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The map label for this gene is gapA [H]

Identifier: 57238440

GI number: 57238440

Start: 1491827

End: 1492825

Strand: Reverse

Name: gapA [H]

Synonym: CJE1590

Alternate gene names: 57238440

Gene position: 1492825-1491827 (Counterclockwise)

Preceding gene: 57238443

Following gene: 57238439

Centisome position: 83.97

GC content: 35.44

Gene sequence:

>999_bases
ATGGCTGTAAAAGTTGCTATAAATGGTTTTGGACGCATAGGCAGATGTGTTGCAAGAATCATCTTAGAAAGAAATGATAT
TGAGCTTGTGGCGATAAATGATACTACGGATATTGAACTTACAAAATACCTTTTTAAATACGATACAGTACATGGTGAAT
TTAAAGGCAGTGTTGATAGTGAAGGCGATGATTTAGTGGTAAATGATAAAAAAATCAAAGTATTTAAAAGTCGCAATGTA
AAAGATCTTGACTTTGCAAAACACGGCGCACAAATTGTTTTAGAGTGCACAGGAGCGCATTTAACTATGGCAAAAAGTCA
AGAATTTATAGATATGGGAGTACAAAAAGTGATCATGAGTGCTCCTGCAAAAGATGATACTCCTACTTATGTTTTAGGAG
TAAATTCAGAACTTTACAAGGGTGAAAGCATTATTTCTAATGCAAGTTGTACAACAAATTGTTTAGGTCCTGTTTGTCGT
GTTTTACAAGATAATTTTGGTATAGAAAAAGGACTTATGACAACAATACATGCTTATACAAATGGACAAAGTATTATTGA
TGCTAAAGCTAAAGATAAACGCCGTTCTCGTGCTGCAGCGCAAAATATCATTCCAACTTCTACAGGCGCAGCAAAAGCTA
TGAAACTTGTTATGCCTGAACTTAATGGCAAGCTTCACGGACAAAGTATGCGTGTGCCAGTGATTGATGTATCAAGCGTG
GATTTAACTGCGCAGCTAAGCCGTAAAGTCAGCAAAGATGAAATCAATGAAGCTTTTAGAAAAGCTGCAGCTACAAATTT
AAAAGGCATTTTAATGGTGGATGATGATGAAAGAGTTTCAAGCGATTTTATCACTTGTTCTTATGGAGCTATTGTAGTAA
GCGATTTAACTCAAGTGATTGCGGATGATTTTATCAAGGTGATTGCTTGGTATGATAATGAATGGGGTTATTCAAGTCGT
CTAGTAGATATGGCAGTATATATTGCAAATAAGGCTTAA

Upstream 100 bases:

>100_bases
TGCGGTGGATCAAAACTGCCACCAAAAAGTGCTATCTTCATTAAAATTTTAACCTTTTTTTTGTAGAATATTAGCATTAT
ATTTTGCAAAAGGAAATTAA

Downstream 100 bases:

>100_bases
TCATGAGTGATATTATTTCTATAAAAGATATTGATTTAGCTAAGAAAAAAGTTTTTATAAGATGTGATTTTAATGTTCCT
CAAGATGATTTTTTAAACAT

Product: glyceraldehyde 3-phosphate dehydrogenase A

Products: NA

Alternate protein names: NAD-dependent glyceraldehyde-3-phosphate dehydrogenase; GAPDH [H]

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MAVKVAINGFGRIGRCVARIILERNDIELVAINDTTDIELTKYLFKYDTVHGEFKGSVDSEGDDLVVNDKKIKVFKSRNV
KDLDFAKHGAQIVLECTGAHLTMAKSQEFIDMGVQKVIMSAPAKDDTPTYVLGVNSELYKGESIISNASCTTNCLGPVCR
VLQDNFGIEKGLMTTIHAYTNGQSIIDAKAKDKRRSRAAAQNIIPTSTGAAKAMKLVMPELNGKLHGQSMRVPVIDVSSV
DLTAQLSRKVSKDEINEAFRKAAATNLKGILMVDDDERVSSDFITCSYGAIVVSDLTQVIADDFIKVIAWYDNEWGYSSR
LVDMAVYIANKA

Sequences:

>Translated_332_residues
MAVKVAINGFGRIGRCVARIILERNDIELVAINDTTDIELTKYLFKYDTVHGEFKGSVDSEGDDLVVNDKKIKVFKSRNV
KDLDFAKHGAQIVLECTGAHLTMAKSQEFIDMGVQKVIMSAPAKDDTPTYVLGVNSELYKGESIISNASCTTNCLGPVCR
VLQDNFGIEKGLMTTIHAYTNGQSIIDAKAKDKRRSRAAAQNIIPTSTGAAKAMKLVMPELNGKLHGQSMRVPVIDVSSV
DLTAQLSRKVSKDEINEAFRKAAATNLKGILMVDDDERVSSDFITCSYGAIVVSDLTQVIADDFIKVIAWYDNEWGYSSR
LVDMAVYIANKA
>Mature_331_residues
AVKVAINGFGRIGRCVARIILERNDIELVAINDTTDIELTKYLFKYDTVHGEFKGSVDSEGDDLVVNDKKIKVFKSRNVK
DLDFAKHGAQIVLECTGAHLTMAKSQEFIDMGVQKVIMSAPAKDDTPTYVLGVNSELYKGESIISNASCTTNCLGPVCRV
LQDNFGIEKGLMTTIHAYTNGQSIIDAKAKDKRRSRAAAQNIIPTSTGAAKAMKLVMPELNGKLHGQSMRVPVIDVSSVD
LTAQLSRKVSKDEINEAFRKAAATNLKGILMVDDDERVSSDFITCSYGAIVVSDLTQVIADDFIKVIAWYDNEWGYSSRL
VDMAVYIANKA

Specific function: More active in catabolism [H]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7669492, Length=332, Percent_Identity=45.7831325301205, Blast_Score=298, Evalue=6e-81,
Organism=Homo sapiens, GI7657116, Length=331, Percent_Identity=44.7129909365559, Blast_Score=292, Evalue=4e-79,
Organism=Escherichia coli, GI1788079, Length=330, Percent_Identity=46.3636363636364, Blast_Score=311, Evalue=5e-86,
Organism=Escherichia coli, GI1789295, Length=337, Percent_Identity=40.3560830860534, Blast_Score=253, Evalue=9e-69,
Organism=Caenorhabditis elegans, GI32566163, Length=337, Percent_Identity=48.0712166172107, Blast_Score=307, Evalue=4e-84,
Organism=Caenorhabditis elegans, GI17568413, Length=337, Percent_Identity=48.0712166172107, Blast_Score=307, Evalue=5e-84,
Organism=Caenorhabditis elegans, GI17534679, Length=337, Percent_Identity=46.8842729970326, Blast_Score=300, Evalue=7e-82,
Organism=Caenorhabditis elegans, GI17534677, Length=337, Percent_Identity=46.5875370919881, Blast_Score=299, Evalue=1e-81,
Organism=Saccharomyces cerevisiae, GI6321631, Length=332, Percent_Identity=45.1807228915663, Blast_Score=298, Evalue=7e-82,
Organism=Saccharomyces cerevisiae, GI6322468, Length=330, Percent_Identity=45.1515151515152, Blast_Score=297, Evalue=2e-81,
Organism=Saccharomyces cerevisiae, GI6322409, Length=330, Percent_Identity=43.3333333333333, Blast_Score=291, Evalue=1e-79,
Organism=Drosophila melanogaster, GI19922412, Length=326, Percent_Identity=46.9325153374233, Blast_Score=300, Evalue=1e-81,
Organism=Drosophila melanogaster, GI17933600, Length=331, Percent_Identity=47.1299093655589, Blast_Score=299, Evalue=2e-81,
Organism=Drosophila melanogaster, GI18110149, Length=331, Percent_Identity=47.1299093655589, Blast_Score=299, Evalue=2e-81,
Organism=Drosophila melanogaster, GI85725000, Length=331, Percent_Identity=46.2235649546828, Blast_Score=294, Evalue=7e-80,
Organism=Drosophila melanogaster, GI22023983, Length=331, Percent_Identity=46.2235649546828, Blast_Score=294, Evalue=7e-80,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 740 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1660 Molecules/Cell In: Growth Phase, Min

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR006424
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.12 [H]

Molecular weight: Translated: 36372; Mature: 36241

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00071 GAPDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVKVAINGFGRIGRCVARIILERNDIELVAINDTTDIELTKYLFKYDTVHGEFKGSVDS
CEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCC
EGDDLVVNDKKIKVFKSRNVKDLDFAKHGAQIVLECTGAHLTMAKSQEFIDMGVQKVIMS
CCCEEEEECCEEEEEECCCCCCCHHHHCCCEEEEEECCCEEEECCCHHHHHHHHHHHHHH
APAKDDTPTYVLGVNSELYKGESIISNASCTTNCLGPVCRVLQDNFGIEKGLMTTIHAYT
CCCCCCCCEEEEECCCHHHCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHEEEEEEC
NGQSIIDAKAKDKRRSRAAAQNIIPTSTGAAKAMKLVMPELNGKLHGQSMRVPVIDVSSV
CCCEEEECHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEECCCEEEEEEEECCCC
DLTAQLSRKVSKDEINEAFRKAAATNLKGILMVDDDERVSSDFITCSYGAIVVSDLTQVI
CHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEECCHHHHHHHHHHH
ADDFIKVIAWYDNEWGYSSRLVDMAVYIANKA
HHHHHEEEEEECCCCCCCHHHHEEEEEEECCC
>Mature Secondary Structure 
AVKVAINGFGRIGRCVARIILERNDIELVAINDTTDIELTKYLFKYDTVHGEFKGSVDS
EEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCC
EGDDLVVNDKKIKVFKSRNVKDLDFAKHGAQIVLECTGAHLTMAKSQEFIDMGVQKVIMS
CCCEEEEECCEEEEEECCCCCCCHHHHCCCEEEEEECCCEEEECCCHHHHHHHHHHHHHH
APAKDDTPTYVLGVNSELYKGESIISNASCTTNCLGPVCRVLQDNFGIEKGLMTTIHAYT
CCCCCCCCEEEEECCCHHHCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHEEEEEEC
NGQSIIDAKAKDKRRSRAAAQNIIPTSTGAAKAMKLVMPELNGKLHGQSMRVPVIDVSSV
CCCEEEECHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEECCCEEEEEEEECCCC
DLTAQLSRKVSKDEINEAFRKAAATNLKGILMVDDDERVSSDFITCSYGAIVVSDLTQVI
CHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEECCHHHHHHHHHHH
ADDFIKVIAWYDNEWGYSSRLVDMAVYIANKA
HHHHHEEEEEECCCCCCCHHHHEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2493629; 9384377; 8755892; 10658653; 10799476 [H]