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The map label for this gene is acs [H]

Identifier: 57238555

GI number: 57238555

Start: 1607275

End: 1609248

Strand: Reverse

Name: acs [H]

Synonym: CJE1708

Alternate gene names: 57238555

Gene position: 1609248-1607275 (Counterclockwise)

Preceding gene: 57238556

Following gene: 57238554

Centisome position: 90.52

GC content: 36.37

Gene sequence:

>1974_bases
ATGCTTAATCAAAATAATCAAGAGCTTTTTAAGCCAAGTAAAGAATTTTCTCGTAATGCTCGTATAAAAAATTTATGTGA
ATACTATGATTTATGCGATGAAGCCAAGGAAGGTTTTGAAGGTTTTTGGAAAAGACAAGCACTTGAGAAGATCGAGTGGT
TTTCGCCTTTTTCAAGAGTGTTAAATGAGGATAAAGCTCCATTTTATAAATGGTTTGAAGGTGGAACTTTAAATGTAAGT
TATCAATGTCTTGATCGTCATATGAAAACAAGACGCAATAAAGCTGCTTTGATTTTTGAAGGTGAAATGGGAGATTATGA
AGTTTATACTTATAGAAGATTATTGCATGAAACTTGCAAGGCGGCCAATTTGCTTAAAAAATTCGGAGTAAAAAAAGGCG
ATAGGGTTGTAATTTATATGCCTATGATTCCAGAAACAGCTATAGTAATGTTAGCTTGCGCAAGGATTGGGGCTATTCAT
AGTGTAGTATTTGGAGGGTTTTCTCCTGAAGCCTTAAGAGATAGAATTATAGATGCAGGAGCTAAACTTGTAGTAACGGC
TGATGGTGCTTTTCGTCGTGGCAAACCTTATATGTTAAAACCTGCAGTAGATAAGGCTTTAAGTGAAGGGTGTGAAAGTG
TAGAAAAAGTACTTATAGTTATACGCAATAATGAGCCTATAGAATATATTAAAGGAAGGGACTATGTTTATAACGAACTT
GTGAAAAATGAGTCTTATAAGTGTGAACCCGAAATTATGGATAGTGAGGATTTGTTGTTTTTGCTTTACACTTCAGGATC
AACAGGCAAGCCAAAAGGAGTTATGCATGCAAGTGCAGGATATATACTTTGGGCACAAATGACTATGGAATGGGTTTTTG
ATATTAAAGATTATGATAATTATTGGTGTAGTGCTGATGTGGGTTGGATTACAGGACATACTTATGTAGTTTATGGGCCT
TTAGCATGTGGAGCAACGACTATAATGCATGAAGGAACTCCTACTTATCCAAATTCTGGGCGTTGGTGGAGAATGATAGA
AGAGTATCAAATAAGCAAATTCTACACTTCGCCAACTGCCATAAGAATGCTTCATGCTGATGCACCTAATGAGCCAAGAA
AATATGATTTAAGTACGCTTGAAGTGCTTGGAACGGTTGGAGAGCCTATCAATCCTAGTGCTTGGAAGTGGTTTTATGAT
GAAATAGGGGGAACTAAAAGTCCTATAGTCGATACTTGGTGGCAAACAGAAACAGGTGGGCATATGATCACGCCTTTACC
AGGCGCCACTCCTTTAAAACCAGGTTGTGCCACCTTGCCTTTGCCAGGGATTTTTGCAGAAGTTATTGATGAAGAAGGCA
ATAAAAAAGATGAAGGTGAAGATGGGTTGCTTTGTATAACTAAACCTTGGCCTTCGATGATTCGTGGAATTTGGGGCAAT
GATGAACGCTATATAGAAAGTTATTTTTCTCAAGCTAAAAAAGATGGAAAAGCTGTATATTTTAGTGGCGATGGTGCTTT
TTATGATAAAAATGGTTATATTACCATCACAGGAAGAACAGATGATGTGGTTAATGTTGCAGGACATCGTATAGGAACGG
CTGAAATTGAAAGCGCTATTGCTAAACATCCAAGTGTAGCAGAATCAGCTGTAGTGAGTATTTTGGATACGATTAAGGGC
GAGTCATTGTTTGCTTTTGTGGTTTTAAGTCCTGCATCCAGTTGTGATCTTGGCGGAGCTATAGAAACTTTAAAAGAACT
TAATGACATTTTAAGAGTAGAAATAGGACCTATAGCTAAAATAGAAAAAATTCTTTATACTCCAGATTTGCCAAAAACTA
GAAGTGGTAAAATAATGAGAAGAATTTTAAGAACTATAGCAAGAGGTGAAGAAATCAAACAGGATATTTCAACACTTGAA
GATTCTAAAGTAGTAGAAACCATTGTTAAATTAGCTAAGGCAGAGTTTGAATAA

Upstream 100 bases:

>100_bases
CCCATTTTTTATAAAATTTATATTAATTATTTTTTAAATTTGTATTTAATACAAATAAACTCTTATATAATGTTTAAAAA
TAACCATATAAGGAGTTTTT

Downstream 100 bases:

>100_bases
CAAGGTAAAAAGAACTTTGCCTAGTTGCATGAAAATTCATAAAAATAAGCTATAATGATAAAAAAATAAAAGGAAATTTT
TATGCTTCAAACTTGTATTT

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 657; Mature: 657

Protein sequence:

>657_residues
MLNQNNQELFKPSKEFSRNARIKNLCEYYDLCDEAKEGFEGFWKRQALEKIEWFSPFSRVLNEDKAPFYKWFEGGTLNVS
YQCLDRHMKTRRNKAALIFEGEMGDYEVYTYRRLLHETCKAANLLKKFGVKKGDRVVIYMPMIPETAIVMLACARIGAIH
SVVFGGFSPEALRDRIIDAGAKLVVTADGAFRRGKPYMLKPAVDKALSEGCESVEKVLIVIRNNEPIEYIKGRDYVYNEL
VKNESYKCEPEIMDSEDLLFLLYTSGSTGKPKGVMHASAGYILWAQMTMEWVFDIKDYDNYWCSADVGWITGHTYVVYGP
LACGATTIMHEGTPTYPNSGRWWRMIEEYQISKFYTSPTAIRMLHADAPNEPRKYDLSTLEVLGTVGEPINPSAWKWFYD
EIGGTKSPIVDTWWQTETGGHMITPLPGATPLKPGCATLPLPGIFAEVIDEEGNKKDEGEDGLLCITKPWPSMIRGIWGN
DERYIESYFSQAKKDGKAVYFSGDGAFYDKNGYITITGRTDDVVNVAGHRIGTAEIESAIAKHPSVAESAVVSILDTIKG
ESLFAFVVLSPASSCDLGGAIETLKELNDILRVEIGPIAKIEKILYTPDLPKTRSGKIMRRILRTIARGEEIKQDISTLE
DSKVVETIVKLAKAEFE

Sequences:

>Translated_657_residues
MLNQNNQELFKPSKEFSRNARIKNLCEYYDLCDEAKEGFEGFWKRQALEKIEWFSPFSRVLNEDKAPFYKWFEGGTLNVS
YQCLDRHMKTRRNKAALIFEGEMGDYEVYTYRRLLHETCKAANLLKKFGVKKGDRVVIYMPMIPETAIVMLACARIGAIH
SVVFGGFSPEALRDRIIDAGAKLVVTADGAFRRGKPYMLKPAVDKALSEGCESVEKVLIVIRNNEPIEYIKGRDYVYNEL
VKNESYKCEPEIMDSEDLLFLLYTSGSTGKPKGVMHASAGYILWAQMTMEWVFDIKDYDNYWCSADVGWITGHTYVVYGP
LACGATTIMHEGTPTYPNSGRWWRMIEEYQISKFYTSPTAIRMLHADAPNEPRKYDLSTLEVLGTVGEPINPSAWKWFYD
EIGGTKSPIVDTWWQTETGGHMITPLPGATPLKPGCATLPLPGIFAEVIDEEGNKKDEGEDGLLCITKPWPSMIRGIWGN
DERYIESYFSQAKKDGKAVYFSGDGAFYDKNGYITITGRTDDVVNVAGHRIGTAEIESAIAKHPSVAESAVVSILDTIKG
ESLFAFVVLSPASSCDLGGAIETLKELNDILRVEIGPIAKIEKILYTPDLPKTRSGKIMRRILRTIARGEEIKQDISTLE
DSKVVETIVKLAKAEFE
>Mature_657_residues
MLNQNNQELFKPSKEFSRNARIKNLCEYYDLCDEAKEGFEGFWKRQALEKIEWFSPFSRVLNEDKAPFYKWFEGGTLNVS
YQCLDRHMKTRRNKAALIFEGEMGDYEVYTYRRLLHETCKAANLLKKFGVKKGDRVVIYMPMIPETAIVMLACARIGAIH
SVVFGGFSPEALRDRIIDAGAKLVVTADGAFRRGKPYMLKPAVDKALSEGCESVEKVLIVIRNNEPIEYIKGRDYVYNEL
VKNESYKCEPEIMDSEDLLFLLYTSGSTGKPKGVMHASAGYILWAQMTMEWVFDIKDYDNYWCSADVGWITGHTYVVYGP
LACGATTIMHEGTPTYPNSGRWWRMIEEYQISKFYTSPTAIRMLHADAPNEPRKYDLSTLEVLGTVGEPINPSAWKWFYD
EIGGTKSPIVDTWWQTETGGHMITPLPGATPLKPGCATLPLPGIFAEVIDEEGNKKDEGEDGLLCITKPWPSMIRGIWGN
DERYIESYFSQAKKDGKAVYFSGDGAFYDKNGYITITGRTDDVVNVAGHRIGTAEIESAIAKHPSVAESAVVSILDTIKG
ESLFAFVVLSPASSCDLGGAIETLKELNDILRVEIGPIAKIEKILYTPDLPKTRSGKIMRRILRTIARGEEIKQDISTLE
DSKVVETIVKLAKAEFE

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=674, Percent_Identity=44.6587537091988, Blast_Score=546, Evalue=1e-155,
Organism=Homo sapiens, GI253970489, Length=687, Percent_Identity=43.6681222707424, Blast_Score=542, Evalue=1e-154,
Organism=Homo sapiens, GI28416953, Length=631, Percent_Identity=44.6909667194929, Blast_Score=531, Evalue=1e-150,
Organism=Homo sapiens, GI13375727, Length=629, Percent_Identity=36.248012718601, Blast_Score=384, Evalue=1e-106,
Organism=Homo sapiens, GI38505220, Length=524, Percent_Identity=29.5801526717557, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI42544132, Length=525, Percent_Identity=29.1428571428571, Blast_Score=192, Evalue=7e-49,
Organism=Homo sapiens, GI122937307, Length=539, Percent_Identity=28.0148423005566, Blast_Score=182, Evalue=1e-45,
Organism=Homo sapiens, GI58082049, Length=536, Percent_Identity=28.1716417910448, Blast_Score=166, Evalue=8e-41,
Organism=Homo sapiens, GI31982927, Length=629, Percent_Identity=25.5961844197138, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI115511026, Length=531, Percent_Identity=27.4952919020716, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI157311624, Length=536, Percent_Identity=27.7985074626866, Blast_Score=158, Evalue=2e-38,
Organism=Homo sapiens, GI157311622, Length=536, Percent_Identity=27.7985074626866, Blast_Score=158, Evalue=2e-38,
Organism=Homo sapiens, GI195947378, Length=441, Percent_Identity=23.8095238095238, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI42544134, Length=349, Percent_Identity=26.0744985673352, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI156151445, Length=575, Percent_Identity=24.5217391304348, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI187761345, Length=400, Percent_Identity=25.25, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI187761343, Length=400, Percent_Identity=25.25, Blast_Score=81, Evalue=3e-15,
Organism=Escherichia coli, GI1790505, Length=637, Percent_Identity=47.8806907378336, Blast_Score=606, Evalue=1e-174,
Organism=Escherichia coli, GI1786529, Length=616, Percent_Identity=37.8246753246753, Blast_Score=416, Evalue=1e-117,
Organism=Escherichia coli, GI1788107, Length=576, Percent_Identity=24.4791666666667, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI221142682, Length=541, Percent_Identity=23.1053604436229, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI145693145, Length=538, Percent_Identity=24.3494423791822, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1786810, Length=532, Percent_Identity=21.9924812030075, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI1786801, Length=456, Percent_Identity=20.8333333333333, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71982997, Length=665, Percent_Identity=43.3082706766917, Blast_Score=511, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI71983001, Length=663, Percent_Identity=43.4389140271493, Blast_Score=510, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17569507, Length=608, Percent_Identity=23.6842105263158, Blast_Score=116, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17531443, Length=435, Percent_Identity=27.1264367816092, Blast_Score=105, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17559526, Length=556, Percent_Identity=22.4820143884892, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17558820, Length=515, Percent_Identity=24.6601941747573, Blast_Score=88, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17557194, Length=561, Percent_Identity=24.5989304812834, Blast_Score=87, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI32563687, Length=526, Percent_Identity=22.2433460076046, Blast_Score=86, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17560140, Length=380, Percent_Identity=22.3684210526316, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71985884, Length=604, Percent_Identity=21.6887417218543, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17560308, Length=529, Percent_Identity=22.117202268431, Blast_Score=72, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6323182, Length=653, Percent_Identity=44.104134762634, Blast_Score=539, Evalue=1e-154,
Organism=Saccharomyces cerevisiae, GI6319264, Length=668, Percent_Identity=45.059880239521, Blast_Score=533, Evalue=1e-152,
Organism=Saccharomyces cerevisiae, GI6319699, Length=395, Percent_Identity=21.7721518987342, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24667955, Length=667, Percent_Identity=47.2263868065967, Blast_Score=583, Evalue=1e-166,
Organism=Drosophila melanogaster, GI62472339, Length=554, Percent_Identity=51.4440433212996, Blast_Score=549, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24667959, Length=524, Percent_Identity=50.763358778626, Blast_Score=508, Evalue=1e-144,
Organism=Drosophila melanogaster, GI21355225, Length=627, Percent_Identity=33.4928229665072, Blast_Score=340, Evalue=1e-93,
Organism=Drosophila melanogaster, GI18859661, Length=538, Percent_Identity=23.7918215613383, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI21355181, Length=537, Percent_Identity=22.3463687150838, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24648260, Length=391, Percent_Identity=22.7621483375959, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21356947, Length=380, Percent_Identity=23.4210526315789, Blast_Score=73, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 73924; Mature: 73924

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNQNNQELFKPSKEFSRNARIKNLCEYYDLCDEAKEGFEGFWKRQALEKIEWFSPFSRV
CCCCCCHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LNEDKAPFYKWFEGGTLNVSYQCLDRHMKTRRNKAALIFEGEMGDYEVYTYRRLLHETCK
HCCCCCCHHHHCCCCEEEEEHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHH
AANLLKKFGVKKGDRVVIYMPMIPETAIVMLACARIGAIHSVVFGGFSPEALRDRIIDAG
HHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
AKLVVTADGAFRRGKPYMLKPAVDKALSEGCESVEKVLIVIRNNEPIEYIKGRDYVYNEL
CEEEEECCCCCCCCCCEEECHHHHHHHHHHHHHHHHEEEEEECCCCCCEECCCHHHHHHH
VKNESYKCEPEIMDSEDLLFLLYTSGSTGKPKGVMHASAGYILWAQMTMEWVFDIKDYDN
HCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEECCCEEEEHHHHHHHHHCCCCCCC
YWCSADVGWITGHTYVVYGPLACGATTIMHEGTPTYPNSGRWWRMIEEYQISKFYTSPTA
EEECCCCCEEECCEEEEEECHHHCCHHEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCE
IRMLHADAPNEPRKYDLSTLEVLGTVGEPINPSAWKWFYDEIGGTKSPIVDTWWQTETGG
EEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCEECCCCCCCCC
HMITPLPGATPLKPGCATLPLPGIFAEVIDEEGNKKDEGEDGLLCITKPWPSMIRGIWGN
EEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCEEEEECCCHHHHHCCCCC
DERYIESYFSQAKKDGKAVYFSGDGAFYDKNGYITITGRTDDVVNVAGHRIGTAEIESAI
CHHHHHHHHHHHCCCCCEEEEECCCCEEECCCEEEEECCCCCHHHHCCCCCCHHHHHHHH
AKHPSVAESAVVSILDTIKGESLFAFVVLSPASSCDLGGAIETLKELNDILRVEIGPIAK
HCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHEECCCCHHH
IEKILYTPDLPKTRSGKIMRRILRTIARGEEIKQDISTLEDSKVVETIVKLAKAEFE
HHHHHCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLNQNNQELFKPSKEFSRNARIKNLCEYYDLCDEAKEGFEGFWKRQALEKIEWFSPFSRV
CCCCCCHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LNEDKAPFYKWFEGGTLNVSYQCLDRHMKTRRNKAALIFEGEMGDYEVYTYRRLLHETCK
HCCCCCCHHHHCCCCEEEEEHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHH
AANLLKKFGVKKGDRVVIYMPMIPETAIVMLACARIGAIHSVVFGGFSPEALRDRIIDAG
HHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
AKLVVTADGAFRRGKPYMLKPAVDKALSEGCESVEKVLIVIRNNEPIEYIKGRDYVYNEL
CEEEEECCCCCCCCCCEEECHHHHHHHHHHHHHHHHEEEEEECCCCCCEECCCHHHHHHH
VKNESYKCEPEIMDSEDLLFLLYTSGSTGKPKGVMHASAGYILWAQMTMEWVFDIKDYDN
HCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEECCCEEEEHHHHHHHHHCCCCCCC
YWCSADVGWITGHTYVVYGPLACGATTIMHEGTPTYPNSGRWWRMIEEYQISKFYTSPTA
EEECCCCCEEECCEEEEEECHHHCCHHEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCE
IRMLHADAPNEPRKYDLSTLEVLGTVGEPINPSAWKWFYDEIGGTKSPIVDTWWQTETGG
EEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCEECCCCCCCCC
HMITPLPGATPLKPGCATLPLPGIFAEVIDEEGNKKDEGEDGLLCITKPWPSMIRGIWGN
EEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCEEEEECCCHHHHHCCCCC
DERYIESYFSQAKKDGKAVYFSGDGAFYDKNGYITITGRTDDVVNVAGHRIGTAEIESAI
CHHHHHHHHHHHCCCCCEEEEECCCCEEECCCEEEEECCCCCHHHHCCCCCCHHHHHHHH
AKHPSVAESAVVSILDTIKGESLFAFVVLSPASSCDLGGAIETLKELNDILRVEIGPIAK
HCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHEECCCCHHH
IEKILYTPDLPKTRSGKIMRRILRTIARGEEIKQDISTLEDSKVVETIVKLAKAEFE
HHHHHCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA