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The map label for this gene is thrB [H]

Identifier: 161485716

GI number: 161485716

Start: 2116674

End: 2117687

Strand: Direct

Name: thrB [H]

Synonym: XAC1821

Alternate gene names: 161485716

Gene position: 2116674-2117687 (Clockwise)

Preceding gene: 21242564

Following gene: 77748613

Centisome position: 40.9

GC content: 66.57

Gene sequence:

>1014_bases
GTGACGCATGCTGTTGTCAGCCAGGCCGGCGTGAGCCAGGCGGCGGTGGCGCAGGGGCAGGGCAGCGATCACGCTTCCCT
GGGCAAGCACGGCTTGCACGAAGCGCGCGCCTTCGCGCCGGCATCGGTTGCGAATGTCGCGGTGGGATTCGATCTGCTCG
GCTATCCGATCGATGGAGTCGGCGACACAGTGACCGTGCGCCGTATCGACGCGCCAGTGGTGCGCATCGCTGCGATTCGC
GGCACGACGGTGGCGCTGCCACTGGATGCCGAGCGCAACACTGCAGGCGCTGCACTCATTTCGCTGCGTGCCGCCTTGCA
ACTGCCTTATGGATTCGAAATCGAGATCGACAAAGGCATCGCGTTGAGCTCGGGCATGGGCGGGTCTGCCGCGTCATGCG
TCGCGGCGTTGGTGGCGGCAAACGCGCTGCTGGCCTCGCCGTTGGATCACCACCAGCTCTACCAATACGCGCTCGATGGC
GAAGCGGTGGCCAGCGGCAGCTGCCACGGCGACAACCTGGGGCCGCTGTTTGTCGGTGGCTTGGTGCTGTGCACGCTGGA
GCGCCTGGTACCGATCGCGGTGCCGCCAGCGTGGCATAGCCTGCTGGTGCATCCGGATGCAGTGCTGGAAACGCGGCGCG
CGCGCGAAGCCTTGGCAGGAAACTATCAATTGCGCGAATTCGTCGCGCAGAGCACCAATCTGGCGTTGGTGTTGGCCGGT
TGCCATGGCGGCGATGCAGACCTGGTACGCGCAGGCTTGCGTGATGTGCTGATCGAACCGCGTCGCGCCCCATTGATCGC
CGGCTTCGCCGAAGCCAAACAGGCAGCGCTGGACCACAACGCCTTCGGCGCCAGCATTTCCGGCGCCGGGCCGAGCGTGT
TTGCCTGGTTCGAATCGCGCGCCGCGGCCGAAGCTGCGGCACCGGCAGTGCAGGCCGGGTTTGCGGCCGTAGGGTTCGAT
AGCCAGGCCTGGGTCTCGCCGATCGCAAGTCCTGCGGCGCGGTTGCTCGAATGA

Upstream 100 bases:

>100_bases
ACCCGTTGGTGGTGCAGGGCCCGGGTGCCGGTCCGGAAGTGACCGCGGCAGGCGTGTTCGCCGATCTGCTGCGCGTGGCG
GCAGGCGAGGGCGCGCGGCT

Downstream 100 bases:

>100_bases
ATCGGGACGCACGCAATGACAACGCGCCGCAGGCAGCCGGTAGCAGGTCTGGCCTGCAGCTTGCCACACGTCATTTAGTC
GACGACGACTTCGCTGATCT

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MTHAVVSQAGVSQAAVAQGQGSDHASLGKHGLHEARAFAPASVANVAVGFDLLGYPIDGVGDTVTVRRIDAPVVRIAAIR
GTTVALPLDAERNTAGAALISLRAALQLPYGFEIEIDKGIALSSGMGGSAASCVAALVAANALLASPLDHHQLYQYALDG
EAVASGSCHGDNLGPLFVGGLVLCTLERLVPIAVPPAWHSLLVHPDAVLETRRAREALAGNYQLREFVAQSTNLALVLAG
CHGGDADLVRAGLRDVLIEPRRAPLIAGFAEAKQAALDHNAFGASISGAGPSVFAWFESRAAAEAAAPAVQAGFAAVGFD
SQAWVSPIASPAARLLE

Sequences:

>Translated_337_residues
MTHAVVSQAGVSQAAVAQGQGSDHASLGKHGLHEARAFAPASVANVAVGFDLLGYPIDGVGDTVTVRRIDAPVVRIAAIR
GTTVALPLDAERNTAGAALISLRAALQLPYGFEIEIDKGIALSSGMGGSAASCVAALVAANALLASPLDHHQLYQYALDG
EAVASGSCHGDNLGPLFVGGLVLCTLERLVPIAVPPAWHSLLVHPDAVLETRRAREALAGNYQLREFVAQSTNLALVLAG
CHGGDADLVRAGLRDVLIEPRRAPLIAGFAEAKQAALDHNAFGASISGAGPSVFAWFESRAAAEAAAPAVQAGFAAVGFD
SQAWVSPIASPAARLLE
>Mature_336_residues
THAVVSQAGVSQAAVAQGQGSDHASLGKHGLHEARAFAPASVANVAVGFDLLGYPIDGVGDTVTVRRIDAPVVRIAAIRG
TTVALPLDAERNTAGAALISLRAALQLPYGFEIEIDKGIALSSGMGGSAASCVAALVAANALLASPLDHHQLYQYALDGE
AVASGSCHGDNLGPLFVGGLVLCTLERLVPIAVPPAWHSLLVHPDAVLETRRAREALAGNYQLREFVAQSTNLALVLAGC
HGGDADLVRAGLRDVLIEPRRAPLIAGFAEAKQAALDHNAFGASISGAGPSVFAWFESRAAAEAAAPAVQAGFAAVGFDS
QAWVSPIASPAARLLE

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=282, Percent_Identity=32.9787234042553, Blast_Score=128, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 34385; Mature: 34254

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHAVVSQAGVSQAAVAQGQGSDHASLGKHGLHEARAFAPASVANVAVGFDLLGYPIDGV
CCCHHHHHCCCCHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCC
GDTVTVRRIDAPVVRIAAIRGTTVALPLDAERNTAGAALISLRAALQLPYGFEIEIDKGI
CCEEEEEECCCCEEEEEEECCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCE
ALSSGMGGSAASCVAALVAANALLASPLDHHQLYQYALDGEAVASGSCHGDNLGPLFVGG
EEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEECCCCCCCCCCHHHHHH
LVLCTLERLVPIAVPPAWHSLLVHPDAVLETRRAREALAGNYQLREFVAQSTNLALVLAG
HHHHHHHHHHCCCCCCCHHHEEECCHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEEE
CHGGDADLVRAGLRDVLIEPRRAPLIAGFAEAKQAALDHNAFGASISGAGPSVFAWFESR
CCCCCHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHCCCCCCCCCCCCCCCEEHHHHHH
AAAEAAAPAVQAGFAAVGFDSQAWVSPIASPAARLLE
HHHHHHHHHHHHCEEEECCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
THAVVSQAGVSQAAVAQGQGSDHASLGKHGLHEARAFAPASVANVAVGFDLLGYPIDGV
CCHHHHHCCCCHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCC
GDTVTVRRIDAPVVRIAAIRGTTVALPLDAERNTAGAALISLRAALQLPYGFEIEIDKGI
CCEEEEEECCCCEEEEEEECCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCE
ALSSGMGGSAASCVAALVAANALLASPLDHHQLYQYALDGEAVASGSCHGDNLGPLFVGG
EEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEECCCCCCCCCCHHHHHH
LVLCTLERLVPIAVPPAWHSLLVHPDAVLETRRAREALAGNYQLREFVAQSTNLALVLAG
HHHHHHHHHHCCCCCCCHHHEEECCHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEEE
CHGGDADLVRAGLRDVLIEPRRAPLIAGFAEAKQAALDHNAFGASISGAGPSVFAWFESR
CCCCCHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHCCCCCCCCCCCCCCCEEHHHHHH
AAAEAAAPAVQAGFAAVGFDSQAWVSPIASPAARLLE
HHHHHHHHHHHHCEEEECCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA