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The map label for this gene is gltA [H]

Identifier: 57238690

GI number: 57238690

Start: 1739831

End: 1741099

Strand: Reverse

Name: gltA [H]

Synonym: CJE1851

Alternate gene names: 57238690

Gene position: 1741099-1739831 (Counterclockwise)

Preceding gene: 57238691

Following gene: 57238689

Centisome position: 97.93

GC content: 35.62

Gene sequence:

>1269_bases
ATGTCAAATTCCGTTACTATAACCGATAATAGAAATGGAAAAAGCTATGAATTTCCTATATATGACGGTACAACTGGGCC
AAGCGTTGTAGATATGTCAAGTTTTTATAAACAAACAGGAATGTTTTCTTATGATGAGGGCTTGACTTCTACAGCTACTT
GTAAATCAAAAATCACTTATATTGATGGAGAAAACGGAATTTTAATGCACCGTGGCTATCCTATAGAGTGGCTTGCTGAA
AACAAACTTTATTTAGATGTGGTTCATCTTTTACTTTATAAAGAATTACCTGATGCTACGCGTCTTGAAGCATTTCGTTA
TGAAATGAAAAAGCGTTCTTTTATCCATGAAGGTATGCATCGTCTTTTTGATTCTTTCCCTGATAATGCTCATCCTATGG
CAGTTTTACAAGGTGCTGTTTCATCGCTTAGTGCTTTTTATCCTGATCATTTAAACATGAATGTAAAAGAAGAATATATG
GAAATGGCAGCTAGAATAGTAGCTAAAATCCCTACTATAGTGGCCACTGCTTATAGATATAAACACGGCTTTCCTATGGC
TTATCCAAATTTAGATCGTGGTTTTACAGAAAATTTCTTATATATGTTAAGAACCTATCCTTACGATCATGTAGAGCTTA
AACCTATAGAAGTAAAAGCACTTGATACAGTTTTTATGCTTCATGCAGATCATGAGCAAAATGCTTCAACTTCAACAGTT
CGTGCTGTGGGTTCAACTCACGCTCATCCTTATGCCTGTATAGCAGCAGGTATTGGTGCGCTTTGGGGTCATGCACATGG
TGGAGCTAATGAAGGTGTTATTAGAATGCTTGAGCAAATAGGTAGTGTTGATAGGGTAGATGAATTCATCAAAAGAGCTA
AGGATAAAAACGATCCTTTCCGCTTGATGGGCTTTGGGCATAGGGTTTATAAAAATTTTGATCCTAGAGCAAAAGTACTT
AAAAAACTTCGTGATCAACTTATTGATGAGTTGGGTATTGATACCAATCTTATTAAAGTAGCAACGCGTATAGAAGAGAT
TGCTTTAAGTGATGATTATTTTGTTCAAAGAGGGCTATATCCGAATGTTGATTTTCATAGTGGACTTATTTTAAAAGCCT
TAGGTATTCCAAATGAAATGTTTGCTACTTTATTTGTTATAGGACGCACCCCAGGATGGATAGCTCAGTGGATAGAGCAA
AAAGAGCAAGAAAGTCTTAAAATAGTCCGTCCAAGACAACTTTATTTGGGTGAAACTAGTAAAATATAA

Upstream 100 bases:

>100_bases
CTCAAAAAAGCAAACAAAATCTTAAAAATTTAATAATAAAAAAACTCATAATCGTCCTTTTTTGTTAGAATTAATAAAAG
TAACAATAAAAGGAGCGAAA

Downstream 100 bases:

>100_bases
TTAAAATTTTTGTGGAAATTAAAAATTCCACAAAATCTTCTTGTATAATTTTAAAAAATCTTATAGAAAGTTTATAATCA
TGCTTAATCTTGATAAATTT

Product: citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 422; Mature: 421

Protein sequence:

>422_residues
MSNSVTITDNRNGKSYEFPIYDGTTGPSVVDMSSFYKQTGMFSYDEGLTSTATCKSKITYIDGENGILMHRGYPIEWLAE
NKLYLDVVHLLLYKELPDATRLEAFRYEMKKRSFIHEGMHRLFDSFPDNAHPMAVLQGAVSSLSAFYPDHLNMNVKEEYM
EMAARIVAKIPTIVATAYRYKHGFPMAYPNLDRGFTENFLYMLRTYPYDHVELKPIEVKALDTVFMLHADHEQNASTSTV
RAVGSTHAHPYACIAAGIGALWGHAHGGANEGVIRMLEQIGSVDRVDEFIKRAKDKNDPFRLMGFGHRVYKNFDPRAKVL
KKLRDQLIDELGIDTNLIKVATRIEEIALSDDYFVQRGLYPNVDFHSGLILKALGIPNEMFATLFVIGRTPGWIAQWIEQ
KEQESLKIVRPRQLYLGETSKI

Sequences:

>Translated_422_residues
MSNSVTITDNRNGKSYEFPIYDGTTGPSVVDMSSFYKQTGMFSYDEGLTSTATCKSKITYIDGENGILMHRGYPIEWLAE
NKLYLDVVHLLLYKELPDATRLEAFRYEMKKRSFIHEGMHRLFDSFPDNAHPMAVLQGAVSSLSAFYPDHLNMNVKEEYM
EMAARIVAKIPTIVATAYRYKHGFPMAYPNLDRGFTENFLYMLRTYPYDHVELKPIEVKALDTVFMLHADHEQNASTSTV
RAVGSTHAHPYACIAAGIGALWGHAHGGANEGVIRMLEQIGSVDRVDEFIKRAKDKNDPFRLMGFGHRVYKNFDPRAKVL
KKLRDQLIDELGIDTNLIKVATRIEEIALSDDYFVQRGLYPNVDFHSGLILKALGIPNEMFATLFVIGRTPGWIAQWIEQ
KEQESLKIVRPRQLYLGETSKI
>Mature_421_residues
SNSVTITDNRNGKSYEFPIYDGTTGPSVVDMSSFYKQTGMFSYDEGLTSTATCKSKITYIDGENGILMHRGYPIEWLAEN
KLYLDVVHLLLYKELPDATRLEAFRYEMKKRSFIHEGMHRLFDSFPDNAHPMAVLQGAVSSLSAFYPDHLNMNVKEEYME
MAARIVAKIPTIVATAYRYKHGFPMAYPNLDRGFTENFLYMLRTYPYDHVELKPIEVKALDTVFMLHADHEQNASTSTVR
AVGSTHAHPYACIAAGIGALWGHAHGGANEGVIRMLEQIGSVDRVDEFIKRAKDKNDPFRLMGFGHRVYKNFDPRAKVLK
KLRDQLIDELGIDTNLIKVATRIEEIALSDDYFVQRGLYPNVDFHSGLILKALGIPNEMFATLFVIGRTPGWIAQWIEQK
EQESLKIVRPRQLYLGETSKI

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=346, Percent_Identity=27.1676300578035, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI1786939, Length=404, Percent_Identity=50.2475247524753, Blast_Score=431, Evalue=1e-122,
Organism=Escherichia coli, GI1786527, Length=365, Percent_Identity=32.6027397260274, Blast_Score=165, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI17555174, Length=433, Percent_Identity=27.7136258660508, Blast_Score=111, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6319850, Length=342, Percent_Identity=29.5321637426901, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6324328, Length=328, Percent_Identity=30.1829268292683, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6325257, Length=404, Percent_Identity=25.4950495049505, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24640126, Length=419, Percent_Identity=26.0143198090692, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24640124, Length=419, Percent_Identity=26.0143198090692, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21356863, Length=352, Percent_Identity=26.9886363636364, Blast_Score=90, Evalue=4e-18,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 48027; Mature: 47895

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSVTITDNRNGKSYEFPIYDGTTGPSVVDMSSFYKQTGMFSYDEGLTSTATCKSKITY
CCCCEEEEECCCCCEEEECEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHCCEEEE
IDGENGILMHRGYPIEWLAENKLYLDVVHLLLYKELPDATRLEAFRYEMKKRSFIHEGMH
EECCCCEEEECCCCCEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
RLFDSFPDNAHPMAVLQGAVSSLSAFYPDHLNMNVKEEYMEMAARIVAKIPTIVATAYRY
HHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KHGFPMAYPNLDRGFTENFLYMLRTYPYDHVELKPIEVKALDTVFMLHADHEQNASTSTV
HCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEEEEEEEEEEECCCCCCCCHHHH
RAVGSTHAHPYACIAAGIGALWGHAHGGANEGVIRMLEQIGSVDRVDEFIKRAKDKNDPF
HHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCE
RLMGFGHRVYKNFDPRAKVLKKLRDQLIDELGIDTNLIKVATRIEEIALSDDYFVQRGLY
EEEECCHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHCCCC
PNVDFHSGLILKALGIPNEMFATLFVIGRTPGWIAQWIEQKEQESLKIVRPRQLYLGETS
CCCCCCCCHHEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEECCHHEECCCCC
KI
CC
>Mature Secondary Structure 
SNSVTITDNRNGKSYEFPIYDGTTGPSVVDMSSFYKQTGMFSYDEGLTSTATCKSKITY
CCCEEEEECCCCCEEEECEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHCCEEEE
IDGENGILMHRGYPIEWLAENKLYLDVVHLLLYKELPDATRLEAFRYEMKKRSFIHEGMH
EECCCCEEEECCCCCEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
RLFDSFPDNAHPMAVLQGAVSSLSAFYPDHLNMNVKEEYMEMAARIVAKIPTIVATAYRY
HHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KHGFPMAYPNLDRGFTENFLYMLRTYPYDHVELKPIEVKALDTVFMLHADHEQNASTSTV
HCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEEEEEEEEEEECCCCCCCCHHHH
RAVGSTHAHPYACIAAGIGALWGHAHGGANEGVIRMLEQIGSVDRVDEFIKRAKDKNDPF
HHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCE
RLMGFGHRVYKNFDPRAKVLKKLRDQLIDELGIDTNLIKVATRIEEIALSDDYFVQRGLY
EEEECCHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHCCCC
PNVDFHSGLILKALGIPNEMFATLFVIGRTPGWIAQWIEQKEQESLKIVRPRQLYLGETS
CCCCCCCCHHEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEECCHHEECCCCC
KI
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8526514 [H]