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The map label for this gene is upp [H]

Identifier: 57238336

GI number: 57238336

Start: 1374939

End: 1375565

Strand: Reverse

Name: upp [H]

Synonym: CJE1478

Alternate gene names: 57238336

Gene position: 1375565-1374939 (Counterclockwise)

Preceding gene: 57238337

Following gene: 57238335

Centisome position: 77.37

GC content: 31.1

Gene sequence:

>627_bases
ATGAAAAATATTCATTGTATCAATCATCCATTGATCGAACATAAATTAGGAATTTTAAGGGCTAAAGAGACAAAGCCCTT
TCAATTTCGTATGTTAATCGATGAAATTTCATCTTTTTTGCTTTTTGAAGCGAGTAAAGATTTTTCTTTAAAAGAAATTG
AAATTTCAACACTTATACAAAAAACTACAGTAAAAAAACTTGATGAAAAGATTATGATTTGTCCTATTTTAAGAGCTGCA
TTAGGAATGCTTGAAAGTGTTTTTAAGATGATTCCTGATGCAAGTGTTGGGTTTTTGGGGTTTGTGAGAAATGAAGAAAC
TTTAAAGGCGGATTTTTATTTTCAAAAACTTCCCAAAGATGCAAAAAAACGCACTGCTATTGTTATAGATCCTATGTTTG
CTACAGGTGGGACTGCTATAGAGGCTTGTAATTTTTTAAAAAGCCAAGGAGTTAAAAAAATAAAATTTATATCCATACTT
GCTGCTCCACAAGGTTTGAAAAAATTTAGCCAAATGCATGATGATGTAGAAGTTTTTGTGGCTTGTATTGATGAAGGTTT
AAATGAAAAAGGTTATATTATCCCAGGGCTTGGAGATGCAGGAGATAGAGTGTTTAACACTCTTTAA

Upstream 100 bases:

>100_bases
TAAAAGCTGCAGTAAGTACAGCTGTAGCAGCAGCTGCGGTAAAAGATGGTGTGGCTAAGGTGAAAAATTTTGATGAGAAA
GCTTATTTTGAAAGCTTAAA

Downstream 100 bases:

>100_bases
AAGAGATGATTTTTGGAAAAATTGATTATATTAATCTTTTACCTTTACATATATATCTTAAGAAATATCCCCTACCTAAT
GGTTATAAAGCAAGTATGGA

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MKNIHCINHPLIEHKLGILRAKETKPFQFRMLIDEISSFLLFEASKDFSLKEIEISTLIQKTTVKKLDEKIMICPILRAA
LGMLESVFKMIPDASVGFLGFVRNEETLKADFYFQKLPKDAKKRTAIVIDPMFATGGTAIEACNFLKSQGVKKIKFISIL
AAPQGLKKFSQMHDDVEVFVACIDEGLNEKGYIIPGLGDAGDRVFNTL

Sequences:

>Translated_208_residues
MKNIHCINHPLIEHKLGILRAKETKPFQFRMLIDEISSFLLFEASKDFSLKEIEISTLIQKTTVKKLDEKIMICPILRAA
LGMLESVFKMIPDASVGFLGFVRNEETLKADFYFQKLPKDAKKRTAIVIDPMFATGGTAIEACNFLKSQGVKKIKFISIL
AAPQGLKKFSQMHDDVEVFVACIDEGLNEKGYIIPGLGDAGDRVFNTL
>Mature_208_residues
MKNIHCINHPLIEHKLGILRAKETKPFQFRMLIDEISSFLLFEASKDFSLKEIEISTLIQKTTVKKLDEKIMICPILRAA
LGMLESVFKMIPDASVGFLGFVRNEETLKADFYFQKLPKDAKKRTAIVIDPMFATGGTAIEACNFLKSQGVKKIKFISIL
AAPQGLKKFSQMHDDVEVFVACIDEGLNEKGYIIPGLGDAGDRVFNTL

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=208, Percent_Identity=27.8846153846154, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI57863312, Length=208, Percent_Identity=27.8846153846154, Blast_Score=68, Evalue=6e-12,
Organism=Escherichia coli, GI87082118, Length=202, Percent_Identity=43.0693069306931, Blast_Score=193, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=25.8706467661692, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=25.8706467661692, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6321920, Length=215, Percent_Identity=30.6976744186047, Blast_Score=97, Evalue=1e-21,
Organism=Drosophila melanogaster, GI45550449, Length=141, Percent_Identity=32.6241134751773, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28573516, Length=141, Percent_Identity=32.6241134751773, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28573514, Length=141, Percent_Identity=32.6241134751773, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28573512, Length=141, Percent_Identity=32.6241134751773, Blast_Score=73, Evalue=1e-13,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 23329; Mature: 23329

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNIHCINHPLIEHKLGILRAKETKPFQFRMLIDEISSFLLFEASKDFSLKEIEISTLIQ
CCCCCCCCCCHHHHHHHHEECCCCCCHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHH
KTTVKKLDEKIMICPILRAALGMLESVFKMIPDASVGFLGFVRNEETLKADFYFQKLPKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHCCHH
AKKRTAIVIDPMFATGGTAIEACNFLKSQGVKKIKFISILAAPQGLKKFSQMHDDVEVFV
HHHCEEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHH
ACIDEGLNEKGYIIPGLGDAGDRVFNTL
HHHHHCCCCCCEEECCCCCCHHHHHHCC
>Mature Secondary Structure
MKNIHCINHPLIEHKLGILRAKETKPFQFRMLIDEISSFLLFEASKDFSLKEIEISTLIQ
CCCCCCCCCCHHHHHHHHEECCCCCCHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHH
KTTVKKLDEKIMICPILRAALGMLESVFKMIPDASVGFLGFVRNEETLKADFYFQKLPKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHCCHH
AKKRTAIVIDPMFATGGTAIEACNFLKSQGVKKIKFISILAAPQGLKKFSQMHDDVEVFV
HHHCEEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHH
ACIDEGLNEKGYIIPGLGDAGDRVFNTL
HHHHHCCCCCCEEECCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA