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The map label for this gene is bioA [H]

Identifier: 57237358

GI number: 57237358

Start: 315263

End: 316546

Strand: Direct

Name: bioA [H]

Synonym: CJE0352

Alternate gene names: 57237358

Gene position: 315263-316546 (Clockwise)

Preceding gene: 57237350

Following gene: 57237362

Centisome position: 17.73

GC content: 34.03

Gene sequence:

>1284_bases
ATGCAAAATGAAATTTTAAAAAAACTCGATTTAGAGCATATTTGGCACCCTTGTACGCAAATGAAAGATCATGAAAATTT
GCCACTCATTCCTATAAAAAGAGCTAAAGGAGTGTGGCTTTATGATTTTGATGATAAGGCTTATATGGACTGTGTGAGCT
CGTGGTGGGTAAATCTTTTTGGGCATTGTAATGAAAAAATCGCAAATGCCATTAAAAAACAAGTTGATGAGCTAGAGCAT
GTGATTTTAGCAGGTTTTACACATGAGCCCATCATCAAGCTTTCTGCAAGACTTTGCGAAAAAGTAGGCAGGAATTTTAA
CAAATGTTTTTACGCAGATAATGGTTCAAGTGCCATTGAAGTAGCACTTAAGATGAGCTTTCATTATCATTTAAATAAGG
GAGTGAAAAAAAGTAAATTTTTATCTTTAAGTAATTCTTATCATGGTGAAACCTTAGGAGCCTTAAGTGTAGGAGATGTA
GCACTTTATAAAGATACTTATAAGCCTTTACTTTTAGAGTGTTTAAGCACGCCTGTGCCACAAGGCAAAGACTACACTCA
AGAGCTTGAAATTTTAAAAGATATTTTAGAAAAAAATGCAAGTGAAATTTGCGCTTTTATACTTGAACCTTTGGTGCAAT
GTGCGGGAAATATGCATATGTATGAAGCAGGGTTCATTGATGAGGCCATAAAGCTTTGCCATAAATTTGGAGTGCAAGTG
ATTTTTGATGAAATTGCAGTGGGCTTTGGACGCACAGGAACTTTGTTTGCCTTACATCAATGCAAACAAAGCCCCGATTT
TATCTGCCTTTCAAAAGGGATAACGGGTGGATTTATGCCACTTTCTGTAGTGCTTACAAGAGATGAAATTTATAATGCTT
TTTATGATACTTATGAAAGCCAAAAGGCTTTTTTACATTCTCATAGCTATACGGGAAATACCTTAGCTTGCGCGGCAGCA
AATGCGGTTTTAGATATCTTTGAGGATGAAAATATTTTAGTAAAAAATCAAATTTTAAGCGAGTTTATCAAAAAAGAATT
TTCAAGACTTGAAAAATTTGACTTTTTGGGTAATTTTAGAACTTGCGGGATGATCAGTGCTTTTGATATTTTAAGCACCA
AGTATAAACGCGTAGGACTTTTTGTATTTCAAAAAGCCTTAGAAAAAGGTTTGCTTTTAAGACCTTTAGCAAATACGATT
TATTTTATGCCTCCTTACATCATCACAAAAGAACAAATCGTTTATGTACTAGAGAGTTTAGAGCAGATTTTTAAGGAATT
TTAA

Upstream 100 bases:

>100_bases
TTTCAAGGGCTTCTAAGATATTTTCAAGGCTCATTTTTTTCCTAAAATTCAGAAATTTAAAGTATTATTTTGCCAAAATA
TATTTAAAAAAGAAGTTATA

Downstream 100 bases:

>100_bases
GTTGTAAAATTTCTTGCATTTGCTCTTTAAAATCTTTATTTAAAATGCTATTTTCATCAAAAAAATCAAGATTGATTATA
GGAATTTTTGCATAATTTTT

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MQNEILKKLDLEHIWHPCTQMKDHENLPLIPIKRAKGVWLYDFDDKAYMDCVSSWWVNLFGHCNEKIANAIKKQVDELEH
VILAGFTHEPIIKLSARLCEKVGRNFNKCFYADNGSSAIEVALKMSFHYHLNKGVKKSKFLSLSNSYHGETLGALSVGDV
ALYKDTYKPLLLECLSTPVPQGKDYTQELEILKDILEKNASEICAFILEPLVQCAGNMHMYEAGFIDEAIKLCHKFGVQV
IFDEIAVGFGRTGTLFALHQCKQSPDFICLSKGITGGFMPLSVVLTRDEIYNAFYDTYESQKAFLHSHSYTGNTLACAAA
NAVLDIFEDENILVKNQILSEFIKKEFSRLEKFDFLGNFRTCGMISAFDILSTKYKRVGLFVFQKALEKGLLLRPLANTI
YFMPPYIITKEQIVYVLESLEQIFKEF

Sequences:

>Translated_427_residues
MQNEILKKLDLEHIWHPCTQMKDHENLPLIPIKRAKGVWLYDFDDKAYMDCVSSWWVNLFGHCNEKIANAIKKQVDELEH
VILAGFTHEPIIKLSARLCEKVGRNFNKCFYADNGSSAIEVALKMSFHYHLNKGVKKSKFLSLSNSYHGETLGALSVGDV
ALYKDTYKPLLLECLSTPVPQGKDYTQELEILKDILEKNASEICAFILEPLVQCAGNMHMYEAGFIDEAIKLCHKFGVQV
IFDEIAVGFGRTGTLFALHQCKQSPDFICLSKGITGGFMPLSVVLTRDEIYNAFYDTYESQKAFLHSHSYTGNTLACAAA
NAVLDIFEDENILVKNQILSEFIKKEFSRLEKFDFLGNFRTCGMISAFDILSTKYKRVGLFVFQKALEKGLLLRPLANTI
YFMPPYIITKEQIVYVLESLEQIFKEF
>Mature_427_residues
MQNEILKKLDLEHIWHPCTQMKDHENLPLIPIKRAKGVWLYDFDDKAYMDCVSSWWVNLFGHCNEKIANAIKKQVDELEH
VILAGFTHEPIIKLSARLCEKVGRNFNKCFYADNGSSAIEVALKMSFHYHLNKGVKKSKFLSLSNSYHGETLGALSVGDV
ALYKDTYKPLLLECLSTPVPQGKDYTQELEILKDILEKNASEICAFILEPLVQCAGNMHMYEAGFIDEAIKLCHKFGVQV
IFDEIAVGFGRTGTLFALHQCKQSPDFICLSKGITGGFMPLSVVLTRDEIYNAFYDTYESQKAFLHSHSYTGNTLACAAA
NAVLDIFEDENILVKNQILSEFIKKEFSRLEKFDFLGNFRTCGMISAFDILSTKYKRVGLFVFQKALEKGLLLRPLANTI
YFMPPYIITKEQIVYVLESLEQIFKEF

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=425, Percent_Identity=28, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI37574042, Length=425, Percent_Identity=25.8823529411765, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI13994255, Length=429, Percent_Identity=26.1072261072261, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI226442705, Length=425, Percent_Identity=25.4117647058824, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI226442709, Length=395, Percent_Identity=25.5696202531646, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI24119277, Length=429, Percent_Identity=23.7762237762238, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI284507298, Length=319, Percent_Identity=26.6457680250784, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1786991, Length=423, Percent_Identity=34.7517730496454, Blast_Score=248, Evalue=6e-67,
Organism=Escherichia coli, GI145693181, Length=388, Percent_Identity=27.319587628866, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1789759, Length=387, Percent_Identity=27.1317829457364, Blast_Score=158, Evalue=5e-40,
Organism=Escherichia coli, GI1789016, Length=415, Percent_Identity=28.433734939759, Blast_Score=151, Evalue=9e-38,
Organism=Escherichia coli, GI1788044, Length=404, Percent_Identity=25.990099009901, Blast_Score=141, Evalue=6e-35,
Organism=Escherichia coli, GI1787560, Length=410, Percent_Identity=25.609756097561, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1786349, Length=303, Percent_Identity=28.3828382838284, Blast_Score=93, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI32564660, Length=437, Percent_Identity=24.7139588100687, Blast_Score=134, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI25144271, Length=401, Percent_Identity=26.1845386533666, Blast_Score=128, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI71992977, Length=433, Percent_Identity=23.094688221709, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25144274, Length=270, Percent_Identity=28.1481481481481, Blast_Score=104, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6324386, Length=466, Percent_Identity=32.8326180257511, Blast_Score=234, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6324432, Length=402, Percent_Identity=28.3582089552239, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6323470, Length=420, Percent_Identity=25.7142857142857, Blast_Score=124, Evalue=4e-29,
Organism=Drosophila melanogaster, GI21356575, Length=434, Percent_Identity=25.1152073732719, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI161085790, Length=429, Percent_Identity=26.5734265734266, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI21357415, Length=417, Percent_Identity=26.1390887290168, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI28574759, Length=430, Percent_Identity=25.8139534883721, Blast_Score=124, Evalue=8e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 48653; Mature: 48653

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNEILKKLDLEHIWHPCTQMKDHENLPLIPIKRAKGVWLYDFDDKAYMDCVSSWWVNLF
CCCHHHHHHCHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHHHH
GHCNEKIANAIKKQVDELEHVILAGFTHEPIIKLSARLCEKVGRNFNKCFYADNGSSAIE
HHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCEE
VALKMSFHYHLNKGVKKSKFLSLSNSYHGETLGALSVGDVALYKDTYKPLLLECLSTPVP
EHHHHHHHHHHCCCCCHHHHEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
QGKDYTQELEILKDILEKNASEICAFILEPLVQCAGNMHMYEAGFIDEAIKLCHKFGVQV
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHCHHH
IFDEIAVGFGRTGTLFALHQCKQSPDFICLSKGITGGFMPLSVVLTRDEIYNAFYDTYES
HHHHHHHCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCHHHHEEEHHHHHHHHHHHHHH
QKAFLHSHSYTGNTLACAAANAVLDIFEDENILVKNQILSEFIKKEFSRLEKFDFLGNFR
HHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCC
TCGMISAFDILSTKYKRVGLFVFQKALEKGLLLRPLANTIYFMPPYIITKEQIVYVLESL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEECCCEEECHHHHHHHHHHH
EQIFKEF
HHHHHHC
>Mature Secondary Structure
MQNEILKKLDLEHIWHPCTQMKDHENLPLIPIKRAKGVWLYDFDDKAYMDCVSSWWVNLF
CCCHHHHHHCHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHHHH
GHCNEKIANAIKKQVDELEHVILAGFTHEPIIKLSARLCEKVGRNFNKCFYADNGSSAIE
HHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCEE
VALKMSFHYHLNKGVKKSKFLSLSNSYHGETLGALSVGDVALYKDTYKPLLLECLSTPVP
EHHHHHHHHHHCCCCCHHHHEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
QGKDYTQELEILKDILEKNASEICAFILEPLVQCAGNMHMYEAGFIDEAIKLCHKFGVQV
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHCHHH
IFDEIAVGFGRTGTLFALHQCKQSPDFICLSKGITGGFMPLSVVLTRDEIYNAFYDTYES
HHHHHHHCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCHHHHEEEHHHHHHHHHHHHHH
QKAFLHSHSYTGNTLACAAANAVLDIFEDENILVKNQILSEFIKKEFSRLEKFDFLGNFR
HHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCC
TCGMISAFDILSTKYKRVGLFVFQKALEKGLLLRPLANTIYFMPPYIITKEQIVYVLESL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEECCCEEECHHHHHHHHHHH
EQIFKEF
HHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]