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The map label for this gene is paaF [C]

Identifier: 21242068

GI number: 21242068

Start: 1518118

End: 1519272

Strand: Direct

Name: paaF [C]

Synonym: XAC1315

Alternate gene names: 21242068

Gene position: 1518118-1519272 (Clockwise)

Preceding gene: 21242067

Following gene: 21242069

Centisome position: 29.33

GC content: 64.85

Gene sequence:

>1155_bases
GTGCTGTTCGAGCAGCGTGCGTGCGCCGATGGGCACCGTATCGGCATCGCTACCTTGAATGCGCCCAAGACGCTCAATGG
CCTGTCGTTACAGATGACGCGGCTGCTGGATGCGCAGTTACGTGTCTGGGCTGAGGATACGCAGATCGCCTGCGTGGTAT
TGCGTGGCGCCGGCGACAAAGCGTTCTGCGCTGGTGGCGATCTGCATGGCCTGTACCAGAGCATGCGCGCGCACCGCGAT
GCAGTGCCCGACGCTGCAGCGCGACGCGCAGCGCCGCAGGCCAACGTGCATGCTGCGGCATTTTTCGAGGAGGAATACCG
GCTCGACTACCGCATCCATACCTATCCGAAGCCGCTGCTGTGTTGGGGCCACGGTATCGTGATGGGCGGTGGCATCGGCC
TGATGTCCGGCGCTAGCCATCGCGTGGTCACCGAACGCTCGCGCCTTGCCATGCCGGAGATCAGCGTCGGCTTGTTCCCG
GATGTGGGTGGCAGCTGGTTGTTGCGTCGCGTGCCCCAGGGTGCTGGCCTGTTTCTGGCGCTGACTGGTGCGCCGCTGGA
TGCCAGCGATGCGATGTACGCGGGGCTAGCAGATGTGCGCCTGGAGCATGCGCAGTACGTAGCGGTGCTGGATGCGCTAA
GCGCGCACGCATGGACAGGCAATGCCGACGACGACCGCACCCAGCTCGGCGCATTCCTGCATGGCATCGCGCAACCGACC
GAACCGGGCCCGTTGCAGCTCCACGCGCAGTTGATCGAACGCCTGGTATCCAGCGAGTCACTGGAGCACATCGTCGCTGC
AATCATGGCGCTGCAAAGCGAAGACAGCTGGCTGCAGGCCGCACGCGCCACCTTGGCGGCCGGTGCTCCTGGATCGGCGC
GCCTGGCCTGGGAGCTGTATCGCCGTCCGGGCACCACGACGCTGGCCGACACCTTTCGGACCGAATACGTGGTCGCATTG
CATGTGGCGGCGCATGGCGATTTTGCCGAAGGCATCCGCGCGCTGTTGATCGATAAGGATCGTCAACCGCGTTGGCAGCC
TGGATCGCTGGAAGAAGCCGATGCGCAGTGGGCCGCAGACTTCTTTGTCGCGCCCTGGTCGCCTGCATCGCATCCGCTTG
CCGATCTGGGGGCAGGCGAGTTGGGTGTGCATTGA

Upstream 100 bases:

>100_bases
ACGCCGATCAGGCCGAAGGCGTGGCCGCATTTCTGGACAAGCGCGCGCCGCAGTGGAGCAACCGCTGATGGCGCAGGTCA
GCGCAACCGACGAGGCAGCG

Downstream 100 bases:

>100_bases
GTGGCTGGCAACTTGCGAAGTACGTTCGGCTCACGCCGGATTGCAGCGCGGTTGCCATGTCGCACCTGCGTCGTCGCAGC
TGAAAACCGGCGGTGGCTCC

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: 3-hydroxypropionyl-CoA dehydratase [H]

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MLFEQRACADGHRIGIATLNAPKTLNGLSLQMTRLLDAQLRVWAEDTQIACVVLRGAGDKAFCAGGDLHGLYQSMRAHRD
AVPDAAARRAAPQANVHAAAFFEEEYRLDYRIHTYPKPLLCWGHGIVMGGGIGLMSGASHRVVTERSRLAMPEISVGLFP
DVGGSWLLRRVPQGAGLFLALTGAPLDASDAMYAGLADVRLEHAQYVAVLDALSAHAWTGNADDDRTQLGAFLHGIAQPT
EPGPLQLHAQLIERLVSSESLEHIVAAIMALQSEDSWLQAARATLAAGAPGSARLAWELYRRPGTTTLADTFRTEYVVAL
HVAAHGDFAEGIRALLIDKDRQPRWQPGSLEEADAQWAADFFVAPWSPASHPLADLGAGELGVH

Sequences:

>Translated_384_residues
MLFEQRACADGHRIGIATLNAPKTLNGLSLQMTRLLDAQLRVWAEDTQIACVVLRGAGDKAFCAGGDLHGLYQSMRAHRD
AVPDAAARRAAPQANVHAAAFFEEEYRLDYRIHTYPKPLLCWGHGIVMGGGIGLMSGASHRVVTERSRLAMPEISVGLFP
DVGGSWLLRRVPQGAGLFLALTGAPLDASDAMYAGLADVRLEHAQYVAVLDALSAHAWTGNADDDRTQLGAFLHGIAQPT
EPGPLQLHAQLIERLVSSESLEHIVAAIMALQSEDSWLQAARATLAAGAPGSARLAWELYRRPGTTTLADTFRTEYVVAL
HVAAHGDFAEGIRALLIDKDRQPRWQPGSLEEADAQWAADFFVAPWSPASHPLADLGAGELGVH
>Mature_384_residues
MLFEQRACADGHRIGIATLNAPKTLNGLSLQMTRLLDAQLRVWAEDTQIACVVLRGAGDKAFCAGGDLHGLYQSMRAHRD
AVPDAAARRAAPQANVHAAAFFEEEYRLDYRIHTYPKPLLCWGHGIVMGGGIGLMSGASHRVVTERSRLAMPEISVGLFP
DVGGSWLLRRVPQGAGLFLALTGAPLDASDAMYAGLADVRLEHAQYVAVLDALSAHAWTGNADDDRTQLGAFLHGIAQPT
EPGPLQLHAQLIERLVSSESLEHIVAAIMALQSEDSWLQAARATLAAGAPGSARLAWELYRRPGTTTLADTFRTEYVVAL
HVAAHGDFAEGIRALLIDKDRQPRWQPGSLEEADAQWAADFFVAPWSPASHPLADLGAGELGVH

Specific function: Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the reversible dehydration of 3-hydroxypropionyl-CoA to form acryloyl- CoA, and the reversible dehydration of (S)-3-hydroxybutyryl-CoA to form crot

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI37594471, Length=362, Percent_Identity=30.939226519337, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI37594469, Length=316, Percent_Identity=30.0632911392405, Blast_Score=153, Evalue=3e-37,
Organism=Escherichia coli, GI1787659, Length=204, Percent_Identity=28.4313725490196, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787660, Length=175, Percent_Identity=32.5714285714286, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI25144157, Length=350, Percent_Identity=35.1428571428571, Blast_Score=205, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI25144160, Length=350, Percent_Identity=35.1428571428571, Blast_Score=204, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6320241, Length=359, Percent_Identity=26.7409470752089, Blast_Score=123, Evalue=6e-29,
Organism=Drosophila melanogaster, GI28571730, Length=348, Percent_Identity=34.1954022988506, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI28571729, Length=348, Percent_Identity=34.1954022988506, Blast_Score=189, Evalue=4e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.116 [H]

Molecular weight: Translated: 41302; Mature: 41302

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFEQRACADGHRIGIATLNAPKTLNGLSLQMTRLLDAQLRVWAEDTQIACVVLRGAGDK
CCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHEEEECCCEEEEEEEECCCCC
AFCAGGDLHGLYQSMRAHRDAVPDAAARRAAPQANVHAAAFFEEEYRLDYRIHTYPKPLL
EEECCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCCEEEEEEHHHHEEEEEEECCCCCEE
CWGHGIVMGGGIGLMSGASHRVVTERSRLAMPEISVGLFPDVGGSWLLRRVPQGAGLFLA
EECCCEEEECCCCCCCCCCCCEEEHHHHCCCCCCCEECCCCCCHHHHHHHCCCCCCEEEE
LTGAPLDASDAMYAGLADVRLEHAQYVAVLDALSAHAWTGNADDDRTQLGAFLHGIAQPT
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCC
EPGPLQLHAQLIERLVSSESLEHIVAAIMALQSEDSWLQAARATLAAGAPGSARLAWELY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHH
RRPGTTTLADTFRTEYVVALHVAAHGDFAEGIRALLIDKDRQPRWQPGSLEEADAQWAAD
HCCCCCHHHHHHCCEEEEEEEEEECCCHHHHHHEEEECCCCCCCCCCCCCCHHCHHHHHH
FFVAPWSPASHPLADLGAGELGVH
EEEECCCCCCCCHHHCCCCCCCCC
>Mature Secondary Structure
MLFEQRACADGHRIGIATLNAPKTLNGLSLQMTRLLDAQLRVWAEDTQIACVVLRGAGDK
CCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHEEEECCCEEEEEEEECCCCC
AFCAGGDLHGLYQSMRAHRDAVPDAAARRAAPQANVHAAAFFEEEYRLDYRIHTYPKPLL
EEECCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCCEEEEEEHHHHEEEEEEECCCCCEE
CWGHGIVMGGGIGLMSGASHRVVTERSRLAMPEISVGLFPDVGGSWLLRRVPQGAGLFLA
EECCCEEEECCCCCCCCCCCCEEEHHHHCCCCCCCEECCCCCCHHHHHHHCCCCCCEEEE
LTGAPLDASDAMYAGLADVRLEHAQYVAVLDALSAHAWTGNADDDRTQLGAFLHGIAQPT
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCC
EPGPLQLHAQLIERLVSSESLEHIVAAIMALQSEDSWLQAARATLAAGAPGSARLAWELY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHH
RRPGTTTLADTFRTEYVVALHVAAHGDFAEGIRALLIDKDRQPRWQPGSLEEADAQWAAD
HCCCCCHHHHHHCCEEEEEEEEEECCCHHHHHHEEEECCCCCCCCCCCCCCHHCHHHHHH
FFVAPWSPASHPLADLGAGELGVH
EEEECCCCCCCCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA