNRYRT
QLEDAGLVISGKSMDDTLVEVVELPRDTHPWFLACQAHPEFLSTPRDGHPLFIGFVRAAREKKAGGKLLKEARA
>Mature_553_residues
TPLIFVTGGVVSSLGKGIAAASLASILEARGLKVTMMKLDPYINVDPGTMSPFQHGEVYVTDDGAETDLDLGHYERYVRT
RLSRKNSVTTGRIYENVIRKERRGDYLGATVQVIPHITDEIRRCIDEATAGFDVALIEIGGTVGDIESLPFLEAIRQVRT
ERGAEKAMFMHLTLVPYIAAAGELKTKPTQHSVKELRSIGIQPDVLLCRSEQAVPDSERRKIALFTNVSERAVISCPDID
VLYGMPLELLRQGLDELVIDQFKLRDKVAAADLSEWAAVVDAVKHPLDEVNIAVVGKYVDHQDAYKSVAEALRHGGLRQR
TKVNLKWLEAQDLEGSDMSALQDIDGILVPGGFGDRGFEGKVQTSKFAREQKVPYFGICYGMQAAVVDYARHVADLDAAN
STENDRQSPHPVIGLITEWRTATGEVEKRDEKSDLGGTMRLGLQEQRLKPGTLAREVYGKDVVAERHRHRYEFNNRYRTQ
LEDAGLVISGKSMDDTLVEVVELPRDTHPWFLACQAHPEFLSTPRDGHPLFIGFVRAAREKKAGGKLLKEARA

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=561, Percent_Identity=42.9590017825312, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI28559085, Length=561, Percent_Identity=41.1764705882353, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI28559083, Length=561, Percent_Identity=41.1764705882353, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI221316689, Length=561, Percent_Identity=41.1764705882353, Blast_Score=432, Evalue=1e-121,
Organism=Escherichia coli, GI1789142, Length=540, Percent_Identity=64.4444444444444, Blast_Score=704, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25148299, Length=605, Percent_Identity=36.0330578512397, Blast_Score=389, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6319432, Length=570, Percent_Identity=40.3508771929825, Blast_Score=419, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6322563, Length=566, Percent_Identity=40.9893992932862, Blast_Score=418, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24664469, Length=560, Percent_Identity=42.3214285714286, Blast_Score=440, Evalue=1e-123,
Organism=Drosophila melanogaster, GI21357815, Length=504, Percent_Identity=41.0714285714286, Blast_Score=371, Evalue=1e-103,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 61483; Mature: 61352

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPLIFVTGGVVSSLGKGIAAASLASILEARGLKVTMMKLDPYINVDPGTMSPFQHGEVY
CCCEEEECCHHHHHHCCHHHHHHHHHHHHHCCCEEEEEEECCEEECCCCCCCCCCCCEEE
VTDDGAETDLDLGHYERYVRTRLSRKNSVTTGRIYENVIRKERRGDYLGATVQVIPHITD
EECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
EIRRCIDEATAGFDVALIEIGGTVGDIESLPFLEAIRQVRTERGAEKAMFMHLTLVPYIA
HHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
AAGELKTKPTQHSVKELRSIGIQPDVLLCRSEQAVPDSERRKIALFTNVSERAVISCPDI
HCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCEEEEEECCCCCEEEECCCC
DVLYGMPLELLRQGLDELVIDQFKLRDKVAAADLSEWAAVVDAVKHPLDEVNIAVVGKYV
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCEEEEEEHH
DHQDAYKSVAEALRHGGLRQRTKVNLKWLEAQDLEGSDMSALQDIDGILVPGGFGDRGFE
CHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCHHHHHHCCCEEECCCCCCCCCC
GKVQTSKFAREQKVPYFGICYGMQAAVVDYARHVADLDAANSTENDRQSPHPVIGLITEW
CCCHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECC
RTATGEVEKRDEKSDLGGTMRLGLQEQRLKPGTLAREVYGKDVVAERHRHRYEFNNRYRT
CCCCCCHHHCCCHHCCCCEEECCCHHHCCCCCHHHHHHHCHHHHHHHHHHHHHCCCCHHH
QLEDAGLVISGKSMDDTLVEVVELPRDTHPWFLACQAHPEFLSTPRDGHPLFIGFVRAAR
HHCCCCEEEECCCCHHHHHHHHHCCCCCCCEEEEEECCHHHHCCCCCCCCEEHHHHHHHH
EKKAGGKLLKEARA
HHHHHHHHHHHHCC
>Mature Secondary Structure 
TPLIFVTGGVVSSLGKGIAAASLASILEARGLKVTMMKLDPYINVDPGTMSPFQHGEVY
CCEEEECCHHHHHHCCHHHHHHHHHHHHHCCCEEEEEEECCEEECCCCCCCCCCCCEEE
VTDDGAETDLDLGHYERYVRTRLSRKNSVTTGRIYENVIRKERRGDYLGATVQVIPHITD
EECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
EIRRCIDEATAGFDVALIEIGGTVGDIESLPFLEAIRQVRTERGAEKAMFMHLTLVPYIA
HHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
AAGELKTKPTQHSVKELRSIGIQPDVLLCRSEQAVPDSERRKIALFTNVSERAVISCPDI
HCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCEEEEEECCCCCEEEECCCC
DVLYGMPLELLRQGLDELVIDQFKLRDKVAAADLSEWAAVVDAVKHPLDEVNIAVVGKYV
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCEEEEEEHH
DHQDAYKSVAEALRHGGLRQRTKVNLKWLEAQDLEGSDMSALQDIDGILVPGGFGDRGFE
CHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCHHHHHHCCCEEECCCCCCCCCC
GKVQTSKFAREQKVPYFGICYGMQAAVVDYARHVADLDAANSTENDRQSPHPVIGLITEW
CCCHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECC
RTATGEVEKRDEKSDLGGTMRLGLQEQRLKPGTLAREVYGKDVVAERHRHRYEFNNRYRT
CCCCCCHHHCCCHHCCCCEEECCCHHHCCCCCHHHHHHHCHHHHHHHHHHHHHCCCCHHH
QLEDAGLVISGKSMDDTLVEVVELPRDTHPWFLACQAHPEFLSTPRDGHPLFIGFVRAAR
HHCCCCEEEECCCCHHHHHHHHHCCCCCCCEEEEEECCHHHHCCCCCCCCEEHHHHHHHH
EKKAGGKLLKEARA
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA