Click here to switch to the map view.

The map label for this gene is frmA [H]

Identifier: 21241505

GI number: 21241505

Start: 874139

End: 875248

Strand: Direct

Name: frmA [H]

Synonym: XAC0734

Alternate gene names: 21241505

Gene position: 874139-875248 (Clockwise)

Preceding gene: 21241504

Following gene: 21241506

Centisome position: 16.89

GC content: 63.15

Gene sequence:

>1110_bases
ATGAAATCCCGTGCAGCAGTCGCATTTGGGCCCGGCAAGCCGCTGGAAATCGTCGAAATCGACGTCGCGCCGCCGAAAGC
CGGGGAAGTGCTGGTCCGCATCACCCACACCGGCGTGTGCCACACCGATGCCTTCACGCTGTCTGGCGACGACCCGGAAG
GCATCTTCCCGTCGGTGCTCGGGCATGAAGGCGGCGGCATCGTCGAACAGGTCGGCGAAGGCGTGACAAGCGTCAAGATC
GGCGATCACGTGATCCCGCTGTACACGGCCGAATGCCGCAAGTGCAAATTCTGTTTGTCCGGCAAGACCAACCTGTGCCA
GGCCGTGCGCGCCACCCAGGGCAAGGGCCTGATGCCCGACGGCACCACGCGCTTCTCCTACAACGGCGAGCCTATTTATC
ACTACATGGGCTGCAGCACCTTCAGCGAATACACCGTCGTGCCGGAAATTTCGCTGGCCGTGGTCAACCCGGAGGCACCG
CTGGAGAAGGTCTGCCTGCTCGGCTGCGGCGTCACCACCGGTATCGGCGCGGTGCACAACACCGCCAAGGTCAAGCCCGG
CGAGAGTGTTGCCGTGTTCGGCCTGGGCGGCATCGGTCTTGCGGTAATCCAGGGCGCGGTACAGGCCAAGGCCGGGCGCA
TCCTGGCCATCGACACCAATCCGGGCAAGTTCGATCTGGCGCGCAGCATGGGTGCCACCGACTGCATCAACCCCAAGGAC
TACGACAAGCCGATTCAGGAGGTCATCGTCGAGTTGACCGATGGCGGCGTGGACTTCAGCTTCGAATGCATCGGCAACGT
CAATGTGATGCGTTCGGCGCTGGAGTGTTGCCACAAGGGCTGGGGCGAGAGCGTCATCATCGGCGTGGCTGGCGCCGGCC
AGGAAATCAGCACGCGTCCCTTCCAGCTGGTGACTGGTCGCGTATGGCGCGGCAGCGCCTTCGGTGGCGTCAAGGGACGT
ACGCAATTGCCGGGCATGGTGGAGCAGTCGATGAAGGGCGCGATCGACCTGGACCCATTCATCACCCACACCATGCCGTT
GGAAGAGATCAACGAGGCCTTCCACCTGATGCACGAGGGCAAGTCGATCCGCACCGTGATCCATTTCTGA

Upstream 100 bases:

>100_bases
CCTGCTCGGTCTGGTCCGGTCCTACCTCAAATAAAACTCCCACCGGGTCGGCGCTGGCCGCGCTCCCGTCCTCGAACCTC
ATCGTCAGGAGCGTCATCCC

Downstream 100 bases:

>100_bases
CCAGGCGGCCAGGAGCGGCGCGCGGCCGCTTCCGCGCACGTAGTACCCGACACTCCGGGAGGGGCATGATGACTAGCGTG
TCGATTCATCCTTCGGTAGA

Product: alcohol dehydrogenase C

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MKSRAAVAFGPGKPLEIVEIDVAPPKAGEVLVRITHTGVCHTDAFTLSGDDPEGIFPSVLGHEGGGIVEQVGEGVTSVKI
GDHVIPLYTAECRKCKFCLSGKTNLCQAVRATQGKGLMPDGTTRFSYNGEPIYHYMGCSTFSEYTVVPEISLAVVNPEAP
LEKVCLLGCGVTTGIGAVHNTAKVKPGESVAVFGLGGIGLAVIQGAVQAKAGRILAIDTNPGKFDLARSMGATDCINPKD
YDKPIQEVIVELTDGGVDFSFECIGNVNVMRSALECCHKGWGESVIIGVAGAGQEISTRPFQLVTGRVWRGSAFGGVKGR
TQLPGMVEQSMKGAIDLDPFITHTMPLEEINEAFHLMHEGKSIRTVIHF

Sequences:

>Translated_369_residues
MKSRAAVAFGPGKPLEIVEIDVAPPKAGEVLVRITHTGVCHTDAFTLSGDDPEGIFPSVLGHEGGGIVEQVGEGVTSVKI
GDHVIPLYTAECRKCKFCLSGKTNLCQAVRATQGKGLMPDGTTRFSYNGEPIYHYMGCSTFSEYTVVPEISLAVVNPEAP
LEKVCLLGCGVTTGIGAVHNTAKVKPGESVAVFGLGGIGLAVIQGAVQAKAGRILAIDTNPGKFDLARSMGATDCINPKD
YDKPIQEVIVELTDGGVDFSFECIGNVNVMRSALECCHKGWGESVIIGVAGAGQEISTRPFQLVTGRVWRGSAFGGVKGR
TQLPGMVEQSMKGAIDLDPFITHTMPLEEINEAFHLMHEGKSIRTVIHF
>Mature_369_residues
MKSRAAVAFGPGKPLEIVEIDVAPPKAGEVLVRITHTGVCHTDAFTLSGDDPEGIFPSVLGHEGGGIVEQVGEGVTSVKI
GDHVIPLYTAECRKCKFCLSGKTNLCQAVRATQGKGLMPDGTTRFSYNGEPIYHYMGCSTFSEYTVVPEISLAVVNPEAP
LEKVCLLGCGVTTGIGAVHNTAKVKPGESVAVFGLGGIGLAVIQGAVQAKAGRILAIDTNPGKFDLARSMGATDCINPKD
YDKPIQEVIVELTDGGVDFSFECIGNVNVMRSALECCHKGWGESVIIGVAGAGQEISTRPFQLVTGRVWRGSAFGGVKGR
TQLPGMVEQSMKGAIDLDPFITHTMPLEEINEAFHLMHEGKSIRTVIHF

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=369, Percent_Identity=64.4986449864499, Blast_Score=487, Evalue=1e-138,
Organism=Homo sapiens, GI34577061, Length=369, Percent_Identity=50.9485094850949, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI71565152, Length=373, Percent_Identity=50.1340482573727, Blast_Score=384, Evalue=1e-107,
Organism=Homo sapiens, GI4501933, Length=369, Percent_Identity=50.1355013550135, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI4501929, Length=369, Percent_Identity=50.1355013550135, Blast_Score=381, Evalue=1e-106,
Organism=Homo sapiens, GI156523966, Length=367, Percent_Identity=46.866485013624, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI262073058, Length=369, Percent_Identity=48.2384823848238, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI71743840, Length=369, Percent_Identity=48.2384823848238, Blast_Score=359, Evalue=2e-99,
Organism=Homo sapiens, GI4501939, Length=361, Percent_Identity=47.0914127423823, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI156627571, Length=368, Percent_Identity=24.1847826086957, Blast_Score=75, Evalue=8e-14,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=81.5718157181572, Blast_Score=611, Evalue=1e-176,
Organism=Escherichia coli, GI1787863, Length=354, Percent_Identity=26.271186440678, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI1790045, Length=358, Percent_Identity=26.8156424581006, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI1788073, Length=365, Percent_Identity=26.3013698630137, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI87082125, Length=384, Percent_Identity=23.9583333333333, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87081918, Length=349, Percent_Identity=31.2320916905444, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1786825, Length=249, Percent_Identity=28.9156626506024, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1788407, Length=228, Percent_Identity=28.9473684210526, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI226510992, Length=368, Percent_Identity=24.7282608695652, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1790718, Length=330, Percent_Identity=25.1515151515152, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1786518, Length=371, Percent_Identity=26.4150943396226, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25146526, Length=373, Percent_Identity=58.9812332439678, Blast_Score=456, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI71997431, Length=375, Percent_Identity=58.6666666666667, Blast_Score=452, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17565904, Length=343, Percent_Identity=58.0174927113703, Blast_Score=419, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17562584, Length=363, Percent_Identity=28.099173553719, Blast_Score=98, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI71988145, Length=372, Percent_Identity=27.4193548387097, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17562582, Length=372, Percent_Identity=25.8064516129032, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6320033, Length=371, Percent_Identity=61.9946091644205, Blast_Score=480, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6319621, Length=277, Percent_Identity=30.6859205776173, Blast_Score=99, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6323961, Length=311, Percent_Identity=29.5819935691318, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324486, Length=285, Percent_Identity=31.2280701754386, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6323729, Length=254, Percent_Identity=29.9212598425197, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323099, Length=370, Percent_Identity=26.4864864864865, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17737895, Length=368, Percent_Identity=64.1304347826087, Blast_Score=489, Evalue=1e-138,
Organism=Drosophila melanogaster, GI17137530, Length=350, Percent_Identity=26, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 39039; Mature: 39039

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSRAAVAFGPGKPLEIVEIDVAPPKAGEVLVRITHTGVCHTDAFTLSGDDPEGIFPSVL
CCCCEEEEECCCCCEEEEEEECCCCCCCCEEEEEEECCEEECCEEEECCCCCCCCCHHHH
GHEGGGIVEQVGEGVTSVKIGDHVIPLYTAECRKCKFCLSGKTNLCQAVRATQGKGLMPD
CCCCCCHHHHHCCCCEEEEECCEEEEEEECCCHHEEEEECCCHHHHHHHHHCCCCCCCCC
GTTRFSYNGEPIYHYMGCSTFSEYTVVPEISLAVVNPEAPLEKVCLLGCGVTTGIGAVHN
CCEEEECCCCEEEEEECCCCCCCEEECCCEEEEEECCCCCHHHHHHHHCCHHHCCCHHCC
TAKVKPGESVAVFGLGGIGLAVIQGAVQAKAGRILAIDTNPGKFDLARSMGATDCINPKD
CCCCCCCCEEEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHCCCCCCCCCCC
YDKPIQEVIVELTDGGVDFSFECIGNVNVMRSALECCHKGWGESVIIGVAGAGQEISTRP
CHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
FQLVTGRVWRGSAFGGVKGRTQLPGMVEQSMKGAIDLDPFITHTMPLEEINEAFHLMHEG
EEEEECEEEECCCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHHHCC
KSIRTVIHF
CCEEEEEEC
>Mature Secondary Structure
MKSRAAVAFGPGKPLEIVEIDVAPPKAGEVLVRITHTGVCHTDAFTLSGDDPEGIFPSVL
CCCCEEEEECCCCCEEEEEEECCCCCCCCEEEEEEECCEEECCEEEECCCCCCCCCHHHH
GHEGGGIVEQVGEGVTSVKIGDHVIPLYTAECRKCKFCLSGKTNLCQAVRATQGKGLMPD
CCCCCCHHHHHCCCCEEEEECCEEEEEEECCCHHEEEEECCCHHHHHHHHHCCCCCCCCC
GTTRFSYNGEPIYHYMGCSTFSEYTVVPEISLAVVNPEAPLEKVCLLGCGVTTGIGAVHN
CCEEEECCCCEEEEEECCCCCCCEEECCCEEEEEECCCCCHHHHHHHHCCHHHCCCHHCC
TAKVKPGESVAVFGLGGIGLAVIQGAVQAKAGRILAIDTNPGKFDLARSMGATDCINPKD
CCCCCCCCEEEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHCCCCCCCCCCC
YDKPIQEVIVELTDGGVDFSFECIGNVNVMRSALECCHKGWGESVIIGVAGAGQEISTRP
CHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
FQLVTGRVWRGSAFGGVKGRTQLPGMVEQSMKGAIDLDPFITHTMPLEEINEAFHLMHEG
EEEEECEEEECCCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHHHCC
KSIRTVIHF
CCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]