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The map label for this gene is algR [H]

Identifier: 21241392

GI number: 21241392

Start: 736179

End: 736916

Strand: Direct

Name: algR [H]

Synonym: XAC0621

Alternate gene names: 21241392

Gene position: 736179-736916 (Clockwise)

Preceding gene: 21241391

Following gene: 21241393

Centisome position: 14.22

GC content: 66.94

Gene sequence:

>738_bases
ATGACGGCCACGCAAGTGCGGGTGCTGATCGCCGATGACGAGCCACTGGCGCGTGAGCGCCTGCGCATGCTGCTGGGCGA
GCATCCGCAGGTCGAGGTGATCGGCGAGGCCGAAAACGGCCAGCAAGTGCTGCAGCAGTGCGAACATCTGCATCCGGACC
TGGTGCTGCTGGACATCGCCATGCCCGGCGTCGACGGCCTGGAAACTGCGCGCCTGCTGCGGCAAAGCCAGCCGCCGCCG
GCGGTGGTGTTCTGCACCGCCTACGACCAGCATGCGTTGTCGGCGTTCGACGCGGCCGCGCTGGATTACCTGATGAAACC
GGTGCGCCCGGAACGGCTGGCGTCTGCACTGGAGAAAGTCGCCACCTTCCTGGCCGGCCGCGTGCCCGGCACCGCGCCCA
GGCCGCTGCGCACCCATCTGTGCGCACGCCTGCGCGGCAGCCTGCGGCTGATCGCCATTGGCGACATTCGCTACCTGCAG
GCCGAAGAGAAGTACGTCATCGTCCATCACACGCGTGGCGAGGACCTGATCGAAGAGTCGCTGAAGTCGCTGGAAGACGA
ATTCGCCGACCGCCTGGTGCGCATCCATCGCAATTGCCTGGTCGCCCGCGATGAGCTGGTGGAACTGCGCCGCAGCGGCG
ATGGCCAGGTCCATGCGGTGCTGCGCAACGTGCCGCAGACCCTGGAAGTGAGTCGTCGCTGCGTGGCCAGCCTGCGCGAT
CAATTACGGCAACTGTGA

Upstream 100 bases:

>100_bases
CGGGGCACGGATGGCGGCCAGCTGGGCTGAAGGCTACTATGCCTGTGAGATCACATTGCCGCTGCCGTGAGGGGAAAGTC
ACTGCAGCGAGGGGGAGTCC

Downstream 100 bases:

>100_bases
GTTCGGTGCCGGCTCCGCGATAATGCCGGCATGACCACGCTCCGAATCGCCACTCGCAAAAGCCCGCTTGCCCTCTGGCA
GAGCGAACACGTCGCCGACG

Product: two-component system regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 245; Mature: 244

Protein sequence:

>245_residues
MTATQVRVLIADDEPLARERLRMLLGEHPQVEVIGEAENGQQVLQQCEHLHPDLVLLDIAMPGVDGLETARLLRQSQPPP
AVVFCTAYDQHALSAFDAAALDYLMKPVRPERLASALEKVATFLAGRVPGTAPRPLRTHLCARLRGSLRLIAIGDIRYLQ
AEEKYVIVHHTRGEDLIEESLKSLEDEFADRLVRIHRNCLVARDELVELRRSGDGQVHAVLRNVPQTLEVSRRCVASLRD
QLRQL

Sequences:

>Translated_245_residues
MTATQVRVLIADDEPLARERLRMLLGEHPQVEVIGEAENGQQVLQQCEHLHPDLVLLDIAMPGVDGLETARLLRQSQPPP
AVVFCTAYDQHALSAFDAAALDYLMKPVRPERLASALEKVATFLAGRVPGTAPRPLRTHLCARLRGSLRLIAIGDIRYLQ
AEEKYVIVHHTRGEDLIEESLKSLEDEFADRLVRIHRNCLVARDELVELRRSGDGQVHAVLRNVPQTLEVSRRCVASLRD
QLRQL
>Mature_244_residues
TATQVRVLIADDEPLARERLRMLLGEHPQVEVIGEAENGQQVLQQCEHLHPDLVLLDIAMPGVDGLETARLLRQSQPPPA
VVFCTAYDQHALSAFDAAALDYLMKPVRPERLASALEKVATFLAGRVPGTAPRPLRTHLCARLRGSLRLIAIGDIRYLQA
EEKYVIVHHTRGEDLIEESLKSLEDEFADRLVRIHRNCLVARDELVELRRSGDGQVHAVLRNVPQTLEVSRRCVASLRDQ
LRQL

Specific function: Positive regulator of the algD gene, which codes for a GDP-mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway [H]

COG id: COG3279

COG function: function code KT; Response regulator of the LytR/AlgR family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082052, Length=241, Percent_Identity=34.4398340248963, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1788724, Length=247, Percent_Identity=29.1497975708502, Blast_Score=110, Evalue=7e-26,
Organism=Escherichia coli, GI1788222, Length=117, Percent_Identity=32.4786324786325, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1788521, Length=117, Percent_Identity=35.8974358974359, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI1787473, Length=116, Percent_Identity=39.6551724137931, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788712, Length=115, Percent_Identity=29.5652173913043, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR007492
- InterPro:   IPR001789 [H]

Pfam domain/function: PF04397 LytTR; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 27513; Mature: 27382

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50930 HTH_LYTTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATQVRVLIADDEPLARERLRMLLGEHPQVEVIGEAENGQQVLQQCEHLHPDLVLLDIA
CCCCEEEEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEEEE
MPGVDGLETARLLRQSQPPPAVVFCTAYDQHALSAFDAAALDYLMKPVRPERLASALEKV
CCCCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
ATFLAGRVPGTAPRPLRTHLCARLRGSLRLIAIGDIRYLQAEEKYVIVHHTRGEDLIEES
HHHHHCCCCCCCCCHHHHHHHHHHHCCEEEEEECCEEEEECCCCEEEEEECCCHHHHHHH
LKSLEDEFADRLVRIHRNCLVARDELVELRRSGDGQVHAVLRNVPQTLEVSRRCVASLRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHH
QLRQL
HHHCC
>Mature Secondary Structure 
TATQVRVLIADDEPLARERLRMLLGEHPQVEVIGEAENGQQVLQQCEHLHPDLVLLDIA
CCCEEEEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEEEE
MPGVDGLETARLLRQSQPPPAVVFCTAYDQHALSAFDAAALDYLMKPVRPERLASALEKV
CCCCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
ATFLAGRVPGTAPRPLRTHLCARLRGSLRLIAIGDIRYLQAEEKYVIVHHTRGEDLIEES
HHHHHCCCCCCCCCHHHHHHHHHHHCCEEEEEECCEEEEECCCCEEEEEECCCHHHHHHH
LKSLEDEFADRLVRIHRNCLVARDELVELRRSGDGQVHAVLRNVPQTLEVSRRCVASLRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHH
QLRQL
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2493441; 10984043; 2544550; 8159168 [H]