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The map label for this gene is hflK [H]

Identifier: 21241909

GI number: 21241909

Start: 1314971

End: 1316098

Strand: Direct

Name: hflK [H]

Synonym: XAC1155

Alternate gene names: 21241909

Gene position: 1314971-1316098 (Clockwise)

Preceding gene: 21241908

Following gene: 21241910

Centisome position: 25.41

GC content: 66.58

Gene sequence:

>1128_bases
ATGGCCTGGAACACACCCGGCAACAAGGGCGGAGACGGCCCGGACCCCAACCGTCGCAGGTCCTGGGGCCCGCGCGGTGG
TGGCAACGGTGGCGGTTGGGGCAATCTGCCCGCTCCGTTGAAGGAGCTGTTCGATGGCGGCGTGGGGCGCTGGATCCTGG
TCGCGGTGGTGCTGATGGTGCTGTTCTCCAGCTTCCAGCTCATCGGCGAGCAGCAGCGTGGCGTGGTGCTGCGCTTCGGC
CAGTTCTCGCGCATCCTGCAGCCCGGCCCGAACTTCAAGCTGCCCTGGCCGATCGAGTCGGTGCGCAAGGTCAATGCCAC
CGAGATCAAGACCTTCAGCAACCAGGTGCCGGTGCTGACGCGCGACGAAAACATCGTCAACGTGTCGCTCAACGTGCAGT
ACCAGATCAGCGACCCGCGCAAATACCTGTTCGGTTCGCGCAATGCCGATCTGGTGCTGGAGCAGGCCGCGCAAAGTGCC
GTGCGTGAGCAGGTGGGGCGTTCGGACCTCAATACCGTGCTCAACAATCGCGGCCCGCTGGCGATCGCGTCCAAGGATCG
TCTGCAGGCGGCGCTGGATGCCTATAACACCGGCCTGGCGGTCACCGGCGTGACCTTGCCGGATGCGCGCCCGCCGGAAG
AAGTGAAGCCGGCCTTCGACGAGGTCAATGGTGCCCAGCAGGTGCGCGAGCGCCTGATCAACGAAGCGCAGGCCTACGCC
GCCAAGGTGGTGCCCGAAGCGCGCGGCCAGGGGGCACGCACCCGTACCGGTGCCGAAGGCTACAAGCAGGCCACCATTTC
GAAGGCCGAGGGTGATGCCGACCGCTTCACGCTGTTGCAGGCCCAGTATGCTGGCGCGCCGGAAGTCACCCGCAAGCGGC
TGTGGCTGGAAACCGTGCAGAAGGTGCTGTCGGAGAACCGCAAGGTCATCGGTAGCGATGGCCGCCAGGTCATCTACGTG
CCATTGCCGGCCGATGCCAGCAAGCCGGCCGCTTCCGGCGGCACTGCCAGCATGCCGTCGATGGTGCCCCAGGACGTGCT
GTTGAATCCGCCGCAAAGCGCCAGTAGCGAGACCATCCGCAACCCGGAGCGCGGCCCGCGCCCGACCGGCCGTGAGGGAA
CCGAATAA

Upstream 100 bases:

>100_bases
TCAAAACGGTGTGTCTGCCCCATCTAGTAGAATCGGCGAATCAAACAACATGGCGGCACTGCGGGACTGGCCCGCACAGC
CCCTCGATCATGGAGCGTGC

Downstream 100 bases:

>100_bases
TGAAGAATTCGCTAGTCATCGGCCTGATCATCGCCGTGTTGCTGACCCTGATGGGCTCGGTATTCGTCGTGCGCGAAGAC
CAGACCGCCATGGTGCTCAA

Product: integral membrane protease subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 375; Mature: 374

Protein sequence:

>375_residues
MAWNTPGNKGGDGPDPNRRRSWGPRGGGNGGGWGNLPAPLKELFDGGVGRWILVAVVLMVLFSSFQLIGEQQRGVVLRFG
QFSRILQPGPNFKLPWPIESVRKVNATEIKTFSNQVPVLTRDENIVNVSLNVQYQISDPRKYLFGSRNADLVLEQAAQSA
VREQVGRSDLNTVLNNRGPLAIASKDRLQAALDAYNTGLAVTGVTLPDARPPEEVKPAFDEVNGAQQVRERLINEAQAYA
AKVVPEARGQGARTRTGAEGYKQATISKAEGDADRFTLLQAQYAGAPEVTRKRLWLETVQKVLSENRKVIGSDGRQVIYV
PLPADASKPAASGGTASMPSMVPQDVLLNPPQSASSETIRNPERGPRPTGREGTE

Sequences:

>Translated_375_residues
MAWNTPGNKGGDGPDPNRRRSWGPRGGGNGGGWGNLPAPLKELFDGGVGRWILVAVVLMVLFSSFQLIGEQQRGVVLRFG
QFSRILQPGPNFKLPWPIESVRKVNATEIKTFSNQVPVLTRDENIVNVSLNVQYQISDPRKYLFGSRNADLVLEQAAQSA
VREQVGRSDLNTVLNNRGPLAIASKDRLQAALDAYNTGLAVTGVTLPDARPPEEVKPAFDEVNGAQQVRERLINEAQAYA
AKVVPEARGQGARTRTGAEGYKQATISKAEGDADRFTLLQAQYAGAPEVTRKRLWLETVQKVLSENRKVIGSDGRQVIYV
PLPADASKPAASGGTASMPSMVPQDVLLNPPQSASSETIRNPERGPRPTGREGTE
>Mature_374_residues
AWNTPGNKGGDGPDPNRRRSWGPRGGGNGGGWGNLPAPLKELFDGGVGRWILVAVVLMVLFSSFQLIGEQQRGVVLRFGQ
FSRILQPGPNFKLPWPIESVRKVNATEIKTFSNQVPVLTRDENIVNVSLNVQYQISDPRKYLFGSRNADLVLEQAAQSAV
REQVGRSDLNTVLNNRGPLAIASKDRLQAALDAYNTGLAVTGVTLPDARPPEEVKPAFDEVNGAQQVRERLINEAQAYAA
KVVPEARGQGARTRTGAEGYKQATISKAEGDADRFTLLQAQYAGAPEVTRKRLWLETVQKVLSENRKVIGSDGRQVIYVP
LPADASKPAASGGTASMPSMVPQDVLLNPPQSASSETIRNPERGPRPTGREGTE

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=362, Percent_Identity=35.3591160220994, Blast_Score=195, Evalue=4e-51,
Organism=Escherichia coli, GI1790617, Length=328, Percent_Identity=23.1707317073171, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1786697, Length=222, Percent_Identity=23.4234234234234, Blast_Score=65, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45550506, Length=218, Percent_Identity=25.2293577981651, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281365664, Length=183, Percent_Identity=29.5081967213115, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24657857, Length=183, Percent_Identity=29.5081967213115, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI62484448, Length=183, Percent_Identity=29.5081967213115, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI62484274, Length=183, Percent_Identity=29.5081967213115, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR020980
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7; PF12221 HflK_N [H]

EC number: NA

Molecular weight: Translated: 40593; Mature: 40462

Theoretical pI: Translated: 10.20; Mature: 10.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAWNTPGNKGGDGPDPNRRRSWGPRGGGNGGGWGNLPAPLKELFDGGVGRWILVAVVLMV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHH
LFSSFQLIGEQQRGVVLRFGQFSRILQPGPNFKLPWPIESVRKVNATEIKTFSNQVPVLT
HHHHHHHHCCCCCCEEEEECHHHHHHCCCCCCCCCCCHHHHHHCCHHHHHHHCCCCCEEE
RDENIVNVSLNVQYQISDPRKYLFGSRNADLVLEQAAQSAVREQVGRSDLNTVLNNRGPL
CCCCEEEEEEEEEEEECCCHHHHCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCE
AIASKDRLQAALDAYNTGLAVTGVTLPDARPPEEVKPAFDEVNGAQQVRERLINEAQAYA
EECCHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
AKVVPEARGQGARTRTGAEGYKQATISKAEGDADRFTLLQAQYAGAPEVTRKRLWLETVQ
HHHCHHHCCCCCCCCCCCHHHHHHHHHHCCCCCHHEEEEHHHHCCCHHHHHHHHHHHHHH
KVLSENRKVIGSDGRQVIYVPLPADASKPAASGGTASMPSMVPQDVLLNPPQSASSETIR
HHHHCCCEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHC
NPERGPRPTGREGTE
CCCCCCCCCCCCCCC
>Mature Secondary Structure 
AWNTPGNKGGDGPDPNRRRSWGPRGGGNGGGWGNLPAPLKELFDGGVGRWILVAVVLMV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHH
LFSSFQLIGEQQRGVVLRFGQFSRILQPGPNFKLPWPIESVRKVNATEIKTFSNQVPVLT
HHHHHHHHCCCCCCEEEEECHHHHHHCCCCCCCCCCCHHHHHHCCHHHHHHHCCCCCEEE
RDENIVNVSLNVQYQISDPRKYLFGSRNADLVLEQAAQSAVREQVGRSDLNTVLNNRGPL
CCCCEEEEEEEEEEEECCCHHHHCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCE
AIASKDRLQAALDAYNTGLAVTGVTLPDARPPEEVKPAFDEVNGAQQVRERLINEAQAYA
EECCHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
AKVVPEARGQGARTRTGAEGYKQATISKAEGDADRFTLLQAQYAGAPEVTRKRLWLETVQ
HHHCHHHCCCCCCCCCCCHHHHHHHHHHCCCCCHHEEEEHHHHCCCHHHHHHHHHHHHHH
KVLSENRKVIGSDGRQVIYVPLPADASKPAASGGTASMPSMVPQDVLLNPPQSASSETIR
HHHHCCCEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHC
NPERGPRPTGREGTE
CCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]