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The map label for this gene is cdtB [H]

Identifier: 57237086

GI number: 57237086

Start: 88474

End: 89271

Strand: Reverse

Name: cdtB [H]

Synonym: CJE0074

Alternate gene names: 57237086

Gene position: 89271-88474 (Counterclockwise)

Preceding gene: 57237087

Following gene: 57237085

Centisome position: 5.02

GC content: 36.47

Gene sequence:

>798_bases
ATGAAAAAAATTATATGTTTATTTTTATCTTTTAACCTTGCTTTTGCAAATTTAGAAAATTTTAATGTTGGCACTTGGAA
TTTGCAAGGCTCATCCGCAGCCACAGAAAGCAAATGGAGTGTTAGCGTAAGACAACTTGTAAGTGGAGCAAACCCCTTAG
ATATCTTAATGATACAAGAAGCAGGAACTTTACCAAGAACAGCCACTCCAACAGGACGCCATGTGCAACAAGGTGGAACA
CCTATTGATGAATATGAGTGGAATTTAGGAACTCTTTCAAGGCCTGATAGGGTTTTTATTTATTATTCTCGCGTTGATGT
AGGAGCTAATCGTGTAAATTTAGCTATAGTTTCAAGAATGCAAGCTGAAGAAGTGATTGTTTTACCTCCACCTACTACAG
TTTCAAGACCCATTATAGGAATTCGCAATGGAAATGATGCTTTTTTCAATATCCATGCTTTAGCTAATGGAGGAACAGAT
GTAGGAGCAATTATCACAGCTGTAGATGCACATTTTGCAAATATGCCTCAAGTTAACTGGATGATAGCAGGGGATTTTAA
CCGTGATCCTTCTACTATAACAAGTACAGTGGATAGAGAATTAGCAAATAGAATTAGAGTGGTTTTTCCAACTAGCGCAA
CTCAAGCAAGCGGAGGGACTCTTGATTATGCAATTACAGGAAATTCAAATAGACAACAAGCCTATACTCCACCGCTTTTA
GCTGCAATTTTAATGCTTGCAAGTTTAAGATCTCATATAGTTTCAGATCATTTTCCAGTAAATTTTAGAAAATTTTAG

Upstream 100 bases:

>100_bases
TTACCGTAGAGTGTGCAAAAAAAGATAATTTTGATCAACAATGGTTTTTAACTACTCCGCCTTTTACTGCAAAACCTTTA
TATCGCCAAGGAGAGGTACG

Downstream 100 bases:

>100_bases
GACATTTAATATGAAAAAAATTATTACTTTGTTTTTTATGTTTATAACTTTAGCCTTTGCAACTCCTACTGGAGATTTGA
AAGATTTTACCGAAATGGTT

Product: cytolethal distending toxin, subunit B

Products: NA

Alternate protein names: CDT B; Deoxyribonuclease CdtB [H]

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MKKIICLFLSFNLAFANLENFNVGTWNLQGSSAATESKWSVSVRQLVSGANPLDILMIQEAGTLPRTATPTGRHVQQGGT
PIDEYEWNLGTLSRPDRVFIYYSRVDVGANRVNLAIVSRMQAEEVIVLPPPTTVSRPIIGIRNGNDAFFNIHALANGGTD
VGAIITAVDAHFANMPQVNWMIAGDFNRDPSTITSTVDRELANRIRVVFPTSATQASGGTLDYAITGNSNRQQAYTPPLL
AAILMLASLRSHIVSDHFPVNFRKF

Sequences:

>Translated_265_residues
MKKIICLFLSFNLAFANLENFNVGTWNLQGSSAATESKWSVSVRQLVSGANPLDILMIQEAGTLPRTATPTGRHVQQGGT
PIDEYEWNLGTLSRPDRVFIYYSRVDVGANRVNLAIVSRMQAEEVIVLPPPTTVSRPIIGIRNGNDAFFNIHALANGGTD
VGAIITAVDAHFANMPQVNWMIAGDFNRDPSTITSTVDRELANRIRVVFPTSATQASGGTLDYAITGNSNRQQAYTPPLL
AAILMLASLRSHIVSDHFPVNFRKF
>Mature_265_residues
MKKIICLFLSFNLAFANLENFNVGTWNLQGSSAATESKWSVSVRQLVSGANPLDILMIQEAGTLPRTATPTGRHVQQGGT
PIDEYEWNLGTLSRPDRVFIYYSRVDVGANRVNLAIVSRMQAEEVIVLPPPTTVSRPIIGIRNGNDAFFNIHALANGGTD
VGAIITAVDAHFANMPQVNWMIAGDFNRDPSTITSTVDRELANRIRVVFPTSATQASGGTLDYAITGNSNRQQAYTPPLL
AAILMLASLRSHIVSDHFPVNFRKF

Specific function: Produces a CDT (cytolethal distending toxin) activity, which causes DNA damage in intoxicated cells. This damage induces G2/M cell cycle arrest, chromatin fragmentation, cell distention and nucleus enlargement [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted. Note=Localized to the nucleus of infected cells [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003539
- InterPro:   IPR005135 [H]

Pfam domain/function: PF03372 Exo_endo_phos [H]

EC number: NA

Molecular weight: Translated: 28943; Mature: 28943

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIICLFLSFNLAFANLENFNVGTWNLQGSSAATESKWSVSVRQLVSGANPLDILMIQE
CCEEEEEEEEECEEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEC
AGTLPRTATPTGRHVQQGGTPIDEYEWNLGTLSRPDRVFIYYSRVDVGANRVNLAIVSRM
CCCCCCCCCCCCCHHHCCCCCCHHEECCCCCCCCCCEEEEEEEEEECCCCEEEEEEEECC
QAEEVIVLPPPTTVSRPIIGIRNGNDAFFNIHALANGGTDVGAIITAVDAHFANMPQVNW
CCCCEEEECCCCCCCCCEEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEE
MIAGDFNRDPSTITSTVDRELANRIRVVFPTSATQASGGTLDYAITGNSNRQQAYTPPLL
EEEECCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCHHH
AAILMLASLRSHIVSDHFPVNFRKF
HHHHHHHHHHHHHHCCCCCCEEECC
>Mature Secondary Structure
MKKIICLFLSFNLAFANLENFNVGTWNLQGSSAATESKWSVSVRQLVSGANPLDILMIQE
CCEEEEEEEEECEEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEC
AGTLPRTATPTGRHVQQGGTPIDEYEWNLGTLSRPDRVFIYYSRVDVGANRVNLAIVSRM
CCCCCCCCCCCCCHHHCCCCCCHHEECCCCCCCCCCEEEEEEEEEECCCCEEEEEEEECC
QAEEVIVLPPPTTVSRPIIGIRNGNDAFFNIHALANGGTDVGAIITAVDAHFANMPQVNW
CCCCEEEECCCCCCCCCEEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEE
MIAGDFNRDPSTITSTVDRELANRIRVVFPTSATQASGGTLDYAITGNSNRQQAYTPPLL
EEEECCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCHHH
AAILMLASLRSHIVSDHFPVNFRKF
HHHHHHHHHHHHHHCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]