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The map label for this gene is hemA [H]

Identifier: 57238258

GI number: 57238258

Start: 582370

End: 583668

Strand: Direct

Name: hemA [H]

Synonym: CJE0646

Alternate gene names: 57238258

Gene position: 582370-583668 (Clockwise)

Preceding gene: 57238259

Following gene: 57238257

Centisome position: 32.76

GC content: 30.79

Gene sequence:

>1299_bases
ATGTATTATTGTATATCTTTTACTCATAAAAATACAGATATTGCCTTAAGGGAAAAGTTAAGCTTTTCCAATGAAGCTAA
AAAAAGTGAGTTTTTAAAAATCATTAGCACTCATGAAAATATTGAAGAATGTTTGGTTATAAGCACTTGCAATCGTGTTG
AAATTGTTGCTTTTGTAAAAATGGCCTGTGCGGAGTTTATTGTTAAATCTTTGGCTTTACTTTGTGATGTTGATAAAGAT
ATTTTACTTGAAAAAGCTGATATTTTTGAAGATAGTGGAGCAATCCACCATCTTTTTTCTGTAGCAAGTTCTTTGGATAG
TTTGGTGGTTGGAGAAACTCAGATAGCAGGACAATTAAAAGATGCCTTTGCTTTTGCTGTAAAAAATAATTTTTGTGGAG
TACACCTTTCAAGAGCAGTACATAGTGCTTTTAAATGTGCTGCTAAGGTACGCAATGAAACTCAAATTTCTAAAAATTCT
ATTTCTGTAGCTAGCGTTGCCGTGGCAAAAGCAAAAGAACTTGCAGATTTAACGCAAAAAAAAGCTGTTGTTATTGGAGC
TGGAGAGATGGGAGAACTTGTGGCAAAACATTTAATTGCTGCGGGTGCTAAGGTGATTATTTTAAATCGTGATTTACAAA
AAGCTAAAGATTTGTGTGAGAGACTTGGTGTTTTAAGCGAATATGATAGTTTAGAAAATTTAAAAAAATATTTAAATCAA
TACGAGTTTTTTTTCTCAGCTACCAATGCACCAAATGCTATTATTACAAATTCTTTAATAGAAGAACTTTCTTATAAAAG
GTATTTTTTTGATATTGCAGTTCCAAGGGATATTGATATCAATGAAAATGAAAATATATCTGTTTTTGCTGTAGATGATC
TTGAAATTGTGGTTCAAAAAAATTTAGCACTAAGAGAACAAGAAGCTCGTATGGCTTATGGGATAATAGGTCGTGAAACA
AGTGAATTTTTTAGGTATTTAAACGATTTGGCTTTGATGCCTATTATCAAAGCTATACGCTTGCAAGCTAAAGAATATGC
AGATAAACAACTTGAAATTGCGTTAAAAAAAGGATATTTGAAAAAATCTGATAAAGAAGAGGCTAGAAAGTTGATTCATC
AAGTTTTTAAGGCTTTTTTACACACGCCTACTGTAAATTTGAAACATTTACAAGGTAAAATGCAAAGCGATACAGTGATT
AATGCTATGCGTTATGTTTTTGATTTGCAAAATAATCTTGAAGGTTTAAATCAATATAAATGTGAATTTGATATGGAGAA
TAATGATGAGATTTACTAA

Upstream 100 bases:

>100_bases
AAGCTAAAACTTATGCAAAAAAGGCTAGAAAAGCAATTGAAAAATATGATAATAACAAGCTTAATGATATTATTAAAGCT
ATGATAGATAGGGAATTTTA

Downstream 100 bases:

>100_bases
ATTTTATGCACCAAGTTTAAAAGAAGCGCCAAAAGATGCGAGTTTACCTAGTCATATTTTTTTAACGCGTGCGGGTTTTG
TAGAACAAATTGGTAGCGGA

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MYYCISFTHKNTDIALREKLSFSNEAKKSEFLKIISTHENIEECLVISTCNRVEIVAFVKMACAEFIVKSLALLCDVDKD
ILLEKADIFEDSGAIHHLFSVASSLDSLVVGETQIAGQLKDAFAFAVKNNFCGVHLSRAVHSAFKCAAKVRNETQISKNS
ISVASVAVAKAKELADLTQKKAVVIGAGEMGELVAKHLIAAGAKVIILNRDLQKAKDLCERLGVLSEYDSLENLKKYLNQ
YEFFFSATNAPNAIITNSLIEELSYKRYFFDIAVPRDIDINENENISVFAVDDLEIVVQKNLALREQEARMAYGIIGRET
SEFFRYLNDLALMPIIKAIRLQAKEYADKQLEIALKKGYLKKSDKEEARKLIHQVFKAFLHTPTVNLKHLQGKMQSDTVI
NAMRYVFDLQNNLEGLNQYKCEFDMENNDEIY

Sequences:

>Translated_432_residues
MYYCISFTHKNTDIALREKLSFSNEAKKSEFLKIISTHENIEECLVISTCNRVEIVAFVKMACAEFIVKSLALLCDVDKD
ILLEKADIFEDSGAIHHLFSVASSLDSLVVGETQIAGQLKDAFAFAVKNNFCGVHLSRAVHSAFKCAAKVRNETQISKNS
ISVASVAVAKAKELADLTQKKAVVIGAGEMGELVAKHLIAAGAKVIILNRDLQKAKDLCERLGVLSEYDSLENLKKYLNQ
YEFFFSATNAPNAIITNSLIEELSYKRYFFDIAVPRDIDINENENISVFAVDDLEIVVQKNLALREQEARMAYGIIGRET
SEFFRYLNDLALMPIIKAIRLQAKEYADKQLEIALKKGYLKKSDKEEARKLIHQVFKAFLHTPTVNLKHLQGKMQSDTVI
NAMRYVFDLQNNLEGLNQYKCEFDMENNDEIY
>Mature_432_residues
MYYCISFTHKNTDIALREKLSFSNEAKKSEFLKIISTHENIEECLVISTCNRVEIVAFVKMACAEFIVKSLALLCDVDKD
ILLEKADIFEDSGAIHHLFSVASSLDSLVVGETQIAGQLKDAFAFAVKNNFCGVHLSRAVHSAFKCAAKVRNETQISKNS
ISVASVAVAKAKELADLTQKKAVVIGAGEMGELVAKHLIAAGAKVIILNRDLQKAKDLCERLGVLSEYDSLENLKKYLNQ
YEFFFSATNAPNAIITNSLIEELSYKRYFFDIAVPRDIDINENENISVFAVDDLEIVVQKNLALREQEARMAYGIIGRET
SEFFRYLNDLALMPIIKAIRLQAKEYADKQLEIALKKGYLKKSDKEEARKLIHQVFKAFLHTPTVNLKHLQGKMQSDTVI
NAMRYVFDLQNNLEGLNQYKCEFDMENNDEIY

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) [H]

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family [H]

Homologues:

Organism=Escherichia coli, GI1787461, Length=399, Percent_Identity=31.8295739348371, Blast_Score=168, Evalue=6e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151 [H]

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH [H]

EC number: =1.2.1.70 [H]

Molecular weight: Translated: 48756; Mature: 48756

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00747 GLUTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYYCISFTHKNTDIALREKLSFSNEAKKSEFLKIISTHENIEECLVISTCNRVEIVAFVK
CEEEEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHEEEECCCCHHHHHHHH
MACAEFIVKSLALLCDVDKDILLEKADIFEDSGAIHHLFSVASSLDSLVVGETQIAGQLK
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHH
DAFAFAVKNNFCGVHLSRAVHSAFKCAAKVRNETQISKNSISVASVAVAKAKELADLTQK
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHC
KAVVIGAGEMGELVAKHLIAAGAKVIILNRDLQKAKDLCERLGVLSEYDSLENLKKYLNQ
CEEEEECCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
YEFFFSATNAPNAIITNSLIEELSYKRYFFDIAVPRDIDINENENISVFAVDDLEIVVQK
HHHHEECCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCEEEEEECCHHHHHHC
NLALREQEARMAYGIIGRETSEFFRYLNDLALMPIIKAIRLQAKEYADKQLEIALKKGYL
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
KKSDKEEARKLIHQVFKAFLHTPTVNLKHLQGKMQSDTVINAMRYVFDLQNNLEGLNQYK
CCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHEE
CEFDMENNDEIY
EEECCCCCCCCC
>Mature Secondary Structure
MYYCISFTHKNTDIALREKLSFSNEAKKSEFLKIISTHENIEECLVISTCNRVEIVAFVK
CEEEEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHEEEECCCCHHHHHHHH
MACAEFIVKSLALLCDVDKDILLEKADIFEDSGAIHHLFSVASSLDSLVVGETQIAGQLK
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHH
DAFAFAVKNNFCGVHLSRAVHSAFKCAAKVRNETQISKNSISVASVAVAKAKELADLTQK
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHC
KAVVIGAGEMGELVAKHLIAAGAKVIILNRDLQKAKDLCERLGVLSEYDSLENLKKYLNQ
CEEEEECCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
YEFFFSATNAPNAIITNSLIEELSYKRYFFDIAVPRDIDINENENISVFAVDDLEIVVQK
HHHHEECCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCEEEEEECCHHHHHHC
NLALREQEARMAYGIIGRETSEFFRYLNDLALMPIIKAIRLQAKEYADKQLEIALKKGYL
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
KKSDKEEARKLIHQVFKAFLHTPTVNLKHLQGKMQSDTVINAMRYVFDLQNNLEGLNQYK
CCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHEE
CEFDMENNDEIY
EEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA