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The map label for this gene is hpt [H]

Identifier: 21242088

GI number: 21242088

Start: 1541106

End: 1541660

Strand: Direct

Name: hpt [H]

Synonym: XAC1335

Alternate gene names: 21242088

Gene position: 1541106-1541660 (Clockwise)

Preceding gene: 21242087

Following gene: 21242089

Centisome position: 29.78

GC content: 65.77

Gene sequence:

>555_bases
ATGTCCACGCTCACCATTTCCCAGGCCCTGGCCCAAGCCGATCTGCTGGTCGACCGTCCGGCCATCGATGCCGCCGTTGC
CACCATCGCCGATGCGATCGCACGCGACTACGCCGGCGAAGTGCCGGTGTATCTCACCATCATGCACGGTGCGCTGCCGT
TCTCCGGACAGCTGGCGCTGGAGCTGGGCGCACGCGGCCAGGACCTGCAATTCGATTACCTGCATGCCACCCGTTACCGC
GGTGAAACCACCGGTGGCGAACTGGTGTGGAAGCACCGCCCGGCCACCGCGCTGTTCGGCCGCCGCGTGATCCTGGTCGA
CGACATTCTCGACGAGGGTTACACGCTGCAGGGCGTGCGCCAGTGGTGCCTGGAGCAGGGCGCCACCGACGTGCGCGTGG
CGGTATTGACCGTCAAGCGGCACGACCGTTGCGTGCCGGGCGTGACGGCCGACTACGTGGGTGTGGAAGTGCCCGACCGT
TACGTGTTCGGCTTCGGCATGGACGTCAACGAGCAGCTACGCGGCATTCCTGCCATCTATGCGATGAAGCAGTAA

Upstream 100 bases:

>100_bases
GCCTGATCGGCCGCGGCGCACTAGGTTGGGATGGCCTGCTCGCCGGCACCGATGCCTCATTTACCACTCCTCTTTCTGCC
CATTTCGGAACAACTGCCTG

Downstream 100 bases:

>100_bases
CGCTCGAAATCCATGCCCGCATCGTTGCGGGCAGCTTGGCGCGCGCGTGCGCGCCCCATCATGTCTTTCGCTGCAGAGGT
CGGTTGTGTCCGCAAATTCC

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 184; Mature: 183

Protein sequence:

>184_residues
MSTLTISQALAQADLLVDRPAIDAAVATIADAIARDYAGEVPVYLTIMHGALPFSGQLALELGARGQDLQFDYLHATRYR
GETTGGELVWKHRPATALFGRRVILVDDILDEGYTLQGVRQWCLEQGATDVRVAVLTVKRHDRCVPGVTADYVGVEVPDR
YVFGFGMDVNEQLRGIPAIYAMKQ

Sequences:

>Translated_184_residues
MSTLTISQALAQADLLVDRPAIDAAVATIADAIARDYAGEVPVYLTIMHGALPFSGQLALELGARGQDLQFDYLHATRYR
GETTGGELVWKHRPATALFGRRVILVDDILDEGYTLQGVRQWCLEQGATDVRVAVLTVKRHDRCVPGVTADYVGVEVPDR
YVFGFGMDVNEQLRGIPAIYAMKQ
>Mature_183_residues
STLTISQALAQADLLVDRPAIDAAVATIADAIARDYAGEVPVYLTIMHGALPFSGQLALELGARGQDLQFDYLHATRYRG
ETTGGELVWKHRPATALFGRRVILVDDILDEGYTLQGVRQWCLEQGATDVRVAVLTVKRHDRCVPGVTADYVGVEVPDRY
VFGFGMDVNEQLRGIPAIYAMKQ

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=163, Percent_Identity=28.2208588957055, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20177; Mature: 20046

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLTISQALAQADLLVDRPAIDAAVATIADAIARDYAGEVPVYLTIMHGALPFSGQLAL
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEE
ELGARGQDLQFDYLHATRYRGETTGGELVWKHRPATALFGRRVILVDDILDEGYTLQGVR
EECCCCCCCEEEEEEHHHCCCCCCCCEEEEEECCCHHHHCCEEEEEEHHHCCCCCHHHHH
QWCLEQGATDVRVAVLTVKRHDRCVPGVTADYVGVEVPDRYVFGFGMDVNEQLRGIPAIY
HHHHHCCCCCEEEEEEEEECCCCCCCCCCCCEEEEECCCCEEEEECCCCCHHHCCCCCEE
AMKQ
EECC
>Mature Secondary Structure 
STLTISQALAQADLLVDRPAIDAAVATIADAIARDYAGEVPVYLTIMHGALPFSGQLAL
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEE
ELGARGQDLQFDYLHATRYRGETTGGELVWKHRPATALFGRRVILVDDILDEGYTLQGVR
EECCCCCCCEEEEEEHHHCCCCCCCCEEEEEECCCHHHHCCEEEEEEHHHCCCCCHHHHH
QWCLEQGATDVRVAVLTVKRHDRCVPGVTADYVGVEVPDRYVFGFGMDVNEQLRGIPAIY
HHHHHCCCCCEEEEEEEEECCCCCCCCCCCCEEEEECCCCEEEEECCCCCHHHCCCCCEE
AMKQ
EECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]