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The map label for this gene is neuB

Identifier: 57238369

GI number: 57238369

Start: 1402996

End: 1404027

Strand: Direct

Name: neuB

Synonym: CJE1512

Alternate gene names: NA

Gene position: 1402996-1404027 (Clockwise)

Preceding gene: 57238365

Following gene: 57238370

Centisome position: 78.92

GC content: 33.53

Gene sequence:

>1032_bases
ATGCAAATAGGAAATTTTAACACCGATAAAAAGGTTTTTATCATAGCAGAACTTAGTGCAAATCACGCAGGAAGTCTTGA
GATGGCACTTCAAAGTATAAAAGCTGCCAAAGAAGCAGGTGCTGATGCGATAAAAATTCAAACTTACACTCCAGATAGCA
TGACTCTAAATAGCAACAAAGAAGATTTTATTATTAAGGGTGGGCTTTGGGATAAAAGAAAACTTTATGAGCTTTACGAA
AGCGCAAAAACTCCTTATGAATGGCATTCTCAAATCTTTGAAACCGCACAAAATGAAGGCATACTTTGTTTTTCAAGTCC
TTTTGCCAAAGAAGATTTAGAATTTCTAAAACGCTTTGATCCTATAGCCTATAAAATCGCTTCTTTTGAAGCCAATGATG
AAAATTTCGTGCGTTTAATCGCCAAAGAAAAAAAACCTACTATCGTTTCAACGGGCATTGCTACAGAAGAAGAACTTTTT
AAAATCTGTGAAATTTTTAAAGAAGAAAAAAATCCTGATTTAATCTTTTTAAAATGCACTTCGGCTTATCCTACTGCCAT
AGAAGATATGAATTTAAAAGGCATAGTAAGTTTAAAAGAAAAATTTAATGTTGAAGTGGGACTAAGTGATCATAGCTTTG
GTTTTTTAGCCCCTGTTATGGCAGTAGCACTTGGAGCTAGAGTGATAGAAAAGCATTTTATGTTAGACAAAAACATAGAA
AGCGAAGACAGTAAATTTAGTCTTGATTTTGATGAATTTAAAGCTATGGTAGATGCAGTAAGACAGGCTGAAAGTGCTTT
AGGTGATGGTAAGTTAGACTTAGATGAAAAAGCTCTTAAAAACCGTGTTTTTGCAAGAAGCTTATATGCAAGCAAGGATA
TCAAAAAAGGTGAAATGTTCAGCGAAGAAAATGTAAAATCCGTGCGTCCTTCTTTTGGACTACATCCTAAATTTTATCAA
GAACTTTTAGGAAAAAAAGCTAGCAAAGATATAGAATTTGGCGATGCTTTAAAACAAGGAGATTTTACATGA

Upstream 100 bases:

>100_bases
AAAGTTGTAATATTTATATAATATAAATATATAAATTGAAGAAATATATAATATAATTATATATCATTTTAGTCAGGAAA
TTTACCAAAGAAAGAAAAGT

Downstream 100 bases:

>100_bases
AAAATATTTTAGTTACAGGCGCTGATGGTTTTATAGGTTCTCATCTTTGTGAAAGTTTGGTCAAAAAAGGTTTTAAAGTC
AGAGCTTTAAGTCAGTATAA

Product: N-acetylneuraminic acid synthetase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MQIGNFNTDKKVFIIAELSANHAGSLEMALQSIKAAKEAGADAIKIQTYTPDSMTLNSNKEDFIIKGGLWDKRKLYELYE
SAKTPYEWHSQIFETAQNEGILCFSSPFAKEDLEFLKRFDPIAYKIASFEANDENFVRLIAKEKKPTIVSTGIATEEELF
KICEIFKEEKNPDLIFLKCTSAYPTAIEDMNLKGIVSLKEKFNVEVGLSDHSFGFLAPVMAVALGARVIEKHFMLDKNIE
SEDSKFSLDFDEFKAMVDAVRQAESALGDGKLDLDEKALKNRVFARSLYASKDIKKGEMFSEENVKSVRPSFGLHPKFYQ
ELLGKKASKDIEFGDALKQGDFT

Sequences:

>Translated_343_residues
MQIGNFNTDKKVFIIAELSANHAGSLEMALQSIKAAKEAGADAIKIQTYTPDSMTLNSNKEDFIIKGGLWDKRKLYELYE
SAKTPYEWHSQIFETAQNEGILCFSSPFAKEDLEFLKRFDPIAYKIASFEANDENFVRLIAKEKKPTIVSTGIATEEELF
KICEIFKEEKNPDLIFLKCTSAYPTAIEDMNLKGIVSLKEKFNVEVGLSDHSFGFLAPVMAVALGARVIEKHFMLDKNIE
SEDSKFSLDFDEFKAMVDAVRQAESALGDGKLDLDEKALKNRVFARSLYASKDIKKGEMFSEENVKSVRPSFGLHPKFYQ
ELLGKKASKDIEFGDALKQGDFT
>Mature_343_residues
MQIGNFNTDKKVFIIAELSANHAGSLEMALQSIKAAKEAGADAIKIQTYTPDSMTLNSNKEDFIIKGGLWDKRKLYELYE
SAKTPYEWHSQIFETAQNEGILCFSSPFAKEDLEFLKRFDPIAYKIASFEANDENFVRLIAKEKKPTIVSTGIATEEELF
KICEIFKEEKNPDLIFLKCTSAYPTAIEDMNLKGIVSLKEKFNVEVGLSDHSFGFLAPVMAVALGARVIEKHFMLDKNIE
SEDSKFSLDFDEFKAMVDAVRQAESALGDGKLDLDEKALKNRVFARSLYASKDIKKGEMFSEENVKSVRPSFGLHPKFYQ
ELLGKKASKDIEFGDALKQGDFT

Specific function: Unknown

COG id: COG2089

COG function: function code M; Sialic acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To B.subtilis spsE [H]

Homologues:

Organism=Homo sapiens, GI12056473, Length=334, Percent_Identity=31.7365269461078, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI21357081, Length=350, Percent_Identity=27.7142857142857, Blast_Score=120, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006190
- InterPro:   IPR013785
- InterPro:   IPR013132
- InterPro:   IPR013974 [H]

Pfam domain/function: PF03102 NeuB; PF08666 SAF [H]

EC number: NA

Molecular weight: Translated: 38636; Mature: 38636

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS50844 AFP_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIGNFNTDKKVFIIAELSANHAGSLEMALQSIKAAKEAGADAIKIQTYTPDSMTLNSNK
CCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEECCCC
EDFIIKGGLWDKRKLYELYESAKTPYEWHSQIFETAQNEGILCFSSPFAKEDLEFLKRFD
CCEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCC
PIAYKIASFEANDENFVRLIAKEKKPTIVSTGIATEEELFKICEIFKEEKNPDLIFLKCT
HHHEEEEECCCCCCHHHEEEECCCCCCEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEEC
SAYPTAIEDMNLKGIVSLKEKFNVEVGLSDHSFGFLAPVMAVALGARVIEKHFMLDKNIE
CCCCCHHHCCCCHHHEEHHHHCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
SEDSKFSLDFDEFKAMVDAVRQAESALGDGKLDLDEKALKNRVFARSLYASKDIKKGEMF
CCCCEEECCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
SEENVKSVRPSFGLHPKFYQELLGKKASKDIEFGDALKQGDFT
CCCCHHHCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHCCCCC
>Mature Secondary Structure
MQIGNFNTDKKVFIIAELSANHAGSLEMALQSIKAAKEAGADAIKIQTYTPDSMTLNSNK
CCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEECCCC
EDFIIKGGLWDKRKLYELYESAKTPYEWHSQIFETAQNEGILCFSSPFAKEDLEFLKRFD
CCEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCC
PIAYKIASFEANDENFVRLIAKEKKPTIVSTGIATEEELFKICEIFKEEKNPDLIFLKCT
HHHEEEEECCCCCCHHHEEEECCCCCCEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEEC
SAYPTAIEDMNLKGIVSLKEKFNVEVGLSDHSFGFLAPVMAVALGARVIEKHFMLDKNIE
CCCCCHHHCCCCHHHEEHHHHCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
SEDSKFSLDFDEFKAMVDAVRQAESALGDGKLDLDEKALKNRVFARSLYASKDIKKGEMF
CCCCEEECCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
SEENVKSVRPSFGLHPKFYQELLGKKASKDIEFGDALKQGDFT
CCCCHHHCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]