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The map label for this gene is lpxB

Identifier: 57237343

GI number: 57237343

Start: 301743

End: 302837

Strand: Reverse

Name: lpxB

Synonym: CJE0336

Alternate gene names: 57237343

Gene position: 302837-301743 (Counterclockwise)

Preceding gene: 57237344

Following gene: 57237342

Centisome position: 17.03

GC content: 29.04

Gene sequence:

>1095_bases
TTGAAAACCTTTTTAGTTTGTGCTTTAGAACCTTCAGCAAATTTGCATTTAAAAGAAGTTTTAAAAGCTTATAAAAAAGA
TTTTGGTGAATTTGAACTTCATGGGATTTATGATGAGAGTTTATGTAAGGAATTTGATTTAAATTCTAAACCACTTTATA
GCTCACATGAATTTAGTGCTATGGGTTTTATAGAAGTTTTACCTTTGATTTTCAAAGCAAAAAAAGCGATCAAAGAATTA
GTGAATCTAACTTTAAGCCAAACAATGGACGCAGTTTTATGTATCGATTCTCCCGCTTTTAATATCCCTTTTGCCAAGGC
TTTAAAAAAAGCAGGCAGTAAAATTCCACGCATTTATTATATCTTGCCTCAAGTTTGGGCGTGGAAAAAAGGTCGCATAC
CTATCATAGAAAGTCATTTTGATATTTTAGCTTCTATTTTGCCCTTTGATAATCAATTTTTTAACAAAAGCACCTATATA
GGCCATCCGCTTTTAGATGAGATAAAAGAATTTAAAAATCAAGAAGATATTAATCATACATTTTCAAAAAAAGATGATGA
AAAAACTATAGCCTTTTTACCAGGTTCAAGGCGTAGTGAAATTAGGCGTTTAATGCCTATTTTTAAAGAACTTTCTCAAA
AATTTAAGGGTGAAAAAATTCTTTGCGTTCCCTCATTTAATCTTGAAAAATTAGAAGTTTATGGTGATATTAGCGAATTT
AAGATAGAAAGTAACACTCCAAAAGTGCTTAAAAAAGCTGATTTTGCCTTTATTTGTAGTGGAACAGCTACTTTAGAAGC
AGCTTTAGTGGGAACTCCTTTTGTTCTTGCTTATAAGGCAAAGGCTATCGATATTTTTATCGCAAAACTTTTTGTAAAAT
TAAAACATATAGGACTTGCAAATATTTTTTGTGATTTCGCTGGAAAAGAAGCTTTAAATCCTGAATTTTTACAAGATAAA
GTCAATGTTTTAAATTTATATGAAGCTTACAATAAATATGATTATAAGGCATTTTTTGCTAAAGTTGATTTTTTAAAAGA
ATATTTACAATTTGGAAGTGCTAAAAATTTAGCAAAAATCCTAAACGAAATATAA

Upstream 100 bases:

>100_bases
ATAAATCTTCATACACGCTTTTTAGCGTGTATTCTTCCATAACTTCTTTTAATTAAGCCAAAATAAGATAAAATGTTTAA
AATATTGATAAGGAAATTTT

Downstream 100 bases:

>100_bases
AAGGATAAATCATGCAAAAAGAACCAATGAGTCAATTTGGCTATGATAAGTTAGCCGCAGAATTAAAAGATTTAAAAGAC
AATCAACGCCCTGCCGTTGT

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MKTFLVCALEPSANLHLKEVLKAYKKDFGEFELHGIYDESLCKEFDLNSKPLYSSHEFSAMGFIEVLPLIFKAKKAIKEL
VNLTLSQTMDAVLCIDSPAFNIPFAKALKKAGSKIPRIYYILPQVWAWKKGRIPIIESHFDILASILPFDNQFFNKSTYI
GHPLLDEIKEFKNQEDINHTFSKKDDEKTIAFLPGSRRSEIRRLMPIFKELSQKFKGEKILCVPSFNLEKLEVYGDISEF
KIESNTPKVLKKADFAFICSGTATLEAALVGTPFVLAYKAKAIDIFIAKLFVKLKHIGLANIFCDFAGKEALNPEFLQDK
VNVLNLYEAYNKYDYKAFFAKVDFLKEYLQFGSAKNLAKILNEI

Sequences:

>Translated_364_residues
MKTFLVCALEPSANLHLKEVLKAYKKDFGEFELHGIYDESLCKEFDLNSKPLYSSHEFSAMGFIEVLPLIFKAKKAIKEL
VNLTLSQTMDAVLCIDSPAFNIPFAKALKKAGSKIPRIYYILPQVWAWKKGRIPIIESHFDILASILPFDNQFFNKSTYI
GHPLLDEIKEFKNQEDINHTFSKKDDEKTIAFLPGSRRSEIRRLMPIFKELSQKFKGEKILCVPSFNLEKLEVYGDISEF
KIESNTPKVLKKADFAFICSGTATLEAALVGTPFVLAYKAKAIDIFIAKLFVKLKHIGLANIFCDFAGKEALNPEFLQDK
VNVLNLYEAYNKYDYKAFFAKVDFLKEYLQFGSAKNLAKILNEI
>Mature_364_residues
MKTFLVCALEPSANLHLKEVLKAYKKDFGEFELHGIYDESLCKEFDLNSKPLYSSHEFSAMGFIEVLPLIFKAKKAIKEL
VNLTLSQTMDAVLCIDSPAFNIPFAKALKKAGSKIPRIYYILPQVWAWKKGRIPIIESHFDILASILPFDNQFFNKSTYI
GHPLLDEIKEFKNQEDINHTFSKKDDEKTIAFLPGSRRSEIRRLMPIFKELSQKFKGEKILCVPSFNLEKLEVYGDISEF
KIESNTPKVLKKADFAFICSGTATLEAALVGTPFVLAYKAKAIDIFIAKLFVKLKHIGLANIFCDFAGKEALNPEFLQDK
VNVLNLYEAYNKYDYKAFFAKVDFLKEYLQFGSAKNLAKILNEI

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family

Homologues:

Organism=Escherichia coli, GI1786379, Length=333, Percent_Identity=27.6276276276276, Blast_Score=120, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXB_CAMJ8 (A8FK76)

Other databases:

- EMBL:   CP000814
- RefSeq:   YP_001481840.1
- ProteinModelPortal:   A8FK76
- STRING:   A8FK76
- GeneID:   5617098
- GenomeReviews:   CP000814_GR
- KEGG:   cju:C8J_0264
- eggNOG:   COG0763
- HOGENOM:   HBG584837
- OMA:   EFAFICS
- ProtClustDB:   PRK14089
- BioCyc:   CJEJ407148:C8J_0264-MONOMER
- HAMAP:   MF_00392
- InterPro:   IPR003835
- TIGRFAMs:   TIGR00215

Pfam domain/function: PF02684 LpxB

EC number: =2.4.1.182

Molecular weight: Translated: 41568; Mature: 41568

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTFLVCALEPSANLHLKEVLKAYKKDFGEFELHGIYDESLCKEFDLNSKPLYSSHEFSA
CCEEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEECCHHHHHHHCCCCCCCCCCCCCCHH
MGFIEVLPLIFKAKKAIKELVNLTLSQTMDAVLCIDSPAFNIPFAKALKKAGSKIPRIYY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHCCCCCEEEE
ILPQVWAWKKGRIPIIESHFDILASILPFDNQFFNKSTYIGHPLLDEIKEFKNQEDINHT
ECCHHHCCCCCCCCEEHHHHHHHHHHCCCCHHHCCCCCCCCCHHHHHHHHHCCHHHHHHH
FSKKDDEKTIAFLPGSRRSEIRRLMPIFKELSQKFKGEKILCVPSFNLEKLEVYGDISEF
HCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEEECHHHE
KIESNTPKVLKKADFAFICSGTATLEAALVGTPFVLAYKAKAIDIFIAKLFVKLKHIGLA
EECCCCHHHHHHCCEEEEECCCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHCCHH
NIFCDFAGKEALNPEFLQDKVNVLNLYEAYNKYDYKAFFAKVDFLKEYLQFGSAKNLAKI
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHH
LNEI
HHCC
>Mature Secondary Structure
MKTFLVCALEPSANLHLKEVLKAYKKDFGEFELHGIYDESLCKEFDLNSKPLYSSHEFSA
CCEEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEECCHHHHHHHCCCCCCCCCCCCCCHH
MGFIEVLPLIFKAKKAIKELVNLTLSQTMDAVLCIDSPAFNIPFAKALKKAGSKIPRIYY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHCCCCCEEEE
ILPQVWAWKKGRIPIIESHFDILASILPFDNQFFNKSTYIGHPLLDEIKEFKNQEDINHT
ECCHHHCCCCCCCCEEHHHHHHHHHHCCCCHHHCCCCCCCCCHHHHHHHHHCCHHHHHHH
FSKKDDEKTIAFLPGSRRSEIRRLMPIFKELSQKFKGEKILCVPSFNLEKLEVYGDISEF
HCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEEECHHHE
KIESNTPKVLKKADFAFICSGTATLEAALVGTPFVLAYKAKAIDIFIAKLFVKLKHIGLA
EECCCCHHHHHHCCEEEEECCCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHCCHH
NIFCDFAGKEALNPEFLQDKVNVLNLYEAYNKYDYKAFFAKVDFLKEYLQFGSAKNLAKI
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHH
LNEI
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA