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The map label for this gene is acbB [H]

Identifier: 57238370

GI number: 57238370

Start: 1404024

End: 1404995

Strand: Direct

Name: acbB [H]

Synonym: CJE1513

Alternate gene names: 57238370

Gene position: 1404024-1404995 (Clockwise)

Preceding gene: 57238369

Following gene: 57238371

Centisome position: 78.97

GC content: 34.26

Gene sequence:

>972_bases
ATGAAAAATATTTTAGTTACAGGCGCTGATGGTTTTATAGGTTCTCATCTTTGTGAAAGTTTGGTCAAAAAAGGTTTTAA
AGTCAGAGCTTTAAGTCAGTATAATTCTTTTAATTTTTGGGGACATTTAGAAAAAAGTCCTTTTTTAAAAGACATGGAAG
TTGTAAGTGGGGATTTAAGAGATAGTTTTTTTTGCGAAAAAATCACCAAAAATATAGATGCGATCTTTCATCTTGGCGCC
TTAATCGCCATCCCCTACTCCTACACAGCCCCACAAAGCTATGTGGATACCAATGTCAATGGCACTTTAAATATGCTCGA
AGCAGCTAAAAAAAACGAAATTTCGCATTTTATCCACACCTCAACAAGCGAAGTTTATGGCACGGCCTTTTATGTGCCCA
TCGATGAAAAACACCCTTTACAACCTCAAAGCCCTTATTCTGCAAGCAAAATCGCTGCAGATATGATGGCGCTGAGTTAT
TATAATTCTTTTAATTTAAATGTCAATATTGCACGCCCTTTTAACACCTATGGACCAAGACAAAGCGCAAGGGCTATCAT
ACCTACCATCATCACACAAATTTTAAGCGGAGCAAAGGAAATCAAACTAGGAGATTTAAGCCCTAAAAGGGATTTAAATT
TTGTGCTAGATACTTGCGAGGGTTTTATCTCTCTTTTAAATTTAAAACATTTTGGAGAAGTTTATAATATAGGCTCAGGA
GTGGAATACTCCATGCAAGAAGTACTTAATCTCATACAAAAAATTTTAGATTCTAAGGTAAAAATCATCCAAGATGAGCA
AAGATTGCGTCCTAAAAATAGCGAAGTTTTTAGACTTTGTTGCGATGCAAACAAGCTTAAAAAAGCTACAAATTGGCAAA
GCAAAATAAGTCTAGAAGAAGGTTTAAGACAAAGCATAGAGTATTTTAAAGAAAATTTAGAAAATTATAAAAGTGAGCTT
TATAATGTTTGA

Upstream 100 bases:

>100_bases
CTTCTTTTGGACTACATCCTAAATTTTATCAAGAACTTTTAGGAAAAAAAGCTAGCAAAGATATAGAATTTGGCGATGCT
TTAAAACAAGGAGATTTTAC

Downstream 100 bases:

>100_bases
AAAAGAAATTTCTTTTATAAAAAGTCTTTTTAATAAAGAAAATATCGCCCTACATGAGCCTTGCTTTATAGGCAATGAGA
AAAAATATCTCTTAGAATGT

Product: NAD-dependent epimerase/dehydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MKNILVTGADGFIGSHLCESLVKKGFKVRALSQYNSFNFWGHLEKSPFLKDMEVVSGDLRDSFFCEKITKNIDAIFHLGA
LIAIPYSYTAPQSYVDTNVNGTLNMLEAAKKNEISHFIHTSTSEVYGTAFYVPIDEKHPLQPQSPYSASKIAADMMALSY
YNSFNLNVNIARPFNTYGPRQSARAIIPTIITQILSGAKEIKLGDLSPKRDLNFVLDTCEGFISLLNLKHFGEVYNIGSG
VEYSMQEVLNLIQKILDSKVKIIQDEQRLRPKNSEVFRLCCDANKLKKATNWQSKISLEEGLRQSIEYFKENLENYKSEL
YNV

Sequences:

>Translated_323_residues
MKNILVTGADGFIGSHLCESLVKKGFKVRALSQYNSFNFWGHLEKSPFLKDMEVVSGDLRDSFFCEKITKNIDAIFHLGA
LIAIPYSYTAPQSYVDTNVNGTLNMLEAAKKNEISHFIHTSTSEVYGTAFYVPIDEKHPLQPQSPYSASKIAADMMALSY
YNSFNLNVNIARPFNTYGPRQSARAIIPTIITQILSGAKEIKLGDLSPKRDLNFVLDTCEGFISLLNLKHFGEVYNIGSG
VEYSMQEVLNLIQKILDSKVKIIQDEQRLRPKNSEVFRLCCDANKLKKATNWQSKISLEEGLRQSIEYFKENLENYKSEL
YNV
>Mature_323_residues
MKNILVTGADGFIGSHLCESLVKKGFKVRALSQYNSFNFWGHLEKSPFLKDMEVVSGDLRDSFFCEKITKNIDAIFHLGA
LIAIPYSYTAPQSYVDTNVNGTLNMLEAAKKNEISHFIHTSTSEVYGTAFYVPIDEKHPLQPQSPYSASKIAADMMALSY
YNSFNLNVNIARPFNTYGPRQSARAIIPTIITQILSGAKEIKLGDLSPKRDLNFVLDTCEGFISLLNLKHFGEVYNIGSG
VEYSMQEVLNLIQKILDSKVKIIQDEQRLRPKNSEVFRLCCDANKLKKATNWQSKISLEEGLRQSIEYFKENLENYKSEL
YNV

Specific function: Probably involved in the biosynthesis of the acarviose moiety of the alpha-glucosidase inhibitor acarbose. Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4- hexulose via a three-step process involving oxidation, dehydration and re

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=326, Percent_Identity=30.6748466257669, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI42516563, Length=326, Percent_Identity=29.7546012269939, Blast_Score=134, Evalue=8e-32,
Organism=Homo sapiens, GI4504031, Length=336, Percent_Identity=29.4642857142857, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI56237023, Length=352, Percent_Identity=24.4318181818182, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI56118217, Length=352, Percent_Identity=24.4318181818182, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI189083684, Length=352, Percent_Identity=24.4318181818182, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI4504507, Length=188, Percent_Identity=30.8510638297872, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1788353, Length=353, Percent_Identity=28.8951841359773, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI48994969, Length=345, Percent_Identity=25.7971014492754, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1788366, Length=348, Percent_Identity=25.2873563218391, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1786974, Length=339, Percent_Identity=26.2536873156342, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788365, Length=342, Percent_Identity=23.0994152046784, Blast_Score=85, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17539532, Length=336, Percent_Identity=27.3809523809524, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17568069, Length=323, Percent_Identity=28.1733746130031, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI133901786, Length=339, Percent_Identity=27.1386430678466, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17539422, Length=339, Percent_Identity=27.1386430678466, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17539424, Length=339, Percent_Identity=27.1386430678466, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI133901788, Length=339, Percent_Identity=27.1386430678466, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI133901790, Length=339, Percent_Identity=27.1386430678466, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17507723, Length=339, Percent_Identity=26.5486725663717, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71982038, Length=337, Percent_Identity=26.1127596439169, Blast_Score=98, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI71982035, Length=335, Percent_Identity=26.5671641791045, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI115532424, Length=328, Percent_Identity=25.3048780487805, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319493, Length=359, Percent_Identity=28.133704735376, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21356223, Length=331, Percent_Identity=28.3987915407855, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24158427, Length=350, Percent_Identity=25.7142857142857, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19923002, Length=353, Percent_Identity=24.6458923512748, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005888
- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.46 [H]

Molecular weight: Translated: 36556; Mature: 36556

Theoretical pI: Translated: 7.89; Mature: 7.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNILVTGADGFIGSHLCESLVKKGFKVRALSQYNSFNFWGHLEKSPFLKDMEVVSGDLR
CCCEEEECCCCHHHHHHHHHHHHCCCEEEEHHHCCCCCCEECCCCCCCHHHHHHHHHHHH
DSFFCEKITKNIDAIFHLGALIAIPYSYTAPQSYVDTNVNGTLNMLEAAKKNEISHFIHT
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHC
STSEVYGTAFYVPIDEKHPLQPQSPYSASKIAADMMALSYYNSFNLNVNIARPFNTYGPR
CCHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCC
QSARAIIPTIITQILSGAKEIKLGDLSPKRDLNFVLDTCEGFISLLNLKHFGEVYNIGSG
HHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VEYSMQEVLNLIQKILDSKVKIIQDEQRLRPKNSEVFRLCCDANKLKKATNWQSKISLEE
CCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHCCHHHHHHCCHHHHHHHHH
GLRQSIEYFKENLENYKSELYNV
HHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKNILVTGADGFIGSHLCESLVKKGFKVRALSQYNSFNFWGHLEKSPFLKDMEVVSGDLR
CCCEEEECCCCHHHHHHHHHHHHCCCEEEEHHHCCCCCCEECCCCCCCHHHHHHHHHHHH
DSFFCEKITKNIDAIFHLGALIAIPYSYTAPQSYVDTNVNGTLNMLEAAKKNEISHFIHT
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHC
STSEVYGTAFYVPIDEKHPLQPQSPYSASKIAADMMALSYYNSFNLNVNIARPFNTYGPR
CCHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCC
QSARAIIPTIITQILSGAKEIKLGDLSPKRDLNFVLDTCEGFISLLNLKHFGEVYNIGSG
HHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VEYSMQEVLNLIQKILDSKVKIIQDEQRLRPKNSEVFRLCCDANKLKKATNWQSKISLEE
CCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHCCHHHHHHCCHHHHHHHHH
GLRQSIEYFKENLENYKSELYNV
HHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10196166 [H]