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The map label for this gene is hisA [H]

Identifier: 57238614

GI number: 57238614

Start: 1670435

End: 1671166

Strand: Direct

Name: hisA [H]

Synonym: CJE1773

Alternate gene names: 57238614

Gene position: 1670435-1671166 (Clockwise)

Preceding gene: 57238613

Following gene: 57238615

Centisome position: 93.96

GC content: 34.56

Gene sequence:

>732_bases
ATGACTCAAATCATACCCGCACTCGATCTTATAGATGGCGAAGTGGTGCGTCTTGTAAAAGGGGATTACGAACAAAAAAA
AGTATATAAATACAATCCCTTAAAGAAATTTAAAGAATACGAAAAAGCAGGAGCGAAAGAACTTCATCTTGTAGATCTTA
CAGGTGCAAAAGATCCTAGCAAAAGACAATTTGCTTTGATAGAAAAATTAGCCAAAGAAGTCAGTGTCAATTTGCAAGTA
GGTGGAGGTATACGCTCTAAAGCAGAAGCTAGAGCTTTGCTTGATTGTGGAGTAAAAAGAGTAGTTATAGGATCTATGGC
AATTAAAGATGCGACTTTATGTCTTGAAATTTTAAAAGAATTTGGTAGTGAAGCTATAGTTTTAGCCTTAGATACGATTT
TAAAAGAAGATTATGTTGTGGCTGTAAATGCTTGGCAAGAAGCAAGCGATAAAAAGCTTATGGAAGTTTTAGATTTTTAT
AGCAATAAAGGCTTAAAACACATACTTTGCACAGATATTTCAAAAGATGGCACCATGCAAGGAGTAAATGCAAGACTTTA
TAAACTTATCCATGAAATTTTTCCTCATATTTGCATTCAGGCAAGTGGTGGAGTAGCAAGCTTAAAAGACCTTGAAAACT
TAAAAGGAATTTGTAGTGGGGTTATCGTAGGAAAAGCTTTATTAGACGGAGTTTTTAGTGTAGAAGAAGGGATAAGATGT
CTGGAAAATTGA

Upstream 100 bases:

>100_bases
CAAGCGTAATGAAAGATAATTTTTACGGAGTGCAATTTCACCCTGAAAGAAGTAGCGAGGCTGGGGAAATTTTAATTTCA
AATTTTATTAAGGATATAGG

Downstream 100 bases:

>100_bases
CCTATAAAGAATTAATTATAGAAGTTTTAAAACAAACTAAAAAGCCTTTAAATGTGAGTGAAATTTGGCAAAAAGCTCTT
GAAAAAGGCTTAGATAAAAA

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MTQIIPALDLIDGEVVRLVKGDYEQKKVYKYNPLKKFKEYEKAGAKELHLVDLTGAKDPSKRQFALIEKLAKEVSVNLQV
GGGIRSKAEARALLDCGVKRVVIGSMAIKDATLCLEILKEFGSEAIVLALDTILKEDYVVAVNAWQEASDKKLMEVLDFY
SNKGLKHILCTDISKDGTMQGVNARLYKLIHEIFPHICIQASGGVASLKDLENLKGICSGVIVGKALLDGVFSVEEGIRC
LEN

Sequences:

>Translated_243_residues
MTQIIPALDLIDGEVVRLVKGDYEQKKVYKYNPLKKFKEYEKAGAKELHLVDLTGAKDPSKRQFALIEKLAKEVSVNLQV
GGGIRSKAEARALLDCGVKRVVIGSMAIKDATLCLEILKEFGSEAIVLALDTILKEDYVVAVNAWQEASDKKLMEVLDFY
SNKGLKHILCTDISKDGTMQGVNARLYKLIHEIFPHICIQASGGVASLKDLENLKGICSGVIVGKALLDGVFSVEEGIRC
LEN
>Mature_242_residues
TQIIPALDLIDGEVVRLVKGDYEQKKVYKYNPLKKFKEYEKAGAKELHLVDLTGAKDPSKRQFALIEKLAKEVSVNLQVG
GGIRSKAEARALLDCGVKRVVIGSMAIKDATLCLEILKEFGSEAIVLALDTILKEDYVVAVNAWQEASDKKLMEVLDFYS
NKGLKHILCTDISKDGTMQGVNARLYKLIHEIFPHICIQASGGVASLKDLENLKGICSGVIVGKALLDGVFSVEEGIRCL
EN

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=243, Percent_Identity=49.3827160493827, Blast_Score=237, Evalue=6e-64,
Organism=Escherichia coli, GI1788336, Length=214, Percent_Identity=28.0373831775701, Blast_Score=75, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 26680; Mature: 26548

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQIIPALDLIDGEVVRLVKGDYEQKKVYKYNPLKKFKEYEKAGAKELHLVDLTGAKDPS
CCCCCCHHHHHCHHHHHHHHCCCHHHHEEECCHHHHHHHHHHCCCCEEEEEEECCCCCCC
KRQFALIEKLAKEVSVNLQVGGGIRSKAEARALLDCGVKRVVIGSMAIKDATLCLEILKE
HHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
FGSEAIVLALDTILKEDYVVAVNAWQEASDKKLMEVLDFYSNKGLKHILCTDISKDGTMQ
HCCCEEEHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCC
GVNARLYKLIHEIFPHICIQASGGVASLKDLENLKGICSGVIVGKALLDGVFSVEEGIRC
CHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEN
HCC
>Mature Secondary Structure 
TQIIPALDLIDGEVVRLVKGDYEQKKVYKYNPLKKFKEYEKAGAKELHLVDLTGAKDPS
CCCCCHHHHHCHHHHHHHHCCCHHHHEEECCHHHHHHHHHHCCCCEEEEEEECCCCCCC
KRQFALIEKLAKEVSVNLQVGGGIRSKAEARALLDCGVKRVVIGSMAIKDATLCLEILKE
HHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
FGSEAIVLALDTILKEDYVVAVNAWQEASDKKLMEVLDFYSNKGLKHILCTDISKDGTMQ
HCCCEEEHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCC
GVNARLYKLIHEIFPHICIQASGGVASLKDLENLKGICSGVIVGKALLDGVFSVEEGIRC
CHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEN
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA