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The map label for this gene is sdhA [H]

Identifier: 57237493

GI number: 57237493

Start: 443615

End: 445345

Strand: Direct

Name: sdhA [H]

Synonym: CJE0488

Alternate gene names: 57237493

Gene position: 443615-445345 (Clockwise)

Preceding gene: 57237492

Following gene: 57237494

Centisome position: 24.95

GC content: 37.26

Gene sequence:

>1731_bases
ATGGATAAAGATATAAATTTACCTTCTTGCGATGTTTTGGTAATTGGATCAGGTGGAGCAGGTTTGCGTGCTGCAGCCGC
AGTGAGAAAAGAAAATCCAAAATTAAGCGTTGTAGTAGCTACAAAGATGATGCCATCGCGTAACGCAACTTGTATGGCAG
AGGGTGGAATTAATGGAGTTACTGATTTTTCTAATGGAGATTCCTATAAATTACATGCTTATGATACTATTAAAGGCGGA
GCTTATTTGGTAGATCAAGACGCGGCTTTAAAATTTTGCGAATTAGCTGGAAAGGCTATTTTTAATATGGATTTTATAGG
AACCTTGTTTTCAAGAAATGAGCAAGGTGGAGTAGCTCAGCGTTTAATGGGAGGAGCTTCTAAGAAACGCTGTAACTATT
CTGCAGATAAAACAGGTCATATTTTAATGCATTCTTGTTTAGATGATGCTATTAGTAGTGGTGTGAAATTTTTAATGGAT
CATGAACTTTTGGATATAGGTGTTGTGGATGGAAAATGCGAGGGTGTCGTTTTAAGAGATATACAAAGCGGTGGAATTTA
TCCTGTGTTATGCAAAGCTTTGGTGATTGCTACAGGGGGATACACAAGGATATTTTATAATAGAACTTCAACTCCTTTTA
TTGCCACAGGAGATGGTGTGGCAGCTGCTCTTAGAGCAGGACTTGGTTTTGAAGATCCTGAGATGATACAATTTCACCCA
ACAGGAGTTGCAAATGGTGGAACTCTTATTACAGAAGCGGCGCGCGGTGAAGGGGGATATCTTTTAAATAATCGTGGTGA
GCGTTTTATGAAAAATTACCATGAAAAAATGGAGCTTGCACCGCGAGATGTGGTTGCGCGTGCTATAGAAACAGAAATTC
GTGAAGGTAGAGGTTATGGCGAGGGACTTGGAGCTTATGTTTTGTGCGATGTACGCCACTTAGGAAAAGAAAAAATTTTA
AAAGATTTACCAAAAATTCGTCACACTGCAATGCTTTTTGAAAATATTGATTTAGTAGATACTCCTGTACCTATCCGTCC
AACGGCACATTATTCTATGGGTGGAATTGAAGTGGCTAAATTTGAAGATATGAGTACTAAAATTGCTGGAATTTATGTAG
GTGGAGAAGCTTCTTGCATTTCTATACATGGAGCTAATAGACTAGGGGGAAATTCTTTAGCCGATGCAGTTGTAACAGGG
CATTTAGCAGGCATTGGTGCGACAAATTATGCTAAAGATGCAAGTTTTGGAAAAGGGGCAAAAACTCATGAACTTGCTCA
AAAATGGCAGGTTAGATTTAAAGAAATTACAAATAATGGCGGAAATGGTCAAGAAATGTATGAATTGCGAGAAGAGCTAG
GAAGTCAAAATTGGGATAATATGGGGATTTTTAGAACTCAAGAAAAACTCGATCTTCTAGCAAAAAAATTAGAAGATATA
CAAGCGAGATATGAAAAAATTCGTATTCCAAATCCTAATGAAGTGATGAATACTGCTTTTACAGATTATGTAGAGCTTGG
TAATTTGATTTTACTTTCTCGCTGTGCTTGTTTAGCAGCTAGAAATAGACTTGAAAGCCGTGGGGCTCATACTAGAGAAG
ATTATCCAAAGCGAGATGATAAAAATTTCTTAAAACATAGCATTGTAAATTTAGAAAATGATGAATTAAAACTTAGTTAT
AAAGATGTCGTGGTAACTGAGTTTTCACTTGATGGAAGGAGAGTACAATGA

Upstream 100 bases:

>100_bases
TGAATTTTCTAGAAGAGATTTTATAAAAACAGCCTGTATTAGTGTAGGAGCTTTAGCTGCAAGTTCAAGTGGAGTTTATG
CTTTAGATGATTCATCTAAG

Downstream 100 bases:

>100_bases
AAATCATCATAGATCGTTTTAATGGCAAGGAAAAATATGAACAAAGTTATGATATTGATGATAAGGATATACAAGGAAAA
ACTCTGCTCTCTCTTTTACT

Product: succinate dehydrogenase, flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 576; Mature: 576

Protein sequence:

>576_residues
MDKDINLPSCDVLVIGSGGAGLRAAAAVRKENPKLSVVVATKMMPSRNATCMAEGGINGVTDFSNGDSYKLHAYDTIKGG
AYLVDQDAALKFCELAGKAIFNMDFIGTLFSRNEQGGVAQRLMGGASKKRCNYSADKTGHILMHSCLDDAISSGVKFLMD
HELLDIGVVDGKCEGVVLRDIQSGGIYPVLCKALVIATGGYTRIFYNRTSTPFIATGDGVAAALRAGLGFEDPEMIQFHP
TGVANGGTLITEAARGEGGYLLNNRGERFMKNYHEKMELAPRDVVARAIETEIREGRGYGEGLGAYVLCDVRHLGKEKIL
KDLPKIRHTAMLFENIDLVDTPVPIRPTAHYSMGGIEVAKFEDMSTKIAGIYVGGEASCISIHGANRLGGNSLADAVVTG
HLAGIGATNYAKDASFGKGAKTHELAQKWQVRFKEITNNGGNGQEMYELREELGSQNWDNMGIFRTQEKLDLLAKKLEDI
QARYEKIRIPNPNEVMNTAFTDYVELGNLILLSRCACLAARNRLESRGAHTREDYPKRDDKNFLKHSIVNLENDELKLSY
KDVVVTEFSLDGRRVQ

Sequences:

>Translated_576_residues
MDKDINLPSCDVLVIGSGGAGLRAAAAVRKENPKLSVVVATKMMPSRNATCMAEGGINGVTDFSNGDSYKLHAYDTIKGG
AYLVDQDAALKFCELAGKAIFNMDFIGTLFSRNEQGGVAQRLMGGASKKRCNYSADKTGHILMHSCLDDAISSGVKFLMD
HELLDIGVVDGKCEGVVLRDIQSGGIYPVLCKALVIATGGYTRIFYNRTSTPFIATGDGVAAALRAGLGFEDPEMIQFHP
TGVANGGTLITEAARGEGGYLLNNRGERFMKNYHEKMELAPRDVVARAIETEIREGRGYGEGLGAYVLCDVRHLGKEKIL
KDLPKIRHTAMLFENIDLVDTPVPIRPTAHYSMGGIEVAKFEDMSTKIAGIYVGGEASCISIHGANRLGGNSLADAVVTG
HLAGIGATNYAKDASFGKGAKTHELAQKWQVRFKEITNNGGNGQEMYELREELGSQNWDNMGIFRTQEKLDLLAKKLEDI
QARYEKIRIPNPNEVMNTAFTDYVELGNLILLSRCACLAARNRLESRGAHTREDYPKRDDKNFLKHSIVNLENDELKLSY
KDVVVTEFSLDGRRVQ
>Mature_576_residues
MDKDINLPSCDVLVIGSGGAGLRAAAAVRKENPKLSVVVATKMMPSRNATCMAEGGINGVTDFSNGDSYKLHAYDTIKGG
AYLVDQDAALKFCELAGKAIFNMDFIGTLFSRNEQGGVAQRLMGGASKKRCNYSADKTGHILMHSCLDDAISSGVKFLMD
HELLDIGVVDGKCEGVVLRDIQSGGIYPVLCKALVIATGGYTRIFYNRTSTPFIATGDGVAAALRAGLGFEDPEMIQFHP
TGVANGGTLITEAARGEGGYLLNNRGERFMKNYHEKMELAPRDVVARAIETEIREGRGYGEGLGAYVLCDVRHLGKEKIL
KDLPKIRHTAMLFENIDLVDTPVPIRPTAHYSMGGIEVAKFEDMSTKIAGIYVGGEASCISIHGANRLGGNSLADAVVTG
HLAGIGATNYAKDASFGKGAKTHELAQKWQVRFKEITNNGGNGQEMYELREELGSQNWDNMGIFRTQEKLDLLAKKLEDI
QARYEKIRIPNPNEVMNTAFTDYVELGNLILLSRCACLAARNRLESRGAHTREDYPKRDDKNFLKHSIVNLENDELKLSY
KDVVVTEFSLDGRRVQ

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=568, Percent_Identity=35.5633802816901, Blast_Score=320, Evalue=2e-87,
Organism=Escherichia coli, GI1790597, Length=546, Percent_Identity=36.6300366300366, Blast_Score=336, Evalue=3e-93,
Organism=Escherichia coli, GI1786942, Length=543, Percent_Identity=36.279926335175, Blast_Score=316, Evalue=3e-87,
Organism=Escherichia coli, GI1788928, Length=566, Percent_Identity=32.8621908127208, Blast_Score=218, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17550100, Length=572, Percent_Identity=34.965034965035, Blast_Score=323, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI17505833, Length=574, Percent_Identity=35.0174216027875, Blast_Score=315, Evalue=5e-86,
Organism=Saccharomyces cerevisiae, GI6322701, Length=553, Percent_Identity=35.8047016274864, Blast_Score=339, Evalue=6e-94,
Organism=Saccharomyces cerevisiae, GI6322416, Length=549, Percent_Identity=36.247723132969, Blast_Score=337, Evalue=2e-93,
Organism=Drosophila melanogaster, GI17137288, Length=573, Percent_Identity=35.0785340314136, Blast_Score=320, Evalue=1e-87,
Organism=Drosophila melanogaster, GI24655642, Length=573, Percent_Identity=35.0785340314136, Blast_Score=320, Evalue=1e-87,
Organism=Drosophila melanogaster, GI24655647, Length=573, Percent_Identity=35.0785340314136, Blast_Score=320, Evalue=1e-87,
Organism=Drosophila melanogaster, GI24663005, Length=529, Percent_Identity=34.593572778828, Blast_Score=288, Evalue=1e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 62834; Mature: 62834

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKDINLPSCDVLVIGSGGAGLRAAAAVRKENPKLSVVVATKMMPSRNATCMAEGGINGV
CCCCCCCCCCCEEEECCCCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCEEEECCCCCCC
TDFSNGDSYKLHAYDTIKGGAYLVDQDAALKFCELAGKAIFNMDFIGTLFSRNEQGGVAQ
CCCCCCCCEEEEEEEECCCCEEEEECHHHHHHHHHHCCHHCCHHHHHHHHCCCCCCCHHH
RLMGGASKKRCNYSADKTGHILMHSCLDDAISSGVKFLMDHELLDIGVVDGKCEGVVLRD
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEE
IQSGGIYPVLCKALVIATGGYTRIFYNRTSTPFIATGDGVAAALRAGLGFEDPEMIQFHP
CCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCEEECCCHHHHHHHHCCCCCCCCEEEEEC
TGVANGGTLITEAARGEGGYLLNNRGERFMKNYHEKMELAPRDVVARAIETEIREGRGYG
CCCCCCCEEEEECCCCCCCEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCC
EGLGAYVLCDVRHLGKEKILKDLPKIRHTAMLFENIDLVDTPVPIRPTAHYSMGGIEVAK
CCCCEEEEEEHHHCCHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCEEEEE
FEDMSTKIAGIYVGGEASCISIHGANRLGGNSLADAVVTGHLAGIGATNYAKDASFGKGA
ECCCCCEEEEEEECCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
KTHELAQKWQVRFKEITNNGGNGQEMYELREELGSQNWDNMGIFRTQEKLDLLAKKLEDI
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHHHH
QARYEKIRIPNPNEVMNTAFTDYVELGNLILLSRCACLAARNRLESRGAHTREDYPKRDD
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
KNFLKHSIVNLENDELKLSYKDVVVTEFSLDGRRVQ
HHHHHHHHCCCCCCCEEEEEEEEEEEEEECCCCCCC
>Mature Secondary Structure
MDKDINLPSCDVLVIGSGGAGLRAAAAVRKENPKLSVVVATKMMPSRNATCMAEGGINGV
CCCCCCCCCCCEEEECCCCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCEEEECCCCCCC
TDFSNGDSYKLHAYDTIKGGAYLVDQDAALKFCELAGKAIFNMDFIGTLFSRNEQGGVAQ
CCCCCCCCEEEEEEEECCCCEEEEECHHHHHHHHHHCCHHCCHHHHHHHHCCCCCCCHHH
RLMGGASKKRCNYSADKTGHILMHSCLDDAISSGVKFLMDHELLDIGVVDGKCEGVVLRD
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEE
IQSGGIYPVLCKALVIATGGYTRIFYNRTSTPFIATGDGVAAALRAGLGFEDPEMIQFHP
CCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCEEECCCHHHHHHHHCCCCCCCCEEEEEC
TGVANGGTLITEAARGEGGYLLNNRGERFMKNYHEKMELAPRDVVARAIETEIREGRGYG
CCCCCCCEEEEECCCCCCCEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCC
EGLGAYVLCDVRHLGKEKILKDLPKIRHTAMLFENIDLVDTPVPIRPTAHYSMGGIEVAK
CCCCEEEEEEHHHCCHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCEEEEE
FEDMSTKIAGIYVGGEASCISIHGANRLGGNSLADAVVTGHLAGIGATNYAKDASFGKGA
ECCCCCEEEEEEECCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
KTHELAQKWQVRFKEITNNGGNGQEMYELREELGSQNWDNMGIFRTQEKLDLLAKKLEDI
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHHHH
QARYEKIRIPNPNEVMNTAFTDYVELGNLILLSRCACLAARNRLESRGAHTREDYPKRDD
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
KNFLKHSIVNLENDELKLSYKDVVVTEFSLDGRRVQ
HHHHHHHHCCCCCCCEEEEEEEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA