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The map label for this gene is kbl [C]

Identifier: 21241781

GI number: 21241781

Start: 1171525

End: 1172733

Strand: Reverse

Name: kbl [C]

Synonym: XAC1016

Alternate gene names: 21241781

Gene position: 1172733-1171525 (Counterclockwise)

Preceding gene: 21241787

Following gene: 21241780

Centisome position: 22.66

GC content: 63.77

Gene sequence:

>1209_bases
ATGACCACCGCTCCCGCCGCGCTGACCGCCCATTACGCCGCCGAACTGGACGCCATCCAGGCCCAGGGCCTGTTCAAGTC
CGAGCGCATCATCACCGGCCCGCAGTCAGCGGAGATCACGCTGGCCGATGGTCGCAGCGTGCTGAATTTCTGCGCCAACA
ACTATCTGGGCCTGGCCGATCACCCGGACATCATCCAGGCCGCCAAGGACGCGCTGGACAGCCACGGCTTCGGCATGGCC
TCGGTACGCTTCATCTGCGGCACCCAGGATCTGCATAAGCAACTGGAACGCACCATCGCCACGTTCTTCGGCACCGAAGA
CACCATCCTCTACGCAGCCTGCTTCGATGCCAATGGCGGCCTGTTCGAACCGCTGCTCGGCGAGCACGACGCCATCATTT
CCGATGCGCTCAACCATGCCTCCATCATCGACGGCGTGCGCCTGTGCAAGGCCAAGCGCTTCCGCTACGCCAACTGCGAC
ATGGCCGACCTGGAAGCGCAGCTGCAGGCCGCCGACGCCGCCGGCTGCAAGACCAAGCTGATCACCAGCGACGGCGTGTT
CTCGATGGACGGCTTCATCGCCCCGCTCGACGAAATCACTGCCCTGGCCCGCAAATACAACGCGCTGGTACATATCGACG
AATGCCATGCCACCGGCTTCCTCGGCGCCACCGGCCGCGGCTCGGCCGAGGTCAAGGGCGTACTCGACCAGATCGACATC
TTCACCGGCACGCTGGGCAAGGCCATGGGCGGCGCATTGGGCGGCTTCACCACCGCAAAGCGCGAAGTGATCGAGCTGCT
GCGCCAGCGTTCGCGTCCCTACTTGTTCTCCAATTCATTGCCGCCGCACGTGGTGGCTGCCGGCATCAAAGCCTTCGAAA
TGCTGGATGCCGCCGGCGAGCTGCGCACGCAGCTGGTCGAAAACACCACGTATTTCCGCGCACGCATGACCGCCGCCGGT
TTCGACGTCAAACCGGGCGTGCATCCGATCAGCCCGGTGATGCTGTACGACGCACCGCTGGCGCAAAAATTCGCCGAGCG
CTTGCTGGAGGAAGGCATCTACGCCATCGGCTTTTTCTTCCCGGTGGTTCCGAAAGGCCAGGCGCGCATTCGCACCCAGA
TCAGCGCAGCGCATACGCGCGAGCACCTGGATCAAGCGATCGAAGCGTTCATCAAGATCGGGCGCGAACTCAAGGTCATC
GAGGCCTGA

Upstream 100 bases:

>100_bases
GAAATGACATCAGCGCCGCCGCTTATGCCGATTTTGCATGACGTAGTGGTATGCCACCGTGATCGTTAAAATCGCGCTTC
TTTCTGCCATTGCGACCGCC

Downstream 100 bases:

>100_bases
GCATGCGCACGGTGCTGCGCCAACGGCTGCTGCTGGCGGCGCAGACCGATGCGCAGGCGCAGCTGCTCGACGGCCATTGG
GAGACGCGCTGCCTGCACTG

Product: 2-amino-3-ketobutyrate coenzyme A ligase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MTTAPAALTAHYAAELDAIQAQGLFKSERIITGPQSAEITLADGRSVLNFCANNYLGLADHPDIIQAAKDALDSHGFGMA
SVRFICGTQDLHKQLERTIATFFGTEDTILYAACFDANGGLFEPLLGEHDAIISDALNHASIIDGVRLCKAKRFRYANCD
MADLEAQLQAADAAGCKTKLITSDGVFSMDGFIAPLDEITALARKYNALVHIDECHATGFLGATGRGSAEVKGVLDQIDI
FTGTLGKAMGGALGGFTTAKREVIELLRQRSRPYLFSNSLPPHVVAAGIKAFEMLDAAGELRTQLVENTTYFRARMTAAG
FDVKPGVHPISPVMLYDAPLAQKFAERLLEEGIYAIGFFFPVVPKGQARIRTQISAAHTREHLDQAIEAFIKIGRELKVI
EA

Sequences:

>Translated_402_residues
MTTAPAALTAHYAAELDAIQAQGLFKSERIITGPQSAEITLADGRSVLNFCANNYLGLADHPDIIQAAKDALDSHGFGMA
SVRFICGTQDLHKQLERTIATFFGTEDTILYAACFDANGGLFEPLLGEHDAIISDALNHASIIDGVRLCKAKRFRYANCD
MADLEAQLQAADAAGCKTKLITSDGVFSMDGFIAPLDEITALARKYNALVHIDECHATGFLGATGRGSAEVKGVLDQIDI
FTGTLGKAMGGALGGFTTAKREVIELLRQRSRPYLFSNSLPPHVVAAGIKAFEMLDAAGELRTQLVENTTYFRARMTAAG
FDVKPGVHPISPVMLYDAPLAQKFAERLLEEGIYAIGFFFPVVPKGQARIRTQISAAHTREHLDQAIEAFIKIGRELKVI
EA
>Mature_401_residues
TTAPAALTAHYAAELDAIQAQGLFKSERIITGPQSAEITLADGRSVLNFCANNYLGLADHPDIIQAAKDALDSHGFGMAS
VRFICGTQDLHKQLERTIATFFGTEDTILYAACFDANGGLFEPLLGEHDAIISDALNHASIIDGVRLCKAKRFRYANCDM
ADLEAQLQAADAAGCKTKLITSDGVFSMDGFIAPLDEITALARKYNALVHIDECHATGFLGATGRGSAEVKGVLDQIDIF
TGTLGKAMGGALGGFTTAKREVIELLRQRSRPYLFSNSLPPHVVAAGIKAFEMLDAAGELRTQLVENTTYFRARMTAAGF
DVKPGVHPISPVMLYDAPLAQKFAERLLEEGIYAIGFFFPVVPKGQARIRTQISAAHTREHLDQAIEAFIKIGRELKVIE
A

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=395, Percent_Identity=55.6962025316456, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI284448556, Length=421, Percent_Identity=52.2565320665083, Blast_Score=436, Evalue=1e-122,
Organism=Homo sapiens, GI83977442, Length=352, Percent_Identity=32.1022727272727, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI83977440, Length=352, Percent_Identity=32.1022727272727, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI83977444, Length=352, Percent_Identity=32.1022727272727, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI4758668, Length=371, Percent_Identity=35.0404312668464, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI119220554, Length=372, Percent_Identity=34.4086021505376, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI4502025, Length=368, Percent_Identity=31.7934782608696, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI40316939, Length=368, Percent_Identity=31.7934782608696, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI5454084, Length=262, Percent_Identity=31.2977099236641, Blast_Score=124, Evalue=1e-28,
Organism=Escherichia coli, GI1790046, Length=386, Percent_Identity=65.2849740932643, Blast_Score=521, Evalue=1e-149,
Organism=Escherichia coli, GI1786993, Length=352, Percent_Identity=30.9659090909091, Blast_Score=173, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71994529, Length=403, Percent_Identity=57.0719602977667, Blast_Score=466, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI32566772, Length=367, Percent_Identity=32.1525885558583, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17560914, Length=367, Percent_Identity=31.3351498637602, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17560912, Length=367, Percent_Identity=31.3351498637602, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71982617, Length=273, Percent_Identity=26.7399267399267, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71982625, Length=273, Percent_Identity=26.7399267399267, Blast_Score=99, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6320438, Length=376, Percent_Identity=32.1808510638298, Blast_Score=190, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6320267, Length=369, Percent_Identity=31.7073170731707, Blast_Score=172, Evalue=9e-44,
Organism=Saccharomyces cerevisiae, GI6323954, Length=267, Percent_Identity=29.5880149812734, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24662918, Length=399, Percent_Identity=59.1478696741855, Blast_Score=483, Evalue=1e-136,
Organism=Drosophila melanogaster, GI17137420, Length=384, Percent_Identity=30.2083333333333, Blast_Score=187, Evalue=8e-48,
Organism=Drosophila melanogaster, GI17136286, Length=370, Percent_Identity=33.2432432432432, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24653280, Length=322, Percent_Identity=28.5714285714286, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24653276, Length=322, Percent_Identity=28.5714285714286, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24653278, Length=322, Percent_Identity=28.5714285714286, Blast_Score=115, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011282
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 43364; Mature: 43233

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAPAALTAHYAAELDAIQAQGLFKSERIITGPQSAEITLADGRSVLNFCANNYLGLAD
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEECCCHHHHHHHHCCCCCCCC
HPDIIQAAKDALDSHGFGMASVRFICGTQDLHKQLERTIATFFGTEDTILYAACFDANGG
CCHHHHHHHHHHHCCCCCHHHEEEEECCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCC
LFEPLLGEHDAIISDALNHASIIDGVRLCKAKRFRYANCDMADLEAQLQAADAAGCKTKL
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEE
ITSDGVFSMDGFIAPLDEITALARKYNALVHIDECHATGFLGATGRGSAEVKGVLDQIDI
EECCCCEECCCCCCCHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHH
FTGTLGKAMGGALGGFTTAKREVIELLRQRSRPYLFSNSLPPHVVAAGIKAFEMLDAAGE
HHHHHHHHHCCHHCCHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHH
LRTQLVENTTYFRARMTAAGFDVKPGVHPISPVMLYDAPLAQKFAERLLEEGIYAIGFFF
HHHHHHHCCHHHHEEHEECCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHCCHHEEHHHH
PVVPKGQARIRTQISAAHTREHLDQAIEAFIKIGRELKVIEA
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
>Mature Secondary Structure 
TTAPAALTAHYAAELDAIQAQGLFKSERIITGPQSAEITLADGRSVLNFCANNYLGLAD
CCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEECCCHHHHHHHHCCCCCCCC
HPDIIQAAKDALDSHGFGMASVRFICGTQDLHKQLERTIATFFGTEDTILYAACFDANGG
CCHHHHHHHHHHHCCCCCHHHEEEEECCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCC
LFEPLLGEHDAIISDALNHASIIDGVRLCKAKRFRYANCDMADLEAQLQAADAAGCKTKL
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEE
ITSDGVFSMDGFIAPLDEITALARKYNALVHIDECHATGFLGATGRGSAEVKGVLDQIDI
EECCCCEECCCCCCCHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHH
FTGTLGKAMGGALGGFTTAKREVIELLRQRSRPYLFSNSLPPHVVAAGIKAFEMLDAAGE
HHHHHHHHHCCHHCCHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHH
LRTQLVENTTYFRARMTAAGFDVKPGVHPISPVMLYDAPLAQKFAERLLEEGIYAIGFFF
HHHHHHHCCHHHHEEHEECCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHCCHHEEHHHH
PVVPKGQARIRTQISAAHTREHLDQAIEAFIKIGRELKVIEA
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]