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The map label for this gene is glyA [H]

Identifier: 21241514

GI number: 21241514

Start: 883693

End: 884946

Strand: Direct

Name: glyA [H]

Synonym: XAC0743

Alternate gene names: 21241514

Gene position: 883693-884946 (Clockwise)

Preceding gene: 21241513

Following gene: 21241515

Centisome position: 17.07

GC content: 64.11

Gene sequence:

>1254_bases
ATGTTCTCGCGCGATGTCCGACTGGAAACCTACGACCCCGAACTGGCCAAGGCCATCGCTGCTGAAGCCGGCCGCCAGGA
GGATCACGTCGAGCTGATCGCCAGCGAAAACTACTGCAGCCCGTTGGTGATGGAAGCGCAGGGCAGCCAGCTGACCAACA
AGTACGCCGAAGGCTATCCGGGCAAGCGCTACTACGGCGGCTGCGAGTTCGTGGATATTGCCGAACAACTGGCGATCGAG
CGCATCAAGCAGGTATTTGGCGCCGATTACGCGAACGTCCAGCCGCACAGCGGTTCGCAGGCCAATCAGGCGGTGTATCT
GGCACTGCTGCAGCCGGGCGACACCATCCTGGGGATGAGCCTGGCGCATGGCGGCCACCTGACCCACGGCGCGAAGGTCA
ACGTCTCCGGCAAGCTGTTCAACGCGGTGCAGTACGGCGTCAACGAGCAGGGCCTGATCGATTACGACGAGGTCCAGCGC
CTGGCGACCGAGCACAAGCCGAAGATGGTGGTGGCCGGTTTCTCTGCGTATTCGCAGAAGATCGACTGGGCCCGCTTCCG
CGCCATCGCCGACAGCGTCGGTGCCTACCTGTTCGTGGACATGGCGCACATCGCCGGCCTGGTCGCCGCCGGGGTGTATC
CCAGCCCGATGGAACATGCGCACGTGGTCACCTCGACCACGCACAAGACACTGCGTGGCCCGCGTGGCGGCATCATCGTC
GCCAAGGGCGCCAGCGAAGAGCTGCAGAAAAAGCTGCAGTCGATCGTGTTCCCCGGCATCCAGGGCGGCCCGCTGATGCA
TGTCATCGCGGCCAAGGCGGTGGCGTTCAAGGAGGCGCTGGAGCCGGCGTTCAAGACCTATCAGCAACAAGTGGTCAAGA
ACGCCCAGGCGATGGCCAATACGCTGATCGCGCGCGGCTACAAGATCGTTTCCGGCGGCACCGAGAACCATCTGATGCTG
GTGGACATGATCGGTCGCGACGTCTCCGGCAAGGATGCCGAAGCCGCGCTTGGCAAGGCGCACATCACCGTCAACAAGAA
TTCGGTCCCCAACGACCCGCGCTCGCCGTTCGTCACCTCCGGTCTGCGCCTGGGCACCCCGGCGATCACCACGCGCGGTT
ACCAGGAACAGGACAGCATCGATCTGGCCAACTGGATCGCCGACGTGCTCGACGCGCCAACCGACGAAGCCGTGCTGGCG
AAGGTGCGCGACGCGGTGACTGCGCAGTGCAAGCGCTATCCGGTGTATGGCTGA

Upstream 100 bases:

>100_bases
GTACGGGGGCACCGGCCGTGCCGGCTGCGCGGTTGGTCACCCGTGCGGCAGGGGCTTACAATCGGCGACCCTACTGGCAA
TAGCTGCCCCGGAGCTTCGA

Downstream 100 bases:

>100_bases
TACGGAATGGGGAATGGGGAGACGAGAATGGTAAAAGCGACGCTGCGATAGCTCTGCTGGCCCGATTCCTTAATTCCCCT
CTCCCTATTCCCGGACGTCT

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MFSRDVRLETYDPELAKAIAAEAGRQEDHVELIASENYCSPLVMEAQGSQLTNKYAEGYPGKRYYGGCEFVDIAEQLAIE
RIKQVFGADYANVQPHSGSQANQAVYLALLQPGDTILGMSLAHGGHLTHGAKVNVSGKLFNAVQYGVNEQGLIDYDEVQR
LATEHKPKMVVAGFSAYSQKIDWARFRAIADSVGAYLFVDMAHIAGLVAAGVYPSPMEHAHVVTSTTHKTLRGPRGGIIV
AKGASEELQKKLQSIVFPGIQGGPLMHVIAAKAVAFKEALEPAFKTYQQQVVKNAQAMANTLIARGYKIVSGGTENHLML
VDMIGRDVSGKDAEAALGKAHITVNKNSVPNDPRSPFVTSGLRLGTPAITTRGYQEQDSIDLANWIADVLDAPTDEAVLA
KVRDAVTAQCKRYPVYG

Sequences:

>Translated_417_residues
MFSRDVRLETYDPELAKAIAAEAGRQEDHVELIASENYCSPLVMEAQGSQLTNKYAEGYPGKRYYGGCEFVDIAEQLAIE
RIKQVFGADYANVQPHSGSQANQAVYLALLQPGDTILGMSLAHGGHLTHGAKVNVSGKLFNAVQYGVNEQGLIDYDEVQR
LATEHKPKMVVAGFSAYSQKIDWARFRAIADSVGAYLFVDMAHIAGLVAAGVYPSPMEHAHVVTSTTHKTLRGPRGGIIV
AKGASEELQKKLQSIVFPGIQGGPLMHVIAAKAVAFKEALEPAFKTYQQQVVKNAQAMANTLIARGYKIVSGGTENHLML
VDMIGRDVSGKDAEAALGKAHITVNKNSVPNDPRSPFVTSGLRLGTPAITTRGYQEQDSIDLANWIADVLDAPTDEAVLA
KVRDAVTAQCKRYPVYG
>Mature_417_residues
MFSRDVRLETYDPELAKAIAAEAGRQEDHVELIASENYCSPLVMEAQGSQLTNKYAEGYPGKRYYGGCEFVDIAEQLAIE
RIKQVFGADYANVQPHSGSQANQAVYLALLQPGDTILGMSLAHGGHLTHGAKVNVSGKLFNAVQYGVNEQGLIDYDEVQR
LATEHKPKMVVAGFSAYSQKIDWARFRAIADSVGAYLFVDMAHIAGLVAAGVYPSPMEHAHVVTSTTHKTLRGPRGGIIV
AKGASEELQKKLQSIVFPGIQGGPLMHVIAAKAVAFKEALEPAFKTYQQQVVKNAQAMANTLIARGYKIVSGGTENHLML
VDMIGRDVSGKDAEAALGKAHITVNKNSVPNDPRSPFVTSGLRLGTPAITTRGYQEQDSIDLANWIADVLDAPTDEAVLA
KVRDAVTAQCKRYPVYG

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI261862352, Length=401, Percent_Identity=47.8802992518703, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI261862350, Length=401, Percent_Identity=47.8802992518703, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI261862348, Length=401, Percent_Identity=47.8802992518703, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI19923315, Length=401, Percent_Identity=47.8802992518703, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI261862346, Length=400, Percent_Identity=46.75, Blast_Score=348, Evalue=4e-96,
Organism=Homo sapiens, GI22547186, Length=401, Percent_Identity=48.6284289276808, Blast_Score=339, Evalue=2e-93,
Organism=Homo sapiens, GI22547189, Length=389, Percent_Identity=47.0437017994859, Blast_Score=308, Evalue=6e-84,
Organism=Escherichia coli, GI1788902, Length=416, Percent_Identity=69.4711538461538, Blast_Score=604, Evalue=1e-174,
Organism=Caenorhabditis elegans, GI25144732, Length=400, Percent_Identity=48.25, Blast_Score=358, Evalue=2e-99,
Organism=Caenorhabditis elegans, GI25144729, Length=400, Percent_Identity=48.25, Blast_Score=358, Evalue=3e-99,
Organism=Saccharomyces cerevisiae, GI6319739, Length=397, Percent_Identity=47.8589420654912, Blast_Score=362, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6323087, Length=397, Percent_Identity=45.5919395465995, Blast_Score=333, Evalue=3e-92,
Organism=Drosophila melanogaster, GI24640005, Length=410, Percent_Identity=48.2926829268293, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI221329721, Length=410, Percent_Identity=48.2926829268293, Blast_Score=374, Evalue=1e-104,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 44998; Mature: 44998

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSRDVRLETYDPELAKAIAAEAGRQEDHVELIASENYCSPLVMEAQGSQLTNKYAEGYP
CCCCCCEEEECCHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEECCCCHHHHHHHCCCC
GKRYYGGCEFVDIAEQLAIERIKQVFGADYANVQPHSGSQANQAVYLALLQPGDTILGMS
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEE
LAHGGHLTHGAKVNVSGKLFNAVQYGVNEQGLIDYDEVQRLATEHKPKMVVAGFSAYSQK
ECCCCCCCCCCEEEECHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEEECHHHHHH
IDWARFRAIADSVGAYLFVDMAHIAGLVAAGVYPSPMEHAHVVTSTTHKTLRGPRGGIIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHCCCCCCEEE
AKGASEELQKKLQSIVFPGIQGGPLMHVIAAKAVAFKEALEPAFKTYQQQVVKNAQAMAN
ECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLIARGYKIVSGGTENHLMLVDMIGRDVSGKDAEAALGKAHITVNKNSVPNDPRSPFVTS
HHHHCCEEEEECCCCCCEEEEEECCCCCCCCCHHHHCCEEEEEECCCCCCCCCCCCHHHC
GLRLGTPAITTRGYQEQDSIDLANWIADVLDAPTDEAVLAKVRDAVTAQCKRYPVYG
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MFSRDVRLETYDPELAKAIAAEAGRQEDHVELIASENYCSPLVMEAQGSQLTNKYAEGYP
CCCCCCEEEECCHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEECCCCHHHHHHHCCCC
GKRYYGGCEFVDIAEQLAIERIKQVFGADYANVQPHSGSQANQAVYLALLQPGDTILGMS
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEE
LAHGGHLTHGAKVNVSGKLFNAVQYGVNEQGLIDYDEVQRLATEHKPKMVVAGFSAYSQK
ECCCCCCCCCCEEEECHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEEECHHHHHH
IDWARFRAIADSVGAYLFVDMAHIAGLVAAGVYPSPMEHAHVVTSTTHKTLRGPRGGIIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHCCCCCCEEE
AKGASEELQKKLQSIVFPGIQGGPLMHVIAAKAVAFKEALEPAFKTYQQQVVKNAQAMAN
ECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLIARGYKIVSGGTENHLMLVDMIGRDVSGKDAEAALGKAHITVNKNSVPNDPRSPFVTS
HHHHCCEEEEECCCCCCEEEEEECCCCCCCCCHHHHCCEEEEEECCCCCCCCCCCCHHHC
GLRLGTPAITTRGYQEQDSIDLANWIADVLDAPTDEAVLAKVRDAVTAQCKRYPVYG
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA