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The map label for this gene is hisI

Identifier: 57238617

GI number: 57238617

Start: 1672859

End: 1673482

Strand: Direct

Name: hisI

Synonym: CJE1776

Alternate gene names: 57238617

Gene position: 1672859-1673482 (Clockwise)

Preceding gene: 57238616

Following gene: 57238620

Centisome position: 94.1

GC content: 32.85

Gene sequence:

>624_bases
ATGCAAAATTTCAAAGAACTTAATGAAAAAATCGCTTGGCAAAAAGTGGATAATCTTTTACCTGTCATCATCCAAGATGC
AAAAACTTGCGAAGTTTTAATGCTAGGCTTTATGAATAATGAAGCCTTAGAAAAAAGCTTAGAAAGTGGCAAAGTAGTCT
TTTTTTCACGCACAAAACAGCGTCTTTGGATGAAGGGTGAAGAAAGTGGAAATTTCTTAAATATCATAGATTTAAGCTTA
GATTGTGATAATGACACGCTTTTAATTTTAGCAAATCCTGTAGGGCCTACTTGTCATACGGGCGATATTTCTTGTTTTGA
AAAAATTTCTAAAAATGCAGATTTTGTTTTTCTAGCCAGACTTGAAAAACTTATTAATGCACGCAAAAATGCCGATGAAA
ATACTTCTTATACAGCAAAACTTTTCAAAAGTGGTACAAAACGCATCGCACAAAAAGTTGGTGAAGAAGGCGTAGAAACA
GCTTTAGCAGCGACAGTAAAAGATAAAGAAGAGCTTATTTGTGAAGCAGCGGATTTAATGTATCATTTAAGTGTTTTACT
TGCAGATGCAAATCTTAGTTTCTCAGATGTGATTTCAAAATTAAAAGAAAGACATAAAGCTTAA

Upstream 100 bases:

>100_bases
GATGGGGCTTTAGCTGCTTCTGTTTTTCATCAAAAACTTATAGACATTAAAGAATTAAAAATTTATCTTAAAAATCAAGG
CTTAAGTATAAGGATATAAT

Downstream 100 bases:

>100_bases
AGCTTTATGTAAAATAAATTTATATCAATGCAAGGCTTCATTAAGTTTGACTGCTTTTTTATTTAAAGCTACTATCATAG
CACCACTTATAGAATCTTGA

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MQNFKELNEKIAWQKVDNLLPVIIQDAKTCEVLMLGFMNNEALEKSLESGKVVFFSRTKQRLWMKGEESGNFLNIIDLSL
DCDNDTLLILANPVGPTCHTGDISCFEKISKNADFVFLARLEKLINARKNADENTSYTAKLFKSGTKRIAQKVGEEGVET
ALAATVKDKEELICEAADLMYHLSVLLADANLSFSDVISKLKERHKA

Sequences:

>Translated_207_residues
MQNFKELNEKIAWQKVDNLLPVIIQDAKTCEVLMLGFMNNEALEKSLESGKVVFFSRTKQRLWMKGEESGNFLNIIDLSL
DCDNDTLLILANPVGPTCHTGDISCFEKISKNADFVFLARLEKLINARKNADENTSYTAKLFKSGTKRIAQKVGEEGVET
ALAATVKDKEELICEAADLMYHLSVLLADANLSFSDVISKLKERHKA
>Mature_207_residues
MQNFKELNEKIAWQKVDNLLPVIIQDAKTCEVLMLGFMNNEALEKSLESGKVVFFSRTKQRLWMKGEESGNFLNIIDLSL
DCDNDTLLILANPVGPTCHTGDISCFEKISKNADFVFLARLEKLINARKNADENTSYTAKLFKSGTKRIAQKVGEEGVET
ALAATVKDKEELICEAADLMYHLSVLLADANLSFSDVISKLKERHKA

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=205, Percent_Identity=63.4146341463415, Blast_Score=270, Evalue=5e-74,
Organism=Saccharomyces cerevisiae, GI6319819, Length=204, Percent_Identity=31.3725490196078, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_CAMJE (Q9PM71)

Other databases:

- EMBL:   AL111168
- PIR:   B81256
- RefSeq:   YP_002344973.1
- ProteinModelPortal:   Q9PM71
- IntAct:   Q9PM71
- GeneID:   905159
- GenomeReviews:   AL111168_GR
- KEGG:   cje:Cj1604
- HOGENOM:   HBG294308
- OMA:   VMACKDD
- PhylomeDB:   Q9PM71
- ProtClustDB:   PRK02759
- BioCyc:   CJEJ192222:CJ1604-MONOMER
- BRENDA:   3.5.4.19
- BRENDA:   3.6.1.31
- GO:   GO:0005737
- HAMAP:   MF_01019
- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH

EC number: =3.5.4.19; =3.6.1.31

Molecular weight: Translated: 23176; Mature: 23176

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNFKELNEKIAWQKVDNLLPVIIQDAKTCEVLMLGFMNNEALEKSLESGKVVFFSRTKQ
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHCCCEEEEECCHH
RLWMKGEESGNFLNIIDLSLDCDNDTLLILANPVGPTCHTGDISCFEKISKNADFVFLAR
HHHCCCCCCCCEEEEEEEEEECCCCEEEEEECCCCCCCCCCCHHHHHHHCCCCCEEHHHH
LEKLINARKNADENTSYTAKLFKSGTKRIAQKVGEEGVETALAATVKDKEELICEAADLM
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHHH
YHLSVLLADANLSFSDVISKLKERHKA
HHHHHHHHCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MQNFKELNEKIAWQKVDNLLPVIIQDAKTCEVLMLGFMNNEALEKSLESGKVVFFSRTKQ
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHCCCEEEEECCHH
RLWMKGEESGNFLNIIDLSLDCDNDTLLILANPVGPTCHTGDISCFEKISKNADFVFLAR
HHHCCCCCCCCEEEEEEEEEECCCCEEEEEECCCCCCCCCCCHHHHHHHCCCCCEEHHHH
LEKLINARKNADENTSYTAKLFKSGTKRIAQKVGEEGVETALAATVKDKEELICEAADLM
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHHH
YHLSVLLADANLSFSDVISKLKERHKA
HHHHHHHHCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10688204