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The map label for this gene is yeaE [H]

Identifier: 21241966

GI number: 21241966

Start: 1386599

End: 1387453

Strand: Reverse

Name: yeaE [H]

Synonym: XAC1212

Alternate gene names: 21241966

Gene position: 1387453-1386599 (Counterclockwise)

Preceding gene: 21241967

Following gene: 21241965

Centisome position: 26.81

GC content: 65.26

Gene sequence:

>855_bases
ATGTCCGAATCGTCTTCCCCTTCCTGCGCGCAGGTGCGCCTGCGCAACGGGCGTCGCGTGCCCGCGTTGGGTCTGGGCTC
CTGGAACCTGGGCCAGGGCCGGCATGCGCCCGAGCAGGAAATCCAAGCGCTGCAACTCGGGCAGCAATTGGGCATGCAGC
TGATCGACACCGCCGAGATGTATGGCAATGGCCGCTCGGAGCAATTGATCAGCCAGGCCATCGGCCGCACGCAACCGCCC
TACGTGGTGTCCAAGGTGTTGCCCAGCAATGCCAGCGCGCGCGGGATTGCGCGTGCCTGCGAAGCCAGCCTGCAACGGCT
GGGAGTGCGCACATTGGACCTGTACCTGTTGCACTGGCGTGGCGGCAGCGATCTGGCCGAAGTGGTGGACGCGTTCGAAG
CGCTACGCGATGCCGGCAAGATCCGCGATTGGGGCGTGTCTAACTTCGACGTCGATGACATGGAGGAGCTCTGGGCAATC
GATGGCGGCCCGCATTGCCTGGTCAACCAGGTGCTGTACCACGCTGGCAGCCGCGGCATCGAATTCGACCTGCTGCCCTG
GTGCGCCGCGCACGAGGTAGCCGTGATGGCGTATTCGCCGCTTGGCAGCCGCGCGTTGCTGGATCATCCGGTCTTGCACG
CCATCGGCCAGCGTCGTGGCGTTGCGGCCACTGCGGTGGCGCTTGCGTGGGCCATCCGCAGCGGCAATGTCATCGCCATT
CCCGAATCCGGAACGCCGGCGCATGTGCGTGCCAATGCCGCTGCCTGCACGCTGCAATTGCACGCAGACGATCTTGCCGA
AATCGATCGTGCGTTCGCGCCGCCTACGCGCAAACAGCCCTTGGATCTGCTGTAA

Upstream 100 bases:

>100_bases
CATGCAGACACTGCGACAACATCGGTGCAGCCATCGTCGCAGTGACAAGGCCACCGATGTAACGGTCATCACCCTCATTC
CAACGCGGCAGGAACCCGTC

Downstream 100 bases:

>100_bases
ATGGCGCAATGGTCGCGTTCGCTGCCTCGCGAGTGCATGGCTATGTGCAACGCGTGACCGATGCAACATCCAACTGCGAC
ATGGTGCAATGTTCGCTGCG

Product: oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 284; Mature: 283

Protein sequence:

>284_residues
MSESSSPSCAQVRLRNGRRVPALGLGSWNLGQGRHAPEQEIQALQLGQQLGMQLIDTAEMYGNGRSEQLISQAIGRTQPP
YVVSKVLPSNASARGIARACEASLQRLGVRTLDLYLLHWRGGSDLAEVVDAFEALRDAGKIRDWGVSNFDVDDMEELWAI
DGGPHCLVNQVLYHAGSRGIEFDLLPWCAAHEVAVMAYSPLGSRALLDHPVLHAIGQRRGVAATAVALAWAIRSGNVIAI
PESGTPAHVRANAAACTLQLHADDLAEIDRAFAPPTRKQPLDLL

Sequences:

>Translated_284_residues
MSESSSPSCAQVRLRNGRRVPALGLGSWNLGQGRHAPEQEIQALQLGQQLGMQLIDTAEMYGNGRSEQLISQAIGRTQPP
YVVSKVLPSNASARGIARACEASLQRLGVRTLDLYLLHWRGGSDLAEVVDAFEALRDAGKIRDWGVSNFDVDDMEELWAI
DGGPHCLVNQVLYHAGSRGIEFDLLPWCAAHEVAVMAYSPLGSRALLDHPVLHAIGQRRGVAATAVALAWAIRSGNVIAI
PESGTPAHVRANAAACTLQLHADDLAEIDRAFAPPTRKQPLDLL
>Mature_283_residues
SESSSPSCAQVRLRNGRRVPALGLGSWNLGQGRHAPEQEIQALQLGQQLGMQLIDTAEMYGNGRSEQLISQAIGRTQPPY
VVSKVLPSNASARGIARACEASLQRLGVRTLDLYLLHWRGGSDLAEVVDAFEALRDAGKIRDWGVSNFDVDDMEELWAID
GGPHCLVNQVLYHAGSRGIEFDLLPWCAAHEVAVMAYSPLGSRALLDHPVLHAIGQRRGVAATAVALAWAIRSGNVIAIP
ESGTPAHVRANAAACTLQLHADDLAEIDRAFAPPTRKQPLDLL

Specific function: Unknown

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI223468663, Length=294, Percent_Identity=28.5714285714286, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI93277124, Length=300, Percent_Identity=26.3333333333333, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI24497577, Length=311, Percent_Identity=25.4019292604502, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI5174391, Length=311, Percent_Identity=25.4019292604502, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI310109922, Length=277, Percent_Identity=26.7148014440433, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI5453543, Length=297, Percent_Identity=25.9259259259259, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI45446745, Length=297, Percent_Identity=25.9259259259259, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI4503285, Length=297, Percent_Identity=25.9259259259259, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI310109920, Length=297, Percent_Identity=25.9259259259259, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI291291012, Length=251, Percent_Identity=28.6852589641434, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI24497585, Length=306, Percent_Identity=24.8366013071895, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI24497583, Length=297, Percent_Identity=26.2626262626263, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI4502049, Length=296, Percent_Identity=26.0135135135135, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI5174695, Length=302, Percent_Identity=24.1721854304636, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI300116273, Length=280, Percent_Identity=25, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1788081, Length=271, Percent_Identity=46.4944649446494, Blast_Score=247, Evalue=8e-67,
Organism=Escherichia coli, GI87082198, Length=265, Percent_Identity=28.3018867924528, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1786400, Length=270, Percent_Identity=28.8888888888889, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1788070, Length=301, Percent_Identity=27.906976744186, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87081735, Length=308, Percent_Identity=26.6233766233766, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1787674, Length=281, Percent_Identity=27.4021352313167, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17552492, Length=275, Percent_Identity=30.9090909090909, Blast_Score=110, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17561298, Length=283, Percent_Identity=28.2685512367491, Blast_Score=97, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17538386, Length=280, Percent_Identity=28.9285714285714, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17537077, Length=295, Percent_Identity=26.7796610169492, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17537075, Length=295, Percent_Identity=26.4406779661017, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17561300, Length=267, Percent_Identity=26.2172284644195, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17550248, Length=303, Percent_Identity=23.4323432343234, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71998625, Length=278, Percent_Identity=25.1798561151079, Blast_Score=80, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6324694, Length=286, Percent_Identity=27.6223776223776, Blast_Score=95, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320079, Length=286, Percent_Identity=25.1748251748252, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24644950, Length=306, Percent_Identity=27.4509803921569, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24662789, Length=302, Percent_Identity=29.4701986754967, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI45553081, Length=292, Percent_Identity=26.027397260274, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI21356425, Length=303, Percent_Identity=24.7524752475248, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24657054, Length=292, Percent_Identity=25.3424657534247, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI20129731, Length=293, Percent_Identity=25.5972696245734, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24663317, Length=313, Percent_Identity=23.961661341853, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24662781, Length=285, Percent_Identity=24.2105263157895, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: NA

Molecular weight: Translated: 30598; Mature: 30467

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESSSPSCAQVRLRNGRRVPALGLGSWNLGQGRHAPEQEIQALQLGQQLGMQLIDTAEM
CCCCCCCCHHHHHHHCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
YGNGRSEQLISQAIGRTQPPYVVSKVLPSNASARGIARACEASLQRLGVRTLDLYLLHWR
HCCCCHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEEC
GGSDLAEVVDAFEALRDAGKIRDWGVSNFDVDDMEELWAIDGGPHCLVNQVLYHAGSRGI
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCC
EFDLLPWCAAHEVAVMAYSPLGSRALLDHPVLHAIGQRRGVAATAVALAWAIRSGNVIAI
EEECCCCHHHHHEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEE
PESGTPAHVRANAAACTLQLHADDLAEIDRAFAPPTRKQPLDLL
CCCCCCCEEECCCEEEEEEECHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SESSSPSCAQVRLRNGRRVPALGLGSWNLGQGRHAPEQEIQALQLGQQLGMQLIDTAEM
CCCCCCCHHHHHHHCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
YGNGRSEQLISQAIGRTQPPYVVSKVLPSNASARGIARACEASLQRLGVRTLDLYLLHWR
HCCCCHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEEC
GGSDLAEVVDAFEALRDAGKIRDWGVSNFDVDDMEELWAIDGGPHCLVNQVLYHAGSRGI
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCC
EFDLLPWCAAHEVAVMAYSPLGSRALLDHPVLHAIGQRRGVAATAVALAWAIRSGNVIAI
EEECCCCHHHHHEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEE
PESGTPAHVRANAAACTLQLHADDLAEIDRAFAPPTRKQPLDLL
CCCCCCCEEECCCEEEEEEECHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]