Click here to switch to the map view.

The map label for this gene is dnaX [H]

Identifier: 57238032

GI number: 57238032

Start: 1210431

End: 1211960

Strand: Direct

Name: dnaX [H]

Synonym: CJE1293

Alternate gene names: 57238032

Gene position: 1210431-1211960 (Clockwise)

Preceding gene: 57238031

Following gene: 57238039

Centisome position: 68.08

GC content: 31.96

Gene sequence:

>1530_bases
ATGCTTCAAGCTTTAGCGATTAAATACAGACCAAAAACCTTTGATGAACTCATAGGACAAAAGACAGTTAGCGTAAGTTT
AAAATACGCCCTAAATCATAATCGCTTAGCTCATGCTTATCTTTTTTCAGGACTTAGAGGAAGTGGAAAAACTTCAAGTG
CTAGAATTTTTTCTCGTGCTTTAGTTTGCGAACAAGGACCAAGTGATACTCCATGTGGCACTTGCAAACACTGTCTTGCA
GCACTTGAAGGCAAACATATAGACATTATAGAAATGGATGCTGCAAGCAACCGTGGGCTTGAAGATATACAAGCCTTAAT
CGAACAAACCAAATACACCCCTTCTATGGCAAGATTTAAAATTTTCATCATTGATGAAGTACATATGCTTACCCCACAGG
CTGCAAATGCACTTTTAAAAACCTTAGAAGAACCCCCAAGTTATGTTAAATTTATACTTGCAACCACAGATCCTTTAAAA
CTCCCAGCTACCGTGCTTTCAAGAACGCAACATTTTCGCTTTAAACAAATTCCCCAGAGTGAAATTTTAAATCATCTTAA
AGAAATTTTACTTAAAGAAAATGTTAAATTTGAAGAAGAAGCTTTAAAATTTATAGCAAGAAGTGGCAACGGATCTTTAA
GAGATACTTTAACCTTGCTTGATCAAGCCATTATTTTTTGTCAAAATGAAATCAGCATTAGTAAAACTACAGATATGCTA
GGATTTTTAGATCCTGAAAAAATCAAAGCCTTTTATCAGGCTATTTTAACAAAAGACAAAGAAAAAGTTTTTGCATACTT
AGAAGAACTACAAGACTATGAAGCCTCAAGCGTGATCGATGAAATGCTTTTTTATTTAAAAGAAAGTTTTTTTGCAAAAA
GTACAGAATTTTCTACTTTAATTTATGAAAGATTTTTCCGTATTTTATCAAAAGCTAAAAATATGCTTTGCGATGATGAT
GGCTTTACGATTTGTGTTATGGCTTTTATGATGATGGAAGCAAGCCATTTAAAAGAAATTGATGCACAAATCCAAGAAAT
CAAACAAGAAAATACAACAAATATTACACCTAGGATCACACCTTCTCCTATCATACCTAATCTTGAGAAAAAAATAGAAA
AAAATGCTTATGAAATCTTGCTTGATAGTATTTATGATAGGGATTTTGATCTTGCAGAATGCTTTAAACAAAGCACGAAA
TTTATTAGTTTTGAAAACAATACCTTAAATATAAGCTCAAATGCACAAGGACAAAATCGCGATACACTCAATAAAGGCTT
TAAACTCATACAAGAACTTTTTAAGGCTAAATTTGGGGAAAATGCTAAAATTAATGTGCAAAAAGTACTAACAATTGATG
AAAATAAGCTTCAATCCTTAACTCAAGAATTACCAAACAATGAAAATAAAAACATAGATATTCAAAGTTCTATTAATATG
CTTAAAGAAGGGGCCAAAAAATTTGACCCACAAGAAGATCTTAAAGAGGCTCTTAAAGATTGTTTTGGAGAGCCTAGTAT
AGAAAATTAA

Upstream 100 bases:

>100_bases
TTCTCAAATGGATGATGTTGAAGCGTTGAAATTTTTATATTCTAAAATGCTTAAAACCAAAGACAATGTAGAACTTTTAT
CTATAATGAACGAGTAGAAA

Downstream 100 bases:

>100_bases
TCATTTTTAAGAGAGATGAAAATCAAAGCCAAAAACATATAAGTTACCAATCTTGTAGTATCAGGTAAACCTTTCCAAAC
CTTACTCATCCACATTCCAA

Product: DNA polymerase III subunits gamma/tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MLQALAIKYRPKTFDELIGQKTVSVSLKYALNHNRLAHAYLFSGLRGSGKTSSARIFSRALVCEQGPSDTPCGTCKHCLA
ALEGKHIDIIEMDAASNRGLEDIQALIEQTKYTPSMARFKIFIIDEVHMLTPQAANALLKTLEEPPSYVKFILATTDPLK
LPATVLSRTQHFRFKQIPQSEILNHLKEILLKENVKFEEEALKFIARSGNGSLRDTLTLLDQAIIFCQNEISISKTTDML
GFLDPEKIKAFYQAILTKDKEKVFAYLEELQDYEASSVIDEMLFYLKESFFAKSTEFSTLIYERFFRILSKAKNMLCDDD
GFTICVMAFMMMEASHLKEIDAQIQEIKQENTTNITPRITPSPIIPNLEKKIEKNAYEILLDSIYDRDFDLAECFKQSTK
FISFENNTLNISSNAQGQNRDTLNKGFKLIQELFKAKFGENAKINVQKVLTIDENKLQSLTQELPNNENKNIDIQSSINM
LKEGAKKFDPQEDLKEALKDCFGEPSIEN

Sequences:

>Translated_509_residues
MLQALAIKYRPKTFDELIGQKTVSVSLKYALNHNRLAHAYLFSGLRGSGKTSSARIFSRALVCEQGPSDTPCGTCKHCLA
ALEGKHIDIIEMDAASNRGLEDIQALIEQTKYTPSMARFKIFIIDEVHMLTPQAANALLKTLEEPPSYVKFILATTDPLK
LPATVLSRTQHFRFKQIPQSEILNHLKEILLKENVKFEEEALKFIARSGNGSLRDTLTLLDQAIIFCQNEISISKTTDML
GFLDPEKIKAFYQAILTKDKEKVFAYLEELQDYEASSVIDEMLFYLKESFFAKSTEFSTLIYERFFRILSKAKNMLCDDD
GFTICVMAFMMMEASHLKEIDAQIQEIKQENTTNITPRITPSPIIPNLEKKIEKNAYEILLDSIYDRDFDLAECFKQSTK
FISFENNTLNISSNAQGQNRDTLNKGFKLIQELFKAKFGENAKINVQKVLTIDENKLQSLTQELPNNENKNIDIQSSINM
LKEGAKKFDPQEDLKEALKDCFGEPSIEN
>Mature_509_residues
MLQALAIKYRPKTFDELIGQKTVSVSLKYALNHNRLAHAYLFSGLRGSGKTSSARIFSRALVCEQGPSDTPCGTCKHCLA
ALEGKHIDIIEMDAASNRGLEDIQALIEQTKYTPSMARFKIFIIDEVHMLTPQAANALLKTLEEPPSYVKFILATTDPLK
LPATVLSRTQHFRFKQIPQSEILNHLKEILLKENVKFEEEALKFIARSGNGSLRDTLTLLDQAIIFCQNEISISKTTDML
GFLDPEKIKAFYQAILTKDKEKVFAYLEELQDYEASSVIDEMLFYLKESFFAKSTEFSTLIYERFFRILSKAKNMLCDDD
GFTICVMAFMMMEASHLKEIDAQIQEIKQENTTNITPRITPSPIIPNLEKKIEKNAYEILLDSIYDRDFDLAECFKQSTK
FISFENNTLNISSNAQGQNRDTLNKGFKLIQELFKAKFGENAKINVQKVLTIDENKLQSLTQELPNNENKNIDIQSSINM
LKEGAKKFDPQEDLKEALKDCFGEPSIEN

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=287, Percent_Identity=28.2229965156794, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI31881687, Length=287, Percent_Identity=28.2229965156794, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI194306571, Length=216, Percent_Identity=26.8518518518519, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI194306567, Length=216, Percent_Identity=26.8518518518519, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI6677723, Length=216, Percent_Identity=26.8518518518519, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI31563534, Length=214, Percent_Identity=28.9719626168224, Blast_Score=77, Evalue=5e-14,
Organism=Escherichia coli, GI1786676, Length=286, Percent_Identity=44.7552447552448, Blast_Score=261, Evalue=8e-71,
Organism=Caenorhabditis elegans, GI17554730, Length=270, Percent_Identity=26.6666666666667, Blast_Score=89, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17541988, Length=220, Percent_Identity=25.9090909090909, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71986063, Length=288, Percent_Identity=22.5694444444444, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324039, Length=281, Percent_Identity=27.0462633451957, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6322528, Length=332, Percent_Identity=25.6024096385542, Blast_Score=84, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6324478, Length=223, Percent_Identity=25.1121076233184, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI18859927, Length=283, Percent_Identity=25.4416961130742, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI17647857, Length=214, Percent_Identity=28.0373831775701, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI19921076, Length=220, Percent_Identity=25.4545454545455, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 57924; Mature: 57924

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQALAIKYRPKTFDELIGQKTVSVSLKYALNHNRLAHAYLFSGLRGSGKTSSARIFSRA
CCCCEEEEECCCHHHHHHCCHHHEEEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHH
LVCEQGPSDTPCGTCKHCLAALEGKHIDIIEMDAASNRGLEDIQALIEQTKYTPSMARFK
HHHCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCHHEEE
IFIIDEVHMLTPQAANALLKTLEEPPSYVKFILATTDPLKLPATVLSRTQHFRFKQIPQS
EEEEECHHHCCHHHHHHHHHHHHCCHHHHEEEEECCCCCCCCHHHHHHHHHHHHHCCCHH
EILNHLKEILLKENVKFEEEALKFIARSGNGSLRDTLTLLDQAIIFCQNEISISKTTDML
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHH
GFLDPEKIKAFYQAILTKDKEKVFAYLEELQDYEASSVIDEMLFYLKESFFAKSTEFSTL
HCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHH
IYERFFRILSKAKNMLCDDDGFTICVMAFMMMEASHLKEIDAQIQEIKQENTTNITPRIT
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
PSPIIPNLEKKIEKNAYEILLDSIYDRDFDLAECFKQSTKFISFENNTLNISSNAQGQNR
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCEEEECCCEEEECCCCCCCCH
DTLNKGFKLIQELFKAKFGENAKINVQKVLTIDENKLQSLTQELPNNENKNIDIQSSINM
HHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECHHHHHHHHHHCCCCCCCCEEHHHHHHH
LKEGAKKFDPQEDLKEALKDCFGEPSIEN
HHHHHHHCCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLQALAIKYRPKTFDELIGQKTVSVSLKYALNHNRLAHAYLFSGLRGSGKTSSARIFSRA
CCCCEEEEECCCHHHHHHCCHHHEEEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHH
LVCEQGPSDTPCGTCKHCLAALEGKHIDIIEMDAASNRGLEDIQALIEQTKYTPSMARFK
HHHCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCHHEEE
IFIIDEVHMLTPQAANALLKTLEEPPSYVKFILATTDPLKLPATVLSRTQHFRFKQIPQS
EEEEECHHHCCHHHHHHHHHHHHCCHHHHEEEEECCCCCCCCHHHHHHHHHHHHHCCCHH
EILNHLKEILLKENVKFEEEALKFIARSGNGSLRDTLTLLDQAIIFCQNEISISKTTDML
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHH
GFLDPEKIKAFYQAILTKDKEKVFAYLEELQDYEASSVIDEMLFYLKESFFAKSTEFSTL
HCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHH
IYERFFRILSKAKNMLCDDDGFTICVMAFMMMEASHLKEIDAQIQEIKQENTTNITPRIT
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
PSPIIPNLEKKIEKNAYEILLDSIYDRDFDLAECFKQSTKFISFENNTLNISSNAQGQNR
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCEEEECCCEEEECCCCCCCCH
DTLNKGFKLIQELFKAKFGENAKINVQKVLTIDENKLQSLTQELPNNENKNIDIQSSINM
HHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECHHHHHHHHHHCCCCCCCCEEHHHHHHH
LKEGAKKFDPQEDLKEALKDCFGEPSIEN
HHHHHHHCCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]