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The map label for this gene is hemC

Identifier: 21241393

GI number: 21241393

Start: 736947

End: 737861

Strand: Direct

Name: hemC

Synonym: XAC0622

Alternate gene names: 21241393

Gene position: 736947-737861 (Clockwise)

Preceding gene: 21241392

Following gene: 21241395

Centisome position: 14.24

GC content: 69.95

Gene sequence:

>915_bases
ATGACCACGCTCCGAATCGCCACTCGCAAAAGCCCGCTTGCCCTCTGGCAGAGCGAACACGTCGCCGACGCGCTGCGTCA
GCATCATCCCGGCCTGGAGGTCGTGCTGGTGCCGATGAGCACCCGCGGCGACGAGGTGCTGGACCGTTCGCTCGCCGCGA
TCGGCGGCAAGGGTCTGTTCCTGAAGGAGCTGGAGCTGGCGATGTTGCGCGGCGAGGCCGATTGCGCGGTGCATTCGCTC
AAGGACGTGCCGATGGAACTGGACGAGCCATTCGTGCTGCCGGCCATCCTGGAACGCGGCGACCCGGCCGATGCGCTGGT
GTCCAATCTCTACGCCAGCCTGCAGGCGCTGCCGCTGGGCGCGCGCGTGGGCACCTCCTCGTTGCGTCGTCAGGCGCAGT
TGCGTGCCGCGCGCCCGGACCTGGAATTGATCGACCTGCGCGGCAACGTCAACACGCGGCTGGCCAAGCTCGACAACGGC
GGTTACGACGCCATCGTGCTGGCCTGCGCCGGCCTGCAGCGGCTCGGGCTGGAAGCACGCATCAGCGCACGGCTGGACGC
GCCGGAATGGTTGCCCGCACCTGCGCAAGGCGCGGTGGCGGTGGAATGCCGTGGCGACGACGCACGCATCCACAGCCTGC
TGGCGGTGCTGGATGCCGGCCGCACGCGTGTCTGCGTGGAAGCCGAGCGGGCCATGAATCGCGCCCTGCACGGCAGCTGC
CATGTGCCGGTGGCCGCCTTCGCGCGCTGGGAAGGGCAGGACCTGTTCCTGCAGGGCATGGTGGGCAGCGCCAGCGACGG
CCGCCTGATCCATGCCGACGCGCACGGCAGCGCCGACGATACCGAAGCGCTTGGCCGCCGCGTTGCGCAAGGACTGTTCG
ACAAGGGCGCCGCGCAGCTGCTGGCCGAGCTGTAG

Upstream 100 bases:

>100_bases
CGTGCCGCAGACCCTGGAAGTGAGTCGTCGCTGCGTGGCCAGCCTGCGCGATCAATTACGGCAACTGTGAGTTCGGTGCC
GGCTCCGCGATAATGCCGGC

Downstream 100 bases:

>100_bases
CGCGCTGTCTTCGCCGGGCCTTTGGCCGCCCGGCCCACGCCCTGGCTGTCGTAGGAGCGGCCCCGGCCGCGACAGGCGTT
CCCGGGAACGCCTGTCGCGG

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MTTLRIATRKSPLALWQSEHVADALRQHHPGLEVVLVPMSTRGDEVLDRSLAAIGGKGLFLKELELAMLRGEADCAVHSL
KDVPMELDEPFVLPAILERGDPADALVSNLYASLQALPLGARVGTSSLRRQAQLRAARPDLELIDLRGNVNTRLAKLDNG
GYDAIVLACAGLQRLGLEARISARLDAPEWLPAPAQGAVAVECRGDDARIHSLLAVLDAGRTRVCVEAERAMNRALHGSC
HVPVAAFARWEGQDLFLQGMVGSASDGRLIHADAHGSADDTEALGRRVAQGLFDKGAAQLLAEL

Sequences:

>Translated_304_residues
MTTLRIATRKSPLALWQSEHVADALRQHHPGLEVVLVPMSTRGDEVLDRSLAAIGGKGLFLKELELAMLRGEADCAVHSL
KDVPMELDEPFVLPAILERGDPADALVSNLYASLQALPLGARVGTSSLRRQAQLRAARPDLELIDLRGNVNTRLAKLDNG
GYDAIVLACAGLQRLGLEARISARLDAPEWLPAPAQGAVAVECRGDDARIHSLLAVLDAGRTRVCVEAERAMNRALHGSC
HVPVAAFARWEGQDLFLQGMVGSASDGRLIHADAHGSADDTEALGRRVAQGLFDKGAAQLLAEL
>Mature_303_residues
TTLRIATRKSPLALWQSEHVADALRQHHPGLEVVLVPMSTRGDEVLDRSLAAIGGKGLFLKELELAMLRGEADCAVHSLK
DVPMELDEPFVLPAILERGDPADALVSNLYASLQALPLGARVGTSSLRRQAQLRAARPDLELIDLRGNVNTRLAKLDNGG
YDAIVLACAGLQRLGLEARISARLDAPEWLPAPAQGAVAVECRGDDARIHSLLAVLDAGRTRVCVEAERAMNRALHGSCH
VPVAAFARWEGQDLFLQGMVGSASDGRLIHADAHGSADDTEALGRRVAQGLFDKGAAQLLAEL

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family

Homologues:

Organism=Homo sapiens, GI66933009, Length=300, Percent_Identity=42.6666666666667, Blast_Score=200, Evalue=1e-51,
Organism=Homo sapiens, GI20149500, Length=300, Percent_Identity=42.6666666666667, Blast_Score=200, Evalue=1e-51,
Organism=Escherichia coli, GI48994974, Length=303, Percent_Identity=54.7854785478548, Blast_Score=310, Evalue=7e-86,
Organism=Saccharomyces cerevisiae, GI6319996, Length=317, Percent_Identity=36.9085173501577, Blast_Score=187, Evalue=1e-48,
Organism=Drosophila melanogaster, GI20130425, Length=257, Percent_Identity=43.9688715953307, Blast_Score=188, Evalue=4e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM3_XANAC (Q8PPR3)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_640975.1
- ProteinModelPortal:   Q8PPR3
- SMR:   Q8PPR3
- GeneID:   1154693
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC0622
- NMPDR:   fig|190486.1.peg.619
- HOGENOM:   HBG624842
- OMA:   SLHAVGQ
- ProtClustDB:   PRK00072
- BioCyc:   XAXO190486:XAC0622-MONOMER
- BRENDA:   2.5.1.61
- HAMAP:   MF_00260
- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418
- Gene3D:   G3DSA:3.30.160.40
- PANTHER:   PTHR11557
- PIRSF:   PIRSF001438
- PRINTS:   PR00151
- TIGRFAMs:   TIGR00212

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC; SSF54782 Porphobil_deam

EC number: =2.5.1.61

Molecular weight: Translated: 32506; Mature: 32374

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLRIATRKSPLALWQSEHVADALRQHHPGLEVVLVPMSTRGDEVLDRSLAAIGGKGLF
CCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCH
LKELELAMLRGEADCAVHSLKDVPMELDEPFVLPAILERGDPADALVSNLYASLQALPLG
HHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEHHHHHHCCCCHHHHHHHHHHHHHHCCCC
ARVGTSSLRRQAQLRAARPDLELIDLRGNVNTRLAKLDNGGYDAIVLACAGLQRLGLEAR
CCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHCCCHHE
ISARLDAPEWLPAPAQGAVAVECRGDDARIHSLLAVLDAGRTRVCVEAERAMNRALHGSC
EEECCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCC
HVPVAAFARWEGQDLFLQGMVGSASDGRLIHADAHGSADDTEALGRRVAQGLFDKGAAQL
CCCHHHHHCCCCCEEEEEECCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
LAEL
HHCC
>Mature Secondary Structure 
TTLRIATRKSPLALWQSEHVADALRQHHPGLEVVLVPMSTRGDEVLDRSLAAIGGKGLF
CEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCH
LKELELAMLRGEADCAVHSLKDVPMELDEPFVLPAILERGDPADALVSNLYASLQALPLG
HHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEHHHHHHCCCCHHHHHHHHHHHHHHCCCC
ARVGTSSLRRQAQLRAARPDLELIDLRGNVNTRLAKLDNGGYDAIVLACAGLQRLGLEAR
CCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHCCCHHE
ISARLDAPEWLPAPAQGAVAVECRGDDARIHSLLAVLDAGRTRVCVEAERAMNRALHGSC
EEECCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCC
HVPVAAFARWEGQDLFLQGMVGSASDGRLIHADAHGSADDTEALGRRVAQGLFDKGAAQL
CCCHHHHHCCCCCEEEEEECCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
LAEL
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217