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The map label for this gene is tdh [H]

Identifier: 21241787

GI number: 21241787

Start: 1178517

End: 1179539

Strand: Reverse

Name: tdh [H]

Synonym: XAC1022

Alternate gene names: 21241787

Gene position: 1179539-1178517 (Counterclockwise)

Preceding gene: 21241788

Following gene: 21241781

Centisome position: 22.79

GC content: 62.27

Gene sequence:

>1023_bases
ATGAAGGCGCTGGTCAAGCGCGAAGCGAACAAGGGCATCTGGCTGGAACAGGTGCCAGTGCCGACGCCCGGCCCCAACGA
GGTGCTGATCAAGCTGGAAAAGACCGCCATTTGCGGCACCGACCTGCACATCTACCTGTGGGACGAATGGAGCCAGCGCA
CGATCGAGCCTGGCCTGACCATCGGTCATGAATTCGTCGGCCGGGTGGCTGAGCTCGGTTCGGCAGTGACCGGCTACCAG
ATCGGCCAACGGGTGTCGGCCGAAGGCCACATCGTGTGCGGCCATTGCCGCAACTGCCGTGGCGGCCGTCCGCACCTGTG
CCCCAACACGGTCGGGATCGGTGTCAACGTCAACGGCGCCTTCGCCGAATACATGGTGATGCCGGCCAGCAACCTGTGGC
CGATCCCGGACCAGATCCCGTCCGAGCTTGCCGCGTTCTTCGACCCCTACGGCAATGCCGCGCATTGCGCGCTGGAATTC
GACGTCATCGGCGAGGATGTGCTGATCACCGGCGCAGGCCCGATCGGCATCATTGCCGCCGGCATCTGCAAGCACATCGG
TGCGCGCAATGTGGTGGTCACCGACGTCAACGATTTCCGTCTCAAGCTGGCTGCCGACATGGGAGCCACGCGCGTAGTCA
ACGTCTCCAAGACCTCGCTCAAGGACGTCATGGCCGACCTGCACATGGAAGGCTTCGACGTGGGCCTGGAAATGAGCGGC
AACTCGCGCGCGTTCAACGACATGCTCGATTGCATGTACCACGGCGGCAAGATCGCCATGCTCGGCATCATGCCGCGTGG
CGCCGGTTGCGACTGGGACAAGATCATCTTCAAGGGCCTCACCGTGCAGGGCATCTACGGCCGCAAGATGTACGAGACCT
GGTACAAGATGACGCAGCTGGTGCTGTCGGGTTTTCCGTTGCACAAGGTGCTGACCCATCAACTGCCGATCGACGATTTC
CAGAAGGGCTTCGACCTGATGGAAGAAGGCAAGGCCGGCAAGGTCGTGCTGAGCTGGAATTGA

Upstream 100 bases:

>100_bases
CATCACGTCCATTCCCGCACCGCCGCATGGCATACAGGCCGCGACGCCTATAATCGCCGGCTTACTTTCACTCAGCAGGT
TCCGCCAGATGGCGCAGACG

Downstream 100 bases:

>100_bases
TCGGCTGACACTGCAGATGTGCGAAAGGCGCCGCGAGGCGCCTTTCGCGTTTTTAAGCTACGCGCGCTGACGAGTGCGCG
AGCGATTTTCTGAAGCTGGC

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MKALVKREANKGIWLEQVPVPTPGPNEVLIKLEKTAICGTDLHIYLWDEWSQRTIEPGLTIGHEFVGRVAELGSAVTGYQ
IGQRVSAEGHIVCGHCRNCRGGRPHLCPNTVGIGVNVNGAFAEYMVMPASNLWPIPDQIPSELAAFFDPYGNAAHCALEF
DVIGEDVLITGAGPIGIIAAGICKHIGARNVVVTDVNDFRLKLAADMGATRVVNVSKTSLKDVMADLHMEGFDVGLEMSG
NSRAFNDMLDCMYHGGKIAMLGIMPRGAGCDWDKIIFKGLTVQGIYGRKMYETWYKMTQLVLSGFPLHKVLTHQLPIDDF
QKGFDLMEEGKAGKVVLSWN

Sequences:

>Translated_340_residues
MKALVKREANKGIWLEQVPVPTPGPNEVLIKLEKTAICGTDLHIYLWDEWSQRTIEPGLTIGHEFVGRVAELGSAVTGYQ
IGQRVSAEGHIVCGHCRNCRGGRPHLCPNTVGIGVNVNGAFAEYMVMPASNLWPIPDQIPSELAAFFDPYGNAAHCALEF
DVIGEDVLITGAGPIGIIAAGICKHIGARNVVVTDVNDFRLKLAADMGATRVVNVSKTSLKDVMADLHMEGFDVGLEMSG
NSRAFNDMLDCMYHGGKIAMLGIMPRGAGCDWDKIIFKGLTVQGIYGRKMYETWYKMTQLVLSGFPLHKVLTHQLPIDDF
QKGFDLMEEGKAGKVVLSWN
>Mature_340_residues
MKALVKREANKGIWLEQVPVPTPGPNEVLIKLEKTAICGTDLHIYLWDEWSQRTIEPGLTIGHEFVGRVAELGSAVTGYQ
IGQRVSAEGHIVCGHCRNCRGGRPHLCPNTVGIGVNVNGAFAEYMVMPASNLWPIPDQIPSELAAFFDPYGNAAHCALEF
DVIGEDVLITGAGPIGIIAAGICKHIGARNVVVTDVNDFRLKLAADMGATRVVNVSKTSLKDVMADLHMEGFDVGLEMSG
NSRAFNDMLDCMYHGGKIAMLGIMPRGAGCDWDKIIFKGLTVQGIYGRKMYETWYKMTQLVLSGFPLHKVLTHQLPIDDF
QKGFDLMEEGKAGKVVLSWN

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=334, Percent_Identity=25.4491017964072, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI71743840, Length=371, Percent_Identity=27.4932614555256, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI262073058, Length=371, Percent_Identity=27.4932614555256, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI4501929, Length=375, Percent_Identity=26.1333333333333, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI71565152, Length=373, Percent_Identity=26.0053619302949, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI34577061, Length=372, Percent_Identity=26.8817204301075, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI4501933, Length=375, Percent_Identity=25.6, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI71565154, Length=378, Percent_Identity=25.3968253968254, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI156523966, Length=357, Percent_Identity=23.5294117647059, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI4501939, Length=351, Percent_Identity=23.6467236467236, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1790045, Length=341, Percent_Identity=63.6363636363636, Blast_Score=464, Evalue=1e-132,
Organism=Escherichia coli, GI1788073, Length=316, Percent_Identity=30.6962025316456, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1788075, Length=365, Percent_Identity=29.8630136986301, Blast_Score=140, Evalue=8e-35,
Organism=Escherichia coli, GI1787863, Length=348, Percent_Identity=26.7241379310345, Blast_Score=137, Evalue=8e-34,
Organism=Escherichia coli, GI87082125, Length=349, Percent_Identity=28.9398280802292, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI226510992, Length=340, Percent_Identity=27.9411764705882, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI87081918, Length=321, Percent_Identity=30.5295950155763, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1790718, Length=324, Percent_Identity=27.1604938271605, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1788407, Length=323, Percent_Identity=26.3157894736842, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1786825, Length=392, Percent_Identity=26.0204081632653, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1786552, Length=373, Percent_Identity=26.0053619302949, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17562876, Length=333, Percent_Identity=28.5285285285285, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17562878, Length=217, Percent_Identity=35.0230414746544, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71988145, Length=266, Percent_Identity=29.3233082706767, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17562582, Length=127, Percent_Identity=35.4330708661417, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI25146526, Length=379, Percent_Identity=25.5936675461741, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562584, Length=126, Percent_Identity=34.9206349206349, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322619, Length=324, Percent_Identity=27.1604938271605, Blast_Score=122, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6319955, Length=324, Percent_Identity=26.8518518518519, Blast_Score=119, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6323099, Length=322, Percent_Identity=28.2608695652174, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6319258, Length=300, Percent_Identity=28.3333333333333, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6319257, Length=272, Percent_Identity=29.0441176470588, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6320033, Length=375, Percent_Identity=24.5333333333333, Blast_Score=92, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6323729, Length=334, Percent_Identity=27.5449101796407, Blast_Score=76, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6323961, Length=350, Percent_Identity=26.5714285714286, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319621, Length=293, Percent_Identity=28.3276450511945, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324486, Length=298, Percent_Identity=26.8456375838926, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17137530, Length=217, Percent_Identity=31.3364055299539, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI17737897, Length=207, Percent_Identity=31.8840579710145, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI17737895, Length=377, Percent_Identity=26.525198938992, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI221457811, Length=331, Percent_Identity=27.190332326284, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI45551930, Length=331, Percent_Identity=27.190332326284, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI45550770, Length=331, Percent_Identity=27.190332326284, Blast_Score=85, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 37127; Mature: 37127

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALVKREANKGIWLEQVPVPTPGPNEVLIKLEKTAICGTDLHIYLWDEWSQRTIEPGLT
CCCHHHHCCCCCEEEEECCCCCCCCCCEEEEEECEEEECCCEEEEEECCCCCCCCCCCCE
IGHEFVGRVAELGSAVTGYQIGQRVSAEGHIVCGHCRNCRGGRPHLCPNTVGIGVNVNGA
ECHHHHHHHHHHCCHHHHHHHCCEECCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCC
FAEYMVMPASNLWPIPDQIPSELAAFFDPYGNAAHCALEFDVIGEDVLITGAGPIGIIAA
EEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEECCCEEEEECCCHHHHHHH
GICKHIGARNVVVTDVNDFRLKLAADMGATRVVNVSKTSLKDVMADLHMEGFDVGLEMSG
HHHHHCCCCCEEEECCCCEEEEEEECCCCEEEEECCHHHHHHHHHHHCCCCEEEEEEECC
NSRAFNDMLDCMYHGGKIAMLGIMPRGAGCDWDKIIFKGLTVQGIYGRKMYETWYKMTQL
CCHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHCCCEEEEECCHHHHHHHHHHHHH
VLSGFPLHKVLTHQLPIDDFQKGFDLMEEGKAGKVVLSWN
HHCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEC
>Mature Secondary Structure
MKALVKREANKGIWLEQVPVPTPGPNEVLIKLEKTAICGTDLHIYLWDEWSQRTIEPGLT
CCCHHHHCCCCCEEEEECCCCCCCCCCEEEEEECEEEECCCEEEEEECCCCCCCCCCCCE
IGHEFVGRVAELGSAVTGYQIGQRVSAEGHIVCGHCRNCRGGRPHLCPNTVGIGVNVNGA
ECHHHHHHHHHHCCHHHHHHHCCEECCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCC
FAEYMVMPASNLWPIPDQIPSELAAFFDPYGNAAHCALEFDVIGEDVLITGAGPIGIIAA
EEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEECCCEEEEECCCHHHHHHH
GICKHIGARNVVVTDVNDFRLKLAADMGATRVVNVSKTSLKDVMADLHMEGFDVGLEMSG
HHHHHCCCCCEEEECCCCEEEEEEECCCCEEEEECCHHHHHHHHHHHCCCCEEEEEEECC
NSRAFNDMLDCMYHGGKIAMLGIMPRGAGCDWDKIIFKGLTVQGIYGRKMYETWYKMTQL
CCHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHCCCEEEEECCHHHHHHHHHHHHH
VLSGFPLHKVLTHQLPIDDFQKGFDLMEEGKAGKVVLSWN
HHCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA