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The map label for this gene is glgC [C]

Identifier: 57238375

GI number: 57238375

Start: 1409043

End: 1410068

Strand: Direct

Name: glgC [C]

Synonym: CJE1518

Alternate gene names: 57238375

Gene position: 1409043-1410068 (Clockwise)

Preceding gene: 57238374

Following gene: 57238376

Centisome position: 79.26

GC content: 31.09

Gene sequence:

>1026_bases
GTGGATATAAACAAACTCAAACTCACCCCTGATTCTAGCATAAAAGAAGCTTTAAAAATAGTCGGGCAAGAGCGCGTTAG
ATTAGGCATTATAGTTGATAAAAAGGATAAATTTTTAGGAGTCATTAGCGATTCAAACATCAGAAAAGCTTTAATTAGTG
GCAAAACTTTAAAAGATAGTATCAAAGATATTTACACTAAAAATCCCATCACCATAAAAGAAAACACAAGCAAAGAACAG
CTTTTAAAAATTTCTGCTAAAACCGATATTTACGACTTTCCTGTTTTAGATGAAAAAGGGCAAATTCTTTCTATAAAATC
TATCTCATCGCTTTTAAAAGCCAATCCAAACTCCATTATCATCATGGCTGGAGGCTTAGGCTCTCGCTTAAAAGAGCTGA
CTAAAGATACTCCAAAACCTATGTTAAAAGTAGGCAAAAAACCCATTTTAGAAAGCATAGTCCAAAGACTTAAAAATCAA
AATTTTGAAAATTTTATCTTTTGTGTGAATTATAAAAAACAAATCATAGAAGATTATTTTCAAAAAGGGCAAAAATTTGG
GGTTAAAATTTCTTATATTAAAGAGCGTAAAAAACTAGGTACAGCAGGGGCTTTAAGCCTTATAAAACAAGAATTTAAAG
AAAGTTTTCTCGTTATGAATGCAGACATTTTAACCGAGCTTGATTTTAATGATCTTTTAAAAGCCCATAAAAAATCAAAA
GCTTTAATGAGCGTTTGCGTGCGTGAGTTTGAGCAACAAATTCCTTATGGAGTAATCACCCAAAAACAAGGTTTTATAGA
AAATATAGAAGAAAAACCTACCCAAAAATTCCTAGTAAGTGCGGGGATTTATGTACTTGAAAATGAAATTTTAAATTTAA
TTGCTAAAAATGAATACTTAGACATGCCCGAACTCATCAAACTTGTATTGCAAAAAGGCAAAGTAAATACCTATATCATC
AACGATTATTGGATTGACATTGGAAGGCCAGATGAGTTTTTAAAAGCCAATGAGGATTTTAAATGA

Upstream 100 bases:

>100_bases
ATAATGATAAAAATCCCAATAAATTCATAAAAACTTGCCTAAAAAATGTAAATTTAGATACAATTTTACATAAAAATTTC
ATCGATTTATAAGGCTTAGT

Downstream 100 bases:

>100_bases
AAGTCTTAATCATAGGCTTTGGAAGCATAGGAAAAAAGCATTTTTTAGCCTTAAAAAATTTAAATCATGAAGTAAGTTTG
CTTTCTTTAAGTGCTAAAAA

Product: nucleotidyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MDINKLKLTPDSSIKEALKIVGQERVRLGIIVDKKDKFLGVISDSNIRKALISGKTLKDSIKDIYTKNPITIKENTSKEQ
LLKISAKTDIYDFPVLDEKGQILSIKSISSLLKANPNSIIIMAGGLGSRLKELTKDTPKPMLKVGKKPILESIVQRLKNQ
NFENFIFCVNYKKQIIEDYFQKGQKFGVKISYIKERKKLGTAGALSLIKQEFKESFLVMNADILTELDFNDLLKAHKKSK
ALMSVCVREFEQQIPYGVITQKQGFIENIEEKPTQKFLVSAGIYVLENEILNLIAKNEYLDMPELIKLVLQKGKVNTYII
NDYWIDIGRPDEFLKANEDFK

Sequences:

>Translated_341_residues
MDINKLKLTPDSSIKEALKIVGQERVRLGIIVDKKDKFLGVISDSNIRKALISGKTLKDSIKDIYTKNPITIKENTSKEQ
LLKISAKTDIYDFPVLDEKGQILSIKSISSLLKANPNSIIIMAGGLGSRLKELTKDTPKPMLKVGKKPILESIVQRLKNQ
NFENFIFCVNYKKQIIEDYFQKGQKFGVKISYIKERKKLGTAGALSLIKQEFKESFLVMNADILTELDFNDLLKAHKKSK
ALMSVCVREFEQQIPYGVITQKQGFIENIEEKPTQKFLVSAGIYVLENEILNLIAKNEYLDMPELIKLVLQKGKVNTYII
NDYWIDIGRPDEFLKANEDFK
>Mature_341_residues
MDINKLKLTPDSSIKEALKIVGQERVRLGIIVDKKDKFLGVISDSNIRKALISGKTLKDSIKDIYTKNPITIKENTSKEQ
LLKISAKTDIYDFPVLDEKGQILSIKSISSLLKANPNSIIIMAGGLGSRLKELTKDTPKPMLKVGKKPILESIVQRLKNQ
NFENFIFCVNYKKQIIEDYFQKGQKFGVKISYIKERKKLGTAGALSLIKQEFKESFLVMNADILTELDFNDLLKAHKKSK
ALMSVCVREFEQQIPYGVITQKQGFIENIEEKPTQKFLVSAGIYVLENEILNLIAKNEYLDMPELIKLVLQKGKVNTYII
NDYWIDIGRPDEFLKANEDFK

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=226, Percent_Identity=30.9734513274336, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI11761619, Length=226, Percent_Identity=30.9734513274336, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI133931050, Length=229, Percent_Identity=27.5109170305677, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17509979, Length=199, Percent_Identity=25.6281407035176, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320148, Length=228, Percent_Identity=28.0701754385965, Blast_Score=119, Evalue=8e-28,
Organism=Drosophila melanogaster, GI21355443, Length=231, Percent_Identity=30.3030303030303, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24644084, Length=231, Percent_Identity=30.3030303030303, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24653912, Length=196, Percent_Identity=24.4897959183673, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 38869; Mature: 38869

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDINKLKLTPDSSIKEALKIVGQERVRLGIIVDKKDKFLGVISDSNIRKALISGKTLKDS
CCCCCEEECCCHHHHHHHHHHCCCCEEEEEEEECCCCEEEEECCCHHHHHHHCCCHHHHH
IKDIYTKNPITIKENTSKEQLLKISAKTDIYDFPVLDEKGQILSIKSISSLLKANPNSII
HHHHHCCCCEEEECCCCHHHHEEEECCCCCEECCCCCCCCCEEEHHHHHHHHHCCCCEEE
IMAGGLGSRLKELTKDTPKPMLKVGKKPILESIVQRLKNQNFENFIFCVNYKKQIIEDYF
EEECCCHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHH
QKGQKFGVKISYIKERKKLGTAGALSLIKQEFKESFLVMNADILTELDFNDLLKAHKKSK
HCCHHCCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHEEECHHHHHCCCHHHHHHHHHHHH
ALMSVCVREFEQQIPYGVITQKQGFIENIEEKPTQKFLVSAGIYVLENEILNLIAKNEYL
HHHHHHHHHHHHHCCCCEEECCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DMPELIKLVLQKGKVNTYIINDYWIDIGRPDEFLKANEDFK
CHHHHHHHHHHCCCCEEEEEEEEEEECCCCHHHHCCCCCCC
>Mature Secondary Structure
MDINKLKLTPDSSIKEALKIVGQERVRLGIIVDKKDKFLGVISDSNIRKALISGKTLKDS
CCCCCEEECCCHHHHHHHHHHCCCCEEEEEEEECCCCEEEEECCCHHHHHHHCCCHHHHH
IKDIYTKNPITIKENTSKEQLLKISAKTDIYDFPVLDEKGQILSIKSISSLLKANPNSII
HHHHHCCCCEEEECCCCHHHHEEEECCCCCEECCCCCCCCCEEEHHHHHHHHHCCCCEEE
IMAGGLGSRLKELTKDTPKPMLKVGKKPILESIVQRLKNQNFENFIFCVNYKKQIIEDYF
EEECCCHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHH
QKGQKFGVKISYIKERKKLGTAGALSLIKQEFKESFLVMNADILTELDFNDLLKAHKKSK
HCCHHCCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHEEECHHHHHCCCHHHHHHHHHHHH
ALMSVCVREFEQQIPYGVITQKQGFIENIEEKPTQKFLVSAGIYVLENEILNLIAKNEYL
HHHHHHHHHHHHHCCCCEEECCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DMPELIKLVLQKGKVNTYIINDYWIDIGRPDEFLKANEDFK
CHHHHHHHHHHCCCCEEEEEEEEEEECCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA