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The map label for this gene is ldh [H]

Identifier: 57238039

GI number: 57238039

Start: 1217523

End: 1218449

Strand: Direct

Name: ldh [H]

Synonym: CJE1301

Alternate gene names: 57238039

Gene position: 1217523-1218449 (Clockwise)

Preceding gene: 57238032

Following gene: 57238045

Centisome position: 68.48

GC content: 30.31

Gene sequence:

>927_bases
ATGGCAAAAATCGGTATAGTTGGTTTAGGTTATGTAGGAGCTGCTAGTGCTTATAGCATAGTTACTCAAGGAATTTGTTC
AGAACTTTACTTATATGATATAAAACAAGATTTAGCTCTAGCTCATGCAAGAGATTTGGAAGATATGTCAGCCATTCATT
TTTCTTATACAAAAATTTTTCATGTGCCAAATTTAGAAAATTTAGCTTCTTGCGATATTATCATTTTAGCTTTTAGAAAA
GAAAGCTTAAAAGAATTACCTAGTCGCTTAGTAGAACTTCAAAACAATATCCTCGAACTTAAAGACATTGTCTTAACCTT
AAAAAATGCTAATTTTAAAGGCAAATACATTGTCGCAACAAATCCAAATGACACCATAACTTACTACACTCAAGTATTAA
GCCAATTACCTAAAAATCATGTTTTTGGTAGTGGAACAAATTTAGATAGTTCAAGACTTAAGAAATTTTTAGCCAAAGAT
TTAAACATAAATTCAAAAGATATTTTTGCTTGTATGATTGGTGAACATGGAGATTCTCAGTTTGCAGCACTTTCTAATGC
AAGCGTTTTAGGACAAAATTTATTAGATTTTTATAAGCAAAAATTAGGCAAAGATTTAGACATACAAGAACTCGAAAAAG
CCGTGATTAGCGAGGGATATTTCATCTATGAACGCAAAGGAAGAACAGAATTTGGCATAGGAACTTCTTGTGTAAATTTG
GCCAAAGCCGTCCTAGAAGATAGAAAAAGTTTACATCCTGTAAGTGTGGTTTTTGATGATATAGCTTTTTCAATGCCCGC
TATCATAGGAAAAGATGGTATAGAAAAGGTTTTTGAATTAAAATTCAATGAAAAAGAAAAAATAAAATTAGAAAATTCAA
AACAACAAATCAAAAACGCCATACAAAGCGTAAAAGATAAAATTTAA

Upstream 100 bases:

>100_bases
AATTAGTTAATCTTTGTATATCAGGTTTTTCCATATTTTAATAATCTTTGATTGAATTTGTTATAATTATAGCAAATTTT
AAAATAAATAAGGAGAAAAA

Downstream 100 bases:

>100_bases
GCCTTTTTAAAAGGCTTTTTGATTTTGATATATAAATTAAACTTGCTAAAATCACAAAAACAATTATAATGATTAAAATT
TGAGTTAAATAAGTTTTAAT

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: L-LDH [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MAKIGIVGLGYVGAASAYSIVTQGICSELYLYDIKQDLALAHARDLEDMSAIHFSYTKIFHVPNLENLASCDIIILAFRK
ESLKELPSRLVELQNNILELKDIVLTLKNANFKGKYIVATNPNDTITYYTQVLSQLPKNHVFGSGTNLDSSRLKKFLAKD
LNINSKDIFACMIGEHGDSQFAALSNASVLGQNLLDFYKQKLGKDLDIQELEKAVISEGYFIYERKGRTEFGIGTSCVNL
AKAVLEDRKSLHPVSVVFDDIAFSMPAIIGKDGIEKVFELKFNEKEKIKLENSKQQIKNAIQSVKDKI

Sequences:

>Translated_308_residues
MAKIGIVGLGYVGAASAYSIVTQGICSELYLYDIKQDLALAHARDLEDMSAIHFSYTKIFHVPNLENLASCDIIILAFRK
ESLKELPSRLVELQNNILELKDIVLTLKNANFKGKYIVATNPNDTITYYTQVLSQLPKNHVFGSGTNLDSSRLKKFLAKD
LNINSKDIFACMIGEHGDSQFAALSNASVLGQNLLDFYKQKLGKDLDIQELEKAVISEGYFIYERKGRTEFGIGTSCVNL
AKAVLEDRKSLHPVSVVFDDIAFSMPAIIGKDGIEKVFELKFNEKEKIKLENSKQQIKNAIQSVKDKI
>Mature_307_residues
AKIGIVGLGYVGAASAYSIVTQGICSELYLYDIKQDLALAHARDLEDMSAIHFSYTKIFHVPNLENLASCDIIILAFRKE
SLKELPSRLVELQNNILELKDIVLTLKNANFKGKYIVATNPNDTITYYTQVLSQLPKNHVFGSGTNLDSSRLKKFLAKDL
NINSKDIFACMIGEHGDSQFAALSNASVLGQNLLDFYKQKLGKDLDIQELEKAVISEGYFIYERKGRTEFGIGTSCVNLA
KAVLEDRKSLHPVSVVFDDIAFSMPAIIGKDGIEKVFELKFNEKEKIKLENSKQQIKNAIQSVKDKI

Specific function: Unknown

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. LDH family [H]

Homologues:

Organism=Homo sapiens, GI47059044, Length=309, Percent_Identity=33.0097087378641, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI221136809, Length=309, Percent_Identity=33.0097087378641, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI15082234, Length=312, Percent_Identity=30.4487179487179, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI9257228, Length=308, Percent_Identity=31.1688311688312, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI4504973, Length=308, Percent_Identity=31.1688311688312, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI5031857, Length=301, Percent_Identity=30.5647840531561, Blast_Score=144, Evalue=9e-35,
Organism=Homo sapiens, GI260099723, Length=301, Percent_Identity=30.5647840531561, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI291575128, Length=316, Percent_Identity=31.0126582278481, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI4557032, Length=316, Percent_Identity=31.0126582278481, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI207028494, Length=301, Percent_Identity=26.9102990033223, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI260099727, Length=217, Percent_Identity=31.3364055299539, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI260099725, Length=217, Percent_Identity=30.4147465437788, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI103472011, Length=315, Percent_Identity=26.984126984127, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI103472015, Length=187, Percent_Identity=31.5508021390374, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17535107, Length=301, Percent_Identity=30.2325581395349, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17136226, Length=311, Percent_Identity=32.1543408360129, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI45550422, Length=302, Percent_Identity=28.476821192053, Blast_Score=128, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001557
- InterPro:   IPR011304
- InterPro:   IPR018177
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N [H]

EC number: =1.1.1.27 [H]

Molecular weight: Translated: 34364; Mature: 34233

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: PS00064 L_LDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIGIVGLGYVGAASAYSIVTQGICSELYLYDIKQDLALAHARDLEDMSAIHFSYTKIF
CCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHEEE
HVPNLENLASCDIIILAFRKESLKELPSRLVELQNNILELKDIVLTLKNANFKGKYIVAT
ECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
NPNDTITYYTQVLSQLPKNHVFGSGTNLDSSRLKKFLAKDLNINSKDIFACMIGEHGDSQ
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCH
FAALSNASVLGQNLLDFYKQKLGKDLDIQELEKAVISEGYFIYERKGRTEFGIGTSCVNL
HHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHH
AKAVLEDRKSLHPVSVVFDDIAFSMPAIIGKDGIEKVFELKFNEKEKIKLENSKQQIKNA
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHEEECCHHHHHHHH
IQSVKDKI
HHHHHHCC
>Mature Secondary Structure 
AKIGIVGLGYVGAASAYSIVTQGICSELYLYDIKQDLALAHARDLEDMSAIHFSYTKIF
CCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHEEE
HVPNLENLASCDIIILAFRKESLKELPSRLVELQNNILELKDIVLTLKNANFKGKYIVAT
ECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
NPNDTITYYTQVLSQLPKNHVFGSGTNLDSSRLKKFLAKDLNINSKDIFACMIGEHGDSQ
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCH
FAALSNASVLGQNLLDFYKQKLGKDLDIQELEKAVISEGYFIYERKGRTEFGIGTSCVNL
HHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHH
AKAVLEDRKSLHPVSVVFDDIAFSMPAIIGKDGIEKVFELKFNEKEKIKLENSKQQIKNA
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHEEECCHHHHHHHH
IQSVKDKI
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11889109 [H]