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The map label for this gene is sucD [H]

Identifier: 57238266

GI number: 57238266

Start: 576795

End: 577664

Strand: Direct

Name: sucD [H]

Synonym: CJE0638

Alternate gene names: 57238266

Gene position: 576795-577664 (Clockwise)

Preceding gene: 57238267

Following gene: 57238265

Centisome position: 32.44

GC content: 37.82

Gene sequence:

>870_bases
ATGAGTATATTGGTTAATAAAAATACAAAAGTAATAGTTCAAGGTTTTACAGGTAAAGAAGCAACTTTTCACGCTGAGCA
ATGCATGGCTTATGGTACAAATATAGTTGGAGGTGTCACCCCTCATAAAGGCGGACAAACTCATTTAGGTAAACCAGTTT
TTGATACCGTTGCAGATGCGGTTAAAGCAACAAAGGCTGATGTGAGCTTGATCTTTGTCCCTGCTTTTGCTGTGGGTGAT
AGCGTGATTGAAGCAGCTGATGCGGGTATTAAGCTTGCAGTTGTAATCACCGAGCATACGCCTGTAAAGGATATGATGTT
TGCTAAGCAATATGCTAATAAAAAGGGTATGAAAATCATTGGACCAAATTGTCCAGGTATTATCACTTCTGAAGAATGTA
AGTTAGGAATTATGCCAGGTTTTATTTTTAAAAAAGGTTGCGTGGGGCTTATTTCAAAAAGTGGAACTTTAACTTATGAA
GCTGCTAATCAGGTAGTTCAAGGTGGTTATGGAATTTCTACTGCAGTAGGAATTGGTGGTGATCCTATCATAGGTCTTGC
TTATAAAGAACTTTTAAGTGAATTCCAAAAAGATGATGAAACTAAAGCTATTGTAATGATAGGTGAAATTGGTGGTAGTT
TGGAAGTGGAAGCGGCTAAATTTATTAAAGAAAATATTAGCAAACCTGTGGTAGCATTCATTGCAGGTGCAACTGCTCCT
AAAGGCAAAAGAATGGGGCATGCAGGTGCCATAGTAGGAAGTGCTGATGAAAGCGCTGCAGCTAAAAAAGAAGCTTTAAA
AAGCTATGGAATTCATGTGGTGGATTCTCCGGCTTTGATTGGTGAAGAAATTCAAAAAATATTAGGTTAA

Upstream 100 bases:

>100_bases
GACAATTTTAGATAATTCAAATCTTAAAAATATCAAAGCAGCAACCAATCTTAAAAACGGTGCAGAGCTTGTAAAAAGTT
TAGTAGGATAAGGATGGAAA

Downstream 100 bases:

>100_bases
TAAAGGAAAAAACATGAGTATGACAGCTCCAAAAGATACCCCTGTTTGGGTAGATGAGCATAGATGTAAAGCATGCAATA
TTTGTGTTAGCTATTGCCCC

Product: succinyl-CoA synthase, alpha subunit

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MSILVNKNTKVIVQGFTGKEATFHAEQCMAYGTNIVGGVTPHKGGQTHLGKPVFDTVADAVKATKADVSLIFVPAFAVGD
SVIEAADAGIKLAVVITEHTPVKDMMFAKQYANKKGMKIIGPNCPGIITSEECKLGIMPGFIFKKGCVGLISKSGTLTYE
AANQVVQGGYGISTAVGIGGDPIIGLAYKELLSEFQKDDETKAIVMIGEIGGSLEVEAAKFIKENISKPVVAFIAGATAP
KGKRMGHAGAIVGSADESAAAKKEALKSYGIHVVDSPALIGEEIQKILG

Sequences:

>Translated_289_residues
MSILVNKNTKVIVQGFTGKEATFHAEQCMAYGTNIVGGVTPHKGGQTHLGKPVFDTVADAVKATKADVSLIFVPAFAVGD
SVIEAADAGIKLAVVITEHTPVKDMMFAKQYANKKGMKIIGPNCPGIITSEECKLGIMPGFIFKKGCVGLISKSGTLTYE
AANQVVQGGYGISTAVGIGGDPIIGLAYKELLSEFQKDDETKAIVMIGEIGGSLEVEAAKFIKENISKPVVAFIAGATAP
KGKRMGHAGAIVGSADESAAAKKEALKSYGIHVVDSPALIGEEIQKILG
>Mature_288_residues
SILVNKNTKVIVQGFTGKEATFHAEQCMAYGTNIVGGVTPHKGGQTHLGKPVFDTVADAVKATKADVSLIFVPAFAVGDS
VIEAADAGIKLAVVITEHTPVKDMMFAKQYANKKGMKIIGPNCPGIITSEECKLGIMPGFIFKKGCVGLISKSGTLTYEA
ANQVVQGGYGISTAVGIGGDPIIGLAYKELLSEFQKDDETKAIVMIGEIGGSLEVEAAKFIKENISKPVVAFIAGATAPK
GKRMGHAGAIVGSADESAAAKKEALKSYGIHVVDSPALIGEEIQKILG

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=289, Percent_Identity=51.9031141868512, Blast_Score=244, Evalue=8e-65,
Organism=Homo sapiens, GI38569423, Length=311, Percent_Identity=29.903536977492, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI38569421, Length=311, Percent_Identity=29.903536977492, Blast_Score=105, Evalue=4e-23,
Organism=Escherichia coli, GI1786949, Length=288, Percent_Identity=59.0277777777778, Blast_Score=331, Evalue=3e-92,
Organism=Caenorhabditis elegans, GI17553126, Length=292, Percent_Identity=52.0547945205479, Blast_Score=283, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI17550194, Length=288, Percent_Identity=52.7777777777778, Blast_Score=281, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI17557344, Length=281, Percent_Identity=29.5373665480427, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17551266, Length=309, Percent_Identity=28.1553398058252, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6324716, Length=292, Percent_Identity=47.6027397260274, Blast_Score=256, Evalue=3e-69,
Organism=Drosophila melanogaster, GI21356559, Length=288, Percent_Identity=50.3472222222222, Blast_Score=282, Evalue=1e-76,
Organism=Drosophila melanogaster, GI28574296, Length=290, Percent_Identity=48.9655172413793, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI281363475, Length=311, Percent_Identity=28.2958199356913, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI281363473, Length=311, Percent_Identity=28.2958199356913, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI281363477, Length=311, Percent_Identity=28.2958199356913, Blast_Score=104, Evalue=5e-23,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 30007; Mature: 29876

Theoretical pI: Translated: 7.98; Mature: 7.98

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSILVNKNTKVIVQGFTGKEATFHAEQCMAYGTNIVGGVTPHKGGQTHLGKPVFDTVADA
CEEEEECCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
VKATKADVSLIFVPAFAVGDSVIEAADAGIKLAVVITEHTPVKDMMFAKQYANKKGMKII
HHHHCCCEEEEEEEHHHHCHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCEEE
GPNCPGIITSEECKLGIMPGFIFKKGCVGLISKSGTLTYEAANQVVQGGYGISTAVGIGG
CCCCCCCEECCCCEEECCCCHHHHHCCHHEEECCCEEEHHHHHHHHHCCCCCEEEECCCC
DPIIGLAYKELLSEFQKDDETKAIVMIGEIGGSLEVEAAKFIKENISKPVVAFIAGATAP
CCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEHHHHHHHHHHCCCCCEEEEECCCCC
KGKRMGHAGAIVGSADESAAAKKEALKSYGIHVVDSPALIGEEIQKILG
CCCCCCCCCEEEECCCHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHC
>Mature Secondary Structure 
SILVNKNTKVIVQGFTGKEATFHAEQCMAYGTNIVGGVTPHKGGQTHLGKPVFDTVADA
EEEEECCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
VKATKADVSLIFVPAFAVGDSVIEAADAGIKLAVVITEHTPVKDMMFAKQYANKKGMKII
HHHHCCCEEEEEEEHHHHCHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCEEE
GPNCPGIITSEECKLGIMPGFIFKKGCVGLISKSGTLTYEAANQVVQGGYGISTAVGIGG
CCCCCCCEECCCCEEECCCCHHHHHCCHHEEECCCEEEHHHHHHHHHCCCCCEEEECCCC
DPIIGLAYKELLSEFQKDDETKAIVMIGEIGGSLEVEAAKFIKENISKPVVAFIAGATAP
CCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEHHHHHHHHHHCCCCCEEEEECCCCC
KGKRMGHAGAIVGSADESAAAKKEALKSYGIHVVDSPALIGEEIQKILG
CCCCCCCCCEEEECCCHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]