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The map label for this gene is mmsB [H]

Identifier: 21242069

GI number: 21242069

Start: 1519442

End: 1520329

Strand: Direct

Name: mmsB [H]

Synonym: XAC1316

Alternate gene names: 21242069

Gene position: 1519442-1520329 (Clockwise)

Preceding gene: 21242068

Following gene: 21242070

Centisome position: 29.36

GC content: 66.55

Gene sequence:

>888_bases
ATGAGCAAGATCGCTTTTATCGGCCTGGGCAATATGGGCGGGCCAATGGCTGCCAATCTGATCAAGGCCGGGCATCAGCT
GCGGGTGTTCGATCTCGCACCGGCTGCCCTGGATGCTGCCTCAGCGGCTGGCGCGCATGCTGCCAGCTCCGTGCAGGATA
CGCTGGTCGATGTCGAGGTCGTGATCTCGATGCTGCCTGCGAGCCGCCACGTCGAAGGGTTGTACCTGGGCGAATCCGGC
ATCTTGGCGCAGATCCCGGATGGTGCCCTGGTCATCGACTGCAGCACCATCGCACCGTTATCCGCACGCAAGGTGGCCGA
CGCGGCCAAGGCGCGTGGCCTGACGATGCTGGACGCCCCGGTCTCCGGTGGCACGGCCGGTGCCGCAGCCGGCACGCTGA
CCTTCATCGTCGGCGGCGCTGCCGATGCGCTGGAGCGCGCGCGCCCGGTGCTGCAGGCCATGGGCAAGAACATCTTCCAC
GTCGGCGACAATGGGGCAGGGCAGGTCGCCAAGCTGTGCAACAACATGGCCTTGGGCGTGATCATGGCGGCCACGGGCGA
AGCGCTGGCGCTTGGCGTCGCGCAAGGCCTGGACCCTGCGGTGCTGTCGCAGATGATGGCGGTCAGCACCGGGCGCAGCT
GGGCTACCGAGGTGTGCAACCCGTGGCCCGGCGTGCTGCCCAATGCGCCGGCGTCGCGTGGGTATAGCGGCGGCTTCGGC
AACGACCTGATGCTCAAGGATCTGGGTTTGGTTGCCGAGTCGGCGGTGCAGGCCGGCGTGTCGATTCCGCTCGGTGAGCT
GGCGCGCAACCTGTATGCAATGAACAGCCAGGCGGGCAACGGGGCGCTGGATTTTTCCAGCGTGGTCAAGCTGTTCGCCA
AGCTCTAA

Upstream 100 bases:

>100_bases
GTCGTCGCAGCTGAAAACCGGCGGTGGCTCCGCGCGCGCCAGCAATCGGTGATGATCCCGGCCATCTATTGAAGATGGTC
CTATTTTGGAAACCGACACC

Downstream 100 bases:

>100_bases
CGAGCCACCTGGCTCGCGCCGCGGATTGTTGGAAGGGCGGTGCGGACCAGACATGCTTCCAGGCCGTGACTGCAGGCCTC
GCGCCCCGCAGTAGCGCAAC

Product: 3-hydroxyisobutirate dehydrogenase

Products: NA

Alternate protein names: HIBADH [H]

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MSKIAFIGLGNMGGPMAANLIKAGHQLRVFDLAPAALDAASAAGAHAASSVQDTLVDVEVVISMLPASRHVEGLYLGESG
ILAQIPDGALVIDCSTIAPLSARKVADAAKARGLTMLDAPVSGGTAGAAAGTLTFIVGGAADALERARPVLQAMGKNIFH
VGDNGAGQVAKLCNNMALGVIMAATGEALALGVAQGLDPAVLSQMMAVSTGRSWATEVCNPWPGVLPNAPASRGYSGGFG
NDLMLKDLGLVAESAVQAGVSIPLGELARNLYAMNSQAGNGALDFSSVVKLFAKL

Sequences:

>Translated_295_residues
MSKIAFIGLGNMGGPMAANLIKAGHQLRVFDLAPAALDAASAAGAHAASSVQDTLVDVEVVISMLPASRHVEGLYLGESG
ILAQIPDGALVIDCSTIAPLSARKVADAAKARGLTMLDAPVSGGTAGAAAGTLTFIVGGAADALERARPVLQAMGKNIFH
VGDNGAGQVAKLCNNMALGVIMAATGEALALGVAQGLDPAVLSQMMAVSTGRSWATEVCNPWPGVLPNAPASRGYSGGFG
NDLMLKDLGLVAESAVQAGVSIPLGELARNLYAMNSQAGNGALDFSSVVKLFAKL
>Mature_294_residues
SKIAFIGLGNMGGPMAANLIKAGHQLRVFDLAPAALDAASAAGAHAASSVQDTLVDVEVVISMLPASRHVEGLYLGESGI
LAQIPDGALVIDCSTIAPLSARKVADAAKARGLTMLDAPVSGGTAGAAAGTLTFIVGGAADALERARPVLQAMGKNIFHV
GDNGAGQVAKLCNNMALGVIMAATGEALALGVAQGLDPAVLSQMMAVSTGRSWATEVCNPWPGVLPNAPASRGYSGGFGN
DLMLKDLGLVAESAVQAGVSIPLGELARNLYAMNSQAGNGALDFSSVVKLFAKL

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=289, Percent_Identity=42.9065743944637, Blast_Score=241, Evalue=6e-64,
Organism=Homo sapiens, GI40556376, Length=201, Percent_Identity=29.8507462686567, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI145693186, Length=293, Percent_Identity=37.542662116041, Blast_Score=177, Evalue=5e-46,
Organism=Escherichia coli, GI1790315, Length=291, Percent_Identity=38.4879725085911, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1786719, Length=288, Percent_Identity=33.6805555555556, Blast_Score=150, Evalue=7e-38,
Organism=Escherichia coli, GI1789092, Length=293, Percent_Identity=32.0819112627986, Blast_Score=112, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17557316, Length=296, Percent_Identity=42.9054054054054, Blast_Score=228, Evalue=4e-60,
Organism=Drosophila melanogaster, GI24655230, Length=291, Percent_Identity=44.3298969072165, Blast_Score=234, Evalue=6e-62,
Organism=Drosophila melanogaster, GI19922568, Length=291, Percent_Identity=44.3298969072165, Blast_Score=234, Evalue=6e-62,
Organism=Drosophila melanogaster, GI28574115, Length=294, Percent_Identity=24.1496598639456, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24655240, Length=63, Percent_Identity=49.2063492063492, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR011548
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.31 [H]

Molecular weight: Translated: 29558; Mature: 29427

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIAFIGLGNMGGPMAANLIKAGHQLRVFDLAPAALDAASAAGAHAASSVQDTLVDVEV
CCCEEEEEECCCCCHHHHHHHHCCCEEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHH
VISMLPASRHVEGLYLGESGILAQIPDGALVIDCSTIAPLSARKVADAAKARGLTMLDAP
HHHHCCCCCCCCEEEECCCCCEEECCCCEEEEEECCCCCCHHHHHHHHHHHCCCEEEECC
VSGGTAGAAAGTLTFIVGGAADALERARPVLQAMGKNIFHVGDNGAGQVAKLCNNMALGV
CCCCCCCHHHHEEEEEECCHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCHHHEE
IMAATGEALALGVAQGLDPAVLSQMMAVSTGRSWATEVCNPWPGVLPNAPASRGYSGGFG
EEECCCCHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCC
NDLMLKDLGLVAESAVQAGVSIPLGELARNLYAMNSQAGNGALDFSSVVKLFAKL
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
SKIAFIGLGNMGGPMAANLIKAGHQLRVFDLAPAALDAASAAGAHAASSVQDTLVDVEV
CCEEEEEECCCCCHHHHHHHHCCCEEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHH
VISMLPASRHVEGLYLGESGILAQIPDGALVIDCSTIAPLSARKVADAAKARGLTMLDAP
HHHHCCCCCCCCEEEECCCCCEEECCCCEEEEEECCCCCCHHHHHHHHHHHCCCEEEECC
VSGGTAGAAAGTLTFIVGGAADALERARPVLQAMGKNIFHVGDNGAGQVAKLCNNMALGV
CCCCCCCHHHHEEEEEECCHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCHHHEE
IMAATGEALALGVAQGLDPAVLSQMMAVSTGRSWATEVCNPWPGVLPNAPASRGYSGGFG
EEECCCCHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCC
NDLMLKDLGLVAESAVQAGVSIPLGELARNLYAMNSQAGNGALDFSSVVKLFAKL
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1339433; 10984043 [H]