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The map label for this gene is guaA [H]

Identifier: 57238122

GI number: 57238122

Start: 1297245

End: 1298780

Strand: Direct

Name: guaA [H]

Synonym: CJE1385

Alternate gene names: 57238122

Gene position: 1297245-1298780 (Clockwise)

Preceding gene: 57238121

Following gene: 57238123

Centisome position: 72.97

GC content: 35.29

Gene sequence:

>1536_bases
ATGAAAAAAGCAGATATTTTAGTTTTAGACTTTGGCTCTCAATACACTCAGCTTATAGCAAGACGCTTAAGGGAACAAGG
AGTTTATGCAGAAATTTTACCTTTTAATGTAAGCTTGACTGATATTAAGGCGAAAGAACCAAAAGGTATTATTTTAAGCG
GAGGTCCAGCAAGCGTATATGCAACTGATGCGTATTTTTGCGATAAAGGCATATTTGACTTAAATCTACCTATTCTTGGA
ATTTGTTATGGTATGCAACTCATGGCACATCATTACAAAGCTACAGTAGCACCTGCAGGACATAAAGAATACGGCAAAGC
AAACATAGAAATTAAAAAAGATAACGCTTTGTTTAAAAATCTTCCAAAAAAACAAACCGTTTGGATGAGTCATTCTGATA
AAGTAGAAAATTTACCTCAAGGTTTTGAAGTTTTAGCCACAAGTGAAAATAGCCCTTTTTGTGTTTTTGGAAACGAAGAT
AAGAAATTCTTTGCTCTACAATTTCACCCAGAAGTACAACACAGCGAATTTGGCAAAAATATCTTAAAAAATTTTGCTAA
ATATGCTTGCAATTGTGAAAGTGTTTGGAATATGGGTTCTTTTGCAAAAACTCAAGCAGAAAAAATCCGTGAAGAAGTAG
GCAATGATAAAGTGCTTTGTGCTGTAAGTGGCGGAGTAGATAGTAGCGTAGTTGCTGCACTTTTAGCTAGCGCTATAAAA
GAGCAAGTTATAGTAGTTTTTGTAGATAATGGACTTTTAAGAAGTAGAGAAAAAGAACAAGTTGAATTTATGTTTAAAAA
CACTTTAGGCATCGATCTCATCAGCATTGATGCAAGTGAAATTTTCTTAAGTCGCTTAGCTAATGTCACAGATCCTGAAC
AAAAAAGAAAAATCATAGGAAATACCTTTATAGAAGTTTTTGAAGAAGAAGCAAAAAAACATAAAGATGTAAAATATCTC
GCTCAAGGCACACTTTATACTGATATCATAGAAAGTTCTGTTGTAGGTGCAAGCAAAACCATTAAAAGCCATCATAATGT
AGGGGGCTTACCTGAAAAAATGAATCTTAAACTCATAGAGCCTTTAAAAGAAATTTTTAAAGATGAAGTGCGTGCCTTAG
GACTTGAGCTTGGACTTAGTAAAGAAGTAGTTTATCGTCATCCTTTCCCTGGACCAGGTCTTGCTATACGTATTATGGGA
GAAGTAAATCGCCCTGGCTTAGAACTATTGCGCAAGGCTGATGTAATTTTACTTGAAGAACTTAAAAGTACAGGTTGGTA
TGATAAAACTTGGCAAGCATTTTGCGTACTTTTAAATGTTAAAAGCGTTGGAGTTATGGGGGATAATCGCACTTATGATA
ATGCAGTTTGCATACGCGTTGTAGATGCAAGCGATGGCATGACAGCTACTTTCTCGCATTTACCTTACGAAGTTTTAGAA
AACATAAGTCGCCGTATCATCAATGAAGTAGAAGGTATAAACCGCGTTGTTTATGATATCTCAAGCAAACCACCTGCAAC
CATAGAATGGGAATGA

Upstream 100 bases:

>100_bases
TGCTTGCGGATATAAAGGCAACCCTCAATACACAAGCTATGAACAAAATGGTTCGGTAAAAACCATTAAAAAATACGAAC
AATTACATAGGTGGTAAATA

Downstream 100 bases:

>100_bases
TCCATTTTTTCTAGCACTTATTTTTATTATAAAATTTTTATAAAAATAAGGCTAGAATTTATTCAAGAAATTTCAAGGAA
GAAATATGCATGGAAAAATA

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 511; Mature: 511

Protein sequence:

>511_residues
MKKADILVLDFGSQYTQLIARRLREQGVYAEILPFNVSLTDIKAKEPKGIILSGGPASVYATDAYFCDKGIFDLNLPILG
ICYGMQLMAHHYKATVAPAGHKEYGKANIEIKKDNALFKNLPKKQTVWMSHSDKVENLPQGFEVLATSENSPFCVFGNED
KKFFALQFHPEVQHSEFGKNILKNFAKYACNCESVWNMGSFAKTQAEKIREEVGNDKVLCAVSGGVDSSVVAALLASAIK
EQVIVVFVDNGLLRSREKEQVEFMFKNTLGIDLISIDASEIFLSRLANVTDPEQKRKIIGNTFIEVFEEEAKKHKDVKYL
AQGTLYTDIIESSVVGASKTIKSHHNVGGLPEKMNLKLIEPLKEIFKDEVRALGLELGLSKEVVYRHPFPGPGLAIRIMG
EVNRPGLELLRKADVILLEELKSTGWYDKTWQAFCVLLNVKSVGVMGDNRTYDNAVCIRVVDASDGMTATFSHLPYEVLE
NISRRIINEVEGINRVVYDISSKPPATIEWE

Sequences:

>Translated_511_residues
MKKADILVLDFGSQYTQLIARRLREQGVYAEILPFNVSLTDIKAKEPKGIILSGGPASVYATDAYFCDKGIFDLNLPILG
ICYGMQLMAHHYKATVAPAGHKEYGKANIEIKKDNALFKNLPKKQTVWMSHSDKVENLPQGFEVLATSENSPFCVFGNED
KKFFALQFHPEVQHSEFGKNILKNFAKYACNCESVWNMGSFAKTQAEKIREEVGNDKVLCAVSGGVDSSVVAALLASAIK
EQVIVVFVDNGLLRSREKEQVEFMFKNTLGIDLISIDASEIFLSRLANVTDPEQKRKIIGNTFIEVFEEEAKKHKDVKYL
AQGTLYTDIIESSVVGASKTIKSHHNVGGLPEKMNLKLIEPLKEIFKDEVRALGLELGLSKEVVYRHPFPGPGLAIRIMG
EVNRPGLELLRKADVILLEELKSTGWYDKTWQAFCVLLNVKSVGVMGDNRTYDNAVCIRVVDASDGMTATFSHLPYEVLE
NISRRIINEVEGINRVVYDISSKPPATIEWE
>Mature_511_residues
MKKADILVLDFGSQYTQLIARRLREQGVYAEILPFNVSLTDIKAKEPKGIILSGGPASVYATDAYFCDKGIFDLNLPILG
ICYGMQLMAHHYKATVAPAGHKEYGKANIEIKKDNALFKNLPKKQTVWMSHSDKVENLPQGFEVLATSENSPFCVFGNED
KKFFALQFHPEVQHSEFGKNILKNFAKYACNCESVWNMGSFAKTQAEKIREEVGNDKVLCAVSGGVDSSVVAALLASAIK
EQVIVVFVDNGLLRSREKEQVEFMFKNTLGIDLISIDASEIFLSRLANVTDPEQKRKIIGNTFIEVFEEEAKKHKDVKYL
AQGTLYTDIIESSVVGASKTIKSHHNVGGLPEKMNLKLIEPLKEIFKDEVRALGLELGLSKEVVYRHPFPGPGLAIRIMG
EVNRPGLELLRKADVILLEELKSTGWYDKTWQAFCVLLNVKSVGVMGDNRTYDNAVCIRVVDASDGMTATFSHLPYEVLE
NISRRIINEVEGINRVVYDISSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=552, Percent_Identity=38.5869565217391, Blast_Score=316, Evalue=3e-86,
Organism=Escherichia coli, GI1788854, Length=521, Percent_Identity=51.6314779270633, Blast_Score=555, Evalue=1e-159,
Organism=Escherichia coli, GI1789760, Length=151, Percent_Identity=32.4503311258278, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI133901714, Length=570, Percent_Identity=35.2631578947368, Blast_Score=279, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI71992717, Length=570, Percent_Identity=35.2631578947368, Blast_Score=279, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI71992710, Length=570, Percent_Identity=35.2631578947368, Blast_Score=279, Evalue=3e-75,
Organism=Saccharomyces cerevisiae, GI6323873, Length=514, Percent_Identity=53.6964980544747, Blast_Score=546, Evalue=1e-156,
Organism=Drosophila melanogaster, GI281365319, Length=549, Percent_Identity=36.6120218579235, Blast_Score=301, Evalue=6e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 57046; Mature: 57046

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKADILVLDFGSQYTQLIARRLREQGVYAEILPFNVSLTDIKAKEPKGIILSGGPASVY
CCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEEEEEEEECCCCCCCEEEEECCCCEEE
ATDAYFCDKGIFDLNLPILGICYGMQLMAHHYKATVAPAGHKEYGKANIEIKKDNALFKN
EECCEECCCCCEECCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCCEEEEEECCCHHHHC
LPKKQTVWMSHSDKVENLPQGFEVLATSENSPFCVFGNEDKKFFALQFHPEVQHSEFGKN
CCCCCEEEECCCCHHHCCCCCCEEEEECCCCCEEEECCCCCEEEEEEECCCCCHHHHHHH
ILKNFAKYACNCESVWNMGSFAKTQAEKIREEVGNDKVLCAVSGGVDSSVVAALLASAIK
HHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHH
EQVIVVFVDNGLLRSREKEQVEFMFKNTLGIDLISIDASEIFLSRLANVTDPEQKRKIIG
CCEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCCHHHHHHHHH
NTFIEVFEEEAKKHKDVKYLAQGTLYTDIIESSVVGASKTIKSHHNVGGLPEKMNLKLIE
HHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCHHHHH
PLKEIFKDEVRALGLELGLSKEVVYRHPFPGPGLAIRIMGEVNRPGLELLRKADVILLEE
HHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCEEEEEEECCCCCHHHHHHHCCHHHHHH
LKSTGWYDKTWQAFCVLLNVKSVGVMGDNRTYDNAVCIRVVDASDGMTATFSHLPYEVLE
HHHCCCCCHHHHHHEEEEEHHHEEEECCCCCCCCEEEEEEEECCCCCEEEHHCCCHHHHH
NISRRIINEVEGINRVVYDISSKPPATIEWE
HHHHHHHHHHHHHHEEEEECCCCCCCEEECC
>Mature Secondary Structure
MKKADILVLDFGSQYTQLIARRLREQGVYAEILPFNVSLTDIKAKEPKGIILSGGPASVY
CCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEEEEEEEECCCCCCCEEEEECCCCEEE
ATDAYFCDKGIFDLNLPILGICYGMQLMAHHYKATVAPAGHKEYGKANIEIKKDNALFKN
EECCEECCCCCEECCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCCEEEEEECCCHHHHC
LPKKQTVWMSHSDKVENLPQGFEVLATSENSPFCVFGNEDKKFFALQFHPEVQHSEFGKN
CCCCCEEEECCCCHHHCCCCCCEEEEECCCCCEEEECCCCCEEEEEEECCCCCHHHHHHH
ILKNFAKYACNCESVWNMGSFAKTQAEKIREEVGNDKVLCAVSGGVDSSVVAALLASAIK
HHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHH
EQVIVVFVDNGLLRSREKEQVEFMFKNTLGIDLISIDASEIFLSRLANVTDPEQKRKIIG
CCEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCCHHHHHHHHH
NTFIEVFEEEAKKHKDVKYLAQGTLYTDIIESSVVGASKTIKSHHNVGGLPEKMNLKLIE
HHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCHHHHH
PLKEIFKDEVRALGLELGLSKEVVYRHPFPGPGLAIRIMGEVNRPGLELLRKADVILLEE
HHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCEEEEEEECCCCCHHHHHHHCCHHHHHH
LKSTGWYDKTWQAFCVLLNVKSVGVMGDNRTYDNAVCIRVVDASDGMTATFSHLPYEVLE
HHHCCCCCHHHHHHEEEEEHHHEEEECCCCCCCCEEEEEEEECCCCCEEEHHCCCHHHHH
NISRRIINEVEGINRVVYDISSKPPATIEWE
HHHHHHHHHHHHHHEEEEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA