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The map label for this gene is pheA [H]

Identifier: 57237367

GI number: 57237367

Start: 322082

End: 323155

Strand: Direct

Name: pheA [H]

Synonym: CJE0361

Alternate gene names: 57237367

Gene position: 322082-323155 (Clockwise)

Preceding gene: 57237366

Following gene: 57237368

Centisome position: 18.12

GC content: 31.28

Gene sequence:

>1074_bases
ATGCCAAATTTAGAAGAATTTAGAAATAAAATCGATGCGGTTGATGATAAAATTTTAGAACTTTTAAATGAAAGAATGAC
TTATGTTAAAAGTATAGGCGAGCTTAAACAAAGTAGTGGGGGAGCTATTTATCGTCCTGAGCGTGAAAGAGCCATTATCA
ATCGTTTAAAAAATGCAAATTTAGGACTTTTAGATCAAAATGCCATAGAGGCAATTTATCAAGAAATTTTTGCAGTTTCA
AGAAATTTAGAAATGCCTCAAACTATAGCTTATTTAGGGCCTGAGGGAACTTATACTCATCAAGCAGCAAGAAGTCGTTT
TGGTGCGATGAGTCGTTATATAGCCTTGGCTAATATCGAAGATGTTTTTAAAGAGTTAAGCAACAAAGAAGCAAAATACG
GTGTTGTGCCTATAGAAAATAATACCGAAGGTGCAGTAGGTATTACTTTAGATTGTCTAGGTAAGTATAATGAGCTTAAA
ATTTTTGGTGAAATTTATATGGATATTCATCATTCTTTTGTGGGAATTAATGAAAATTTAAAAGAAATCAAACGCATTTA
TTCGCATCCGCAAGGTTATAATCAATGTCGTAAATTTTTAGAAAGTCATGAACTTAGCGCTATAGAATTTGTTCCTTCAA
AATCTACGGCTAATGCGGCTTATTTAGCTTCGCAAGATAAATATGCGGCAGCAATTTGCTCTAAAATAGCGGCTAAGCTT
TATAATGTGCCTGTGCTTTTTGATAAAATAGAAGATAATGCAGCCAATAAAACAAGATTTTTAATTTTAAGCGATATTAA
AAATCCTAAAATGCCAAATTGTAAAACTTCTATTTTAGCACACACAGCACATAAACCTGGTGGGCTTAGCTTTTTATTAG
AGCAGTTTAAAAAAGAAAATATCAATCTTACTAAGCTTGAATCTCGTCCTGTAAAATCAAAAGAATTTTTACACAGTTTT
TACATAGATTTTGAAGGGCATATTGATGATGAAAATGTAAAAAAAGCTTTAAAAGATATACAAGAGATTGTTTGGCTTGG
ATCTTATTTATCAGGAGAAAAAGATGAAATTTAA

Upstream 100 bases:

>100_bases
TGCTGGTTTTAAGCGGAAAGATAAGCGACACAAAAGGGCTTGATACGGATTTGCTTGATGGAGTTTATCCTAGTGTTTTT
GAGTTTTTAAAGGAGCTAAA

Downstream 100 bases:

>100_bases
TGAATTTTTAAATCATTTAAGCAATTATGAACCCGGAAAAGATATAGAAGTTATTGCCAAAGAATATGGCGTTAAAGAAG
TGATAAAATTAGCAAGTAAT

Product: chorismate mutase/prephenate dehydratase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydratase; PDT [H]

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MPNLEEFRNKIDAVDDKILELLNERMTYVKSIGELKQSSGGAIYRPERERAIINRLKNANLGLLDQNAIEAIYQEIFAVS
RNLEMPQTIAYLGPEGTYTHQAARSRFGAMSRYIALANIEDVFKELSNKEAKYGVVPIENNTEGAVGITLDCLGKYNELK
IFGEIYMDIHHSFVGINENLKEIKRIYSHPQGYNQCRKFLESHELSAIEFVPSKSTANAAYLASQDKYAAAICSKIAAKL
YNVPVLFDKIEDNAANKTRFLILSDIKNPKMPNCKTSILAHTAHKPGGLSFLLEQFKKENINLTKLESRPVKSKEFLHSF
YIDFEGHIDDENVKKALKDIQEIVWLGSYLSGEKDEI

Sequences:

>Translated_357_residues
MPNLEEFRNKIDAVDDKILELLNERMTYVKSIGELKQSSGGAIYRPERERAIINRLKNANLGLLDQNAIEAIYQEIFAVS
RNLEMPQTIAYLGPEGTYTHQAARSRFGAMSRYIALANIEDVFKELSNKEAKYGVVPIENNTEGAVGITLDCLGKYNELK
IFGEIYMDIHHSFVGINENLKEIKRIYSHPQGYNQCRKFLESHELSAIEFVPSKSTANAAYLASQDKYAAAICSKIAAKL
YNVPVLFDKIEDNAANKTRFLILSDIKNPKMPNCKTSILAHTAHKPGGLSFLLEQFKKENINLTKLESRPVKSKEFLHSF
YIDFEGHIDDENVKKALKDIQEIVWLGSYLSGEKDEI
>Mature_356_residues
PNLEEFRNKIDAVDDKILELLNERMTYVKSIGELKQSSGGAIYRPERERAIINRLKNANLGLLDQNAIEAIYQEIFAVSR
NLEMPQTIAYLGPEGTYTHQAARSRFGAMSRYIALANIEDVFKELSNKEAKYGVVPIENNTEGAVGITLDCLGKYNELKI
FGEIYMDIHHSFVGINENLKEIKRIYSHPQGYNQCRKFLESHELSAIEFVPSKSTANAAYLASQDKYAAAICSKIAAKLY
NVPVLFDKIEDNAANKTRFLILSDIKNPKMPNCKTSILAHTAHKPGGLSFLLEQFKKENINLTKLESRPVKSKEFLHSFY
IDFEGHIDDENVKKALKDIQEIVWLGSYLSGEKDEI

Specific function: L-phenylalanine biosynthesis. [C]

COG id: COG0077

COG function: function code E; Prephenate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate dehydratase domain [H]

Homologues:

Organism=Escherichia coli, GI1788951, Length=373, Percent_Identity=32.7077747989276, Blast_Score=167, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6324013, Length=325, Percent_Identity=25.5384615384615, Blast_Score=85, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR008242
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR010957
- InterPro:   IPR001086
- InterPro:   IPR018528 [H]

Pfam domain/function: PF01842 ACT; PF01817 CM_2; PF00800 PDT [H]

EC number: =5.4.99.5; =4.2.1.51 [H]

Molecular weight: Translated: 40448; Mature: 40316

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00857 PREPHENATE_DEHYDR_1 ; PS00858 PREPHENATE_DEHYDR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNLEEFRNKIDAVDDKILELLNERMTYVKSIGELKQSSGGAIYRPERERAIINRLKNAN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHCCCC
LGLLDQNAIEAIYQEIFAVSRNLEMPQTIAYLGPEGTYTHQAARSRFGAMSRYIALANIE
CCCCCHHHHHHHHHHHHHHHCCCCCCHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
DVFKELSNKEAKYGVVPIENNTEGAVGITLDCLGKYNELKIFGEIYMDIHHSFVGINENL
HHHHHHCCCCCCCCEEECCCCCCCCEEEEHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCH
KEIKRIYSHPQGYNQCRKFLESHELSAIEFVPSKSTANAAYLASQDKYAAAICSKIAAKL
HHHHHHHCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCEEECCHHHHHHHHHHHHHHH
YNVPVLFDKIEDNAANKTRFLILSDIKNPKMPNCKTSILAHTAHKPGGLSFLLEQFKKEN
HCCCCEEECCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHCC
INLTKLESRPVKSKEFLHSFYIDFEGHIDDENVKKALKDIQEIVWLGSYLSGEKDEI
CCEEEECCCCCHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PNLEEFRNKIDAVDDKILELLNERMTYVKSIGELKQSSGGAIYRPERERAIINRLKNAN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHCCCC
LGLLDQNAIEAIYQEIFAVSRNLEMPQTIAYLGPEGTYTHQAARSRFGAMSRYIALANIE
CCCCCHHHHHHHHHHHHHHHCCCCCCHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
DVFKELSNKEAKYGVVPIENNTEGAVGITLDCLGKYNELKIFGEIYMDIHHSFVGINENL
HHHHHHCCCCCCCCEEECCCCCCCCEEEEHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCH
KEIKRIYSHPQGYNQCRKFLESHELSAIEFVPSKSTANAAYLASQDKYAAAICSKIAAKL
HHHHHHHCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCEEECCHHHHHHHHHHHHHHH
YNVPVLFDKIEDNAANKTRFLILSDIKNPKMPNCKTSILAHTAHKPGGLSFLLEQFKKEN
HCCCCEEECCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHCC
INLTKLESRPVKSKEFLHSFYIDFEGHIDDENVKKALKDIQEIVWLGSYLSGEKDEI
CCEEEECCCCCHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]