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The map label for this gene is galM [H]

Identifier: 21242040

GI number: 21242040

Start: 1475438

End: 1476559

Strand: Direct

Name: galM [H]

Synonym: XAC1287

Alternate gene names: 21242040

Gene position: 1475438-1476559 (Clockwise)

Preceding gene: 21242037

Following gene: 21242042

Centisome position: 28.51

GC content: 66.76

Gene sequence:

>1122_bases
GTGCGCAGCAGCATGGTCGGCAGCCACCGCATGCGGCTATGCTCGCGGGCTACCTCATCGGCAGGACGATCCATGCAGCG
AGTGTTCGGGCAGTTGCCAGACGGTGTCGAGATCCACGCGCTCACGCTACGCAGCGAGGCTGGTCTGGAAGCGGAGGTGC
TTACCTACGGCGGCATCCTGCATACGCTGCAGTTGATCACCGCACAGGGTGTGGTGCCGCTGGTGCTGAACCTGCCGGAT
CTACCCGCCTATGCTGCCGACGGCGACAGCCTCAACATTCTGGTGGGCCGCTTCGGCAACCGCATCGCCGGTGCGCGTTA
CACCCTGGAGGGCGTCACCCACGTGCTGGCCGCCAATGAAGGGCGCAACCAGCTGCACGGCGGGCTGCGCGGCTTCGGAC
GACGGGTGTGGAGCGTGCTGGAGCAGGCGCCGGACCAGGTGCTGCTGGGCTACGACTCACCCAATGGCGAAGAGGGCTAC
CCCGGCAATCTGCACGTGCGTGCGCGCCTGCAGCTTCAGGGGTTGAGCCTGCAGCTGGAGTTCGAAGCGCACTGCGATGC
CGCGACTGCGTTGAATCTTACCCATCACCCGTATTTCAATCTGTCCGGCGACCCGCAGCTGCGGGCCGCAGCGCAGGTGC
TGCGCGTGCCAGCCGATCGCTACCTGCCGGTGGATGCCGAGTCGATCCCCACGGGCGAGATCGCATCGGTGACCGGTACG
CCATTCGATTTCCGCCAACCTGCCGCGCTGGCAGACAACACCGACACGGCGCATCCCCAGATCATCCTCGGCAAGGGCTA
TGACCAGTGTCTGGTGCTGGCCGCCGACGCGGACTGCGTTGCCGAGCTGTACTCCCCGCACAGTGGCGTGGCGCTGCGTA
TCAGCAGCGATGCCCCGGCGGTGCAGGTGTACGAGGGCCAACATCTGGACGCCCACCATCCCGGACTGGGCCGTGGCGTA
TGCCTGGAGCCGCAGGATTATCCGGACGCCCCCAATCACCCCAACTTTCCTTCGACCATCCTGCGGCCGGGCGACACCTA
TCGCCGCCGTATCAGCTATCGCTTTGCCAACGCGGGGCCGGGCCAGCCCTGGGACGCCGTGCGTGCCGCGCTGGATGCGT
GA

Upstream 100 bases:

>100_bases
AGCGTAGTGCCGGTGGCCGCCCTTTGTATTGCTGCAGCGCGGCCGTTGCAGGCGGGCGCGGCAGTCGCTTCGCCGCCGCA
ATCGCCTCGCCGGCCAGGAT

Downstream 100 bases:

>100_bases
GAGGTTTCAGAGCTGAGGAGTTAGCTGGGCTGCGTCGTGCGGGCGCGACCCAGTGCCGCTGATCGCAGTGTCAGTCTGGT
GCGGGTCTATGCCCGTCGCA

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MRSSMVGSHRMRLCSRATSSAGRSMQRVFGQLPDGVEIHALTLRSEAGLEAEVLTYGGILHTLQLITAQGVVPLVLNLPD
LPAYAADGDSLNILVGRFGNRIAGARYTLEGVTHVLAANEGRNQLHGGLRGFGRRVWSVLEQAPDQVLLGYDSPNGEEGY
PGNLHVRARLQLQGLSLQLEFEAHCDAATALNLTHHPYFNLSGDPQLRAAAQVLRVPADRYLPVDAESIPTGEIASVTGT
PFDFRQPAALADNTDTAHPQIILGKGYDQCLVLAADADCVAELYSPHSGVALRISSDAPAVQVYEGQHLDAHHPGLGRGV
CLEPQDYPDAPNHPNFPSTILRPGDTYRRRISYRFANAGPGQPWDAVRAALDA

Sequences:

>Translated_373_residues
MRSSMVGSHRMRLCSRATSSAGRSMQRVFGQLPDGVEIHALTLRSEAGLEAEVLTYGGILHTLQLITAQGVVPLVLNLPD
LPAYAADGDSLNILVGRFGNRIAGARYTLEGVTHVLAANEGRNQLHGGLRGFGRRVWSVLEQAPDQVLLGYDSPNGEEGY
PGNLHVRARLQLQGLSLQLEFEAHCDAATALNLTHHPYFNLSGDPQLRAAAQVLRVPADRYLPVDAESIPTGEIASVTGT
PFDFRQPAALADNTDTAHPQIILGKGYDQCLVLAADADCVAELYSPHSGVALRISSDAPAVQVYEGQHLDAHHPGLGRGV
CLEPQDYPDAPNHPNFPSTILRPGDTYRRRISYRFANAGPGQPWDAVRAALDA
>Mature_373_residues
MRSSMVGSHRMRLCSRATSSAGRSMQRVFGQLPDGVEIHALTLRSEAGLEAEVLTYGGILHTLQLITAQGVVPLVLNLPD
LPAYAADGDSLNILVGRFGNRIAGARYTLEGVTHVLAANEGRNQLHGGLRGFGRRVWSVLEQAPDQVLLGYDSPNGEEGY
PGNLHVRARLQLQGLSLQLEFEAHCDAATALNLTHHPYFNLSGDPQLRAAAQVLRVPADRYLPVDAESIPTGEIASVTGT
PFDFRQPAALADNTDTAHPQIILGKGYDQCLVLAADADCVAELYSPHSGVALRISSDAPAVQVYEGQHLDAHHPGLGRGV
CLEPQDYPDAPNHPNFPSTILRPGDTYRRRISYRFANAGPGQPWDAVRAALDA

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=342, Percent_Identity=35.3801169590643, Blast_Score=199, Evalue=5e-51,
Organism=Escherichia coli, GI1786971, Length=337, Percent_Identity=35.0148367952522, Blast_Score=188, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17557428, Length=329, Percent_Identity=30.6990881458967, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI115533334, Length=329, Percent_Identity=30.6990881458967, Blast_Score=153, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6322004, Length=350, Percent_Identity=27.7142857142857, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6319493, Length=285, Percent_Identity=27.3684210526316, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324399, Length=340, Percent_Identity=25.5882352941176, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24659048, Length=345, Percent_Identity=32.463768115942, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24668278, Length=347, Percent_Identity=30.835734870317, Blast_Score=165, Evalue=6e-41,
Organism=Drosophila melanogaster, GI24583720, Length=336, Percent_Identity=30.952380952381, Blast_Score=164, Evalue=8e-41,
Organism=Drosophila melanogaster, GI24668282, Length=341, Percent_Identity=29.3255131964809, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24641876, Length=360, Percent_Identity=25.5555555555556, Blast_Score=119, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 40148; Mature: 40148

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSSMVGSHRMRLCSRATSSAGRSMQRVFGQLPDGVEIHALTLRSEAGLEAEVLTYGGIL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCEEEEHHHHHH
HTLQLITAQGVVPLVLNLPDLPAYAADGDSLNILVGRFGNRIAGARYTLEGVTHVLAANE
HHHHHHHHCCCEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCEEEHHHHHHEECCCC
GRNQLHGGLRGFGRRVWSVLEQAPDQVLLGYDSPNGEEGYPGNLHVRARLQLQGLSLQLE
CCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCEEEEEEEEEECCEEEEE
FEAHCDAATALNLTHHPYFNLSGDPQLRAAAQVLRVPADRYLPVDAESIPTGEIASVTGT
EECCCCCEEEEEECCCCEECCCCCCHHHHHHHHHHCCCHHCCCCCCCCCCCCCEEECCCC
PFDFRQPAALADNTDTAHPQIILGKGYDQCLVLAADADCVAELYSPHSGVALRISSDAPA
CCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEECHHHHHHHHCCCCCEEEEECCCCCE
VQVYEGQHLDAHHPGLGRGVCLEPQDYPDAPNHPNFPSTILRPGDTYRRRISYRFANAGP
EEEECCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCHHHCCCCHHHHHEEEEEECCCCC
GQPWDAVRAALDA
CCCHHHHHHHHCC
>Mature Secondary Structure
MRSSMVGSHRMRLCSRATSSAGRSMQRVFGQLPDGVEIHALTLRSEAGLEAEVLTYGGIL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCEEEEHHHHHH
HTLQLITAQGVVPLVLNLPDLPAYAADGDSLNILVGRFGNRIAGARYTLEGVTHVLAANE
HHHHHHHHCCCEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCEEEHHHHHHEECCCC
GRNQLHGGLRGFGRRVWSVLEQAPDQVLLGYDSPNGEEGYPGNLHVRARLQLQGLSLQLE
CCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCEEEEEEEEEECCEEEEE
FEAHCDAATALNLTHHPYFNLSGDPQLRAAAQVLRVPADRYLPVDAESIPTGEIASVTGT
EECCCCCEEEEEECCCCEECCCCCCHHHHHHHHHHCCCHHCCCCCCCCCCCCCEEECCCC
PFDFRQPAALADNTDTAHPQIILGKGYDQCLVLAADADCVAELYSPHSGVALRISSDAPA
CCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEECHHHHHHHHCCCCCEEEEECCCCCE
VQVYEGQHLDAHHPGLGRGVCLEPQDYPDAPNHPNFPSTILRPGDTYRRRISYRFANAGP
EEEECCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCHHHCCCCHHHHHEEEEEECCCCC
GQPWDAVRAALDA
CCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]