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The map label for this gene is hrcA

Identifier: 21242271

GI number: 21242271

Start: 1753445

End: 1754476

Strand: Direct

Name: hrcA

Synonym: XAC1520

Alternate gene names: 21242271

Gene position: 1753445-1754476 (Clockwise)

Preceding gene: 21242269

Following gene: 21242272

Centisome position: 33.88

GC content: 68.6

Gene sequence:

>1032_bases
ATGCTCGACCCCCGCGCCCGTCAGTTGCTGCGCACACTGATTGCGCGCTACATCCGCGACGGCGAGCCGGTGGGCTCCAA
GACGCTGGCCCAGCATGCGGGCCTGGACGTCAGTCCGGCCACCATCCGCAATATCCTGGCCGACCTGGAAGACGTGGGCC
TGCTCAGCTCCCCGCATACCTCGGCCGGACGCGTGCCGACCGCGCATGGCTACCGGGTGTTCGTCGACAGCCTGGTGCAG
ATGCAGCCGCCCGGCGAAGAGGAAGTACGTCGCCTGCGCGCGGAGCTGGCCAGCGGCAACGGCACGCAATCGTTGCTGGG
CAGCGCCTCGCAGATGCTGTCGGCGATGAGCCACTTCGTCGGCGTGGTCAGCGCGCCGCGCCGCGAGCAGTTCGCGTTTC
GGCATATCGATTTCGTGGCGCTGGATGCGCGCCGCGTGCTGGCGATCCTGGTGTTTGCCGACAACGAGGTGCAGAACCGG
GTGATCGAGCCGCGGCGCGCCTACGAGCCGGCCGAGCTGGAACGGGTGGCCAACTACCTCAATGCGCAGTTCGCCGGGCG
CGCGCTGGCCGACATCCGCGCCTGCCTGCTGCGCGAGCTGCGCATGGCCAAGAGCGAGATGGAACAACTGCTGGCGCACA
GCGTGGAGCTGGCCAGCGAGGCGCTGGTGCCGGCCGATGCCGACGACATGGTGATGGCCGGGCAGACCCGGCTGATGGGC
GTGCAGGACCTGTCGGACCTGGATCGCCTGCGCGAACTGTTCGAGGCCTTCGCCAGCAAGCGCGAGATTTTGCAGCTGCT
CGAACGCACCATCCAGGCCCCGGGCGTGCGCATCTTCATCGGCGAGGAAACCGGCATGGTGTCGCTGGAAGACGTCTCGC
TGGTCACTGCACCTTACGCCGCCAATGGCCAGGTGCTGGGCGTGCTGGGGGTGATCGGGCCCAAACGCATGGCCTACGAC
CGGCTGATTCCGCTGGTGCAGACCGCCGCCGACGTGCTGGGTGCGGCCATGCAGTCGCCCGGCGCGCGATAA

Upstream 100 bases:

>100_bases
GCAGGGGCAAACGGGGAATCGGATGCTTGCCATCCCCGGGGCCAGACATTATCTATGCGCTGTCTCACCGGATGATCCCA
TGCGCGCGTCCCAGTCCCCA

Downstream 100 bases:

>100_bases
CCGGCATCGATCGGCGCGATCGTGTTTGCTTGAAACGCGCGCAGGCGCCCATATACGGGGTGACGTTGGGGCGGGCGTTC
CGCTTGCCCGGGAACTGCAC

Product: heat-inducible transcription repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MLDPRARQLLRTLIARYIRDGEPVGSKTLAQHAGLDVSPATIRNILADLEDVGLLSSPHTSAGRVPTAHGYRVFVDSLVQ
MQPPGEEEVRRLRAELASGNGTQSLLGSASQMLSAMSHFVGVVSAPRREQFAFRHIDFVALDARRVLAILVFADNEVQNR
VIEPRRAYEPAELERVANYLNAQFAGRALADIRACLLRELRMAKSEMEQLLAHSVELASEALVPADADDMVMAGQTRLMG
VQDLSDLDRLRELFEAFASKREILQLLERTIQAPGVRIFIGEETGMVSLEDVSLVTAPYAANGQVLGVLGVIGPKRMAYD
RLIPLVQTAADVLGAAMQSPGAR

Sequences:

>Translated_343_residues
MLDPRARQLLRTLIARYIRDGEPVGSKTLAQHAGLDVSPATIRNILADLEDVGLLSSPHTSAGRVPTAHGYRVFVDSLVQ
MQPPGEEEVRRLRAELASGNGTQSLLGSASQMLSAMSHFVGVVSAPRREQFAFRHIDFVALDARRVLAILVFADNEVQNR
VIEPRRAYEPAELERVANYLNAQFAGRALADIRACLLRELRMAKSEMEQLLAHSVELASEALVPADADDMVMAGQTRLMG
VQDLSDLDRLRELFEAFASKREILQLLERTIQAPGVRIFIGEETGMVSLEDVSLVTAPYAANGQVLGVLGVIGPKRMAYD
RLIPLVQTAADVLGAAMQSPGAR
>Mature_343_residues
MLDPRARQLLRTLIARYIRDGEPVGSKTLAQHAGLDVSPATIRNILADLEDVGLLSSPHTSAGRVPTAHGYRVFVDSLVQ
MQPPGEEEVRRLRAELASGNGTQSLLGSASQMLSAMSHFVGVVSAPRREQFAFRHIDFVALDARRVLAILVFADNEVQNR
VIEPRRAYEPAELERVANYLNAQFAGRALADIRACLLRELRMAKSEMEQLLAHSVELASEALVPADADDMVMAGQTRLMG
VQDLSDLDRLRELFEAFASKREILQLLERTIQAPGVRIFIGEETGMVSLEDVSLVTAPYAANGQVLGVLGVIGPKRMAYD
RLIPLVQTAADVLGAAMQSPGAR

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HRCA_XANAC (Q8PMB2)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_641853.1
- ProteinModelPortal:   Q8PMB2
- SMR:   Q8PMB2
- GeneID:   1155591
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1520
- NMPDR:   fig|190486.1.peg.1497
- HOGENOM:   HBG729878
- OMA:   LEQPHTS
- ProtClustDB:   PRK00082
- BioCyc:   XAXO190486:XAC1520-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_00081
- InterPro:   IPR005104
- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PIRSF:   PIRSF005485
- TIGRFAMs:   TIGR00331

Pfam domain/function: PF03444 DUF293; PF01628 HrcA

EC number: NA

Molecular weight: Translated: 37442; Mature: 37442

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDPRARQLLRTLIARYIRDGEPVGSKTLAQHAGLDVSPATIRNILADLEDVGLLSSPHT
CCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCC
SAGRVPTAHGYRVFVDSLVQMQPPGEEEVRRLRAELASGNGTQSLLGSASQMLSAMSHFV
CCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
GVVSAPRREQFAFRHIDFVALDARRVLAILVFADNEVQNRVIEPRRAYEPAELERVANYL
HHHCCCCHHHHHHHHHHHHEECHHHHHEEEEECCCHHHHHHCCCHHCCCHHHHHHHHHHH
NAQFAGRALADIRACLLRELRMAKSEMEQLLAHSVELASEALVPADADDMVMAGQTRLMG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCHHHCC
VQDLSDLDRLRELFEAFASKREILQLLERTIQAPGVRIFIGEETGMVSLEDVSLVTAPYA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEECCCCEEECCCC
ANGQVLGVLGVIGPKRMAYDRLIPLVQTAADVLGAAMQSPGAR
CCCCEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLDPRARQLLRTLIARYIRDGEPVGSKTLAQHAGLDVSPATIRNILADLEDVGLLSSPHT
CCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCC
SAGRVPTAHGYRVFVDSLVQMQPPGEEEVRRLRAELASGNGTQSLLGSASQMLSAMSHFV
CCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
GVVSAPRREQFAFRHIDFVALDARRVLAILVFADNEVQNRVIEPRRAYEPAELERVANYL
HHHCCCCHHHHHHHHHHHHEECHHHHHEEEEECCCHHHHHHCCCHHCCCHHHHHHHHHHH
NAQFAGRALADIRACLLRELRMAKSEMEQLLAHSVELASEALVPADADDMVMAGQTRLMG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCHHHCC
VQDLSDLDRLRELFEAFASKREILQLLERTIQAPGVRIFIGEETGMVSLEDVSLVTAPYA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEECCCCEEECCCC
ANGQVLGVLGVIGPKRMAYDRLIPLVQTAADVLGAAMQSPGAR
CCCCEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217