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The map label for this gene is hisC [H]

Identifier: 57237368

GI number: 57237368

Start: 323145

End: 324239

Strand: Direct

Name: hisC [H]

Synonym: CJE0362

Alternate gene names: 57237368

Gene position: 323145-324239 (Clockwise)

Preceding gene: 57237367

Following gene: 57237369

Centisome position: 18.18

GC content: 28.86

Gene sequence:

>1095_bases
ATGAAATTTAATGAATTTTTAAATCATTTAAGCAATTATGAACCCGGAAAAGATATAGAAGTTATTGCCAAAGAATATGG
CGTTAAAGAAGTGATAAAATTAGCAAGTAATGAAAATCCTTTTGGTACGCCACCAAAAGCCATAGAATGCTTAAGACAAA
ATGCAAACAAAGCTCATCTTTACCCTGATGATAGTATGATAGAACTTAAAAGCACATTGGCTCAAAAATACAAAGTTCAA
AATGAAAATATCATCATCGGTGCAGGTAGTGATCAAGTGATTGAATTTGCTATACATGCTAAGTTAAATTCTAAAAATGC
TTTTTTACAAGCTGGAGTTACCTTTGCTATGTATGAAATTTATGCCAAACAATGCGGTGCAAAGTGTTATAAAACTCAAA
GCATTACTCATGATTTAAATGAGTTTAAAAAGCTTTATGAAGCACACAAAGATGAAATTAAACTCATTTTCTTATGCTTG
CCAAATAATCCTTTAGGCGAGTGTTTGGATGCAAGTGAAGTGACCAAGTTTATTAAAGGTGTGGATGAGGATTGTTTAGT
TGTGATTGATGCAGCTTATAATGAATTTGCAAGTTTTAAAGATAGCAAAAAACATTTAGAACCTTGTGAATTGATTAAAG
AATTTGACAATGTACTTTATTTGGGAACTTTTTCTAAACTTTATGGATTAGGAGGCTTACGCATTGGTTATGGTATAGCT
AATGCTAATATTATTAGTGCATTTTACAAGCTTCGTGCTCCTTTTAATGTGAGCAATCTTGCTTTAAAAGCAGCAGTTGC
AGCAATAAATGATGATGAATTTGCTAAAAAAACTTTAGAGAATAATTTTTCTCAAATGGAGCTTTATAAAGAATTTGCTA
AAAAACATAATATCAAAATCATTGATAGTTATACAAATTTCATCACTTATTTTTTTAATGAAAAAAATAGTACAGATTTG
TCTGAAAAATTGCTTAAAAAGGGTATAATAATAAGAAATTTAAAAAGCTATGGTTTAAATGCTATACGCATTACTATAGG
AACATCTTATGAAAATGAAAAATTTTTTACAGAATTTGATAAGATTTTAAGATAG

Upstream 100 bases:

>100_bases
ATAGATTTTGAAGGGCATATTGATGATGAAAATGTAAAAAAAGCTTTAAAAGATATACAAGAGATTGTTTGGCTTGGATC
TTATTTATCAGGAGAAAAAG

Downstream 100 bases:

>100_bases
ATAAATCAAATAAAAATATGTAAAATTCGCTAAACTAAGGGATGAGAATTAATGGATTTTAAAAATATGCTTCATCAAAT
TGGGCAACTTTATCAAAATT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MKFNEFLNHLSNYEPGKDIEVIAKEYGVKEVIKLASNENPFGTPPKAIECLRQNANKAHLYPDDSMIELKSTLAQKYKVQ
NENIIIGAGSDQVIEFAIHAKLNSKNAFLQAGVTFAMYEIYAKQCGAKCYKTQSITHDLNEFKKLYEAHKDEIKLIFLCL
PNNPLGECLDASEVTKFIKGVDEDCLVVIDAAYNEFASFKDSKKHLEPCELIKEFDNVLYLGTFSKLYGLGGLRIGYGIA
NANIISAFYKLRAPFNVSNLALKAAVAAINDDEFAKKTLENNFSQMELYKEFAKKHNIKIIDSYTNFITYFFNEKNSTDL
SEKLLKKGIIIRNLKSYGLNAIRITIGTSYENEKFFTEFDKILR

Sequences:

>Translated_364_residues
MKFNEFLNHLSNYEPGKDIEVIAKEYGVKEVIKLASNENPFGTPPKAIECLRQNANKAHLYPDDSMIELKSTLAQKYKVQ
NENIIIGAGSDQVIEFAIHAKLNSKNAFLQAGVTFAMYEIYAKQCGAKCYKTQSITHDLNEFKKLYEAHKDEIKLIFLCL
PNNPLGECLDASEVTKFIKGVDEDCLVVIDAAYNEFASFKDSKKHLEPCELIKEFDNVLYLGTFSKLYGLGGLRIGYGIA
NANIISAFYKLRAPFNVSNLALKAAVAAINDDEFAKKTLENNFSQMELYKEFAKKHNIKIIDSYTNFITYFFNEKNSTDL
SEKLLKKGIIIRNLKSYGLNAIRITIGTSYENEKFFTEFDKILR
>Mature_364_residues
MKFNEFLNHLSNYEPGKDIEVIAKEYGVKEVIKLASNENPFGTPPKAIECLRQNANKAHLYPDDSMIELKSTLAQKYKVQ
NENIIIGAGSDQVIEFAIHAKLNSKNAFLQAGVTFAMYEIYAKQCGAKCYKTQSITHDLNEFKKLYEAHKDEIKLIFLCL
PNNPLGECLDASEVTKFIKGVDEDCLVVIDAAYNEFASFKDSKKHLEPCELIKEFDNVLYLGTFSKLYGLGGLRIGYGIA
NANIISAFYKLRAPFNVSNLALKAAVAAINDDEFAKKTLENNFSQMELYKEFAKKHNIKIIDSYTNFITYFFNEKNSTDL
SEKLLKKGIIIRNLKSYGLNAIRITIGTSYENEKFFTEFDKILR

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=323, Percent_Identity=26.625386996904, Blast_Score=108, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6322075, Length=372, Percent_Identity=27.6881720430108, Blast_Score=104, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 41323; Mature: 41323

Theoretical pI: Translated: 7.46; Mature: 7.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFNEFLNHLSNYEPGKDIEVIAKEYGVKEVIKLASNENPFGTPPKAIECLRQNANKAHL
CCHHHHHHHHHCCCCCCCHHHHHHHHCHHHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEE
YPDDSMIELKSTLAQKYKVQNENIIIGAGSDQVIEFAIHAKLNSKNAFLQAGVTFAMYEI
CCCCHHHHHHHHHHHHHEECCCCEEEECCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHH
YAKQCGAKCYKTQSITHDLNEFKKLYEAHKDEIKLIFLCLPNNPLGECLDASEVTKFIKG
HHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHCCHHHHHHHHHC
VDEDCLVVIDAAYNEFASFKDSKKHLEPCELIKEFDNVLYLGTFSKLYGLGGLRIGYGIA
CCCCCEEEEEHHHHHHHHHCCCHHCCCHHHHHHHHHCEEEEECHHHHHCCCCCEEEEECC
NANIISAFYKLRAPFNVSNLALKAAVAAINDDEFAKKTLENNFSQMELYKEFAKKHNIKI
CHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCEE
IDSYTNFITYFFNEKNSTDLSEKLLKKGIIIRNLKSYGLNAIRITIGTSYENEKFFTEFD
EECHHHEEEEEECCCCCCCHHHHHHHCCHHEECHHHCCCEEEEEEEECCCCCCHHHHHHH
KILR
HHHC
>Mature Secondary Structure
MKFNEFLNHLSNYEPGKDIEVIAKEYGVKEVIKLASNENPFGTPPKAIECLRQNANKAHL
CCHHHHHHHHHCCCCCCCHHHHHHHHCHHHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEE
YPDDSMIELKSTLAQKYKVQNENIIIGAGSDQVIEFAIHAKLNSKNAFLQAGVTFAMYEI
CCCCHHHHHHHHHHHHHEECCCCEEEECCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHH
YAKQCGAKCYKTQSITHDLNEFKKLYEAHKDEIKLIFLCLPNNPLGECLDASEVTKFIKG
HHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHCCHHHHHHHHHC
VDEDCLVVIDAAYNEFASFKDSKKHLEPCELIKEFDNVLYLGTFSKLYGLGGLRIGYGIA
CCCCCEEEEEHHHHHHHHHCCCHHCCCHHHHHHHHHCEEEEECHHHHHCCCCCEEEEECC
NANIISAFYKLRAPFNVSNLALKAAVAAINDDEFAKKTLENNFSQMELYKEFAKKHNIKI
CHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCEE
IDSYTNFITYFFNEKNSTDLSEKLLKKGIIIRNLKSYGLNAIRITIGTSYENEKFFTEFD
EECHHHEEEEEECCCCCCCHHHHHHHCCHHEECHHHCCCEEEEEEEECCCCCCHHHHHHH
KILR
HHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA